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Calpain-10 (EC 3.4.22.-) (Calcium-activated neutral proteinase 10) (CANP 10)

 CAN10_RAT               Reviewed;         666 AA.
Q9ES66;
12-FEB-2003, integrated into UniProtKB/Swiss-Prot.
01-MAR-2001, sequence version 1.
10-MAY-2017, entry version 91.
RecName: Full=Calpain-10;
EC=3.4.22.-;
AltName: Full=Calcium-activated neutral proteinase 10;
Short=CANP 10;
Name=Capn10;
Rattus norvegicus (Rat).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Rattus.
NCBI_TaxID=10116;
[1]
NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
STRAIN=Sprague-Dawley;
PubMed=11375982; DOI=10.1074/jbc.M100603200;
Ma H., Fukiage C., Kim Y.H., Duncan M.K., Reed N.A., Shih M.,
Azuma M., Shearer T.R.;
"Characterization and expression of calpain 10. A novel ubiquitous
calpain with nuclear localization.";
J. Biol. Chem. 276:28525-28531(2001).
-!- FUNCTION: Calcium-regulated non-lysosomal thiol-protease which
catalyze limited proteolysis of substrates involved in
cytoskeletal remodeling and signal transduction. May play a role
in insulin-stimulated glucose uptake (By similarity).
{ECO:0000250}.
-!- CATALYTIC ACTIVITY: Broad endopeptidase specificity.
-!- SUBCELLULAR LOCATION: Cytoplasm. Nucleus.
-!- TISSUE SPECIFICITY: Ubiquitous. {ECO:0000269|PubMed:11375982}.
-!- SIMILARITY: Belongs to the peptidase C2 family. {ECO:0000305}.
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EMBL; AF227909; AAG09736.3; -; mRNA.
RefSeq; NP_113861.1; NM_031673.2.
UniGene; Rn.176334; -.
ProteinModelPortal; Q9ES66; -.
STRING; 10116.ENSRNOP00000067567; -.
ChEMBL; CHEMBL6130; -.
MEROPS; C02.018; -.
PaxDb; Q9ES66; -.
PRIDE; Q9ES66; -.
GeneID; 63834; -.
KEGG; rno:63834; -.
CTD; 11132; -.
RGD; 69354; Capn10.
eggNOG; KOG0045; Eukaryota.
eggNOG; ENOG410XP0B; LUCA.
HOVERGEN; HBG050787; -.
InParanoid; Q9ES66; -.
KO; K08579; -.
PhylomeDB; Q9ES66; -.
BRENDA; 3.4.22.B30; 5301.
PRO; PR:Q9ES66; -.
Proteomes; UP000002494; Unplaced.
GO; GO:0005938; C:cell cortex; IDA:RGD.
GO; GO:0005737; C:cytoplasm; IDA:RGD.
GO; GO:0005856; C:cytoskeleton; IDA:RGD.
GO; GO:0005829; C:cytosol; IDA:BHF-UCL.
GO; GO:0043231; C:intracellular membrane-bounded organelle; IDA:RGD.
GO; GO:0005743; C:mitochondrial inner membrane; IDA:RGD.
GO; GO:0005758; C:mitochondrial intermembrane space; IDA:RGD.
GO; GO:0005759; C:mitochondrial matrix; IDA:RGD.
GO; GO:0005741; C:mitochondrial outer membrane; IDA:RGD.
GO; GO:0005634; C:nucleus; IDA:RGD.
GO; GO:0005886; C:plasma membrane; IDA:BHF-UCL.
GO; GO:0004198; F:calcium-dependent cysteine-type endopeptidase activity; IDA:RGD.
GO; GO:0008092; F:cytoskeletal protein binding; IDA:BHF-UCL.
GO; GO:0000149; F:SNARE binding; IDA:BHF-UCL.
GO; GO:0031532; P:actin cytoskeleton reorganization; IMP:RGD.
GO; GO:0007568; P:aging; IDA:RGD.
GO; GO:0032869; P:cellular response to insulin stimulus; IEA:InterPro.
GO; GO:0007005; P:mitochondrion organization; IMP:RGD.
GO; GO:0000422; P:mitophagy; IMP:RGD.
GO; GO:0043065; P:positive regulation of apoptotic process; IMP:RGD.
GO; GO:0006508; P:proteolysis; IDA:RGD.
GO; GO:0009749; P:response to glucose; IEP:RGD.
GO; GO:0031667; P:response to nutrient levels; IDA:RGD.
CDD; cd00214; Calpain_III; 2.
CDD; cd00044; CysPc; 1.
InterPro; IPR033883; C2_III.
InterPro; IPR022684; Calpain_cysteine_protease.
InterPro; IPR022682; Calpain_domain_III.
InterPro; IPR022683; Calpain_III.
InterPro; IPR028791; CAPN10.
InterPro; IPR000169; Pept_cys_AS.
InterPro; IPR001300; Peptidase_C2_calpain_cat.
PANTHER; PTHR10183:SF326; PTHR10183:SF326; 1.
Pfam; PF01067; Calpain_III; 2.
Pfam; PF00648; Peptidase_C2; 1.
PRINTS; PR00704; CALPAIN.
SMART; SM00720; calpain_III; 2.
SMART; SM00230; CysPc; 1.
SUPFAM; SSF49758; SSF49758; 2.
PROSITE; PS50203; CALPAIN_CAT; 1.
PROSITE; PS00139; THIOL_PROTEASE_CYS; 1.
2: Evidence at transcript level;
Complete proteome; Cytoplasm; Hydrolase; Nucleus; Protease;
Reference proteome; Repeat; Thiol protease.
CHAIN 1 666 Calpain-10.
/FTId=PRO_0000207728.
DOMAIN 13 321 Calpain catalytic. {ECO:0000255|PROSITE-
ProRule:PRU00239}.
REGION 322 488 Domain III 1.
REGION 507 648 Domain III 2.
ACT_SITE 73 73 {ECO:0000250}.
ACT_SITE 238 238 {ECO:0000250}.
ACT_SITE 263 263 {ECO:0000250}.
SEQUENCE 666 AA; 74527 MW; A92263A9C8C4947D CRC64;
MRAVRAETRA RELFRDAAFP ASDSSLFYNL STPLAQFRED ITWRRPQDIC ATPQLFPDNP
WEGQVKQGLL GDCWFLCACA ALQKSRHLLD QVFPPGQPGW SDQEYQGFFT CRIWQFGHWE
EVTIDDRLPC LAGRLCFSRC QREDVFWLPL LEKAYAKVHG SYEHLWAGQV ADALVDLTGS
LAERWSLKDI RKASGQQDRP SGGEHRACQQ LLRLKDQCLL SCSVLSPRAG ARELGEFHAF
IISDLQELRS QTGQGILLLR IHNPWGRRCW QGLWREGGEG WNQVEPAKES ELLAQLQEGE
FWVEEEEFLR EFDEVTIGYP VTEAGHLQSL YTEKVLCHTR ALPGAWVTGQ SAGGCRNNSC
FPCNPKFWLR LLEPSEVCVA VLQRPRRRLV GQTRALAGAS PAPVNLPGKD YQAVGLHIWK
VEKRKISLPR VLSAPPVAGT ACHAYDREIH LRCELSPGYY LAVPSTFLKD VPGQFLLRVF
STGKISLSAV RLATKGASPG AALPAGEWET VQLQGSWRAG QTAGGSRNFA SYPCNPCLPF
SVPEGAGPRY IRITLQQHCR LSDSQLHPIG FHVFQVPADG EKQDACSLLL QEPLLSCVPH
CYAQEVSRLC LLSAGNYRIV PSTYLPDTEG TFTVTIATRI DRQSIHSQEM LGQLLQEVSF
MAVMKA


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