Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

Carbohydrate sulfotransferase 6 (EC 2.8.2.-) (Corneal N-acetylglucosamine-6-O-sulfotransferase) (C-GlcNAc6ST) (hCGn6ST) (Galactose/N-acetylglucosamine/N-acetylglucosamine 6-O-sulfotransferase 4-beta) (GST4-beta) (N-acetylglucosamine 6-O-sulfotransferase 5) (GlcNAc6ST-5) (Gn6st-5)

 CHST6_HUMAN             Reviewed;         395 AA.
Q9GZX3; D3DUK3;
15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
01-MAR-2001, sequence version 1.
18-JUL-2018, entry version 140.
RecName: Full=Carbohydrate sulfotransferase 6;
EC=2.8.2.-;
AltName: Full=Corneal N-acetylglucosamine-6-O-sulfotransferase;
Short=C-GlcNAc6ST;
Short=hCGn6ST;
AltName: Full=Galactose/N-acetylglucosamine/N-acetylglucosamine 6-O-sulfotransferase 4-beta;
Short=GST4-beta;
AltName: Full=N-acetylglucosamine 6-O-sulfotransferase 5;
Short=GlcNAc6ST-5;
Short=Gn6st-5;
Name=CHST6;
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
NCBI_TaxID=9606;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], TISSUE SPECIFICITY, AND
VARIANTS MCD CYS-50; ARG-174; GLU-203; TRP-211 AND LYS-274.
PubMed=11017086; DOI=10.1038/79987;
Akama T.O., Nishida K., Nakayama J., Watanabe H., Ozaki K.,
Nakamura T., Dota A., Kawasaki S., Inoue Y., Maeda N., Yamamoto S.,
Fujiwara T., Thonar E.J.-M.A., Shimomura Y., Kinoshita S.,
Tanigami A., Fukuda M.N.;
"Macular corneal dystrophy type I and type II are caused by distinct
mutations in a new sulphotransferase gene.";
Nat. Genet. 26:237-241(2000).
[2]
NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
PubMed=11181564; DOI=10.1093/glycob/11.1.75;
Hemmerich S., Lee J.K., Bhakta S., Bistrup A., Ruddle N.R.,
Rosen S.D.;
"Chromosomal localization and genomic organization for the galactose/
N-acetylgalactosamine/N-acetylglucosamine 6-O-sulfotransferase gene
family.";
Glycobiology 11:75-87(2001).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
Venter J.C.;
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Lung;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[5]
FUNCTION, AND TISSUE SPECIFICITY.
PubMed=11352640; DOI=10.1006/bbrc.2001.4668;
Bartes A., Bhakta S., Hemmerich S.;
"Sulfation of endothelial mucin by corneal keratan N-acetylglucosamine
6-O-sulfotransferase (GST-4beta).";
Biochem. Biophys. Res. Commun. 282:928-933(2001).
[6]
FUNCTION, SUBSTRATE SPECIFICITY, AND VARIANTS MCD CYS-50; ARG-174;
GLU-203; TRP-211; THR-217 AND LYS-274.
PubMed=12218059; DOI=10.1074/jbc.M207412200;
Akama T.O., Misra A.K., Hindsgaul O., Fukuda M.N.;
"Enzymatic synthesis in vitro of the disulfated disaccharide unit of
corneal keratan sulfate.";
J. Biol. Chem. 277:42505-42513(2002).
[7]
VARIANTS MCD VAL-128 AND PRO-166.
PubMed=11139648;
Liu N.-P., Dew-Knight S., Rayner M., Jonasson F., Akama T.O.,
Fukuda M.N., Bao W., Gilbert J.R., Vance J.M., Klintworth G.K.;
"Mutations in corneal carbohydrate sulfotransferase 6 gene (CHST6)
cause macular corneal dystrophy in Iceland.";
Mol. Vis. 6:261-264(2000).
[8]
VARIANTS MCD SER-31; SER-72; SER-107; ARG-200 AND VAL-206.
PubMed=11818380;
El-Ashry M.F., El-Aziz M.M., Wilkins S., Cheetham M.E., Wilkie S.E.,
Hardcastle A.J., Halford S., Bayoumi A.Y., Ficker L.A., Tuft S.,
Bhattacharya S.S., Ebenezer N.D.;
"Identification of novel mutations in the carbohydrate
sulfotransferase gene (CHST6) causing macular corneal dystrophy.";
Invest. Ophthalmol. Vis. Sci. 43:377-382(2002).
[9]
VARIANTS MCD PRO-15; THR-61; HIS-68; LEU-70; GLY-102; PRO-131;
PRO-152; PRO-166; ARG-200 AND GLN-204.
PubMed=12824236; DOI=10.1167/iovs.02-0740;
Niel F., Ellies P., Dighiero P., Soria J., Sabbagh C., San C.,
Renard G., Delpech M., Valleix S.;
"Truncating mutations in the carbohydrate sulfotransferase 6 gene
(CHST6) result in macular corneal dystrophy.";
Invest. Ophthalmol. Vis. Sci. 44:2949-2953(2003).
[10]
VARIANTS MCD HIS-177; GLN-204; LEU-205; TRP-211 AND THR-217.
PubMed=12882769; DOI=10.1167/iovs.02-0910;
Iida-Hasegawa N., Furuhata A., Hayatsu H., Murakami A., Fujiki K.,
Nakayasu K., Kanai A.;
"Mutations in the CHST6 gene in patients with macular corneal
dystrophy: immunohistochemical evidence of heterogeneity.";
Invest. Ophthalmol. Vis. Sci. 44:3272-3277(2003).
[11]
VARIANT MCD GLN-211.
PubMed=12883341; DOI=10.1097/00003226-200308000-00004;
Ha N.T., Chau H.M., Cung le X., Thanh T.K., Fujiki K., Murakami A.,
Hiratsuka Y., Hasegawa N., Kanai A.;
"Identification of novel mutations of the CHST6 gene in Vietnamese
families affected with macular corneal dystrophy in two generations.";
Cornea 22:508-511(2003).
[12]
VARIANTS MCD LEU-51; PRO-59; LEU-66; MET-76; GLN-211; GLN-211; CYS-268
AND CYS-268.
PubMed=12882775; DOI=10.1167/iovs.03-0031;
Ha N.T., Chau H.M., Cung le X., Thanh T.K., Fujiki K., Murakami A.,
Hiratsuka Y., Kanai A.;
"Mutation analysis of the carbohydrate sulfotransferase gene in
Vietnamese with macular corneal dystrophy.";
Invest. Ophthalmol. Vis. Sci. 44:3310-3316(2003).
[13]
VARIANTS MCD ARG-22; TYR-42; LEU-53; HIS-93; PRO-97; TYR-102; CYS-127;
GLN-205; THR-206; PRO-249 AND LYS-274.
PubMed=14609920; DOI=10.1001/archopht.121.11.1608;
Warren J.F., Aldave A.J., Srinivasan M., Thonar E.J., Kumar A.B.,
Cevallos V., Whitcher J.P., Margolis T.P.;
"Novel mutations in the CHST6 gene associated with macular corneal
dystrophy in southern India.";
Arch. Ophthalmol. 121:1608-1612(2003).
[14]
VARIANTS MCD ASP-52; LEU-53; TRP-98; SER-107; LEU-121; SER-202;
GLN-204; PHE-210; GLU-221 AND TYR-221.
PubMed=14735064;
Sultana A., Sridhar M.S., Jagannathan A., Balasubramanian D.,
Kannabiran C., Klintworth G.K.;
"Novel mutations of the carbohydrate sulfotransferase-6 (CHST6) gene
causing macular corneal dystrophy in India.";
Mol. Vis. 9:730-734(2003).
[15]
VARIANTS MCD GLY-102; GLY-162; GLU-198 AND ARG-200.
PubMed=14984470; DOI=10.1111/j.0009-9163.2004.00191.x;
Abbruzzese C., Kuhn U., Molina F., Rama P., De Luca M.;
"Novel mutations in the CHST6 gene causing macular corneal
dystrophy.";
Clin. Genet. 65:120-125(2004).
[16]
VARIANTS MCD LEU-51; SER-72; GLY-102; VAL-104; CYS-110; PRO-122;
ARG-200 AND PRO-276.
PubMed=15013869; DOI=10.1016/j.ajo.2003.09.036;
Aldave A.J., Yellore V.S., Thonar E.J., Udar N., Warren J.F.,
Yoon M.K., Cohen E.J., Rapuano C.J., Laibson P.R., Margolis T.P.,
Small K.;
"Novel mutations in the carbohydrate sulfotransferase gene (CHST6) in
American patients with macular corneal dystrophy.";
Am. J. Ophthalmol. 137:465-473(2004).
[17]
VARIANTS MCD ARG-200; PRO-276 AND ASP-358.
PubMed=15652851; DOI=10.1016/j.ajo.2004.07.001;
El-Ashry M.F., Abd El-Aziz M.M., Shalaby O., Wilkins S.,
Poopalasundaram S., Cheetham M., Tuft S.J., Hardcastle A.J.,
Bhattacharya S.S., Ebenezer N.D.;
"Novel CHST6 nonsense and missense mutations responsible for macular
corneal dystrophy.";
Am. J. Ophthalmol. 139:192-193(2005).
[18]
VARIANT MCD HIS-358.
PubMed=19365571;
Dang X., Zhu Q., Wang L., Su H., Lin H., Zhou N., Liang T., Wang Z.,
Huang S., Ren Q., Qi Y.;
"Macular corneal dystrophy in a Chinese family related with novel
mutations of CHST6.";
Mol. Vis. 15:700-705(2009).
[19]
VARIANTS MCD GLY-177; ARG-186 AND GLN-211.
PubMed=21242781; DOI=10.1097/ICO.0b013e3182012888;
Patel D.A., Harocopos G.J., Chang S.H., Vora S.C., Lubniewski A.J.,
Huang A.J.;
"Novel CHST6 gene mutations in 2 unrelated cases of macular corneal
dystrophy.";
Cornea 30:664-669(2011).
[20]
VARIANT MCD TRP-205.
PubMed=24311932; DOI=10.3341/kjo.2013.27.6.454;
Lee Y.K., Chang D.J., Chung S.K.;
"A case of Korean patient with macular corneal dystrophy associated
with novel mutation in the CHST6 gene.";
Korean J. Ophthalmol. 27:454-458(2013).
[21]
VARIANTS MCD PHE-118; ARG-174; ARG-186; TRP-205; LYS-274; TYR-308 AND
HIS-358.
PubMed=26604660;
Park S.H., Ahn Y.J., Chae H., Kim Y., Kim M.S., Kim M.;
"Molecular analysis of the CHST6 gene in Korean patients with macular
corneal dystrophy: Identification of three novel mutations.";
Mol. Vis. 21:1201-1209(2015).
-!- FUNCTION: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl
sulfate (PAPS) as sulfonate donor to catalyze the transfer of
sulfate to position 6 of non-reducing N-acetylglucosamine (GlcNAc)
residues of keratan. Mediates sulfation of keratan in cornea.
Keratan sulfate plays a central role in maintaining corneal
transparency. Acts on the non-reducing terminal GlcNAc of short
and long carbohydrate substrates that have poly-N-
acetyllactosamine structures. {ECO:0000269|PubMed:11352640,
ECO:0000269|PubMed:12218059}.
-!- SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250};
Single-pass type II membrane protein {ECO:0000250}.
-!- TISSUE SPECIFICITY: Expressed in cornea. Mainly expressed in
brain. Also expressed in spinal cord and trachea.
{ECO:0000269|PubMed:11017086, ECO:0000269|PubMed:11181564,
ECO:0000269|PubMed:11352640}.
-!- DISEASE: Macular dystrophy, corneal (MCD) [MIM:217800]: An ocular
disease characterized by bilateral, progressive corneal
opacification, and reduced corneal sensitivity. Onset occurs in
the first decade, usually between ages 5 and 9. Painful attacks
with photophobia, foreign body sensations, and recurrent erosions
occur in most patients. The disease is due to deposition of an
unsulfated keratan sulfate both within the intracellular space
(within the keratocytes and endothelial cells) and in the
extracellular corneal stroma. Macular corneal dystrophy is divided
into the clinically indistinguishable types I, IA, and II based on
analysis of the normally sulfated, or antigenic, keratan sulfate
levels in serum and immunohistochemical evaluation of the cornea.
Patients with types I and IA macular corneal dystrophy have
undetectable serum levels of antigenic keratan sulfate, whereas
those with type II macular corneal dystrophy have normal or low
levels, depending on the population examined.
{ECO:0000269|PubMed:11017086, ECO:0000269|PubMed:11139648,
ECO:0000269|PubMed:11818380, ECO:0000269|PubMed:12218059,
ECO:0000269|PubMed:12824236, ECO:0000269|PubMed:12882769,
ECO:0000269|PubMed:12882775, ECO:0000269|PubMed:12883341,
ECO:0000269|PubMed:14609920, ECO:0000269|PubMed:14735064,
ECO:0000269|PubMed:14984470, ECO:0000269|PubMed:15013869,
ECO:0000269|PubMed:15652851, ECO:0000269|PubMed:19365571,
ECO:0000269|PubMed:21242781, ECO:0000269|PubMed:24311932,
ECO:0000269|PubMed:26604660}. Note=The disease is caused by
mutations affecting the gene represented in this entry. CHST6
homozygous missense mutations have been observed in patients with
macular corneal dystrophy type I, while type II patients show a
large deletion and replacement in the upstream region of CHST6.
The only missense mutation for type II is Cys-50, which is
heterozygous with a replacement in the upstream region on the
other allele of CHST6.
-!- SIMILARITY: Belongs to the sulfotransferase 1 family.
Gal/GlcNAc/GalNAc subfamily. {ECO:0000305}.
-!- CAUTION: PubMed:12824236 reported a Gly-204 variant, however
according to their results reported in figure 1, it is a Gln-204
variant. {ECO:0000305}.
-----------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
Distributed under the Creative Commons Attribution (CC BY 4.0) License
-----------------------------------------------------------------------
EMBL; AF219990; AAG26325.1; -; mRNA.
EMBL; AF219991; AAG26327.1; -; Genomic_DNA.
EMBL; AF280086; AAG48244.1; -; mRNA.
EMBL; CH471114; EAW95640.1; -; Genomic_DNA.
EMBL; CH471114; EAW95641.1; -; Genomic_DNA.
EMBL; BC074883; AAH74883.1; -; mRNA.
EMBL; BC074834; AAH74834.1; -; mRNA.
CCDS; CCDS10918.1; -.
RefSeq; NP_067628.1; NM_021615.4.
RefSeq; XP_005256012.1; XM_005255955.4.
RefSeq; XP_011521387.1; XM_011523085.2.
UniGene; Hs.655622; -.
ProteinModelPortal; Q9GZX3; -.
BioGrid; 110334; 14.
STRING; 9606.ENSP00000328983; -.
iPTMnet; Q9GZX3; -.
PhosphoSitePlus; Q9GZX3; -.
BioMuta; CHST6; -.
EPD; Q9GZX3; -.
PaxDb; Q9GZX3; -.
PeptideAtlas; Q9GZX3; -.
PRIDE; Q9GZX3; -.
ProteomicsDB; 80165; -.
Ensembl; ENST00000332272; ENSP00000328983; ENSG00000183196.
Ensembl; ENST00000390664; ENSP00000375079; ENSG00000183196.
GeneID; 4166; -.
KEGG; hsa:4166; -.
UCSC; uc002fef.4; human.
CTD; 4166; -.
DisGeNET; 4166; -.
EuPathDB; HostDB:ENSG00000183196.8; -.
GeneCards; CHST6; -.
HGNC; HGNC:6938; CHST6.
MalaCards; CHST6; -.
MIM; 217800; phenotype.
MIM; 605294; gene.
neXtProt; NX_Q9GZX3; -.
OpenTargets; ENSG00000183196; -.
Orphanet; 98969; Macular corneal dystrophy.
PharmGKB; PA26506; -.
eggNOG; ENOG410IJXD; Eukaryota.
eggNOG; ENOG4110V0B; LUCA.
GeneTree; ENSGT00530000062902; -.
HOGENOM; HOG000261614; -.
HOVERGEN; HBG050949; -.
InParanoid; Q9GZX3; -.
KO; K09671; -.
OMA; KPLCARQ; -.
OrthoDB; EOG091G0V3Y; -.
PhylomeDB; Q9GZX3; -.
TreeFam; TF342871; -.
Reactome; R-HSA-2022854; Keratan sulfate biosynthesis.
Reactome; R-HSA-3656225; Defective CHST6 causes MCDC1.
ChiTaRS; CHST6; human.
GeneWiki; CHST6; -.
GenomeRNAi; 4166; -.
PRO; PR:Q9GZX3; -.
Proteomes; UP000005640; Chromosome 16.
Bgee; ENSG00000183196; -.
CleanEx; HS_CHST6; -.
Genevisible; Q9GZX3; HS.
GO; GO:0005794; C:Golgi apparatus; TAS:UniProtKB.
GO; GO:0000139; C:Golgi membrane; TAS:Reactome.
GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
GO; GO:0001517; F:N-acetylglucosamine 6-O-sulfotransferase activity; IDA:UniProtKB.
GO; GO:0005975; P:carbohydrate metabolic process; IEA:UniProtKB-KW.
GO; GO:0018146; P:keratan sulfate biosynthetic process; IDA:UniProtKB.
GO; GO:0006044; P:N-acetylglucosamine metabolic process; IDA:UniProtKB.
GO; GO:0006790; P:sulfur compound metabolic process; IDA:UniProtKB.
InterPro; IPR016469; Carbohydrate_sulfotransferase.
InterPro; IPR027417; P-loop_NTPase.
InterPro; IPR000863; Sulfotransferase_dom.
Pfam; PF00685; Sulfotransfer_1; 1.
PIRSF; PIRSF005883; Carbohydrate_sulfotransferase; 1.
SUPFAM; SSF52540; SSF52540; 2.
1: Evidence at protein level;
Carbohydrate metabolism; Complete proteome; Corneal dystrophy;
Disease mutation; Glycoprotein; Golgi apparatus; Membrane;
Polymorphism; Reference proteome; Signal-anchor; Transferase;
Transmembrane; Transmembrane helix.
CHAIN 1 395 Carbohydrate sulfotransferase 6.
/FTId=PRO_0000085197.
TOPO_DOM 1 5 Cytoplasmic. {ECO:0000255}.
TRANSMEM 6 26 Helical; Signal-anchor for type II
membrane protein. {ECO:0000255}.
