Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

Caprin-2 (RNA granule protein 140)

 CAPR2_DANRE             Reviewed;         914 AA.
Q5RJ80; Q6PFL5;
11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
21-DEC-2004, sequence version 1.
12-SEP-2018, entry version 83.
RecName: Full=Caprin-2;
AltName: Full=RNA granule protein 140;
Name=caprin2 {ECO:0000312|EMBL:AAH57503.1}; Synonyms=rng140;
ORFNames=si:ch211-11c20.4;
Danio rerio (Zebrafish) (Brachydanio rerio).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
Cyprinidae; Danio.
NCBI_TaxID=7955;
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Tuebingen;
PubMed=23594743; DOI=10.1038/nature12111;
Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C.,
Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L.,
McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C.,
Koch R., Rauch G.J., White S., Chow W., Kilian B., Quintais L.T.,
Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T.,
Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F.,
Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H.,
Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
Clee C., Oliver K., Clark R., Riddle C., Eliott D., Threadgold G.,
Harden G., Ware D., Mortimer B., Kerry G., Heath P., Phillimore B.,
Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S., Pelan S.,
Griffiths G., Smith M., Glithero R., Howden P., Barker N., Stevens C.,
Harley J., Holt K., Panagiotidis G., Lovell J., Beasley H.,
Henderson C., Gordon D., Auger K., Wright D., Collins J., Raisen C.,
Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
Humphries M., Sycamore N., Barker D., Saunders D., Wallis J.,
Babbage A., Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S.,
Wray P., Ellington A., Matthews N., Ellwood M., Woodmansey R.,
Clark G., Cooper J., Tromans A., Grafham D., Skuce C., Pandian R.,
Andrews R., Harrison E., Kimberley A., Garnett J., Fosker N., Hall R.,
Garner P., Kelly D., Bird C., Palmer S., Gehring I., Berger A.,
Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M.,
Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M.,
Rudolph-Geiger S., Teucke M., Osoegawa K., Zhu B., Rapp A., Widaa S.,
Langford C., Yang F., Carter N.P., Harrow J., Ning Z., Herrero J.,
Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C.,
Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H.,
Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J.,
Stemple D.L.;
"The zebrafish reference genome sequence and its relationship to the
human genome.";
Nature 496:498-503(2013).
[2] {ECO:0000305, ECO:0000312|EMBL:CAI11565.1}
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 714-914.
TISSUE=Embryo {ECO:0000312|EMBL:AAH57503.1};
NIH - Zebrafish Gene Collection (ZGC) project;
Submitted (SEP-2003) to the EMBL/GenBank/DDBJ databases.
[3]
DISRUPTION PHENOTYPE.
PubMed=18762581; DOI=10.1083/jcb.200803147;
Ding Y., Xi Y., Chen T., Wang J.Y., Tao D.L., Wu Z.L., Li Y.P., Li C.,
Zeng R., Li L.;
"Caprin-2 enhances canonical Wnt signaling through regulating LRP5/6
phosphorylation.";
J. Cell Biol. 182:865-872(2008).
[4] {ECO:0000244|PDB:4OUS}
X-RAY CRYSTALLOGRAPHY (1.05 ANGSTROMS) OF 780-914 IN COMPLEX WITH
CALCIUM, AND SUBUNIT.
PubMed=25331957; DOI=10.1074/jbc.M114.591636;
Miao H., Jia Y., Xie S., Wang X., Zhao J., Chu Y., Zhou Z., Shi Z.,
Song X., Li L.;
"Structural insights into the C1q domain of Caprin-2 in canonical Wnt
signaling.";
J. Biol. Chem. 289:34104-34113(2014).
-!- FUNCTION: Promotes phosphorylation of the Wnt coreceptor LRP6,
leading to increased activity of the canonical Wnt signaling
pathway. Faciliates constitutive LRP6 phosphorylation by
CDK14/CCNY during G2/M stage of the cell cycle, which may
potentiate cells for Wnt signaling. May regulate the transport and
translation of mRNAs, modulating for instance the expression of
proteins involved in synaptic plasticity in neurons. Involved in
regulation of growth as erythroblasts shift from a highly
proliferative state towards their terminal phase of
differentiation. May be involved in apoptosis.
{ECO:0000250|UniProtKB:Q6IMN6}.
-!- SUBUNIT: Homotrimer; via C1q domain.
{ECO:0000269|PubMed:25331957}.
-!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q6IMN6}.
Cell membrane; Peripheral membrane protein
{ECO:0000250|UniProtKB:Q6IMN6}.
-!- DOMAIN: The C1q domain is essential for the function in Wnt
signaling. {ECO:0000250|UniProtKB:Q6IMN6}.
-!- DISRUPTION PHENOTYPE: Morpholino knockdown results in a dorsalized
phenotype, with enlargement of the telencephalon and reduction of
the tail at 24 hours post-fertilization. Expression of the dorsal
marker goosecoid is expanded, whereas expression of the ventral
markers eve1 and tbx6 is reduced. In addition, expression of the
telencephalon marker opl and the midbrain/hindbrain boundary
marker pax2.1 is expanded posteriorly.
{ECO:0000269|PubMed:18762581}.
-!- SIMILARITY: Belongs to the caprin family. {ECO:0000305}.
-----------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
Distributed under the Creative Commons Attribution (CC BY 4.0) License
-----------------------------------------------------------------------
EMBL; BX001012; CAI11565.1; -; Genomic_DNA.
EMBL; BC057503; AAH57503.1; -; mRNA.
RefSeq; NP_001013291.1; NM_001013273.1.
UniGene; Dr.81341; -.
PDB; 4OUS; X-ray; 1.05 A; A=780-914.
PDBsum; 4OUS; -.
ProteinModelPortal; Q5RJ80; -.
SMR; Q5RJ80; -.
STRING; 7955.ENSDARP00000040707; -.
PaxDb; Q5RJ80; -.
PRIDE; Q5RJ80; -.
Ensembl; ENSDART00000040708; ENSDARP00000040707; ENSDARG00000020749.
GeneID; 407729; -.
KEGG; dre:407729; -.
CTD; 65981; -.
ZFIN; ZDB-GENE-040812-2; caprin2.
eggNOG; ENOG410IEA8; Eukaryota.
eggNOG; ENOG4110M5Q; LUCA.
GeneTree; ENSGT00760000119052; -.
HOGENOM; HOG000082543; -.
HOVERGEN; HBG057777; -.
InParanoid; Q5RJ80; -.
KO; K18744; -.
OMA; YFWDLLE; -.
OrthoDB; EOG091G0UOF; -.
PhylomeDB; Q5RJ80; -.
TreeFam; TF329471; -.
PRO; PR:Q5RJ80; -.
Proteomes; UP000000437; Chromosome 4.
Bgee; ENSDARG00000020749; Expressed in 24 organ(s), highest expression level in cleaving embryo.
ExpressionAtlas; Q5RJ80; baseline.
GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
GO; GO:0009953; P:dorsal/ventral pattern formation; IMP:ZFIN.
GO; GO:0017148; P:negative regulation of translation; IEA:UniProtKB-KW.
GO; GO:0090263; P:positive regulation of canonical Wnt signaling pathway; IMP:BHF-UCL.
GO; GO:0050775; P:positive regulation of dendrite morphogenesis; ISS:UniProtKB.
GO; GO:0061003; P:positive regulation of dendritic spine morphogenesis; ISS:UniProtKB.
GO; GO:0030177; P:positive regulation of Wnt signaling pathway; IMP:ZFIN.
GO; GO:2000055; P:positive regulation of Wnt signaling pathway involved in dorsal/ventral axis specification; IMP:BHF-UCL.
GO; GO:0040008; P:regulation of growth; IEA:UniProtKB-KW.
Gene3D; 2.60.120.40; -; 1.
InterPro; IPR001073; C1q_dom.
InterPro; IPR028816; Caprin.
InterPro; IPR022070; Caprin-1_C.
InterPro; IPR008983; Tumour_necrosis_fac-like_dom.
PANTHER; PTHR22922; PTHR22922; 2.
Pfam; PF00386; C1q; 1.
Pfam; PF12287; Caprin-1_C; 1.
PRINTS; PR00007; COMPLEMNTC1Q.
SMART; SM00110; C1Q; 1.
SUPFAM; SSF49842; SSF49842; 1.
PROSITE; PS50871; C1Q; 1.
1: Evidence at protein level;
3D-structure; Calcium; Cell membrane; Complete proteome; Cytoplasm;
Differentiation; Growth regulation; Membrane; Metal-binding;
Protein synthesis inhibitor; Reference proteome; RNA-binding.
CHAIN 1 914 Caprin-2.
/FTId=PRO_0000302084.
DOMAIN 780 914 C1q. {ECO:0000255|PROSITE-
ProRule:PRU00368}.
METAL 865 865 Calcium 1; shared with neighboring
subunits. {ECO:0000250|UniProtKB:Q6IMN6}.
METAL 871 871 Calcium 2; shared with neighboring
subunits. {ECO:0000269|PubMed:25331957}.
CONFLICT 726 726 S -> N (in Ref. 2; AAH57503).
{ECO:0000305}.
STRAND 786 791 {ECO:0000244|PDB:4OUS}.
STRAND 798 803 {ECO:0000244|PDB:4OUS}.
STRAND 808 813 {ECO:0000244|PDB:4OUS}.
TURN 819 822 {ECO:0000244|PDB:4OUS}.
STRAND 823 825 {ECO:0000244|PDB:4OUS}.
STRAND 827 840 {ECO:0000244|PDB:4OUS}.
STRAND 842 845 {ECO:0000244|PDB:4OUS}.
STRAND 847 853 {ECO:0000244|PDB:4OUS}.
STRAND 856 863 {ECO:0000244|PDB:4OUS}.
STRAND 872 881 {ECO:0000244|PDB:4OUS}.
STRAND 886 894 {ECO:0000244|PDB:4OUS}.
STRAND 904 913 {ECO:0000244|PDB:4OUS}.
SEQUENCE 914 AA; 101570 MW; B84AEF8EFE4B780F CRC64;
MRKTETMVQL SPSRTLETLT PSELTVEKDD GQGSPKPESP RMLSALQLAL SSTTVYCGYE
KYIEDGLICL KHKIRNIEKK KLKLERYSDK LKKGEKLNED QLEAVGKYDE VVHNLKFAKE
LQKTIGSLTQ DLLKAQRKAV RQEKQMKTDE EKSRLSLMLQ VQYVLHSLQR EDVRKNFCNT
RQYSCYMSTQ DMEGLMDLAS LVGCKRDYSI SLEDQMRRAA IVYWELLEGN EKPVAGSTYK
HMKEKLLRLV DSGFFDNIPL PKSDSQEKTE TIKPDSQSRP SGLTTLVKLS SNEVPSKEFL
NRRYMPETDE RRRGETASPR NWKEDFLAMK EREPPDSWEM EELADPPASS QSPIQKPWKG
AAGLIPKTVD IVKRSTTDPK EKRQRKKAEQ DSKSMPVAVE VFSSPSPLPK DPVQRRQQLE
TLMDQISGSF SFMQESLLDG ESSPVNTQTK RCRPSPGSST PIVQRELTKS PSDILPSSQR
STPLRILLSG EGKGCLSNGD RSINGSDLEL HSEDKPRKQA EGFNSPPLYR RGSSISVSLE
NQSTVQAGRQ MLCNGVSSSG SAQTFSTPPS RRSISAENPF HNIHSVFNVI GESSGMKADE
SGFSESIHRS FTSAKTSSVT TASTQTPPEL NPPEEDLQIE GQYPLECAVS AGGPVFSSSH
SRVGQSCYSR GAVRGGYDAY RVNVRSPGGS FMSQTHREPA SALYMARENG YQQNFKRGAG
TATQRSSAGW SDSSQVSSPD RDGAYPLDSG LSDTLSIPAM EVPMNPQGPH TLMPVHVYPL
TQLRVAFSAA RTANFAPGTL DQPIAFDLLH TNLGDMFDTG SGRFTCPATG AYVFIFHILK
LAISVPLYIN LMRNEEVMVS AYANDGAPDH ETASNHAVLQ LFQGDQVWLR LHRGAIYGSS
WKYSTFSGFL LYQD


Related products :

Catalog number Product name Quantity
EIAAB05295 Bos taurus,Bovine,CAPRIN1,Caprin-1,Cytoplasmic activation- and proliferation-associated protein 1,RNA granule protein 105,RNG105
EIAAB05299 C1q domain-containing protein 1,C1qdc1,Caprin2,Caprin-2,Cytoplasmic activation_proliferation-associated protein 2,Kiaa1873,Mouse,Mus musculus,RNA granule protein 140,Rng140
EIAAB05296 Caprin1,Caprin-1,Cytoplasmic activation- and proliferation-associated protein 1,GPI-anchored protein p137,Gpiap1,GPI-p137,p137GPI,Rat,Rattus norvegicus,RNA granule protein 105,Rng105
U0115r CLIA CD62 antigen-like family member P,GMP-140,Granule membrane protein 140,LECAM3,Leukocyte-endothelial cell adhesion molecule 3,PADGEM,Platelet activation dependent granule-external membrane protein 96T
E0115b ELISA kit Bos taurus,Bovine,CD62 antigen-like family member P,GMP-140,Granule membrane protein 140,LECAM3,Leukocyte-endothelial cell adhesion molecule 3,PADGEM,Platelet activation dependent granule-e 96T
EIAAB47153 Homo sapiens,Human,hZG16,Secretory lectin ZG16,ZG16,Zymogen granule membrane protein 16,Zymogen granule protein 16
E0115b ELISA Bos taurus,Bovine,CD62 antigen-like family member P,GMP-140,Granule membrane protein 140,LECAM3,Leukocyte-endothelial cell adhesion molecule 3,PADGEM,Platelet activation dependent granule-extern 96T
U0115b CLIA Bos taurus,Bovine,CD62 antigen-like family member P,GMP-140,Granule membrane protein 140,LECAM3,Leukocyte-endothelial cell adhesion molecule 3,PADGEM,Platelet activation dependent granule-externa 96T
U0115m CLIA CD62 antigen-like family member P,GMP-140,Granule membrane protein 140,Grmp,LECAM3,Leukocyte-endothelial cell adhesion molecule 3,Mouse,Mus musculus,PADGEM,Platelet activation dependent granule-e 96T
E0115m ELISA CD62 antigen-like family member P,GMP-140,Granule membrane protein 140,Grmp,LECAM3,Leukocyte-endothelial cell adhesion molecule 3,Mouse,Mus musculus,PADGEM,Platelet activation dependent granule- 96T
EIAAB39885 Chondroitin sulfate proteoglycan core protein,Cytolytic granule proteoglycan core protein,PG19 core protein,Pgsg,Prg,Prg1,Proteoglycan 10K core protein,Rat,Rattus norvegicus,Secretory granule proteogl
EIAAB47152 Mouse,Mus musculus,Secretory lectin ZG16,Zg16,Zymogen granule membrane protein 16,Zymogen granule protein 16
EIAAB47154 Rat,Rattus norvegicus,Secretory lectin ZG16,Zg16,Zymogen granule membrane protein 16,Zymogen granule protein 16
E0115r ELISA kit CD62 antigen-like family member P,GMP-140,Granule membrane protein 140,LECAM3,Leukocyte-endothelial cell adhesion molecule 3,PADGEM,Platelet activation dependent granule-external membrane p 96T
E0115r ELISA CD62 antigen-like family member P,GMP-140,Granule membrane protein 140,LECAM3,Leukocyte-endothelial cell adhesion molecule 3,PADGEM,Platelet activation dependent granule-external membrane protei 96T
EIAAB05298 C1q domain-containing protein 1,C1QDC1,CAPRIN2,Caprin-2,Cytoplasmic activation_proliferation-associated protein 2,EEG1,Gastric cancer multidrug resistance-associated protein,Homo sapiens,Human,KIAA187
PC-CPRN1 Cytoplasmic cell cycle associated protein 1(Caprin 1) Abs, WB control 100-150ul
P-CPRN1 Cytoplasmic cell cycle associated protein 1(Caprin 1) Abs, Antigen blocking peptide 100ul
EIAAB05294 CAPRIN1,Caprin-1,Cell cycle-associated protein 1,Cytoplasmic activation- and proliferation-associated protein 1,GPI-anchored membrane protein 1,GPI-anchored protein p137,GPIAP1,GPIP137,GPI-p137,Homo s
E1773h ELISA kit G-CSF-induced gene 1 protein,GIG1,GIG-1 protein,GMP-17,Granule membrane protein of 17 kDa,Homo sapiens,Human,Natural killer cell protein 7,NKG7,p15-TIA-1,Protein NKG7 96T
U1773h CLIA G-CSF-induced gene 1 protein,GIG1,GIG-1 protein,GMP-17,Granule membrane protein of 17 kDa,Homo sapiens,Human,Natural killer cell protein 7,NKG7,p15-TIA-1,Protein NKG7 96T
E1773h ELISA G-CSF-induced gene 1 protein,GIG1,GIG-1 protein,GMP-17,Granule membrane protein of 17 kDa,Homo sapiens,Human,Natural killer cell protein 7,NKG7,p15-TIA-1,Protein NKG7 96T
EIAAB39705 DNA polymerase-transactivated protein 6,DNAPTP6,Homo sapiens,Human,SGNP,SP1224,SPATS2L,SPATS2-like protein,Stress granule and nucleolar protein
CPRN1-101AP Cytoplasmic cell cycle associated protein 1(Caprin 1) Abs, Host species: rabbit, polyclonal antibody 200ul
RD172229100 Zymogen Granule Membrane Protein 16, E.coli, Human Recombinant protein 0.1 mg


 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur





GENTAUR Ltd.
Howard Frank Turnberry House
1404-1410 High Road
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017

BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG

france@gentaur.com | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: 0035929830070
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.


ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur