GENTAUR Molecular Products.

 A0A144HXY0_HBV          Unreviewed;       183 AA.
 A0A144HXY0;
 08-JUN-2016, integrated into UniProtKB/TrEMBL.
 08-JUN-2016, sequence version 1.
 31-JAN-2018, entry version 13.
 RecName: Full=Capsid protein {ECO:0000256|HAMAP-Rule:MF_04076};
 AltName: Full=Core antigen {ECO:0000256|HAMAP-Rule:MF_04076};
 AltName: Full=Core protein {ECO:0000256|HAMAP-Rule:MF_04076};
 AltName: Full=HBcAg {ECO:0000256|HAMAP-Rule:MF_04076};
 AltName: Full=p21.5 {ECO:0000256|HAMAP-Rule:MF_04076};
 Name=C {ECO:0000256|HAMAP-Rule:MF_04076, ECO:0000313|EMBL:AMS75088.1};
 Hepatitis B virus (HBV).
 Viruses; Retro-transcribing viruses; Hepadnaviridae;
 Orthohepadnavirus.
 NCBI_TaxID=10407 {ECO:0000313|EMBL:AMS75088.1, ECO:0000313|Proteomes:UP000159686};
 NCBI_TaxID=9606; Homo sapiens (Human).
 NCBI_TaxID=9598; Pan troglodytes (Chimpanzee).
 [1] {ECO:0000313|EMBL:AMS75088.1, ECO:0000313|Proteomes:UP000159686}
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
 STRAIN=IND-DIB-RMRC-2052 {ECO:0000313|EMBL:AMS75088.1};
 Borkakoty B.;
 "Circulation of genotype-I hepatitis B virus in Dibang Valley,
 Arunachal Pradesh.";
 Submitted (MAR-2016) to the EMBL/GenBank/DDBJ databases.
 -!- FUNCTION: Encapsidates hepatitis delta genome. {ECO:0000256|HAMAP-
     Rule:MF_04076}.
 -!- FUNCTION: Self assembles to form an icosahedral capsid. Most
     capsid appear to be large particles with a icosahedral symmetry of
     T=4 and consist of 240 copies of capsid protein, though a fraction
     forms smaller T=3 particles consisting of 180 capsid proteins.
     Entering capsid are transported along microtubules to the nucleus.
     Phosphorylation of the capsid is thought to induce exposure of
     nuclear localization signal in the C-terminal portion of the
     capsid protein that allows binding to the nuclear pore complex via
     the importin (karyopherin-) alpha and beta. Capsids are imported
     in intact form through the nuclear pore into the nuclear basket,
     where it probably binds NUP153. Only capsids that contain the
     mature viral genome can release the viral DNA and capsid protein
     into the nucleoplasm. Immature capsids get stucked in the basket.
     Capsids encapsulate the pre-genomic RNA and the P protein. Pre-
     genomic RNA is reverse transcribed into DNA while the capsid is
     still in the cytoplasm. The capsid can then either be directed to
     the nucleus, providing more genome for transcription, or bud
     through the endoplasmic reticulum to provide new virions.
     {ECO:0000256|HAMAP-Rule:MF_04076}.
 -!- SUBUNIT: Homodimerizes, then multimerizes. Interacts with cytosol
     exposed regions of viral L glycoprotein present in the reticulum-
     to-Golgi compartment. Interacts with human FLNB. Phosphorylated
     form interacts with host importin alpha; this interaction depends
     on the exposure of the NLS, which itself depends upon genome
     maturation and/or phosphorylation of the capsid protein. Interacts
     with host NUP153. {ECO:0000256|HAMAP-Rule:MF_04076}.
 -!- SUBCELLULAR LOCATION: Virion {ECO:0000256|HAMAP-Rule:MF_04076}.
     Host cytoplasm {ECO:0000256|HAMAP-Rule:MF_04076}.
 -!- PTM: Phosphorylated by host SRPK1, SRPK2, and maybe protein kinase
     C or GAPDH. Phosphorylation is critical for pregenomic RNA
     packaging. Protein kinase C phosphorylation is stimulated by HBx
     protein and may play a role in transport of the viral genome to
     the nucleus at the late step during viral replication cycle.
     {ECO:0000256|HAMAP-Rule:MF_04076}.
 -!- SIMILARITY: Belongs to the orthohepadnavirus core antigen family.
     {ECO:0000256|HAMAP-Rule:MF_04076}.
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 EMBL; KU950741; AMS75088.1; -; Genomic_DNA.
 Proteomes; UP000159686; Genome.
 GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
 GO; GO:0039619; C:T=4 icosahedral viral capsid; IEA:UniProtKB-UniRule.
 GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
 GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
 GO; GO:0005198; F:structural molecule activity; IEA:UniProtKB-UniRule.
 GO; GO:0075521; P:microtubule-dependent intracellular transport of viral material towards nucleus; IEA:UniProtKB-UniRule.
 GO; GO:0009405; P:pathogenesis; IEA:UniProtKB-UniRule.
 GO; GO:0046718; P:viral entry into host cell; IEA:UniProtKB-UniRule.
 GO; GO:0075732; P:viral penetration into host nucleus; IEA:UniProtKB-UniRule.
 Gene3D; 1.10.4090.10; -; 1.
 HAMAP; MF_04076; HBV_HBEAG; 1.
 InterPro; IPR002006; Hepatitis_core.
 InterPro; IPR036459; Viral_capsid_core_dom_sf_HBV.
 Pfam; PF00906; Hepatitis_core; 3.
 SUPFAM; SSF47852; SSF47852; 1.
 3: Inferred from homology;
 Capsid protein {ECO:0000256|HAMAP-Rule:MF_04076};
 Complete proteome {ECO:0000313|Proteomes:UP000159686};
 Cytoplasmic inwards viral transport {ECO:0000256|HAMAP-Rule:MF_04076};
 DNA-binding {ECO:0000256|HAMAP-Rule:MF_04076};
 Host cytoplasm {ECO:0000256|HAMAP-Rule:MF_04076};
 Host-virus interaction {ECO:0000256|HAMAP-Rule:MF_04076};
 Microtubular inwards viral transport {ECO:0000256|HAMAP-
 Rule:MF_04076}; Phosphoprotein {ECO:0000256|HAMAP-Rule:MF_04076};
 Repeat {ECO:0000256|HAMAP-Rule:MF_04076,
 ECO:0000256|SAAS:SAAS00779256};
 RNA-binding {ECO:0000256|HAMAP-Rule:MF_04076};
 T=4 icosahedral capsid protein {ECO:0000256|HAMAP-Rule:MF_04076};
 Viral penetration into host nucleus {ECO:0000256|HAMAP-Rule:MF_04076};
 Virion {ECO:0000256|HAMAP-Rule:MF_04076};
 Virus entry into host cell {ECO:0000256|HAMAP-Rule:MF_04076}.
 REGION      177    183       RNA binding. {ECO:0000256|HAMAP-
                              Rule:MF_04076}.
 MOTIF       158    175       Bipartite nuclear localization signal.
                              {ECO:0000256|HAMAP-Rule:MF_04076}.
 MOD_RES     155    155       Phosphoserine; by host.
                              {ECO:0000256|HAMAP-Rule:MF_04076}.
 MOD_RES     162    162       Phosphoserine; by host.
                              {ECO:0000256|HAMAP-Rule:MF_04076}.
 MOD_RES     170    170       Phosphoserine; by host.
                              {ECO:0000256|HAMAP-Rule:MF_04076}.
 SEQUENCE   183 AA;  21046 MW;  5A7294EA8EE61460 CRC64;
 MDIDPYKEFG ASVELLSFLP SDFFPSIRDL LDTASALYRE ALESPEHCSP HHTALRQAVL
 CWGELMTLAT WVGSNLEDPA SRDLVVSYVN VNMGLKIRQL LWFHISCLTF GRETVLEYLV
 SFGVWIRTPP AYRPSNAPIL STLPETCVVR RRGRSPRRRT PSPRRRRSQS PRRRRSQSRE
 SQC

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