TOPO_DOM 27 395 Lumenal. {ECO:0000255}.
NP_BIND 49 55 PAPS. {ECO:0000250}.
NP_BIND 202 210 PAPS. {ECO:0000250}.
CARBOHYD 116 116 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 229 229 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 305 305 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 328 328 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
VARIANT 15 15 L -> P (in MCD).
{ECO:0000269|PubMed:12824236}.
/FTId=VAR_021417.
VARIANT 22 22 L -> R (in MCD; dbSNP:rs68043642).
{ECO:0000269|PubMed:14609920}.
/FTId=VAR_021418.
VARIANT 31 31 P -> S (in MCD; dbSNP:rs72547549).
{ECO:0000269|PubMed:11818380}.
/FTId=VAR_021419.
VARIANT 42 42 H -> Y (in MCD).
{ECO:0000269|PubMed:14609920}.
/FTId=VAR_021420.
VARIANT 50 50 R -> C (in MCD; abolishes ability to
sulfate keratan; dbSNP:rs28937877).
{ECO:0000269|PubMed:11017086,
ECO:0000269|PubMed:12218059}.
/FTId=VAR_021421.
VARIANT 51 51 S -> L (in MCD; dbSNP:rs370335460).
{ECO:0000269|PubMed:12882775,
ECO:0000269|PubMed:15013869}.
/FTId=VAR_021422.
VARIANT 52 52 G -> D (in MCD).
{ECO:0000269|PubMed:14735064}.
/FTId=VAR_021423.
VARIANT 53 53 S -> L (in MCD).
{ECO:0000269|PubMed:14609920,
ECO:0000269|PubMed:14735064}.
/FTId=VAR_021424.
VARIANT 59 59 L -> P (in MCD).
{ECO:0000269|PubMed:12882775}.
/FTId=VAR_021425.
VARIANT 61 61 N -> T (in MCD; dbSNP:rs72547548).
{ECO:0000269|PubMed:12824236}.
/FTId=VAR_021426.
VARIANT 66 66 V -> L (in MCD; dbSNP:rs72547547).
{ECO:0000269|PubMed:12882775}.
/FTId=VAR_021427.
VARIANT 68 68 Y -> H (in MCD; dbSNP:rs775742450).
{ECO:0000269|PubMed:12824236}.
/FTId=VAR_021428.
VARIANT 70 70 M -> L (in MCD).
{ECO:0000269|PubMed:12824236}.
/FTId=VAR_021429.
VARIANT 72 72 P -> S (in MCD; dbSNP:rs377617168).
{ECO:0000269|PubMed:11818380,
ECO:0000269|PubMed:15013869}.
/FTId=VAR_021430.
VARIANT 76 76 V -> M (in MCD).
{ECO:0000269|PubMed:12882775}.
/FTId=VAR_021431.
VARIANT 93 93 R -> H (in MCD).
{ECO:0000269|PubMed:14609920}.
/FTId=VAR_021432.
VARIANT 97 97 R -> P (in MCD; dbSNP:rs72547546).
{ECO:0000269|PubMed:14609920}.
/FTId=VAR_021433.
VARIANT 98 98 S -> W (in MCD).
{ECO:0000269|PubMed:14735064}.
/FTId=VAR_021434.
VARIANT 102 102 C -> G (in MCD; dbSNP:rs121917822).
{ECO:0000269|PubMed:12824236,
ECO:0000269|PubMed:14984470,
ECO:0000269|PubMed:15013869}.
/FTId=VAR_021435.
VARIANT 102 102 C -> Y (in MCD).
{ECO:0000269|PubMed:14609920}.
/FTId=VAR_021436.
VARIANT 104 104 M -> V (in MCD).
{ECO:0000269|PubMed:15013869}.
/FTId=VAR_021437.
VARIANT 107 107 F -> S (in MCD; dbSNP:rs72547545).
{ECO:0000269|PubMed:11818380,
ECO:0000269|PubMed:14735064}.
/FTId=VAR_021438.
VARIANT 110 110 Y -> C (in MCD; dbSNP:rs72547544).
{ECO:0000269|PubMed:15013869}.
/FTId=VAR_021439.
VARIANT 118 118 S -> F (in MCD; unknown pathological
significance).
{ECO:0000269|PubMed:26604660}.
/FTId=VAR_075522.
VARIANT 121 121 F -> L (in MCD).
{ECO:0000269|PubMed:14735064}.
/FTId=VAR_021440.
VARIANT 122 122 Q -> P (in MCD; dbSNP:rs758105699).
{ECO:0000269|PubMed:15013869}.
/FTId=VAR_021441.
VARIANT 127 127 R -> C (in MCD).
{ECO:0000269|PubMed:14609920}.
/FTId=VAR_021442.
