Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

Caspase-2 (CASP-2) (EC 3.4.22.55) (Protease ICH-1) [Cleaved into: Caspase-2 subunit p18; Caspase-2 subunit p13; Caspase-2 subunit p12]

 CASP2_RAT               Reviewed;         452 AA.
P55215; O35398; O55194; Q9WUI6;
01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
06-DEC-2005, sequence version 3.
23-MAY-2018, entry version 161.
RecName: Full=Caspase-2;
Short=CASP-2;
EC=3.4.22.55;
AltName: Full=Protease ICH-1;
Contains:
RecName: Full=Caspase-2 subunit p18;
Contains:
RecName: Full=Caspase-2 subunit p13;
Contains:
RecName: Full=Caspase-2 subunit p12;
Flags: Precursor;
Name=Casp2; Synonyms=Ich1;
Rattus norvegicus (Rat).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Rattus.
NCBI_TaxID=10116;
[1]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
PubMed=9427555; DOI=10.1016/S0378-1119(97)00463-0;
Sato N., Milligan C.E., Uchiyama Y., Oppenheim R.W.;
"Cloning and expression of the cDNA encoding rat caspase-2.";
Gene 202:127-132(1997).
[2]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
STRAIN=Sprague-Dawley; TISSUE=Brain;
PubMed=12067235; DOI=10.1046/j.1471-4159.2002.00781.x;
Jin K., Nagayama T., Mao X., Kawaguchi K., Hickey R.W.,
Greenberg D.A., Simon R.P., Graham S.H.;
"Two caspase-2 transcripts are expressed in rat hippocampus after
global cerebral ischemia.";
J. Neurochem. 81:25-35(2002).
[3]
NUCLEOTIDE SEQUENCE [MRNA] OF 67-324.
STRAIN=Sprague-Dawley; TISSUE=Kidney cortex;
PubMed=9530276;
Kaushal G.P., Singh A.B., Shah S.V.;
"Identification of gene family of caspases in rat kidney and altered
expression in ischemia-reperfusion injury.";
Am. J. Physiol. 274:F587-F595(1998).
[4]
NUCLEOTIDE SEQUENCE [MRNA] OF 198-379.
TISSUE=Ovary;
PubMed=7588240; DOI=10.1210/endo.136.11.7588240;
Flaws J.A., Kugu K., Trbovich A.M., Desanti A., Tilly K.I.,
Hirshfield A.N., Tilly J.L.;
"Interleukin-1 beta-converting enzyme-related proteases (IRPs) and
mammalian cell death: dissociation of IRP-induced oligonucleosomal
endonuclease activity from morphological apoptosis in granulosa cells
of the ovarian follicle.";
Endocrinology 136:5042-5053(1995).
[5]
INTERACTION WITH NOL3.
PubMed=16639714; DOI=10.1002/jcb.20946;
Zhang Y.Q., Herman B.;
"ARC protects rat cardiomyocytes against oxidative stress through
inhibition of caspase-2 mediated mitochondrial pathway.";
J. Cell. Biochem. 99:575-588(2006).
-!- FUNCTION: Involved in the activation cascade of caspases
responsible for apoptosis execution. Might function by either
activating some proteins required for cell death or inactivating
proteins necessary for cell survival (By similarity).
{ECO:0000250}.
-!- CATALYTIC ACTIVITY: Strict requirement for an Asp residue at P1,
with 316-asp being essential for proteolytic activity and has a
preferred cleavage sequence of Val-Asp-Val-Ala-Asp-|-.
-!- SUBUNIT: Heterotetramer that consists of two anti-parallel
arranged heterodimers, each one formed by a p18 subunit and a p12
subunit. Interacts with LRDD (By similarity). Interacts with NOL3
(via CARD domain); inhibits CASP2 activity in a phosphorylation-
dependent manner. {ECO:0000250, ECO:0000269|PubMed:16639714}.
-!- ALTERNATIVE PRODUCTS:
Event=Alternative splicing; Named isoforms=2;
Name=1; Synonyms=caspase-2L;
IsoId=P55215-1; Sequence=Displayed;
Name=2; Synonyms=caspase-2S;
IsoId=P55215-2; Sequence=VSP_016555, VSP_016556;
-!- PTM: The mature protease can process its own propeptide, but not
that of other caspases. {ECO:0000250}.
-!- SIMILARITY: Belongs to the peptidase C14A family. {ECO:0000305}.
-!- SEQUENCE CAUTION:
Sequence=AAB82567.1; Type=Frameshift; Positions=137, 189; Evidence={ECO:0000305};
-----------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
Distributed under the Creative Commons Attribution (CC BY 4.0) License
-----------------------------------------------------------------------
EMBL; U77933; AAB96379.1; -; mRNA.
EMBL; AF136231; AAD33684.1; -; mRNA.
EMBL; AF136232; AAD33685.1; -; mRNA.
EMBL; AF025671; AAB82567.1; ALT_FRAME; mRNA.
EMBL; U34684; AAC52260.1; -; mRNA.
PIR; I67436; I67436.
PIR; JC6507; JC6507.
RefSeq; NP_071967.2; NM_022522.2. [P55215-1]
UniGene; Rn.1438; -.
ProteinModelPortal; P55215; -.
SMR; P55215; -.
DIP; DIP-48602N; -.
IntAct; P55215; 2.
STRING; 10116.ENSRNOP00000022672; -.
MEROPS; C14.006; -.
iPTMnet; P55215; -.
PhosphoSitePlus; P55215; -.
PaxDb; P55215; -.
PRIDE; P55215; -.
Ensembl; ENSRNOT00000022672; ENSRNOP00000022672; ENSRNOG00000016707. [P55215-1]
GeneID; 64314; -.
KEGG; rno:64314; -.
UCSC; RGD:69274; rat. [P55215-1]
CTD; 835; -.
RGD; 69274; Casp2.
eggNOG; KOG3573; Eukaryota.
eggNOG; ENOG410ZQIE; LUCA.
GeneTree; ENSGT00760000118912; -.
HOGENOM; HOG000290714; -.
HOVERGEN; HBG103962; -.
InParanoid; P55215; -.
KO; K02186; -.
OMA; VMVLMTH; -.
OrthoDB; EOG091G05YD; -.
PhylomeDB; P55215; -.
TreeFam; TF102023; -.
BRENDA; 3.4.22.55; 5301.
Reactome; R-RNO-168638; NOD1/2 Signaling Pathway.
Reactome; R-RNO-205025; NADE modulates death signalling.
Reactome; R-RNO-6803207; TP53 Regulates Transcription of Caspase Activators and Caspases.
PRO; PR:P55215; -.
Proteomes; UP000002494; Chromosome 4.
Bgee; ENSRNOG00000016707; -.
ExpressionAtlas; P55215; baseline and differential.
Genevisible; P55215; RN.
GO; GO:0016020; C:membrane; IDA:RGD.
GO; GO:0005739; C:mitochondrion; IDA:RGD.
GO; GO:0005634; C:nucleus; IEA:Ensembl.
GO; GO:0097200; F:cysteine-type endopeptidase activity involved in execution phase of apoptosis; IBA:GO_Central.
GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
GO; GO:0019904; F:protein domain specific binding; IEA:Ensembl.
GO; GO:0007568; P:aging; IEP:RGD.
GO; GO:0006915; P:apoptotic process; IMP:RGD.
GO; GO:0007420; P:brain development; IEP:RGD.
GO; GO:0071260; P:cellular response to mechanical stimulus; IEA:Ensembl.
GO; GO:0006977; P:DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; IEA:Ensembl.
GO; GO:0035234; P:ectopic germ cell programmed cell death; IEA:Ensembl.
GO; GO:0097194; P:execution phase of apoptosis; IBA:GO_Central.
GO; GO:0097192; P:extrinsic apoptotic signaling pathway in absence of ligand; IEA:Ensembl.
GO; GO:0001554; P:luteolysis; IEP:RGD.
GO; GO:0003407; P:neural retina development; IEP:RGD.
GO; GO:2001235; P:positive regulation of apoptotic signaling pathway; IEA:Ensembl.
GO; GO:0043525; P:positive regulation of neuron apoptotic process; IMP:RGD.
GO; GO:0012501; P:programmed cell death; TAS:RGD.
GO; GO:0016485; P:protein processing; IEA:Ensembl.
GO; GO:0006508; P:proteolysis; TAS:RGD.
CDD; cd00032; CASc; 1.
InterPro; IPR001315; CARD.
InterPro; IPR029030; Caspase-like_dom_sf.
InterPro; IPR035702; Caspase_2.
InterPro; IPR033139; Caspase_cys_AS.
InterPro; IPR016129; Caspase_his_AS.
InterPro; IPR011029; DEATH-like_dom_sf.
InterPro; IPR002138; Pept_C14_p10.
InterPro; IPR001309; Pept_C14_p20.
InterPro; IPR015917; Pept_C14A.
PANTHER; PTHR10454:SF151; PTHR10454:SF151; 1.
Pfam; PF00619; CARD; 1.
PRINTS; PR00376; IL1BCENZYME.
SMART; SM00114; CARD; 1.
SMART; SM00115; CASc; 1.
SUPFAM; SSF47986; SSF47986; 1.
SUPFAM; SSF52129; SSF52129; 1.
PROSITE; PS50209; CARD; 1.
PROSITE; PS01122; CASPASE_CYS; 1.
PROSITE; PS01121; CASPASE_HIS; 1.
PROSITE; PS50207; CASPASE_P10; 1.
PROSITE; PS50208; CASPASE_P20; 1.
1: Evidence at protein level;
Acetylation; Alternative splicing; Apoptosis; Complete proteome;
Hydrolase; Phosphoprotein; Protease; Reference proteome;
Thiol protease; Zymogen.
INIT_MET 1 1 Removed. {ECO:0000250|UniProtKB:P42575}.
PROPEP 2 169
/FTId=PRO_0000043403.
CHAIN 170 325 Caspase-2 subunit p18. {ECO:0000250}.
/FTId=PRO_0000044573.
PROPEP 326 333
/FTId=PRO_0000044574.
CHAIN 334 452 Caspase-2 subunit p13. {ECO:0000250}.
/FTId=PRO_0000004551.
CHAIN 348 452 Caspase-2 subunit p12. {ECO:0000250}.
/FTId=PRO_0000004552.
DOMAIN 32 121 CARD. {ECO:0000255|PROSITE-
ProRule:PRU00046}.
ACT_SITE 277 277 {ECO:0000250}.
ACT_SITE 320 320 {ECO:0000250}.
MOD_RES 2 2 N-acetylalanine.
{ECO:0000250|UniProtKB:P42575}.
MOD_RES 157 157 Phosphoserine.
{ECO:0000250|UniProtKB:P42575}.
MOD_RES 340 340 Phosphoserine.
{ECO:0000250|UniProtKB:P42575}.
VAR_SEQ 323 343 DETDRGVDQQDGKNHAQSPGC -> GAIGSLGPLLLFTAAT
ASLAL (in isoform 2).
{ECO:0000303|PubMed:12067235}.
/FTId=VSP_016555.
VAR_SEQ 344 452 Missing (in isoform 2).
{ECO:0000303|PubMed:12067235}.
/FTId=VSP_016556.
CONFLICT 145 145 C -> Y (in Ref. 3; AAB82567).
{ECO:0000305}.
CONFLICT 166 166 D -> H (in Ref. 3; AAB82567).
{ECO:0000305}.
CONFLICT 177 177 K -> E (in Ref. 3; AAB82567).
{ECO:0000305}.
CONFLICT 197 197 Q -> R (in Ref. 3; AAB82567).
{ECO:0000305}.
CONFLICT 340 340 S -> P (in Ref. 4; AAC52260).
{ECO:0000305}.
CONFLICT 348 349 AG -> TV (in Ref. 4; AAC52260).
{ECO:0000305}.
CONFLICT 367 367 G -> V (in Ref. 4; AAC52260).
{ECO:0000305}.
CONFLICT 373 373 G -> D (in Ref. 4; AAC52260).
{ECO:0000305}.
CONFLICT 376 377 AM -> PI (in Ref. 4; AAC52260).
{ECO:0000305}.
SEQUENCE 452 AA; 50728 MW; 03F9D096BB741CE3 CRC64;
MAASSGRSQS SLHRKGLMAA DRRSRILAVC GMHPDHQETL KKNRVVLAKQ LLLSELLEHL
LEKDIITLEM RELIQAKGGS FSQNVELLNL LPKRGPQAFD AFCEALRETR QGHLEDLLLT
TLSDIQHILP PLSCDYDSSL PFSVCESCPP HKQSRLSTDT MEHSLDNGDG PPCLQVKPCT
PEFYQAHYQL AYRLQSQPRG LALVMSNVHF TGEKDLEFRS GGDVDHTTLV TLFKLLGYNV
HVLYDQTAQE MQEKLQNFAQ LPAHRVTDSC IVALLSHGVE GGIYGVDGKL LQLQEVFRLF
DNANCPSLQN KPKMFFIQAC RGDETDRGVD QQDGKNHAQS PGCEESDAGK EELMKMRLPT
RSDMICGYAC LKGNAAMRNT KRGSWYIEAL TQVFSERACD MHVADMLVKV NALIKEREGY
APGTEFHRCK EMSEYCSTLC QQLYLFPGYP PT


Related products :

Catalog number Product name Quantity
U1058h CLIA CAD,CAD,Caspase-activated deoxyribonuclease,Caspase-activated DNase,Caspase-activated nuclease,CPAN,DFF2,DFF40,DFF-40,DFFB,DNA fragmentation factor 40 kDa subunit,DNA fragmentation factor subunit 96T
E1735m ELISA kit Casp11,CASP-11,Casp4,CASP-4,Caspase-11,Caspase-4,Caspl,Ich3,Mouse,Mus musculus,Protease ICH-3 96T
U1735m CLIA Casp11,CASP-11,Casp4,CASP-4,Caspase-11,Caspase-4,Caspl,Ich3,Mouse,Mus musculus,Protease ICH-3 96T
E1735m ELISA Casp11,CASP-11,Casp4,CASP-4,Caspase-11,Caspase-4,Caspl,Ich3,Mouse,Mus musculus,Protease ICH-3 96T
18-661-15031 DNA fragmentation factor subunit beta - EC 3.-.-.-; DNA fragmentation factor 40 kDa subunit; DFF-40; Caspase-activated deoxyribonuclease; Caspase-activated DNase; CAD; Caspase-activated nuclease; CPAN 0.1 mg
18-661-15032 DNA fragmentation factor subunit beta - EC 3.-.-.-; DNA fragmentation factor 40 kDa subunit; DFF-40; Caspase-activated deoxyribonuclease; Caspase-activated DNase; CAD; Caspase-activated nuclease; CPAN 0.1 mg
18-661-15069 DNA fragmentation factor subunit beta - EC 3.-.-.-; DNA fragmentation factor 40 kDa subunit; DFF-40; Caspase-activated deoxyribonuclease; Caspase-activated DNase; CAD; Caspase-activated nuclease; CPAN 0.1 mg
18-661-15054 DNA fragmentation factor subunit beta - EC 3.-.-.-; DNA fragmentation factor 40 kDa subunit; DFF-40; Caspase-activated deoxyribonuclease; Caspase-activated DNase; CAD; Caspase-activated nuclease; CPAN 0.1 mg
18-661-15034 DNA fragmentation factor subunit beta - EC 3.-.-.-; DNA fragmentation factor 40 kDa subunit; DFF-40; Caspase-activated deoxyribonuclease; Caspase-activated DNase; CAD; Caspase-activated nuclease; CPAN 0.1 mg
18-661-15033 DNA fragmentation factor subunit beta - EC 3.-.-.-; DNA fragmentation factor 40 kDa subunit; DFF-40; Caspase-activated deoxyribonuclease; Caspase-activated DNase; CAD; Caspase-activated nuclease; CPAN 0.1 mg
20-002-35037 Caspase-2 (anti-human Caspase-2. clone 1C10) - EC 3.4.22.-; CASP-2; ICH-1 protease; ICH-1L_1S Monoclonal 0.1 ml
20-002-35037 Caspase-2 (anti-human Caspase-2. clone 1C10) - EC 3.4.22.-; CASP-2; ICH-1 protease; ICH-1L_1S Monoclonal 0.05 ml
bs-0087P Peptides: active Caspase 3(caspase-3 p12 subunit) Protein Length:12-25 amino acids. 200ug lyophilized
20-272-190222 Caspase 10 - Rat monoclonal [25C2] to Caspase 10; EC 3.4.22.63; CASP-10; ICE-like apoptotic protease 4; Apoptotic protease Mch-4; FAS-associated death domain protein interleukin-1B-converting enzyme 2 0.1 ml
18-272-195092 Caspase 10 - Rabbit polyclonal to Caspase 10; EC 3.4.22.63; CASP-10; ICE-like apoptotic protease 4; Apoptotic protease Mch-4; FAS-associated death domain protein interleukin-1B-converting enzyme 2; FL 0.1 ml
18-272-197016 Caspase 10 - Rabbit polyclonal to Caspase 10; EC 3.4.22.63; CASP-10; ICE-like apoptotic protease 4; Apoptotic protease Mch-4; FAS-associated death domain protein interleukin-1B-converting enzyme 2; FL 0.1 mg
18-272-196464 Caspase 8 prediluted - Rabbit polyclonal to Caspase 8 prediluted; EC 3.4.22.61; CASP-8; ICE-like apoptotic protease 5; MORT1-associated CED-3 homolog; MACH; FADD-homologous ICE_CED-3-like protease; FA 7 ml
20-272-192408 Caspase 8 - Mouse monoclonal [C502S] to Caspase 8; EC 3.4.22.61; CASP-8; ICE-like apoptotic protease 5; MORT1-associated CED-3 homolog; MACH; FADD-homologous ICE_CED-3-like protease; FADD-like ICE; FL 0.05 mg
18-272-195091 Caspase 8 - Rabbit polyclonal to Caspase 8; EC 3.4.22.61; CASP-8; ICE-like apoptotic protease 5; MORT1-associated CED-3 homolog; MACH; FADD-homologous ICE_CED-3-like protease; FADD-like ICE; FLICE; Ap 0.1 ml
18-272-195090 Caspase 8 - Rabbit polyclonal to Caspase 8; EC 3.4.22.61; CASP-8; ICE-like apoptotic protease 5; MORT1-associated CED-3 homolog; MACH; FADD-homologous ICE_CED-3-like protease; FADD-like ICE; FLICE; Ap 0.1 ml
E1058r ELISA CAD,Cad,Caspase-activated deoxyribonuclease,Caspase-activated DNase,DFF-40,Dffb,DNA fragmentation factor 40 kDa subunit,DNA fragmentation factor subunit beta,Rat,Rattus norvegicus 96T
E1058m ELISA CAD,Cad,Caspase-activated deoxyribonuclease,Caspase-activated DNase,DFF-40,Dffb,DNA fragmentation factor 40 kDa subunit,DNA fragmentation factor subunit beta,Mouse,Mus musculus 96T
U1058m CLIA CAD,Cad,Caspase-activated deoxyribonuclease,Caspase-activated DNase,DFF-40,Dffb,DNA fragmentation factor 40 kDa subunit,DNA fragmentation factor subunit beta,Mouse,Mus musculus 96T
E1058m ELISA kit CAD,Cad,Caspase-activated deoxyribonuclease,Caspase-activated DNase,DFF-40,Dffb,DNA fragmentation factor 40 kDa subunit,DNA fragmentation factor subunit beta,Mouse,Mus musculus 96T
U1058r CLIA CAD,Cad,Caspase-activated deoxyribonuclease,Caspase-activated DNase,DFF-40,Dffb,DNA fragmentation factor 40 kDa subunit,DNA fragmentation factor subunit beta,Rat,Rattus norvegicus 96T


 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur





GENTAUR Ltd.
Howard Frank Turnberry House
1404-1410 High Road
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017

BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG

france@gentaur.com | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: 0035929830070
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.


ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur