Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

Calpain-3 (EC 3.4.22.54) (Calcium-activated neutral proteinase 3) (CANP 3) (Calpain L3) (Calpain p94) (Muscle-specific calcium-activated neutral protease 3) (New calpain 1) (nCL-1)

 CAN3_BOVIN              Reviewed;         822 AA.
P51186; O97700; Q9TTH9;
01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
16-JUN-2003, sequence version 2.
30-AUG-2017, entry version 130.
RecName: Full=Calpain-3;
EC=3.4.22.54;
AltName: Full=Calcium-activated neutral proteinase 3;
Short=CANP 3;
AltName: Full=Calpain L3;
AltName: Full=Calpain p94;
AltName: Full=Muscle-specific calcium-activated neutral protease 3;
AltName: Full=New calpain 1;
Short=nCL-1;
Name=CAPN3; Synonyms=NCL1;
Bos taurus (Bovine).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
Pecora; Bovidae; Bovinae; Bos.
NCBI_TaxID=9913;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Skeletal muscle;
PubMed=10612236; DOI=10.1046/j.1365-2052.1999.00550.x;
Nonneman D., Koohmaraie M.;
"Molecular cloning and mapping of the bovine and ovine skeletal
muscle-specific calpains.";
Anim. Genet. 30:456-458(1999).
[2]
NUCLEOTIDE SEQUENCE [MRNA] OF 278-394.
TISSUE=Skeletal muscle;
Sun W., Bidwell C.A., Ji S., Hancock D.L.;
Submitted (APR-1994) to the EMBL/GenBank/DDBJ databases.
[3]
NUCLEOTIDE SEQUENCE [MRNA] OF 288-604.
PubMed=11204692; DOI=10.2527/2001.791122x;
Ilian M.A., Morton J.D., Kent M.P., Le Couteur C.E., Hickford J.,
Cowley R., Bickerstaffe R.;
"Intermuscular variation in tenderness: association with the
ubiquitous and muscle-specific calpains.";
J. Anim. Sci. 79:122-132(2001).
-!- FUNCTION: Calcium-regulated non-lysosomal thiol-protease.
-!- CATALYTIC ACTIVITY: Broad endopeptidase activity.
-!- ENZYME REGULATION: Activated by micromolar concentrations of
calcium and inhibited by calpastatin.
-!- SUBUNIT: Homodimer; via EF-hand domain 4. Interacts with
TTN/titin. Interacts with CMYA5; this interaction, which results
in CMYA5 proteolysis, may protect CAPN3 from autolysis.
{ECO:0000250|UniProtKB:P20807}.
-!- SUBCELLULAR LOCATION: Cytoplasm.
-!- TISSUE SPECIFICITY: Skeletal muscle.
-!- SIMILARITY: Belongs to the peptidase C2 family. {ECO:0000305}.
-----------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
Distributed under the Creative Commons Attribution-NoDerivs License
-----------------------------------------------------------------------
EMBL; AF087569; AAF23261.1; -; mRNA.
EMBL; U07858; AAC24459.1; -; mRNA.
EMBL; AF115744; AAD05333.1; -; mRNA.
RefSeq; NP_776685.1; NM_174260.2.
UniGene; Bt.3961; -.
ProteinModelPortal; P51186; -.
SMR; P51186; -.
STRING; 9913.ENSBTAP00000011677; -.
MEROPS; C02.004; -.
PaxDb; P51186; -.
PRIDE; P51186; -.
GeneID; 281663; -.
KEGG; bta:281663; -.
CTD; 825; -.
eggNOG; KOG0045; Eukaryota.
eggNOG; ENOG410XP0B; LUCA.
HOGENOM; HOG000232035; -.
HOVERGEN; HBG012645; -.
InParanoid; P51186; -.
KO; K08573; -.
BRENDA; 3.4.22.54; 908.
Proteomes; UP000009136; Unplaced.
GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
GO; GO:0005829; C:cytosol; ISS:UniProtKB.
GO; GO:0030016; C:myofibril; ISS:UniProtKB.
GO; GO:0005634; C:nucleus; ISS:UniProtKB.
GO; GO:0005886; C:plasma membrane; ISS:UniProtKB.
GO; GO:0043234; C:protein complex; ISS:UniProtKB.
GO; GO:0030315; C:T-tubule; ISS:UniProtKB.
GO; GO:0030018; C:Z disc; ISS:UniProtKB.
GO; GO:0005509; F:calcium ion binding; ISS:UniProtKB.
GO; GO:0004198; F:calcium-dependent cysteine-type endopeptidase activity; ISS:UniProtKB.
GO; GO:0003824; F:catalytic activity; ISS:UniProtKB.
GO; GO:0055103; F:ligase regulator activity; ISS:UniProtKB.
GO; GO:0008233; F:peptidase activity; ISS:UniProtKB.
GO; GO:0032947; F:protein complex scaffold activity; ISS:UniProtKB.
GO; GO:0031402; F:sodium ion binding; ISS:UniProtKB.
GO; GO:0008307; F:structural constituent of muscle; ISS:UniProtKB.
GO; GO:0031432; F:titin binding; ISS:UniProtKB.
GO; GO:0071277; P:cellular response to calcium ion; ISS:UniProtKB.
GO; GO:0071472; P:cellular response to salt stress; ISS:UniProtKB.
GO; GO:0061061; P:muscle structure development; ISS:UniProtKB.
GO; GO:0030239; P:myofibril assembly; ISS:UniProtKB.
GO; GO:0043066; P:negative regulation of apoptotic process; ISS:UniProtKB.
GO; GO:0033234; P:negative regulation of protein sumoylation; ISS:UniProtKB.
GO; GO:0045892; P:negative regulation of transcription, DNA-templated; ISS:UniProtKB.
GO; GO:0051092; P:positive regulation of NF-kappaB transcription factor activity; ISS:UniProtKB.
GO; GO:0045862; P:positive regulation of proteolysis; ISS:UniProtKB.
GO; GO:0051281; P:positive regulation of release of sequestered calcium ion into cytosol; ISS:UniProtKB.
GO; GO:0014718; P:positive regulation of satellite cell activation involved in skeletal muscle regeneration; ISS:UniProtKB.
GO; GO:0045893; P:positive regulation of transcription, DNA-templated; ISS:UniProtKB.
GO; GO:0006461; P:protein complex assembly; ISS:UniProtKB.
GO; GO:0072657; P:protein localization to membrane; ISS:UniProtKB.
GO; GO:0006508; P:proteolysis; ISS:UniProtKB.
GO; GO:0050790; P:regulation of catalytic activity; ISS:UniProtKB.
GO; GO:0043122; P:regulation of I-kappaB kinase/NF-kappaB signaling; ISS:UniProtKB.
GO; GO:0051592; P:response to calcium ion; ISS:UniProtKB.
GO; GO:0014850; P:response to muscle activity; ISS:UniProtKB.
GO; GO:0045214; P:sarcomere organization; ISS:UniProtKB.
GO; GO:0097264; P:self proteolysis; ISS:UniProtKB.
CDD; cd00214; Calpain_III; 1.
CDD; cd00044; CysPc; 1.
InterPro; IPR033883; C2_III.
InterPro; IPR022684; Calpain_cysteine_protease.
InterPro; IPR022682; Calpain_domain_III.
InterPro; IPR022683; Calpain_III.