VARIANT 128 128 A -> V (in MCD; dbSNP:rs72547543).
{ECO:0000269|PubMed:11139648}.
/FTId=VAR_021443.
VARIANT 131 131 S -> P (in MCD).
{ECO:0000269|PubMed:12824236}.
/FTId=VAR_021444.
VARIANT 152 152 L -> P (in MCD; dbSNP:rs142954809).
{ECO:0000269|PubMed:12824236}.
/FTId=VAR_021445.
VARIANT 162 162 R -> G (in MCD; dbSNP:rs117435647).
{ECO:0000269|PubMed:14984470}.
/FTId=VAR_021446.
VARIANT 166 166 R -> P (in MCD; dbSNP:rs72547542).
{ECO:0000269|PubMed:11139648,
ECO:0000269|PubMed:12824236}.
/FTId=VAR_021447.
VARIANT 174 174 K -> R (in MCD; abolishes ability to
sulfate keratan; dbSNP:rs28937877).
{ECO:0000269|PubMed:11017086,
ECO:0000269|PubMed:12218059,
ECO:0000269|PubMed:26604660}.
/FTId=VAR_021448.
VARIANT 177 177 R -> G (in MCD).
{ECO:0000269|PubMed:21242781}.
/FTId=VAR_075523.
VARIANT 177 177 R -> H (in MCD).
{ECO:0000269|PubMed:12882769}.
/FTId=VAR_021449.
VARIANT 186 186 P -> R (in MCD; dbSNP:rs376162109).
{ECO:0000269|PubMed:21242781,
ECO:0000269|PubMed:26604660}.
/FTId=VAR_075524.
VARIANT 198 198 V -> E (in MCD).
{ECO:0000269|PubMed:14984470}.
/FTId=VAR_021450.
VARIANT 200 200 L -> R (in MCD; dbSNP:rs28937879).
{ECO:0000269|PubMed:11818380,
ECO:0000269|PubMed:12824236,
ECO:0000269|PubMed:14984470,
ECO:0000269|PubMed:15013869,
ECO:0000269|PubMed:15652851}.
/FTId=VAR_021451.
VARIANT 202 202 R -> S (in MCD).
{ECO:0000269|PubMed:14735064}.
/FTId=VAR_021452.
VARIANT 203 203 D -> E (in MCD; abolishes ability to
sulfate keratan; dbSNP:rs28937878).
{ECO:0000269|PubMed:11017086,
ECO:0000269|PubMed:12218059}.
/FTId=VAR_021453.
VARIANT 204 204 P -> Q (in MCD; dbSNP:rs759870075).
{ECO:0000269|PubMed:12824236,
ECO:0000269|PubMed:12882769,
ECO:0000269|PubMed:14735064}.
/FTId=VAR_021454.
VARIANT 205 205 R -> L (in MCD).
{ECO:0000269|PubMed:12882769}.
/FTId=VAR_021455.
VARIANT 205 205 R -> Q (in MCD; dbSNP:rs377706989).
{ECO:0000269|PubMed:14609920}.
/FTId=VAR_021456.
VARIANT 205 205 R -> W (in MCD; dbSNP:rs750219546).
{ECO:0000269|PubMed:24311932,
ECO:0000269|PubMed:26604660}.
/FTId=VAR_075525.
VARIANT 206 206 A -> T (in MCD; dbSNP:rs374493344).
{ECO:0000269|PubMed:14609920}.
/FTId=VAR_021457.
VARIANT 206 206 A -> V (in MCD).
{ECO:0000269|PubMed:11818380}.
/FTId=VAR_021458.
VARIANT 210 210 S -> F (in MCD; dbSNP:rs745571211).
{ECO:0000269|PubMed:14735064}.
/FTId=VAR_021459.
VARIANT 211 211 R -> Q (in MCD; dbSNP:rs771397083).
{ECO:0000269|PubMed:12882775,
ECO:0000269|PubMed:12883341,
ECO:0000269|PubMed:21242781}.
/FTId=VAR_021460.
VARIANT 211 211 R -> W (in MCD; abolishes ability to
sulfate keratan; dbSNP:rs202175444).
{ECO:0000269|PubMed:11017086,
ECO:0000269|PubMed:12218059,
ECO:0000269|PubMed:12882769}.
/FTId=VAR_021461.
VARIANT 217 217 A -> T (in MCD; abolishes ability to
sulfate keratan; dbSNP:rs752785520).
{ECO:0000269|PubMed:12218059,
ECO:0000269|PubMed:12882769}.
/FTId=VAR_021462.
VARIANT 221 221 D -> E (in MCD).
{ECO:0000269|PubMed:14735064}.
/FTId=VAR_021463.
VARIANT 221 221 D -> Y (in MCD).
{ECO:0000269|PubMed:14735064}.
/FTId=VAR_021464.
VARIANT 249 249 H -> P (in MCD; dbSNP:rs72547540).
{ECO:0000269|PubMed:14609920}.
/FTId=VAR_021465.
VARIANT 268 268 Y -> C (in MCD; dbSNP:rs72547539).
{ECO:0000269|PubMed:12882775}.
/FTId=VAR_021466.
VARIANT 274 274 E -> K (in MCD; abolishes ability to
sulfate keratan; dbSNP:rs72547538).
{ECO:0000269|PubMed:11017086,
ECO:0000269|PubMed:12218059,
ECO:0000269|PubMed:14609920,
ECO:0000269|PubMed:26604660}.
/FTId=VAR_021467.
VARIANT 276 276 L -> P (in MCD; dbSNP:rs121917824).
{ECO:0000269|PubMed:15013869,
ECO:0000269|PubMed:15652851}.
/FTId=VAR_021468.
VARIANT 308 308 H -> Y (in MCD; unknown pathological
significance).
{ECO:0000269|PubMed:26604660}.
/FTId=VAR_075526.
VARIANT 358 358 Y -> D (in MCD).
{ECO:0000269|PubMed:15652851}.
/FTId=VAR_021469.
VARIANT 358 358 Y -> H (in MCD).
{ECO:0000269|PubMed:19365571,
ECO:0000269|PubMed:26604660}.
/FTId=VAR_075527.
VARIANT 369 369 N -> D (in dbSNP:rs35036798).
/FTId=VAR_033735.
SEQUENCE 395 AA; 44099 MW; 433CA60248A48F67 CRC64;
MWLPRVSSTA VTALLLAQTF LLLFLVSRPG PSSPAGGEAR VHVLVLSSWR SGSSFVGQLF
NQHPDVFYLM EPAWHVWTTL SQGSAATLHM AVRDLVRSVF LCDMDVFDAY LPWRRNLSDL
FQWAVSRALC SPPACSAFPR GAISSEAVCK PLCARQSFTL AREACRSYSH VVLKEVRFFN
LQVLYPLLSD PALNLRIVHL VRDPRAVLRS REQTAKALAR DNGIVLGTNG TWVEADPGLR
VVREVCRSHV RIAEAATLKP PPFLRGRYRL VRFEDLAREP LAEIRALYAF TGLSLTPQLE
AWIHNITHGS GPGARREAFK TSSRNALNVS QAWRHALPFA KIRRVQELCA GALQLLGYRP
VYSEDEQRNL ALDLVLPRGL NGFTWASSTA SHPRN


Related products :

Catalog number Product name Quantity
EIAAB07281 Carbohydrate sulfotransferase 6,C-GlcNAc6ST,CHST6,Corneal N-acetylglucosamine-6-O-sulfotransferase,Galactose_N-acetylglucosamine_N-acetylglucosamine 6-O-sulfotransferase 4-beta,GlcNAc6ST-5,Gn6st-5,GST
EIAAB07278 Carbohydrate sulfotransferase 4,Chst4,Galactose_N-acetylglucosamine_N-acetylglucosamine 6-O-sulfotransferase 3,GlcNAc6ST-2,Gn6st-2,Gst3,GST-3,HEC-GlcNAc6ST,High endothelial cells N-acetylglucosamine 6
EIAAB07277 Carbohydrate sulfotransferase 4,CHST4,Galactose_N-acetylglucosamine_N-acetylglucosamine 6-O-sulfotransferase 3,GlcNAc6ST-2,Gn6st-2,GST-3,HEC-GlcNAc6ST,High endothelial cells N-acetylglucosamine 6-O-su
EIAAB07282 C6ST-2,Carbohydrate sulfotransferase 7,Chondroitin 6-sulfotransferase 2,Chst7,Galactose_N-acetylglucosamine_N-acetylglucosamine 6-O-sulfotransferase 5,GlcNAc6ST-4,Gn6st-4,GST-5,N-acetylglucosamine 6-O
EIAAB07279 Carbohydrate sulfotransferase 5,Chst5,Galactose_N-acetylglucosamine_N-acetylglucosamine 6-O-sulfotransferase 4,GlcNAc6ST-3,Gn6st-3,GST4,Gst4,I-GlcNAc6ST,Intestinal GlcNAc-6-sulfotransferase,Intestinal
18-003-42700 Carbohydrate sulfotransferase 4 - EC 2.8.2.-; N-acetylglucosamine 6-O-sulfotransferase 2; GlcNAc6ST-2; High endothelial cells N-acetylglucosamine 6-O-sulfotransferase; HEC-GlcNAc6ST; L-selectin ligand 0.1 mg Protein A
18-003-42699 Carbohydrate sulfotransferase 4 - EC 2.8.2.-; N-acetylglucosamine 6-O-sulfotransferase 2; GlcNAc6ST-2; High endothelial cells N-acetylglucosamine 6-O-sulfotransferase; HEC-GlcNAc6ST; L-selectin ligand 0.05 mg Aff Pur
EIAAB07271 Carbohydrate sulfotransferase 2,CHST2,Galactose_N-acetylglucosamine_N-acetylglucosamine 6-O-sulfotransferase 2,GlcNAc6ST-1,GN6ST,Gn6ST-1,GST-2,Homo sapiens,Human,N-acetylglucosamine 6-O-sulfotransfera
EIAAB07272 Carbohydrate sulfotransferase 2,Chst2,Galactose_N-acetylglucosamine_N-acetylglucosamine 6-O-sulfotransferase 2,GlcNAc6ST-1,Gn6st-1,Gst2,GST-2,Mouse,Mus musculus,N-acetylglucosamine 6-O-sulfotransferas
EIAAB07280 Carbohydrate sulfotransferase 5,CHST5,Galactose_N-acetylglucosamine_N-acetylglucosamine 6-O-sulfotransferase 4-alpha,GlcNAc6ST-3,Gn6st-3,GST4-alpha,hIGn6ST,Homo sapiens,Human,I-GlcNAc6ST,Intestinal Gl
EIAAB07283 C6ST-2,Carbohydrate sulfotransferase 7,Chondroitin 6-sulfotransferase 2,Chst7,Galactose_N-acetylglucosamine_N-acetylglucosamine 6-O-sulfotransferase 5,GlcNAc6ST-4,Gn6st-4,Gst5,GST-5,mC6ST-2,Mouse,Mus
EIAAB07284 C6ST-2,Carbohydrate sulfotransferase 7,Chondroitin 6-sulfotransferase 2,CHST7,Galactose_N-acetylglucosamine_N-acetylglucosamine 6-O-sulfotransferase 5,GlcNAc6ST-4,Gn6st-4,GST-5,Homo sapiens,Human,N-ac
18-003-44263 Carbohydrate sulfotransferase 7 - EC 2.8.2.17; EC 2.8.2.-; Chondroitin 6-sulfotransferase 2; C6ST-2; N-acetylglucosamine 6-O-sulfotransferase 1; GlcNAc6ST-4; Galactose_N-acetylglucosamine_N-acetylgluc 0.1 mg Protein A
EIAAB07274 C6ST-1,Carbohydrate sulfotransferase 3,Chondroitin 6-O-sulfotransferase 1,Chondroitin 6-sulfotransferase,CHST3,Galactose_N-acetylglucosamine_N-acetylglucosamine 6-O-sulfotransferase 0,GST-0,Homo sapie
EIAAB07276 C6ST-1,Carbohydrate sulfotransferase 3,Chondroitin 6-O-sulfotransferase 1,Chst3,Galactose_N-acetylglucosamine_N-acetylglucosamine 6-O-sulfotransferase 0,GST-0,Rat,Rattus norvegicus
EIAAB07269 Carbohydrate sulfotransferase 1,Chst1,Galactose_N-acetylglucosamine_N-acetylglucosamine 6-O-sulfotransferase 1,GST-1,Keratan sulfate Gal-6 sulfotransferase,KS6ST,KSGal6ST,KSST,Rat,Rattus norvegicus
EIAAB07270 Carbohydrate sulfotransferase 1,CHST1,Galactose_N-acetylglucosamine_N-acetylglucosamine 6-O-sulfotransferase 1,GST-1,Homo sapiens,Human,Keratan sulfate Gal-6 sulfotransferase,KS6ST,KSGal6ST,KSST
EIAAB07268 Carbohydrate sulfotransferase 1,Chst1,Galactose_N-acetylglucosamine_N-acetylglucosamine 6-O-sulfotransferase 1,Gst1,GST-1,Keratan sulfate Gal-6 sulfotransferase,KS6ST,KSGal6ST,KSST,Mouse,Mus musculus
EIAAB07275 C6st,C6ST-1,Carbohydrate sulfotransferase 3,Chondroitin 6-O-sulfotransferase 1,Chst3,Galactose_N-acetylglucosamine_N-acetylglucosamine 6-O-sulfotransferase 0,Gst0,GST-0,Mouse,Mus musculus
CHST6 CHST4 Gene carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 4
CHST9 CHST7 Gene carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 7
CHST7 CHST5 Gene carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 5
CHST8 CHST6 Gene carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 6
CHST4 CHST2 Gene carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2
GWB-9446C9 Anti- CHST4 (carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 4) Antibody


 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur





GENTAUR Ltd.
Howard Frank Turnberry House
1404-1410 High Road
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017

BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG

france@gentaur.com | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: 0035929830070
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.


ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur