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Caspase-13 (CASP-13) (EC 3.4.22.-) (Evolutionary related interleukin-1-beta-converting enzyme) (ERICE) [Cleaved into: Caspase-13 subunit 1; Caspase-13 subunit 2]

 CASPD_BOVIN             Reviewed;         377 AA.
O75601;
01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
01-NOV-1998, sequence version 1.
28-FEB-2018, entry version 136.
RecName: Full=Caspase-13;
Short=CASP-13;
EC=3.4.22.-;
AltName: Full=Evolutionary related interleukin-1-beta-converting enzyme;
Short=ERICE;
Contains:
RecName: Full=Caspase-13 subunit 1;
Contains:
RecName: Full=Caspase-13 subunit 2;
Flags: Precursor;
Name=CASP13;
Bos taurus (Bovine).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
Pecora; Bovidae; Bovinae; Bos.
NCBI_TaxID=9913;
[1]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A), AND MUTAGENESIS OF CYS-258.
TISSUE=Fibroblast;
PubMed=9624166; DOI=10.1074/jbc.273.25.15702;
Humke E.W., Ni J., Dixit V.M.;
"ERICE, a novel FLICE-activatable caspase.";
J. Biol. Chem. 273:15702-15707(1998).
[2]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS A AND B).
PubMed=11478774; DOI=10.1006/bbrc.2001.5315;
Koenig U., Eckhart L., Tschachler E.;
"Evidence that caspase-13 is not a human but a bovine gene.";
Biochem. Biophys. Res. Commun. 285:1150-1154(2001).
-!- FUNCTION: Involved in the activation cascade of caspases
responsible for apoptosis execution. Might function by either
activating some proteins required for cell death or inactivating
proteins necessary for cell survival.
-!- SUBUNIT: Heterotetramer that consists of two anti-parallel
arranged heterodimers, each one formed by a small and a large
subunit. {ECO:0000250}.
-!- ALTERNATIVE PRODUCTS:
Event=Alternative splicing; Named isoforms=2;
Name=A;
IsoId=O75601-1; Sequence=Displayed;
Name=B;
IsoId=O75601-2; Sequence=VSP_000823;
-!- TISSUE SPECIFICITY: Mainly expressed in peripheral blood
lymphocytes, spleen and placenta.
-!- PTM: The two subunits are derived from the precursor sequence by
an autocatalytic mechanism or by cleavage by Caspase-8.
-!- SIMILARITY: Belongs to the peptidase C14A family. {ECO:0000305}.
-!- CAUTION: Was originally thought to originate from human.
{ECO:0000305|PubMed:9624166}.
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EMBL; AF078533; AAC28380.1; -; mRNA.
EMBL; AF383946; AAK77964.1; -; mRNA.
EMBL; AF383947; AAK77965.1; -; mRNA.
RefSeq; NP_788811.1; NM_176638.5. [O75601-1]
UniGene; Bt.16018; -.
ProteinModelPortal; O75601; -.
SMR; O75601; -.
MEROPS; C14.017; -.
PeptideAtlas; O75601; -.
PRIDE; O75601; -.
Ensembl; ENSBTAT00000027820; ENSBTAP00000027820; ENSBTAG00000020884. [O75601-1]
GeneID; 338039; -.
KEGG; bta:338039; -.
CTD; 837; -.
eggNOG; KOG3573; Eukaryota.
eggNOG; ENOG410ZQIE; LUCA.
HOVERGEN; HBG076981; -.
InParanoid; O75601; -.
KO; K04394; -.
OrthoDB; EOG091G07NO; -.
TreeFam; TF102023; -.
Reactome; R-BTA-168638; NOD1/2 Signaling Pathway.
Proteomes; UP000009136; Chromosome 15.
Bgee; ENSBTAG00000020884; -.
ExpressionAtlas; O75601; baseline and differential.
GO; GO:0097169; C:AIM2 inflammasome complex; IBA:GO_Central.
GO; GO:0072557; C:IPAF inflammasome complex; IBA:GO_Central.
GO; GO:0072559; C:NLRP3 inflammasome complex; IBA:GO_Central.
GO; GO:0004197; F:cysteine-type endopeptidase activity; TAS:ProtInc.
GO; GO:0097153; F:cysteine-type endopeptidase activity involved in apoptotic process; IBA:GO_Central.
GO; GO:0006915; P:apoptotic process; TAS:ProtInc.
GO; GO:0035234; P:ectopic germ cell programmed cell death; IEA:Ensembl.
GO; GO:0050718; P:positive regulation of interleukin-1 beta secretion; IEA:Ensembl.
GO; GO:0070269; P:pyroptosis; IEA:Ensembl.
GO; GO:0042981; P:regulation of apoptotic process; IEA:InterPro.
GO; GO:0050727; P:regulation of inflammatory response; IBA:GO_Central.
CDD; cd00032; CASc; 1.
InterPro; IPR001315; CARD.
InterPro; IPR029030; Caspase-like_dom_sf.
InterPro; IPR033139; Caspase_cys_AS.
InterPro; IPR016129; Caspase_his_AS.
InterPro; IPR011029; DEATH-like_dom_sf.
InterPro; IPR002138; Pept_C14_p10.
InterPro; IPR001309; Pept_C14_p20.
InterPro; IPR015917; Pept_C14A.
Pfam; PF00619; CARD; 1.
PRINTS; PR00376; IL1BCENZYME.
SMART; SM00114; CARD; 1.
SMART; SM00115; CASc; 1.
SUPFAM; SSF47986; SSF47986; 1.
SUPFAM; SSF52129; SSF52129; 1.
PROSITE; PS50209; CARD; 1.
PROSITE; PS01122; CASPASE_CYS; 1.
PROSITE; PS01121; CASPASE_HIS; 1.
PROSITE; PS50207; CASPASE_P10; 1.
PROSITE; PS50208; CASPASE_P20; 1.
1: Evidence at protein level;
Alternative splicing; Apoptosis; Complete proteome; Hydrolase;
Protease; Reference proteome; Thiol protease; Zymogen.
PROPEP 1 ? {ECO:0000255}.
/FTId=PRO_0000004649.
CHAIN ? 289 Caspase-13 subunit 1.
/FTId=PRO_0000004650.
CHAIN 290 377 Caspase-13 subunit 2.
/FTId=PRO_0000004651.
DOMAIN 1 86 CARD. {ECO:0000255|PROSITE-
ProRule:PRU00046}.
ACT_SITE 210 210 {ECO:0000250}.
ACT_SITE 258 258 {ECO:0000250}.
VAR_SEQ 68 124 Missing (in isoform B).
{ECO:0000303|PubMed:11478774}.
/FTId=VSP_000823.
MUTAGEN 258 258 C->S: Inactivation.
{ECO:0000269|PubMed:9624166}.
SEQUENCE 377 AA; 43012 MW; 959A59424DAECBF4 CRC64;
MAEDKHNKNP LKMLESLGKE LISGLLDDFV EKNVLKLEEE EKKKIYDAKL QDKARVLVDS
IRQKNQEAGQ VFVQTFLNID KNSTSIKAPE ETVAGPDESV GSAATLKLCP HEEFLKLCKE
RAGEIYPIKE RKDRTRLALI ICNTEFDHMP PRNGAALDIL GMKQLLEGLG YTVEVEEKLT
ARDMESVLWK FAAREEHKSS DSTFLVFMSH GILDGICGTM HSEEEPDVLP YDTIFRTFNN
RNCLSLKDKP KVIIVQACRG ANRGELWVSD SPPALADSFS QSSENLEEDA VYKTHVEKDF
IAFCSSTPHN VSWRDIKKGS LFITRLITCF QKYAWCCHLE EVFRKVQQSF EKPNVKAQMP
TVERLSMTRY FYLFPGN


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