Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

Caprin-2 (C1q domain-containing protein 1) (Cytoplasmic activation/proliferation-associated protein 2) (RNA granule protein 140)

 CAPR2_MOUSE             Reviewed;        1031 AA.
Q05A80; Q58E31; Q6ZPG7;
11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
14-NOV-2006, sequence version 1.
23-MAY-2018, entry version 84.
RecName: Full=Caprin-2;
AltName: Full=C1q domain-containing protein 1;
AltName: Full=Cytoplasmic activation/proliferation-associated protein 2;
AltName: Full=RNA granule protein 140;
Name=Caprin2 {ECO:0000312|MGI:MGI:2448541};
Synonyms=C1qdc1 {ECO:0000312|MGI:MGI:2448541},
Kiaa1873 {ECO:0000312|EMBL:BAC98270.1}, Rng140;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1] {ECO:0000305, ECO:0000312|EMBL:BAC98270.1}
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
TISSUE=Embryonic tail {ECO:0000312|EMBL:BAC98270.1};
PubMed=14621295; DOI=10.1093/dnares/10.4.167;
Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S.,
Saga Y., Nagase T., Ohara O., Koga H.;
"Prediction of the coding sequences of mouse homologues of KIAA gene:
III. The complete nucleotide sequences of 500 mouse KIAA-homologous
cDNAs identified by screening of terminal sequences of cDNA clones
randomly sampled from size-fractionated libraries.";
DNA Res. 10:167-180(2003).
[2] {ECO:0000305, ECO:0000312|EMBL:AAI25376.1}
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
TISSUE=Brain {ECO:0000312|EMBL:AAI25376.1}, and
Mammary tumor {ECO:0000312|EMBL:AAH92093.1};
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[3]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-852 AND SER-853, AND
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Testis;
PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
"A tissue-specific atlas of mouse protein phosphorylation and
expression.";
Cell 143:1174-1189(2010).
[4]
FUNCTION, TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE.
PubMed=20516077; DOI=10.1074/jbc.M110.108944;
Shiina N., Tokunaga M.;
"RNA granule protein 140 (RNG140), a paralog of RNG105 localized to
distinct RNA granules in neuronal dendrites in the adult vertebrate
brain.";
J. Biol. Chem. 285:24260-24269(2010).
-!- FUNCTION: Promotes phosphorylation of the Wnt coreceptor LRP6,
leading to increased activity of the canonical Wnt signaling
pathway (By similarity). Faciliates constitutive LRP6
phosphorylation by CDK14/CCNY during G2/M stage of the cell cycle,
which may potentiate cells for Wnt signaling (By similarity). May
regulate the transport and translation of mRNAs, modulating for
instance the expression of proteins involved in synaptic
plasticity in neurons (PubMed:20516077). Involved in regulation of
growth as erythroblasts shift from a highly proliferative state
towards their terminal phase of differentiation (By similarity).
May be involved in apoptosis (By similarity).
{ECO:0000250|UniProtKB:Q6IMN6, ECO:0000269|PubMed:20516077}.
-!- SUBUNIT: Homotrimer; via C1q domain. Found in a complex with LRP6,
CCNY and CDK14 during G2/M stage; CAPRIN2 functions as a scaffold
for the complex by binding to CCNY via its N terminus and to CDK14
via its C terminus. Interacts with LRP5. Interacts with LRP6.
{ECO:0000250|UniProtKB:Q6IMN6}.
-!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q6IMN6}.
Cell membrane; Peripheral membrane protein
{ECO:0000250|UniProtKB:Q6IMN6}.
-!- ALTERNATIVE PRODUCTS:
Event=Alternative splicing; Named isoforms=2;
Name=1 {ECO:0000269|PubMed:15489334};
IsoId=Q05A80-1; Sequence=Displayed;
Note=No experimental confirmation available. {ECO:0000305};
Name=2 {ECO:0000269|PubMed:14621295};
IsoId=Q05A80-2; Sequence=VSP_052540;
Note=No experimental confirmation available. {ECO:0000305};
-!- TISSUE SPECIFICITY: Specifically expressed in brain (at protein
level). {ECO:0000269|PubMed:20516077}.
-!- DEVELOPMENTAL STAGE: Detected at E17.5 in brain (at protein
level). {ECO:0000269|PubMed:20516077}.
-!- DOMAIN: The C1q domain is essential for the function in Wnt
signaling. {ECO:0000250|UniProtKB:Q6IMN6}.
-!- SIMILARITY: Belongs to the caprin family. {ECO:0000305}.
-!- SEQUENCE CAUTION:
Sequence=BAC98270.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};
-----------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
Distributed under the Creative Commons Attribution-NoDerivs License
-----------------------------------------------------------------------
EMBL; AK129460; BAC98270.1; ALT_INIT; mRNA.
EMBL; BC092093; AAH92093.1; -; mRNA.
EMBL; BC125373; AAI25374.1; -; mRNA.
EMBL; BC125375; AAI25376.1; -; mRNA.
CCDS; CCDS39720.1; -. [Q05A80-1]
RefSeq; NP_001288280.1; NM_001301351.1.
RefSeq; NP_853519.2; NM_181541.4. [Q05A80-1]
RefSeq; XP_006507102.1; XM_006507039.3. [Q05A80-1]
RefSeq; XP_006507105.1; XM_006507042.3. [Q05A80-2]
RefSeq; XP_017177051.1; XM_017321562.1. [Q05A80-1]
UniGene; Mm.150568; -.
UniGene; Mm.425358; -.
ProteinModelPortal; Q05A80; -.
SMR; Q05A80; -.
STRING; 10090.ENSMUSP00000107195; -.
iPTMnet; Q05A80; -.
PhosphoSitePlus; Q05A80; -.
MaxQB; Q05A80; -.
PaxDb; Q05A80; -.
PRIDE; Q05A80; -.
Ensembl; ENSMUST00000072324; ENSMUSP00000072165; ENSMUSG00000030309. [Q05A80-2]
Ensembl; ENSMUST00000111569; ENSMUSP00000107195; ENSMUSG00000030309. [Q05A80-1]
GeneID; 232560; -.
KEGG; mmu:232560; -.
UCSC; uc009eto.2; mouse. [Q05A80-2]
UCSC; uc009etp.2; mouse. [Q05A80-1]
CTD; 65981; -.
MGI; MGI:2448541; Caprin2.
eggNOG; ENOG410IEA8; Eukaryota.
eggNOG; ENOG4110M5Q; LUCA.
GeneTree; ENSGT00760000119052; -.
HOGENOM; HOG000082543; -.
HOVERGEN; HBG057777; -.
InParanoid; Q05A80; -.
KO; K18744; -.
OMA; YFWDLLE; -.
OrthoDB; EOG091G0UOF; -.
TreeFam; TF329471; -.
PRO; PR:Q05A80; -.
Proteomes; UP000000589; Chromosome 6.
Bgee; ENSMUSG00000030309; -.
CleanEx; MM_CAPRIN2; -.
ExpressionAtlas; Q05A80; baseline and differential.
Genevisible; Q05A80; MM.
GO; GO:0005813; C:centrosome; ISO:MGI.
GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
GO; GO:0005829; C:cytosol; ISO:MGI.
GO; GO:0005739; C:mitochondrion; ISS:UniProtKB.
GO; GO:0005634; C:nucleus; ISO:MGI.
GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO; GO:0043235; C:receptor complex; ISO:MGI.
GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
GO; GO:0005102; F:signaling receptor binding; ISO:MGI.
GO; GO:0030308; P:negative regulation of cell growth; ISS:UniProtKB.
GO; GO:0017148; P:negative regulation of translation; IEA:UniProtKB-KW.
GO; GO:0090263; P:positive regulation of canonical Wnt signaling pathway; ISO:MGI.
GO; GO:0050775; P:positive regulation of dendrite morphogenesis; IMP:UniProtKB.
GO; GO:0061003; P:positive regulation of dendritic spine morphogenesis; IMP:UniProtKB.
GO; GO:0033138; P:positive regulation of peptidyl-serine phosphorylation; ISO:MGI.
GO; GO:0032092; P:positive regulation of protein binding; ISO:MGI.
GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISO:MGI.
Gene3D; 2.60.120.40; -; 1.
InterPro; IPR001073; C1q_dom.
InterPro; IPR028816; Caprin.
InterPro; IPR022070; Caprin-1_C.
InterPro; IPR008983; Tumour_necrosis_fac-like_dom.
PANTHER; PTHR22922; PTHR22922; 1.
Pfam; PF00386; C1q; 1.
Pfam; PF12287; Caprin-1_C; 1.
PRINTS; PR00007; COMPLEMNTC1Q.
SMART; SM00110; C1Q; 1.
SUPFAM; SSF49842; SSF49842; 1.
PROSITE; PS50871; C1Q; 1.
1: Evidence at protein level;
Alternative splicing; Calcium; Cell membrane; Complete proteome;
Cytoplasm; Differentiation; Growth regulation; Membrane;
Metal-binding; Phosphoprotein; Protein synthesis inhibitor;
Reference proteome; RNA-binding.
CHAIN 1 1031 Caprin-2.
/FTId=PRO_0000302083.
DOMAIN 897 1031 C1q. {ECO:0000255|PROSITE-
ProRule:PRU00368}.
METAL 982 982 Calcium 1; shared with neighboring
subunits. {ECO:0000250|UniProtKB:Q6IMN6}.
METAL 988 988 Calcium 2; shared with neighboring
subunits. {ECO:0000250|UniProtKB:Q6IMN6}.
MOD_RES 852 852 Phosphoserine.
{ECO:0000244|PubMed:21183079}.
MOD_RES 853 853 Phosphoserine.
{ECO:0000244|PubMed:21183079}.
VAR_SEQ 284 502 Missing (in isoform 2).
{ECO:0000303|PubMed:14621295}.
/FTId=VSP_052540.
CONFLICT 843 843 Missing (in Ref. 1; BAC98270).
{ECO:0000305}.
SEQUENCE 1031 AA; 114491 MW; DA2A62E64372F6A6 CRC64;
MKSAKSQVNQ DQQGENQRAL SPLQSTLSSA ASPSQAYETY IDNGLICLKH KIRNIEKKKL
KLEDYKDRLK NGEQLNPDQL EAVEKYEEVL HNLEFAKELQ KTFSALSQDL LKAQKKAQRR
EHMLKLETEK KKLRTMLQIQ YVLQNLTQEH VQKDFKGGLN GAMYLPSKEL DYLIKFSKLT
CPERNESLSV EDQMEQSSLY FWDLLEGSEK TVVGTTYKHV KDLLSKLLHS GYFESVPVLR
NSKEKAEEVL MQSEMKKQLL KSESIKESES LTELVQPEIQ PQEFLNRRYM TEVKFSRKQE
NVEQSWEADY ARKPSLLKCW NTLPEPDGQE KKKESLESWK SSLKTQEVSK PVVSLVQGKL
RPTLQEEQKQ QVPITPVSQW KPESPKSKVG SPQEEQNVQE TPKPWVVQSQ KEQDPKKLPP
GSWAVSVQSE QSGSRSWTTP VCREQASVQP GTPVSWENNA ENQKHSLVPQ SQISLKSWGA
ASAGLLPNGQ VLTRKLNVEP KDVPKPLPQP IDSSSALPKD PVLRKEKLQD LMSQIQGTYN
FMQESVLDFD KPSSAIPSSQ PPSACPVSTV SAEQNLSNQS DFLQEPSQAS SPVTCSSNAC
LVTTDQASSG SETEFTTSET PEMVVSPCKP KPASALASPN PPLSKSFQLP PASGSSEAIS
TAPFQAMQTV FNVNAPLPPR KEQEMKEPPY SSGYNQNFTS SSTQTVSQCQ LPAVHIDQTT
QPPETGAGYH PDGTVQVSNG SLAFYPAPTS MFPRPAQPFI SSRGTLRGCS HGGRLLMSSY
QSPGGYKGFD SYRGLPSVSS GNYSQLQLQA REYSGTAYSQ RDNFQQCYKR SGTSSGLQAN
SRAGWSDSSQ VSSPERDSET FNSGDSGLGD SRSMTPVDVP VTSPAAAILP VHIYPLPQQM
RVAFSAARTS NLAPGTLDQP IVFDLLLNNL GETFDLQLGR FNCPVNGTYV FIFHMLKLAV
NVPLYVNLMK NEEVLVSAYA NDGAPDHETA SNHAVLQLLQ GDQIWLRLHR GAIYGSSWKY
STFSGYLLYQ D


