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Calpain small subunit 1 (Fragment)

 A0A075B7C0_HUMAN        Unreviewed;       197 AA.
A0A075B7C0;
01-OCT-2014, integrated into UniProtKB/TrEMBL.
01-OCT-2014, sequence version 1.
30-AUG-2017, entry version 26.
SubName: Full=Calpain small subunit 1 {ECO:0000313|Ensembl:ENSP00000474036};
Flags: Fragment;
Name=CAPNS1 {ECO:0000313|Ensembl:ENSP00000474036};
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000474036, ECO:0000313|Proteomes:UP000005640};
[1] {ECO:0000313|Ensembl:ENSP00000474036, ECO:0000313|Proteomes:UP000005640}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
PubMed=15057824; DOI=10.1038/nature02399;
Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J.,
Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M.,
Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E.,
Caenepeel S., Carrano A.V., Caoile C., Chan Y.M., Christensen M.,
Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C.,
Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M.,
Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T.,
Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H.,
Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S.,
Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J.,
Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M.,
Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J.,
Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D.,
Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A.,
Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I.,
Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
Rubin E.M., Lucas S.M.;
"The DNA sequence and biology of human chromosome 19.";
Nature 428:529-535(2004).
[2] {ECO:0000213|PubMed:19608861}
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
PubMed=19608861; DOI=10.1126/science.1175371;
Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M.,
Walther T.C., Olsen J.V., Mann M.;
"Lysine acetylation targets protein complexes and co-regulates major
cellular functions.";
Science 325:834-840(2009).
[3] {ECO:0000213|PubMed:21269460}
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
PubMed=21269460; DOI=10.1186/1752-0509-5-17;
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
Burckstummer T., Bennett K.L., Superti-Furga G., Colinge J.;
"Initial characterization of the human central proteome.";
BMC Syst. Biol. 5:17-17(2011).
[4] {ECO:0000213|PubMed:24275569}
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D.,
Wang L., Ye M., Zou H.;
"An enzyme assisted RP-RPLC approach for in-depth analysis of human
liver phosphoproteome.";
J. Proteomics 96:253-262(2014).
[5] {ECO:0000313|Ensembl:ENSP00000474036}
IDENTIFICATION.
Ensembl;
Submitted (JUL-2014) to UniProtKB.
[6] {ECO:0000213|PubMed:25944712}
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
PubMed=25944712;
Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M.,
Ayoub D., Lane L., Bairoch A., Van Dorsselaer A., Carapito C.;
"N-terminome analysis of the human mitochondrial proteome.";
Proteomics 15:2519-2524(2015).
-!- CAUTION: Lacks conserved residue(s) required for the propagation
of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00448}.
-!- CAUTION: The sequence shown here is derived from an Ensembl
automatic analysis pipeline and should be considered as
preliminary data. {ECO:0000313|Ensembl:ENSP00000474036}.
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EMBL; AD001527; -; NOT_ANNOTATED_CDS; Genomic_DNA.
ProteinModelPortal; A0A075B7C0; -.
SMR; A0A075B7C0; -.
PaxDb; A0A075B7C0; -.
PeptideAtlas; A0A075B7C0; -.
Ensembl; ENST00000590049; ENSP00000474036; ENSG00000126247.
UCSC; uc060xno.1; human.
HGNC; HGNC:1481; CAPNS1.
OpenTargets; ENSG00000126247; -.
eggNOG; KOG0037; Eukaryota.
eggNOG; ENOG410YKQK; LUCA.
GeneTree; ENSGT00620000087734; -.
Proteomes; UP000005640; Chromosome 19.
Bgee; ENSG00000126247; -.
ExpressionAtlas; A0A075B7C0; baseline and differential.
GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
InterPro; IPR011992; EF-hand-dom_pair.
InterPro; IPR018247; EF_Hand_1_Ca_BS.
InterPro; IPR002048; EF_hand_dom.
Pfam; PF13833; EF-hand_8; 1.
SUPFAM; SSF47473; SSF47473; 1.
PROSITE; PS00018; EF_HAND_1; 1.
PROSITE; PS50222; EF_HAND_2; 3.
1: Evidence at protein level;
Calcium {ECO:0000256|PROSITE-ProRule:PRU00448};
Complete proteome {ECO:0000313|Proteomes:UP000005640};
Proteomics identification {ECO:0000213|EPD:A0A075B7C0,
ECO:0000213|MaxQB:A0A075B7C0, ECO:0000213|PeptideAtlas:A0A075B7C0};
Reference proteome {ECO:0000313|Proteomes:UP000005640};
Signal {ECO:0000256|SAM:SignalP}.
SIGNAL 1 25 {ECO:0000256|SAM:SignalP}.
CHAIN 26 197 {ECO:0000256|SAM:SignalP}.
/FTId=PRO_5001705786.
DOMAIN 90 118 EF-hand. {ECO:0000259|PROSITE:PS50222}.
DOMAIN 120 155 EF-hand. {ECO:0000259|PROSITE:PS50222}.
DOMAIN 170 190 EF-hand. {ECO:0000259|PROSITE:PS50222}.
CA_BIND 103 114 {ECO:0000256|PROSITE-ProRule:PRU00448}.
CA_BIND 133 144 {ECO:0000256|PROSITE-ProRule:PRU00448}.
NON_TER 1 1 {ECO:0000313|Ensembl:ENSP00000474036}.
SEQUENCE 197 AA; 21912 MW; EB4F64DE30CE097E CRC64;
GGGGGGGTAM RILGGVISAI SEAAAQYNPE PPPPRTHYSN IEANESEEVR QFRRLFAQLA
GDDMEVSATE LMNILNKVVT RHPDLKTDGF GIDTCRSMVA VMDSDTTGKL GFEEFKYLWN
NIKRWQAIYK QFDTDRSGTI CSSELPGAFE AAGFHLNEHL YNMIIRRYSD ESGNMDFDNF
ISCLAQEEIN MPQLLIS


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