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Caspase recruitment domain family, member 15 (Predicted) (Nucleotide-binding oligomerization domain-containing 2)

 D4A5W3_RAT              Unreviewed;       932 AA.
D4A5W3;
20-APR-2010, integrated into UniProtKB/TrEMBL.
20-APR-2010, sequence version 1.
18-JUL-2018, entry version 82.
SubName: Full=Caspase recruitment domain family, member 15 (Predicted) {ECO:0000313|EMBL:EDL87529.1};
SubName: Full=Nucleotide-binding oligomerization domain-containing 2 {ECO:0000313|Ensembl:ENSRNOP00000061463};
Name=Nod2 {ECO:0000313|Ensembl:ENSRNOP00000061463,
ECO:0000313|RGD:1306368};
Synonyms=Card15_predicted {ECO:0000313|EMBL:EDL87529.1};
ORFNames=rCG_63140 {ECO:0000313|EMBL:EDL87529.1};
Rattus norvegicus (Rat).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Rattus.
NCBI_TaxID=10116 {ECO:0000313|Ensembl:ENSRNOP00000061463, ECO:0000313|Proteomes:UP000002494};
[1] {ECO:0000313|Ensembl:ENSRNOP00000061463, ECO:0000313|Proteomes:UP000002494}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000061463,
ECO:0000313|Proteomes:UP000002494};
PubMed=15057822; DOI=10.1038/nature02426;
Rat Genome Sequencing Project Consortium;
Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J.,
Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G.,
Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G.,
Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G.,
Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S.,
Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T.,
Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T.,
Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A.,
Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M.,
Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K.,
Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S.,
Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J.,
Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y.,
Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A.,
Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J.,
D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R.,
Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A.,
Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E.,
Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E.,
Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J.,
Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D.,
Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M.,
Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O.,
Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O.,
Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H.,
Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S.,
Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J.,
Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M.,
Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E.,
Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F.,
Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K.,
Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S.,
Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M.,
Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M.,
Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A.,
Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S.,
Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G.,
Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H.,
Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R.,
Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M.,
Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H.,
Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S.,
Collins F.S.;
"Genome sequence of the Brown Norway rat yields insights into
mammalian evolution.";
Nature 428:493-521(2004).
[2] {ECO:0000313|EMBL:EDL87529.1}
NUCLEOTIDE SEQUENCE.
STRAIN=BN {ECO:0000313|EMBL:EDL87529.1};
PubMed=15632090; DOI=10.1101/gr.2889405;
Florea L., Di Francesco V., Miller J., Turner R., Yao A., Harris M.,
Walenz B., Mobarry C., Merkulov G.V., Charlab R., Dew I., Deng Z.,
Istrail S., Li P., Sutton G.;
"Gene and alternative splicing annotation with AIR.";
Genome Res. 15:54-66(2005).
[3] {ECO:0000313|EMBL:EDL87529.1}
NUCLEOTIDE SEQUENCE.
STRAIN=BN {ECO:0000313|EMBL:EDL87529.1};
Mural R.J., Li P.W., Adams M.D., Amanatides P.G., Baden-Tillson H.,
Barnstead M., Chin S.H., Dew I., Evans C.A., Ferriera S., Flanigan M.,
Fosler C., Glodek A., Gu Z., Holt R.A., Jennings D., Kraft C.L.,
Lu F., Nguyen T., Nusskern D.R., Pfannkoch C.M., Sitter C.,
Sutton G.G., Venter J.C., Wang Z., Woodage T., Zheng X.H., Zhong F.;
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
[4] {ECO:0000313|Ensembl:ENSRNOP00000061463}
IDENTIFICATION.
STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000061463};
Ensembl;
Submitted (JUL-2011) to UniProtKB.
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EMBL; AABR07043075; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AABR07043076; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; CH474037; EDL87529.1; -; Genomic_DNA.
RefSeq; NP_001099642.1; NM_001106172.1.
UniGene; Rn.218600; -.
STRING; 10116.ENSRNOP00000061463; -.
Ensembl; ENSRNOT00000065103; ENSRNOP00000061463; ENSRNOG00000014124.
GeneID; 291912; -.
KEGG; rno:291912; -.
CTD; 64127; -.
RGD; 1306368; Nod2.
eggNOG; KOG4308; Eukaryota.
eggNOG; ENOG410ZBX3; LUCA.
GeneTree; ENSGT00860000133673; -.
KO; K10165; -.
Reactome; R-RNO-168638; NOD1/2 Signaling Pathway.
Reactome; R-RNO-445989; TAK1 activates NFkB by phosphorylation and activation of IKKs complex.
Reactome; R-RNO-450302; activated TAK1 mediates p38 MAPK activation.
Reactome; R-RNO-450321; JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1.
Reactome; R-RNO-5689896; Ovarian tumor domain proteases.
Reactome; R-RNO-9020702; Interleukin-1 signaling.
Proteomes; UP000002494; Chromosome 19.
Bgee; ENSRNOG00000014124; -.
GO; GO:0005737; C:cytoplasm; IDA:RGD.
GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO; GO:0032500; F:muramyl dipeptide binding; IDA:RGD.
GO; GO:0071407; P:cellular response to organic cyclic compound; IEP:RGD.
GO; GO:0071224; P:cellular response to peptidoglycan; IEP:RGD.
GO; GO:0008284; P:positive regulation of cell proliferation; IDA:RGD.
GO; GO:0002732; P:positive regulation of dendritic cell cytokine production; IDA:RGD.
GO; GO:0042981; P:regulation of apoptotic process; IEA:InterPro.
GO; GO:0032495; P:response to muramyl dipeptide; IDA:RGD.
GO; GO:0007584; P:response to nutrient; IEP:RGD.
Gene3D; 3.80.10.10; -; 1.
InterPro; IPR001315; CARD.
InterPro; IPR011029; DEATH-like_dom_sf.
InterPro; IPR001611; Leu-rich_rpt.
InterPro; IPR032675; LRR_dom_sf.
InterPro; IPR007111; NACHT_NTPase.
InterPro; IPR027417; P-loop_NTPase.
Pfam; PF00619; CARD; 2.
Pfam; PF13516; LRR_6; 3.
Pfam; PF05729; NACHT; 1.
SUPFAM; SSF47986; SSF47986; 2.
SUPFAM; SSF52540; SSF52540; 1.
PROSITE; PS50209; CARD; 2.
PROSITE; PS50837; NACHT; 1.
4: Predicted;
ATP-binding {ECO:0000256|SAAS:SAAS01046498};
Complete proteome {ECO:0000313|Proteomes:UP000002494};
Nucleotide-binding {ECO:0000256|SAAS:SAAS01046498};
Reference proteome {ECO:0000313|Proteomes:UP000002494};
Repeat {ECO:0000256|SAAS:SAAS01046485}.
DOMAIN 1 82 CARD. {ECO:0000259|PROSITE:PS50209}.
DOMAIN 107 191 CARD. {ECO:0000259|PROSITE:PS50209}.
DOMAIN 266 402 NACHT. {ECO:0000259|PROSITE:PS50837}.
SEQUENCE 932 AA; 103398 MW; C0A7A4271FF7DEA9 CRC64;
MCSQEDFQAQ RSQLVALLVS GSLEGFESIL DWLLSWDVLS REDYEGLSLP GQPLSHSARR
LLDTVCNKGV WGCQKLFEAV QEAQANSHTF ELQGCWDVHS LHPTRDLQSH RPAIVRRLCS
HVEAILELAR DEGFLSQYEC EEIRLPIFTS SQRARRLLDL AAVKANGLAA FLLQHVRKLP
ASLSLPYEAA ECQKFTAKLR TMVSAQSRFL STYDGSENLC LEDIYTENTL ELRTEVGTAG
ALQKSPATLG LEELFGTHGH LNKDADTILV VGEAGSGKST LLQRLHLLWA SGQNFREFLF
IFPFSCRQLQ CMTKPLSLRT LLFEHCCWPD VGQDDVFQFL LDHPDRVLLT FDGLDEFKFR
FTDRERHCSP LDPTSVQTLL FNLLQGNLLK NACKVLTSRP DAVSALLRKF VRTECHLKGF
SEEGIKLYLR KHHREPGVAD RLIHLIQATS ALHGLCHLPV FSWMVSRCHR ELLLQNRGFP
TTSTDMYLLI LQHFLLHASP PDSFPLGLGP GLLQSRLSTL LHLGHLALQG LAMSCYVFSA
QQLQAAQVDS EDISLGFLVR AQSVVPGSKA PLEFLHITFQ CFFAAFYLAV SADTSAASLK
HLFSCGRPGN SLLLRLLPNL CIQGSRVKGG QAALLQKAEP HNLQITAAFL AGLLSQQHRD
LLAACQVPER VLLQRQARAR SCLAHSLREH FHSIPPAVPG ETKSMHAMPG FIWLIRSLYE
MQEVQLAREA VRRLDIGHLK LTFCRVGPAE CAALAFVLQH LQRPVALQLD HNSVGDVGVE
QLLPCLGVCT ALYLRDNNIS DRGARTLVEC ALRCEQLQKL ALFNNKLTDG CASSVAKLLA
HKQNFLSLRV GNNHITAAGA EVLAQGLKSN TSLQFLGFWG NSVGDKGSQA LAEVVADHQR
LKWLSLVGNN IGSVGAHALA LMLEKNKSLE EL


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