Related products :

Catalog number Product name Quantity
EIAAB05295 Bos taurus,Bovine,CAPRIN1,Caprin-1,Cytoplasmic activation- and proliferation-associated protein 1,RNA granule protein 105,RNG105
EIAAB05296 Caprin1,Caprin-1,Cytoplasmic activation- and proliferation-associated protein 1,GPI-anchored protein p137,Gpiap1,GPI-p137,p137GPI,Rat,Rattus norvegicus,RNA granule protein 105,Rng105
EIAAB05299 C1q domain-containing protein 1,C1qdc1,Caprin2,Caprin-2,Cytoplasmic activation_proliferation-associated protein 2,Kiaa1873,Mouse,Mus musculus,RNA granule protein 140,Rng140
EIAAB05294 CAPRIN1,Caprin-1,Cell cycle-associated protein 1,Cytoplasmic activation- and proliferation-associated protein 1,GPI-anchored membrane protein 1,GPI-anchored protein p137,GPIAP1,GPIP137,GPI-p137,Homo s
EIAAB05297 Caprin1,Caprin-1,Cytoplasmic activation- and proliferation-associated protein 1,G5E5,GPI-anchored membrane protein 1,GPI-anchored protein p137,Gpiap,Gpiap1,Gpip137,GPI-p137,M11s1,Membrane component ch
EIAAB05298 C1q domain-containing protein 1,C1QDC1,CAPRIN2,Caprin-2,Cytoplasmic activation_proliferation-associated protein 2,EEG1,Gastric cancer multidrug resistance-associated protein,Homo sapiens,Human,KIAA187
U0115r CLIA CD62 antigen-like family member P,GMP-140,Granule membrane protein 140,LECAM3,Leukocyte-endothelial cell adhesion molecule 3,PADGEM,Platelet activation dependent granule-external membrane protein 96T
E0115b ELISA kit Bos taurus,Bovine,CD62 antigen-like family member P,GMP-140,Granule membrane protein 140,LECAM3,Leukocyte-endothelial cell adhesion molecule 3,PADGEM,Platelet activation dependent granule-e 96T
E0115b ELISA Bos taurus,Bovine,CD62 antigen-like family member P,GMP-140,Granule membrane protein 140,LECAM3,Leukocyte-endothelial cell adhesion molecule 3,PADGEM,Platelet activation dependent granule-extern 96T
E0115m ELISA CD62 antigen-like family member P,GMP-140,Granule membrane protein 140,Grmp,LECAM3,Leukocyte-endothelial cell adhesion molecule 3,Mouse,Mus musculus,PADGEM,Platelet activation dependent granule- 96T
U0115b CLIA Bos taurus,Bovine,CD62 antigen-like family member P,GMP-140,Granule membrane protein 140,LECAM3,Leukocyte-endothelial cell adhesion molecule 3,PADGEM,Platelet activation dependent granule-externa 96T
U0115m CLIA CD62 antigen-like family member P,GMP-140,Granule membrane protein 140,Grmp,LECAM3,Leukocyte-endothelial cell adhesion molecule 3,Mouse,Mus musculus,PADGEM,Platelet activation dependent granule-e 96T
E0115r ELISA kit CD62 antigen-like family member P,GMP-140,Granule membrane protein 140,LECAM3,Leukocyte-endothelial cell adhesion molecule 3,PADGEM,Platelet activation dependent granule-external membrane p 96T
EIAAB33291 E3 ubiquitin-protein ligase PDZRN3,Kiaa1095,Mouse,Mus musculus,PDZ domain-containing RING finger protein 3,Pdzrn3,Protein SEMACAP3,Semaphorin cytoplasmic domain-associated protein 3,Semcap3
EIAAB09918 ATPBD3,ATP-binding domain-containing protein 3,Cancer-associated gene protein,CTU1,Cytoplasmic tRNA 2-thiolation protein 1,Cytoplasmic tRNA adenylyltransferase 1,Homo sapiens,Human,NCS6
EIAAB33289 E3 ubiquitin-protein ligase PDZRN3,PDZ domain-containing RING finger protein 3,Pdzrn3,Protein SEMACAP3,Rat,Rattus norvegicus,Semaphorin cytoplasmic domain-associated protein 3,Semcap3
E0115r ELISA CD62 antigen-like family member P,GMP-140,Granule membrane protein 140,LECAM3,Leukocyte-endothelial cell adhesion molecule 3,PADGEM,Platelet activation dependent granule-external membrane protei 96T
PC-CPRN1 Cytoplasmic cell cycle associated protein 1(Caprin 1) Abs, WB control 100-150ul
EIAAB33290 E3 ubiquitin-protein ligase PDZRN3,Homo sapiens,Human,KIAA1095,Ligand of Numb protein X 3,LNX3,PDZ domain-containing RING finger protein 3,PDZRN3,Protein SEMACAP3,Semaphorin cytoplasmic domain-associa
EIAAB07910 CAP-Gly domain-containing linker protein 1,CLIP1,CLIP-170,CYLN1,Cytoplasmic linker protein 1,Cytoplasmic linker protein 170 alpha-2,Homo sapiens,Human,Reed-Sternberg intermediate filament-associated p
P-CPRN1 Cytoplasmic cell cycle associated protein 1(Caprin 1) Abs, Antigen blocking peptide 100ul
EIAAB07913 CAP-Gly domain-containing linker protein 2,CLIP-115,CLIP2,CYLN2,Cytoplasmic linker protein 115,Cytoplasmic linker protein 2,Homo sapiens,Human,KIAA0291,WBSCR3,WBSCR4,Williams-Beuren syndrome chromosom
EIAAB38179 DSHP,Duncan disease SH2-protein,Homo sapiens,Human,SAP,SH2 domain-containing protein 1A,SH2D1A,Signaling lymphocytic activation molecule-associated protein,SLAM-associated protein,T-cell signal transd
EIAAB07912 CAP-Gly domain-containing linker protein 2,CLIP-115,Clip2,Cyln2,Cytoplasmic linker protein 115,Cytoplasmic linker protein 2,Kiaa0291,Mouse,Mus musculus
25-803 This gene is a member of the PAR6 family and encodes a protein with a PSD95_Discs-large_ZO1 (PDZ) domain, an OPR domain and a semi-Cdc42_Rac interactive binding (CRIB) domain. This cytoplasmic protein 0.05 mg


 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur





GENTAUR Ltd.
Howard Frank Turnberry House
1404-1410 High Road
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017

BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG

france@gentaur.com | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: 0035929830070
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.


ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur