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Casein kinase I isoform delta (CKI-delta) (CKId) (EC 2.7.11.1) (Tau-protein kinase CSNK1D) (EC 2.7.11.26)

 KC1D_BOVIN              Reviewed;         415 AA.
P35508;
01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
23-JAN-2007, sequence version 2.
10-OCT-2018, entry version 152.
RecName: Full=Casein kinase I isoform delta;
Short=CKI-delta;
Short=CKId;
EC=2.7.11.1;
AltName: Full=Tau-protein kinase CSNK1D;
EC=2.7.11.26;
Name=CSNK1D; Synonyms=HCKID;
Bos taurus (Bovine).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
Pecora; Bovidae; Bovinae; Bos.
NCBI_TaxID=9913;
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Hereford;
PubMed=19390049; DOI=10.1126/science.1169588;
The bovine genome sequencing and analysis consortium;
"The genome sequence of taurine cattle: a window to ruminant biology
and evolution.";
Science 324:522-528(2009).
[2]
NUCLEOTIDE SEQUENCE [MRNA] OF 137-178.
TISSUE=Brain;
PubMed=1946367; DOI=10.1073/pnas.88.21.9548;
Rowles J., Slaughter C., Moomaw C., Hsu J., Cobb M.H.;
"Purification of casein kinase I and isolation of cDNAs encoding
multiple casein kinase I-like enzymes.";
Proc. Natl. Acad. Sci. U.S.A. 88:9548-9552(1991).
-!- FUNCTION: Essential serine/threonine-protein kinase that regulates
diverse cellular growth and survival processes including Wnt
signaling, DNA repair and circadian rhythms. It can phosphorylate
a large number of proteins. Casein kinases are operationally
defined by their preferential utilization of acidic proteins such
as caseins as substrates. Phosphorylates connexin-43/GJA1, MAP1A,
SNAPIN, MAPT/TAU, TOP2A, DCK, HIF1A, EIF6, p53/TP53, DVL2, DVL3,
ESR1, AIB1/NCOA3, DNMT1, PKD2, YAP1, PER1 and PER2. Central
component of the circadian clock. In balance with PP1, determines
the circadian period length through the regulation of the speed
and rhythmicity of PER1 and PER2 phosphorylation. Controls PER1
and PER2 nuclear transport and degradation. YAP1 phosphorylation
promotes its SCF(beta-TRCP) E3 ubiquitin ligase-mediated
ubiquitination and subsequent degradation. DNMT1 phosphorylation
reduces its DNA-binding activity. Phosphorylation of ESR1 and
AIB1/NCOA3 stimulates their activity and coactivation.
Phosphorylation of DVL2 and DVL3 regulates WNT3A signaling pathway
that controls neurite outgrowth. EIF6 phosphorylation promotes its
nuclear export. Triggers down-regulation of dopamine receptors in
the forebrain. Activates DCK in vitro by phosphorylation. TOP2A
phosphorylation favors DNA cleavable complex formation. May
regulate the formation of the mitotic spindle apparatus in
extravillous trophoblast. Modulates connexin-43/GJA1 gap junction
assembly by phosphorylation. Probably involved in lymphocyte
physiology. Regulates fast synaptic transmission mediated by
glutamate (By similarity). {ECO:0000250}.
-!- CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein.
-!- CATALYTIC ACTIVITY: ATP + [tau protein] = ADP + [tau protein]
phosphate.
-!- ACTIVITY REGULATION: Drug-mediated inhibition leads to a delay of
the oscillations with the magnitude of this effect dependent upon
the timing of drug administration. Inhibited by phosphorylation
(By similarity). Exhibits substrate-dependent heparin activation.
{ECO:0000250}.
-!- SUBUNIT: Binds to DNMT1 and MAP1A. Monomer. Component of the
circadian core oscillator, which includes the CRY proteins, CLOCK,
or NPAS2, ARTNL/BMAL1 or ARTNL2/BMAL2, CSNK1D and/or CSNK1E,
TIMELESS and the PER proteins. Interacts directly with PER1 and
PER2 which may lead to their degradation. Interacts with MAPT/TAU,
SNAPIN, DBNDD2, AIB1/NCOA3 and ESR1. AKAP9/AKAP450 binding
promotes centrosomal subcellular location. Binds to tubulins in
mitotic cells upon DNA damage (By similarity). {ECO:0000250}.
-!- SUBCELLULAR LOCATION: Cytoplasm. Nucleus {ECO:0000250}. Cytoplasm,
cytoskeleton, microtubule organizing center, centrosome
{ECO:0000250}. Cytoplasm, perinuclear region {ECO:0000250}. Cell
membrane {ECO:0000250}. Cytoplasm, cytoskeleton, spindle
{ECO:0000250}. Golgi apparatus {ECO:0000250}. Note=Localized at
mitotic spindle microtubules, and at the centrosomes and
interphase in interphase cells. Recruited to the spindle apparatus
and the centrosomes in response to DNA-damage. Correct subcellular
localization requires kinase activity (By similarity).
{ECO:0000250}.
-!- PTM: Autophosphorylated on serine and threonine residues; this
autophosphorylation represses activity. Reactivated by
phosphatase-mediated dephosphorylation. May be dephosphorylated by
PP1 (By similarity). {ECO:0000250}.
-!- SIMILARITY: Belongs to the protein kinase superfamily. CK1 Ser/Thr
protein kinase family. Casein kinase I subfamily. {ECO:0000305}.
-----------------------------------------------------------------------
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EMBL; M76545; AAA30453.1; -; mRNA.
PIR; C56406; C56406.
RefSeq; XP_005221107.1; XM_005221050.2.
UniGene; Bt.106858; -.
UniGene; Bt.21018; -.
UniGene; Bt.46945; -.
UniGene; Bt.91118; -.
ProteinModelPortal; P35508; -.
SMR; P35508; -.
STRING; 9913.ENSBTAP00000026621; -.
PaxDb; P35508; -.
PRIDE; P35508; -.
Ensembl; ENSBTAT00000026621; ENSBTAP00000026621; ENSBTAG00000019986.
GeneID; 523542; -.
VGNC; VGNC:27766; CSNK1D.
eggNOG; KOG1164; Eukaryota.
eggNOG; ENOG410XPGP; LUCA.
GeneTree; ENSGT00920000148982; -.
HOGENOM; HOG000182055; -.
HOVERGEN; HBG000176; -.
InParanoid; P35508; -.
OMA; RWYGTEC; -.
OrthoDB; EOG091G0AFG; -.
TreeFam; TF300544; -.
Reactome; R-BTA-204005; COPII-mediated vesicle transport.
Reactome; R-BTA-2565942; Regulation of PLK1 Activity at G2/M Transition.
Reactome; R-BTA-380259; Loss of Nlp from mitotic centrosomes.
Reactome; R-BTA-380270; Recruitment of mitotic centrosome proteins and complexes.
Reactome; R-BTA-380320; Recruitment of NuMA to mitotic centrosomes.
Reactome; R-BTA-5620912; Anchoring of the basal body to the plasma membrane.
Reactome; R-BTA-8854518; AURKA Activation by TPX2.
Proteomes; UP000009136; Chromosome 19.
Bgee; ENSBTAG00000019986; Expressed in 9 organ(s), highest expression level in testis.
ExpressionAtlas; P35508; baseline and differential.
GO; GO:0005813; C:centrosome; IEA:Ensembl.
GO; GO:0000139; C:Golgi membrane; IDA:AgBase.
GO; GO:0005634; C:nucleus; ISS:UniProtKB.
GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO; GO:0005876; C:spindle microtubule; IEA:Ensembl.
GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO; GO:0004672; F:protein kinase activity; ISS:UniProtKB.
GO; GO:0004674; F:protein serine/threonine kinase activity; IDA:AgBase.
GO; GO:0050321; F:tau-protein kinase activity; IEA:UniProtKB-EC.
GO; GO:0032922; P:circadian regulation of gene expression; ISS:UniProtKB.
GO; GO:0006897; P:endocytosis; IBA:GO_Central.
GO; GO:0007030; P:Golgi organization; IEA:Ensembl.
GO; GO:0007020; P:microtubule nucleation; IEA:Ensembl.
GO; GO:1905515; P:non-motile cilium assembly; IEA:Ensembl.
GO; GO:0018105; P:peptidyl-serine phosphorylation; IDA:AgBase.
GO; GO:0090263; P:positive regulation of canonical Wnt signaling pathway; IEA:Ensembl.
GO; GO:2000052; P:positive regulation of non-canonical Wnt signaling pathway; IEA:Ensembl.
GO; GO:0032436; P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process; ISS:UniProtKB.
GO; GO:0001934; P:positive regulation of protein phosphorylation; IEA:Ensembl.
GO; GO:0071539; P:protein localization to centrosome; IEA:Ensembl.
GO; GO:0061512; P:protein localization to cilium; IEA:Ensembl.
GO; GO:0034067; P:protein localization to Golgi apparatus; IEA:Ensembl.
GO; GO:0006468; P:protein phosphorylation; ISS:UniProtKB.
GO; GO:0008360; P:regulation of cell shape; IBA:GO_Central.
GO; GO:0042752; P:regulation of circadian rhythm; ISS:UniProtKB.
GO; GO:0051225; P:spindle assembly; IEA:Ensembl.
GO; GO:0016055; P:Wnt signaling pathway; IBA:GO_Central.
InterPro; IPR011009; Kinase-like_dom_sf.
InterPro; IPR000719; Prot_kinase_dom.
InterPro; IPR017441; Protein_kinase_ATP_BS.
InterPro; IPR008271; Ser/Thr_kinase_AS.
Pfam; PF00069; Pkinase; 1.
SMART; SM00220; S_TKc; 1.
SUPFAM; SSF56112; SSF56112; 1.
PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
2: Evidence at transcript level;
ATP-binding; Biological rhythms; Cell membrane; Complete proteome;
Cytoplasm; Cytoskeleton; Golgi apparatus; Kinase; Membrane;
Methylation; Nucleotide-binding; Nucleus; Phosphoprotein;
Reference proteome; Serine/threonine-protein kinase; Transferase;
Wnt signaling pathway.
CHAIN 1 415 Casein kinase I isoform delta.
/FTId=PRO_0000192832.
DOMAIN 9 277 Protein kinase. {ECO:0000255|PROSITE-
ProRule:PRU00159}.
NP_BIND 15 23 ATP. {ECO:0000255|PROSITE-
ProRule:PRU00159}.
REGION 278 364 Centrosomal localization signal (CLS).
{ECO:0000250}.
REGION 317 342 Autoinhibitory. {ECO:0000250}.
ACT_SITE 128 128 Proton acceptor. {ECO:0000255|PROSITE-
ProRule:PRU00159, ECO:0000255|PROSITE-
ProRule:PRU10027}.
BINDING 38 38 ATP. {ECO:0000255|PROSITE-
ProRule:PRU00159}.
MOD_RES 328 328 Phosphoserine.
{ECO:0000250|UniProtKB:P48730}.
MOD_RES 331 331 Phosphoserine.
{ECO:0000250|UniProtKB:P48730}.
MOD_RES 370 370 Phosphoserine.
{ECO:0000250|UniProtKB:Q06486}.
MOD_RES 375 375 Omega-N-methylarginine.
{ECO:0000250|UniProtKB:Q9DC28}.
MOD_RES 382 382 Phosphoserine.
{ECO:0000250|UniProtKB:P48730}.
MOD_RES 383 383 Phosphoserine.
{ECO:0000250|UniProtKB:P48730}.
MOD_RES 384 384 Phosphoserine.
{ECO:0000250|UniProtKB:P48730}.
MOD_RES 407 407 Phosphoserine.
{ECO:0000250|UniProtKB:P48730}.
MOD_RES 411 411 Phosphoserine.
{ECO:0000250|UniProtKB:P48730}.
SEQUENCE 415 AA; 47330 MW; B97F1717A52466D2 CRC64;
MELRVGNRYR LGRKIGSGSF GDIYLGTDIA AGEEVAIKLE CVKTKHPQLH IESKIYKMMQ
GGVGIPTIRW CGAEGDYNVM VMELLGPSLE DLFNFCSRKF SLKTVLLLAD QMISRIEYIH
SKNFIHRDVK PDNFLMGLGK KGNLVYIIDF GLAKKYRDAR THQHIPYREN KNLTGTARYA
SINTHLGIEQ SRRDDLESLG YVLMYFNLGS LPWQGLKAAT KRQKYERISE KKMSTPIEVL
CKGYPSEFAT YLNFCRSLRF DDKPDYSYLR QLFRNLFHRQ GFSYDYVFDW NMLKFGASRA
ADDAERERRD REERLRHSRN PATRGLPSTA SGRLRGTQEV APPTPLTPTS HTANTSPRPV
SGMERERKVS MRLHRGAPVN ISSSDLTGRQ DTSRMSTSQI PGRVASSGLQ SVVHR


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