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Carbohydrate sulfotransferase 11 (EC 2.8.2.5) (Chondroitin 4-O-sulfotransferase 1) (Chondroitin 4-sulfotransferase 1) (C4S-1) (C4ST-1) (C4ST1)

 CHSTB_MOUSE             Reviewed;         352 AA.
Q9JME2; Q9JJS2;
15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
01-OCT-2000, sequence version 1.
12-SEP-2018, entry version 119.
RecName: Full=Carbohydrate sulfotransferase 11;
EC=2.8.2.5;
AltName: Full=Chondroitin 4-O-sulfotransferase 1;
AltName: Full=Chondroitin 4-sulfotransferase 1;
Short=C4S-1;
Short=C4ST-1;
Short=C4ST1;
Name=Chst11;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [MRNA], ENZYME ACTIVITY, AND TISSUE SPECIFICITY.
TISSUE=Brain;
PubMed=10722746; DOI=10.1074/jbc.275.12.8975;
Yamauchi S., Mita S., Matsubara T., Fukuta M., Habuchi H., Kimata K.,
Habuchi O.;
"Molecular cloning and expression of chondroitin 4-sulfotransferase.";
J. Biol. Chem. 275:8975-8981(2000).
[2]
NUCLEOTIDE SEQUENCE [MRNA].
Xia G., Evers M.R., Schachner M.;
"Cloning and expression of molecules homologous to HNK-1
sulfotransferase.";
Submitted (MAY-2000) to the EMBL/GenBank/DDBJ databases.
[3]
DEVELOPMENTAL STAGE, AND INDUCTION.
PubMed=12351172; DOI=10.1016/S0925-4773(02)00198-3;
Klueppel M., Vallis K.A., Wrana J.L.;
"A high-throughput induction gene trap approach defines C4ST as a
target of BMP signaling.";
Mech. Dev. 118:77-89(2002).
-!- FUNCTION: Catalyzes the transfer of sulfate to position 4 of the
N-acetylgalactosamine (GalNAc) residue of chondroitin. Chondroitin
sulfate constitutes the predominant proteoglycan present in
cartilage and is distributed on the surfaces of many cells and
extracellular matrices. Can also sulfate Gal residues in
desulfated dermatan sulfate. Preferentially sulfates in
GlcA->GalNAc unit than in IdoA->GalNAc unit. Does not form 4, 6-
di-O-sulfated GalNAc when chondroitin sulfate C is used as an
acceptor.
-!- CATALYTIC ACTIVITY: 3'-phosphoadenylyl sulfate + chondroitin =
adenosine 3',5'-bisphosphate + chondroitin 4'-sulfate.
{ECO:0000269|PubMed:10722746}.
-!- SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250};
Single-pass type II membrane protein {ECO:0000250}.
-!- TISSUE SPECIFICITY: Predominantly expressed in brain and kidney.
Also expressed at weaker level in heart, spleen and lung.
Expressed in developing chondrocytes.
{ECO:0000269|PubMed:10722746}.
-!- DEVELOPMENTAL STAGE: First expressed at day 9.75 of embryogenesis
in the apical ectodermal ridge (AER) of the developing limb buds
and at the edges of branchial arches 1 and 2. Also expressed in
the ventral neural tube, notochord and sympathetic ganglia and the
mesonephric tubules of the developing kidneys. In the heart, it is
expressed in the myocardium of the atrium and in the endocardial
cushions of both the developing inflow tract and the
atrioventricular valves. At day 15, it is expressed in the
cartilage of developing bones, in vertebrae and cartilage of the
trachea as well as in the thymus. In the forelimb, it is expressed
in all developing bones, but absent from developing joint regions
and was down-regulated in chondrocytes beginning to undergo
mineralization, such as in the center of the ulna. At day 15, no
expression in the neural tube is observed. In the heart at day 15,
it is still expressed in the atrial valve, the atrioventricular
valves and in the myocardium of the atrium, while in the kidney,
it is expressed in the collecting tubules as well as in Bowman
capsule. Interestingly, the liver displays a punctate expression
at day 15. Also expressed in tooth primordia, hair follicles and
mammary glands. {ECO:0000269|PubMed:12351172}.
-!- INDUCTION: By BMP2, suggesting it is a target of BMP signaling.
{ECO:0000269|PubMed:12351172}.
-!- PTM: N-glycosylated; required for activity and stability.
{ECO:0000250}.
-!- SIMILARITY: Belongs to the sulfotransferase 2 family.
{ECO:0000305}.
-----------------------------------------------------------------------
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EMBL; AB030378; BAA92942.1; -; mRNA.
EMBL; AJ289133; CAB92141.1; -; mRNA.
CCDS; CCDS24074.1; -.
RefSeq; NP_067414.2; NM_021439.2.
UniGene; Mm.360747; -.
ProteinModelPortal; Q9JME2; -.
STRING; 10090.ENSMUSP00000045349; -.
iPTMnet; Q9JME2; -.
PhosphoSitePlus; Q9JME2; -.
MaxQB; Q9JME2; -.
PaxDb; Q9JME2; -.
PRIDE; Q9JME2; -.
Ensembl; ENSMUST00000040110; ENSMUSP00000045349; ENSMUSG00000034612.
GeneID; 58250; -.
KEGG; mmu:58250; -.
UCSC; uc007gke.1; mouse.
CTD; 50515; -.
MGI; MGI:1927166; Chst11.
eggNOG; KOG4651; Eukaryota.
eggNOG; ENOG4111GJR; LUCA.
GeneTree; ENSGT00760000119214; -.
HOGENOM; HOG000231801; -.
HOVERGEN; HBG050952; -.
InParanoid; Q9JME2; -.
KO; K01017; -.
OMA; PLNEHWQ; -.
OrthoDB; EOG091G0FZO; -.
PhylomeDB; Q9JME2; -.
TreeFam; TF325581; -.
BRENDA; 2.8.2.5; 3474.
Reactome; R-MMU-2022870; Chondroitin sulfate biosynthesis.
SABIO-RK; Q9JME2; -.
ChiTaRS; Chst11; mouse.
PRO; PR:Q9JME2; -.
Proteomes; UP000000589; Chromosome 10.
Bgee; ENSMUSG00000034612; Expressed in 260 organ(s), highest expression level in humerus cartilage element.
CleanEx; MM_CHST11; -.
ExpressionAtlas; Q9JME2; baseline and differential.
Genevisible; Q9JME2; MM.
GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0047756; F:chondroitin 4-sulfotransferase activity; ISO:MGI.
GO; GO:0001537; F:N-acetylgalactosamine 4-O-sulfotransferase activity; ISO:MGI.
GO; GO:0050659; F:N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase activity; IDA:MGI.
GO; GO:0008146; F:sulfotransferase activity; IDA:MGI.
GO; GO:0016051; P:carbohydrate biosynthetic process; IEA:InterPro.
GO; GO:0051216; P:cartilage development; IMP:MGI.
GO; GO:0002063; P:chondrocyte development; IMP:MGI.
GO; GO:0030206; P:chondroitin sulfate biosynthetic process; IDA:MGI.
GO; GO:0030204; P:chondroitin sulfate metabolic process; IMP:MGI.
GO; GO:0048589; P:developmental growth; IMP:MGI.
GO; GO:0042733; P:embryonic digit morphogenesis; IMP:MGI.
GO; GO:0030326; P:embryonic limb morphogenesis; IMP:MGI.
GO; GO:0048704; P:embryonic skeletal system morphogenesis; IMP:MGI.
GO; GO:0048703; P:embryonic viscerocranium morphogenesis; IMP:MGI.
GO; GO:0043066; P:negative regulation of apoptotic process; IMP:MGI.
GO; GO:0030512; P:negative regulation of transforming growth factor beta receptor signaling pathway; IMP:MGI.
GO; GO:0033037; P:polysaccharide localization; IMP:MGI.
GO; GO:0036342; P:post-anal tail morphogenesis; IMP:MGI.
GO; GO:0009791; P:post-embryonic development; IMP:MGI.
GO; GO:0042127; P:regulation of cell proliferation; IMP:MGI.
GO; GO:0007585; P:respiratory gaseous exchange; IMP:MGI.
InterPro; IPR018011; Carb_sulfotrans_8-10.
InterPro; IPR005331; Sulfotransferase.
PANTHER; PTHR12137; PTHR12137; 1.
Pfam; PF03567; Sulfotransfer_2; 1.
2: Evidence at transcript level;
Carbohydrate metabolism; Complete proteome; Glycoprotein;
Golgi apparatus; Membrane; Reference proteome; Signal-anchor;
Transferase; Transmembrane; Transmembrane helix.
CHAIN 1 352 Carbohydrate sulfotransferase 11.
/FTId=PRO_0000189665.
TOPO_DOM 1 16 Cytoplasmic. {ECO:0000255}.
TRANSMEM 17 37 Helical; Signal-anchor for type II
membrane protein. {ECO:0000255}.
TOPO_DOM 38 352 Lumenal. {ECO:0000255}.
NP_BIND 124 130 PAPS. {ECO:0000250}.
NP_BIND 186 194 PAPS. {ECO:0000250}.
CARBOHYD 205 205 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 223 223 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 321 321 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 342 342 N-linked (GlcNAc...) asparagine.
{ECO:0000250}.
CONFLICT 255 255 F -> L (in Ref. 2; CAB92141).
{ECO:0000305}.
SEQUENCE 352 AA; 41632 MW; 6573EA72EB0C4FA1 CRC64;
MKPALLEVMR MNRICRMVLA TCFGSFILVI FYFQSMLHPV MRRNPFGVDI CCRKGSRSPL
QELYNPIQLE LSNTAILHQM RRDQVTDTCR ANSAMSRKRR VLTPNDLKHL VVDEDHELIY
CYVPKVACTN WKRLMMVLSG RGKYSDPMEI PANEAHVSAN LKTLNQYSIP EINHRLKSYM
KFLFVREPFE RLVSAYRNKF TQKYNTSFHK RYGTKIIRRQ RKNATQEALR KGDDVKFEEF
VAYLIDPHTQ REEPFNEHWQ TVYSLCHPCH IHYDLVGKYE TLEEDSNYVL QLAGVSGYLK
FPTYAKSTRT TDEMTTEFFQ NISAEHQTQL YEVYKLDFLM FNYSVPNYLK LD


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