InterPro; IPR011992; EF-hand-dom_pair.
InterPro; IPR018247; EF_Hand_1_Ca_BS.
InterPro; IPR002048; EF_hand_dom.
InterPro; IPR000169; Pept_cys_AS.
InterPro; IPR001300; Peptidase_C2_calpain_cat.
Pfam; PF01067; Calpain_III; 1.
Pfam; PF13202; EF-hand_5; 1.
Pfam; PF13833; EF-hand_8; 1.
Pfam; PF00648; Peptidase_C2; 1.
PRINTS; PR00704; CALPAIN.
SMART; SM00720; calpain_III; 1.
SMART; SM00230; CysPc; 1.
SMART; SM00054; EFh; 3.
SUPFAM; SSF47473; SSF47473; 1.
SUPFAM; SSF49758; SSF49758; 1.
PROSITE; PS50203; CALPAIN_CAT; 1.
PROSITE; PS00018; EF_HAND_1; 2.
PROSITE; PS50222; EF_HAND_2; 4.
PROSITE; PS00139; THIOL_PROTEASE_CYS; 1.
2: Evidence at transcript level;
Calcium; Complete proteome; Cytoplasm; Hydrolase; Metal-binding;
Protease; Reference proteome; Repeat; Thiol protease.
CHAIN 1 822 Calpain-3.
/FTId=PRO_0000207705.
DOMAIN 74 418 Calpain catalytic. {ECO:0000255|PROSITE-
ProRule:PRU00239}.
DOMAIN 650 684 EF-hand 1. {ECO:0000255|PROSITE-
ProRule:PRU00448}.
DOMAIN 693 726 EF-hand 2. {ECO:0000255|PROSITE-
ProRule:PRU00448}.
DOMAIN 723 758 EF-hand 3. {ECO:0000255|PROSITE-
ProRule:PRU00448}.
DOMAIN 788 822 EF-hand 4. {ECO:0000255|PROSITE-
ProRule:PRU00448}.
CA_BIND 663 673 1. {ECO:0000250|UniProtKB:P20807}.
CA_BIND 706 717 2. {ECO:0000250|UniProtKB:P20807,
ECO:0000255|PROSITE-ProRule:PRU00448}.
CA_BIND 736 742 3. {ECO:0000250|UniProtKB:P20807,
ECO:0000255|PROSITE-ProRule:PRU00448}.
CA_BIND 801 807 4. {ECO:0000250|UniProtKB:P20807}.
REGION 419 587 Domain III.
REGION 588 650 Linker.
REGION 651 822 Domain IV.
ACT_SITE 129 129 {ECO:0000255|PROSITE-ProRule:PRU00239}.
ACT_SITE 335 335 {ECO:0000255|PROSITE-ProRule:PRU00239}.
ACT_SITE 359 359 {ECO:0000255|PROSITE-ProRule:PRU00239}.
CONFLICT 282 282 K -> N (in Ref. 2; AAC24459).
{ECO:0000305}.
CONFLICT 308 309 GC -> V (in Ref. 2; AAC24459).
{ECO:0000305}.
SEQUENCE 822 AA; 94603 MW; AEDE66F67508D743 CRC64;
MPTVISASVA PRTGAEPMSP GPIAQAAQDK GTEAGGGNPS GIYSAIISRN FPIIGVKEKT
FEQLHKKCLE KKVLFVDPEF PPDETSLFYS QKFPIQFVWK RPPEICENPR FIVGGANRTD
ICQGDLGDCW FLAAIACLTL NKRLLFRVIP HDQSFTENYA GIFHFQFWRY GDWVDVVIDD
CLPTYNNQLV FTKSNHRNEF WNALLEKAYA KLHGSYEALK GGNTTEAMED FTGGVTEFFE
IKDAPRDMYK IMKKAIERGS LMGCSIDDGT NMTYGTSPSG LKMGELIERM VRNMDNSRLR
DSDLIPEGCS DDRPTRMIVP VQFETRMACG LVKGHAYSVT GLEEALYKGE KVKLVRLRNP
WGQVEWNGSW SDSWKDWSYV DKDEKARLQH QVTEDGEFWM SYDDFIYHFT KLEICNLTAD
ALESDKLQTW TVSVNEGRWV RGCSAGGCRN FPDTFWTNPQ YRLKLLEEDD DPDDSEVICS
FLVALMQKNR RKDRKLGANL FTIGFAIYEV PKEMHGNKQH LQKDFFLYNA SKARSRTYIN
MREVSERFRL PPSEYVIVPS TYEPHQEGEF ILRVFSEKRN LSEEVENTIS VDRPVKKKKN
KPIIFVSDRA NSNKELGVDQ ETEEGKDNTS PDKQAKSPQL EPGNTDQESE EQRQFRNIFR
QIAGDDMEIC ADELKNVLNR VVNKHKDLKT QGFTLESCRS MIALMDTDGS GRLNLQEFHH
LWKKIKTWQK IFKHYDTDQS GTINSYEMRN AVKDAGFHLN NQLYDIITMR YADKYMNIDF
DSFICCFVRL EGMFRAFNAF DKDGDGIIKL NVLEWLQLTM YA


Related products :

Catalog number Product name Quantity
E2250h Calcium-activated neutral proteinase 3,Calpain L3,Calpain p94,Calpain-3,CANP 3,CANP3,CANPL3,CAPN3,Homo sapiens,Human,Muscle-specific calcium-activated neutral protease 3,NCL1,nCL-1,New calpain 1
U2250h CLIA Calcium-activated neutral proteinase 3,Calpain L3,Calpain p94,Calpain-3,CANP 3,CANP3,CANPL3,CAPN3,Homo sapiens,Human,Muscle-specific calcium-activated neutral protease 3,NCL1,nCL-1,New calpain 1 96T
E2250h ELISA Calcium-activated neutral proteinase 3,Calpain L3,Calpain p94,Calpain-3,CANP 3,CANP3,CANPL3,CAPN3,Homo sapiens,Human,Muscle-specific calcium-activated neutral protease 3,NCL1,nCL-1,New calpain 1 96T
U2250b CLIA Bos taurus,Bovine,Calcium-activated neutral proteinase 3,Calpain L3,Calpain p94,Calpain-3,CANP 3,CAPN3,Muscle-specific calcium-activated neutral protease 3,NCL1,nCL-1,New calpain 1 96T
E2250b ELISA Bos taurus,Bovine,Calcium-activated neutral proteinase 3,Calpain L3,Calpain p94,Calpain-3,CANP 3,CAPN3,Muscle-specific calcium-activated neutral protease 3,NCL1,nCL-1,New calpain 1 96T
E2250b ELISA kit Bos taurus,Bovine,Calcium-activated neutral proteinase 3,Calpain L3,Calpain p94,Calpain-3,CANP 3,CAPN3,Muscle-specific calcium-activated neutral protease 3,NCL1,nCL-1,New calpain 1 96T
U2250b CLIA kit Bos taurus,Bovine,Calcium-activated neutral proteinase 3,Calpain L3,Calpain p94,Calpain-3,CANP 3,CAPN3,Muscle-specific calcium-activated neutral protease 3,NCL1,nCL-1,New calpain 1 96T
U2250p CLIA Calcium-activated neutral proteinase 3,Calpain L3,Calpain p94,Calpain-3,CANP 3,CAPN3,Muscle-specific calcium-activated neutral protease 3,NCL1,nCL-1,New calpain 1,Pig,Sus scrofa 96T
U2250p CLIA kit Calcium-activated neutral proteinase 3,Calpain L3,Calpain p94,Calpain-3,CANP 3,CAPN3,Muscle-specific calcium-activated neutral protease 3,NCL1,nCL-1,New calpain 1,Pig,Sus scrofa 96T
E2250b Bos taurus,Bovine,Calcium-activated neutral proteinase 3,Calpain L3,Calpain p94,Calpain-3,CANP 3,CAPN3,Muscle-specific calcium-activated neutral protease 3,NCL1,nCL-1,New calpain 1
E2250p ELISA kit Calcium-activated neutral proteinase 3,Calpain L3,Calpain p94,Calpain-3,CANP 3,CAPN3,Muscle-specific calcium-activated neutral protease 3,NCL1,nCL-1,New calpain 1,Pig,Sus scrofa 96T
E2250p ELISA Calcium-activated neutral proteinase 3,Calpain L3,Calpain p94,Calpain-3,CANP 3,CAPN3,Muscle-specific calcium-activated neutral protease 3,NCL1,nCL-1,New calpain 1,Pig,Sus scrofa 96T
18-272-195238 Calpain 3 - Rabbit polyclonal to Calpain 3; EC 3.4.22.54; Calpain L3; Calpain p94; Calcium-activated neutral proteinase 3; CANP 3; Muscle-specific calcium-activated neutral protease 3; nCL-1 Polyclona 0.05 mg
E2250p Calcium-activated neutral proteinase 3,Calpain L3,Calpain p94,Calpain-3,CANP 3,CAPN3,Muscle-specific calcium-activated neutral protease 3,NCL1,nCL-1,New calpain 1,Pig,Sus scrofa
U2250h CLIA kit Calcium-activated neutral proteinase 3,Calpain L3,Calpain p94,Calpain-3,CANP 3,CANP3,CANPL3,CAPN3,Homo sapiens,Human,Muscle-specific calcium-activated neutral protease 3,NCL1,nCL-1,New calpa 96T
E2250h ELISA kit Calcium-activated neutral proteinase 3,Calpain L3,Calpain p94,Calpain-3,CANP 3,CANP3,CANPL3,CAPN3,Homo sapiens,Human,Muscle-specific calcium-activated neutral protease 3,NCL1,nCL-1,New calp 96T
U2250m CLIA kit Calcium-activated neutral proteinase 3,Calpain L3,Calpain p94,Calpain-3,CANP 3,Capn3,Mouse,Mus musculus,Muscle-specific calcium-activated neutral protease 3 96T
U2250m CLIA Calcium-activated neutral proteinase 3,Calpain L3,Calpain p94,Calpain-3,CANP 3,Capn3,Mouse,Mus musculus,Muscle-specific calcium-activated neutral protease 3 96T
U2250r CLIA kit Calcium-activated neutral proteinase 3,Calpain L3,Calpain p94,Calpain-3,CANP 3,Capn3,Muscle-specific calcium-activated neutral protease 3,Rat,Rattus norvegicus 96T
E2250r ELISA Calcium-activated neutral proteinase 3,Calpain L3,Calpain p94,Calpain-3,CANP 3,Capn3,Muscle-specific calcium-activated neutral protease 3,Rat,Rattus norvegicus 96T
U2250r CLIA Calcium-activated neutral proteinase 3,Calpain L3,Calpain p94,Calpain-3,CANP 3,Capn3,Muscle-specific calcium-activated neutral protease 3,Rat,Rattus norvegicus 96T
E2250m ELISA Calcium-activated neutral proteinase 3,Calpain L3,Calpain p94,Calpain-3,CANP 3,Capn3,Mouse,Mus musculus,Muscle-specific calcium-activated neutral protease 3 96T
E2250m ELISA kit Calcium-activated neutral proteinase 3,Calpain L3,Calpain p94,Calpain-3,CANP 3,Capn3,Mouse,Mus musculus,Muscle-specific calcium-activated neutral protease 3 96T
E2250r ELISA kit Calcium-activated neutral proteinase 3,Calpain L3,Calpain p94,Calpain-3,CANP 3,Capn3,Muscle-specific calcium-activated neutral protease 3,Rat,Rattus norvegicus 96T
E2250r Calcium-activated neutral proteinase 3,Calpain L3,Calpain p94,Calpain-3,CANP 3,Capn3,Muscle-specific calcium-activated neutral protease 3,Rat,Rattus norvegicus


 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur





GENTAUR Ltd.
Howard Frank Turnberry House
1404-1410 High Road
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017

BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG

france@gentaur.com | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: 0035929830070
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.


ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur