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Calcium-transporting ATPase type 2C member 1 (ATPase 2C1) (EC 3.6.3.8) (ATP-dependent Ca(2 ) pump PMR1)

 AT2C1_RAT               Reviewed;         919 AA.
Q64566; Q64567;
30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
01-NOV-1996, sequence version 1.
20-JUN-2018, entry version 146.
RecName: Full=Calcium-transporting ATPase type 2C member 1;
Short=ATPase 2C1;
EC=3.6.3.8;
AltName: Full=ATP-dependent Ca(2+) pump PMR1;
Name=Atp2c1;
Rattus norvegicus (Rat).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Rattus.
NCBI_TaxID=10116;
[1]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS LONG AND SHORT), AND TISSUE
SPECIFICITY.
STRAIN=Sprague-Dawley; TISSUE=Stomach, and Testis;
PubMed=1380825; DOI=10.1021/bi00148a023;
Gunteski-Hamblin A.-M., Clarke D.M., Shull G.E.;
"Molecular cloning and tissue distribution of alternatively spliced
mRNAs encoding possible mammalian homologues of the yeast secretory
pathway calcium pump.";
Biochemistry 31:7600-7608(1992).
-!- FUNCTION: This magnesium-dependent enzyme catalyzes the hydrolysis
of ATP coupled with the transport of the calcium. {ECO:0000250}.
-!- CATALYTIC ACTIVITY: ATP + H(2)O + Ca(2+)(Side 1) = ADP + phosphate
+ Ca(2+)(Side 2).
-!- SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250};
Multi-pass membrane protein {ECO:0000250}.
-!- ALTERNATIVE PRODUCTS:
Event=Alternative splicing; Named isoforms=2;
Name=Short;
IsoId=Q64566-1; Sequence=Displayed;
Name=Long;
IsoId=Q64566-2; Sequence=VSP_000411;
-!- TISSUE SPECIFICITY: Ubiquitously expressed. The long isoform is
only found in testis. {ECO:0000269|PubMed:1380825}.
-!- SIMILARITY: Belongs to the cation transport ATPase (P-type) (TC
3.A.3) family. Type IIA subfamily. {ECO:0000305}.
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EMBL; M93017; AAA73341.1; -; mRNA.
EMBL; M93018; AAA73342.1; -; mRNA.
PIR; A42764; A42764.
UniGene; Rn.5805; -.
ProteinModelPortal; Q64566; -.
SMR; Q64566; -.
STRING; 10116.ENSRNOP00000018175; -.
iPTMnet; Q64566; -.
PhosphoSitePlus; Q64566; -.
SwissPalm; Q64566; -.
PaxDb; Q64566; -.
PRIDE; Q64566; -.
UCSC; RGD:621311; rat. [Q64566-1]
RGD; 621311; Atp2c1.
eggNOG; KOG0202; Eukaryota.
eggNOG; COG0474; LUCA.
HOGENOM; HOG000265621; -.
HOVERGEN; HBG106478; -.
InParanoid; Q64566; -.
PhylomeDB; Q64566; -.
PRO; PR:Q64566; -.
Proteomes; UP000002494; Unplaced.
GO; GO:0005794; C:Golgi apparatus; IDA:RGD.
GO; GO:0000139; C:Golgi membrane; ISS:UniProtKB.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0043231; C:intracellular membrane-bounded organelle; IDA:RGD.
GO; GO:0005886; C:plasma membrane; IDA:RGD.
GO; GO:0030141; C:secretory granule; IDA:RGD.
GO; GO:0005802; C:trans-Golgi network; ISS:UniProtKB.
GO; GO:0030133; C:transport vesicle; IDA:RGD.
GO; GO:0005524; F:ATP binding; ISS:UniProtKB.
GO; GO:0005509; F:calcium ion binding; ISS:UniProtKB.
GO; GO:0005388; F:calcium-transporting ATPase activity; IDA:RGD.
GO; GO:0030145; F:manganese ion binding; ISS:UniProtKB.
GO; GO:0015410; F:manganese-transporting ATPase activity; ISS:UniProtKB.
GO; GO:0031532; P:actin cytoskeleton reorganization; ISS:UniProtKB.
GO; GO:0070509; P:calcium ion import; IC:RGD.
GO; GO:0006816; P:calcium ion transport; IDA:RGD.
GO; GO:0016339; P:calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules; ISS:UniProtKB.
GO; GO:0006874; P:cellular calcium ion homeostasis; IMP:RGD.
GO; GO:0030026; P:cellular manganese ion homeostasis; ISS:UniProtKB.
GO; GO:0008544; P:epidermis development; ISS:UniProtKB.
GO; GO:0032468; P:Golgi calcium ion homeostasis; ISS:UniProtKB.
GO; GO:0032472; P:Golgi calcium ion transport; ISS:UniProtKB.
GO; GO:0006828; P:manganese ion transport; ISS:UniProtKB.
GO; GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB signaling; ISS:UniProtKB.
Gene3D; 3.40.1110.10; -; 1.
Gene3D; 3.40.50.1000; -; 2.
InterPro; IPR030336; ATP2C1.
InterPro; IPR006068; ATPase_P-typ_cation-transptr_C.
InterPro; IPR004014; ATPase_P-typ_cation-transptr_N.
InterPro; IPR023299; ATPase_P-typ_cyto_dom_N.
InterPro; IPR018303; ATPase_P-typ_P_site.
InterPro; IPR023298; ATPase_P-typ_TM_dom_sf.
InterPro; IPR008250; ATPase_P-typ_transduc_dom_A_sf.
InterPro; IPR036412; HAD-like_sf.
InterPro; IPR023214; HAD_sf.
InterPro; IPR006413; P-type_ATPase_IIA_PMR1.
InterPro; IPR001757; P_typ_ATPase.
PANTHER; PTHR42861:SF2; PTHR42861:SF2; 1.
Pfam; PF00689; Cation_ATPase_C; 1.
Pfam; PF00690; Cation_ATPase_N; 1.
PRINTS; PR00120; HATPASE.
SMART; SM00831; Cation_ATPase_N; 1.
SUPFAM; SSF56784; SSF56784; 2.
SUPFAM; SSF81653; SSF81653; 1.
SUPFAM; SSF81660; SSF81660; 1.
SUPFAM; SSF81665; SSF81665; 3.
TIGRFAMs; TIGR01522; ATPase-IIA2_Ca; 1.
TIGRFAMs; TIGR01494; ATPase_P-type; 3.
PROSITE; PS00154; ATPASE_E1_E2; 1.
2: Evidence at transcript level;
Alternative splicing; ATP-binding; Calcium; Calcium transport;
Complete proteome; Golgi apparatus; Hydrolase; Ion transport;
Magnesium; Membrane; Metal-binding; Nucleotide-binding;
Reference proteome; Transmembrane; Transmembrane helix; Transport.
CHAIN 1 919 Calcium-transporting ATPase type 2C
member 1.
/FTId=PRO_0000046225.
TOPO_DOM 1 78 Cytoplasmic. {ECO:0000255}.
TRANSMEM 79 95 Helical. {ECO:0000255}.
TOPO_DOM 96 99 Extracellular. {ECO:0000255}.
TRANSMEM 100 121 Helical. {ECO:0000255}.
TOPO_DOM 122 263 Cytoplasmic. {ECO:0000255}.
TRANSMEM 264 283 Helical. {ECO:0000255}.
TOPO_DOM 284 295 Extracellular. {ECO:0000255}.
TRANSMEM 296 317 Helical. {ECO:0000255}.
TOPO_DOM 318 700 Cytoplasmic. {ECO:0000255}.
TRANSMEM 701 723 Helical. {ECO:0000255}.
TOPO_DOM 724 728 Extracellular. {ECO:0000255}.
TRANSMEM 729 752 Helical. {ECO:0000255}.
TOPO_DOM 753 776 Cytoplasmic. {ECO:0000255}.
TRANSMEM 777 795 Helical. {ECO:0000255}.
TOPO_DOM 796 802 Extracellular. {ECO:0000255}.
TRANSMEM 803 828 Helical. {ECO:0000255}.
TOPO_DOM 829 843 Cytoplasmic. {ECO:0000255}.
TRANSMEM 844 863 Helical. {ECO:0000255}.
TOPO_DOM 864 876 Extracellular. {ECO:0000255}.
TRANSMEM 877 893 Helical. {ECO:0000255}.
TOPO_DOM 894 919 Cytoplasmic. {ECO:0000255}.
ACT_SITE 350 350 4-aspartylphosphate intermediate.
{ECO:0000250}.
METAL 644 644 Magnesium. {ECO:0000250}.
METAL 648 648 Magnesium. {ECO:0000250}.
VAR_SEQ 919 919 V -> FYPKI (in isoform Long).
{ECO:0000303|PubMed:1380825}.
/FTId=VSP_000411.
CONFLICT 538 538 L -> F (in Ref. 1; AAA73342).
{ECO:0000305}.
SEQUENCE 919 AA; 100500 MW; D26C8C95C14DFB8A CRC64;
MKVARFQKIP NVENETMIPV LTSKRASELA VSEVAGLLQA DLQNGLNKSE VSHRRAFHGW
NEFDISEDEP LWKKYISQFK NPLIMLLLAS AVISVLMRQF DDAVSITVAI LIVVTVAFVQ
EYRSEKSLEE LSKLVPPECH CVREGKLEHT LARDLVPGDT VCLSVGDRVP ADLRLFEAVD
LSIDESSLTG ETTPCSKVTA PQPAATNGDL ASRSNIAFMG TLVRCGKAKG IVIGTGENSE
FGEVFKMMQA EEAPKTPLQK SMDLLGKQLS FYSFGIIGII MLVGWLLGKD ILEMFTISVS
LAVAAIPEGL PIVVTVTLAL GVMRMVKKRA IVKKLPIVET LGCCNVICSD KTGTLTKNEM
TVTHILTSDG LHAEVTGVGY NQFGEVIVDG DVVHGFYNPA VSRIVEAGCV CNDAVIRNNT
LMGKPTEGAL IALAMKMGLD GLQQDYIRKA EYPFSSEQKW MAVKCVHRTQ QDRPEICFMK
GAYEQVIKYC TTYNSKGQTL ALTQQQRDLY QQEKAQMGSA GLRVLALASG PDLGQLTLLG
LVGIIDPPRT GVKEAVTTLI ASGVSIKMIT GDSQETAIAI ASRLGLYSKT SQSVSGEEVD
TMEVQHLSQI VPKVAVFYRA SPRHKMKIIK SLQKNGSVVA MTGDGVNDAV ALKAADIGVA
MGQTGTDVCK EAADMILVDD DFQTIMSAIE EGKGIYNNIK NFVRFQLSTS IAALTLISLA
TLMNFPNPLN AMQILWINII MDGPPAQSLG VEPVDKDVIR KPPRNWKDSI LTKNLILKIL
VSSIIIVCGT LFVFWRELRD NVITPRDTTM TFTCFVFFDM FNALSSRSQT KSVFEIGLCS
NKMFCYAVLG SIMGQLLVIY FPPLQKVFQT ESLSILDLLF LLGLTSSVCI VSEIIKKVER
SREKTQKNTT STPSSFLEV


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