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Caspase-6 (CASP-6) (EC 3.4.22.59) (Apoptotic protease Mch-2) [Cleaved into: Caspase-6 subunit p18; Caspase-6 subunit p11]

 CASP6_RAT               Reviewed;         277 AA.
O35397;
02-MAY-2006, integrated into UniProtKB/Swiss-Prot.
01-NOV-1998, sequence version 2.
23-MAY-2018, entry version 115.
RecName: Full=Caspase-6;
Short=CASP-6;
EC=3.4.22.59;
AltName: Full=Apoptotic protease Mch-2;
Contains:
RecName: Full=Caspase-6 subunit p18;
Contains:
RecName: Full=Caspase-6 subunit p11;
Flags: Precursor;
Name=Casp6; Synonyms=Mch2;
Rattus norvegicus (Rat).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Rattus.
NCBI_TaxID=10116;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=Sprague-Dawley; TISSUE=Kidney cortex;
PubMed=9530276;
Kaushal G.P., Singh A.B., Shah S.V.;
"Identification of gene family of caspases in rat kidney and altered
expression in ischemia-reperfusion injury.";
Am. J. Physiol. 274:F587-F595(1998).
-!- FUNCTION: Involved in the activation cascade of caspases
responsible for apoptosis execution. Cleaves poly(ADP-ribose)
polymerase in vitro, as well as lamins. Overexpression promotes
programmed cell death (By similarity). {ECO:0000250}.
-!- CATALYTIC ACTIVITY: Strict requirement for Asp at position P1 and
has a preferred cleavage sequence of Val-Glu-His-Asp-|-.
-!- ENZYME REGULATION: Activation is suppressed by phosphorylation at
Ser-240. {ECO:0000250}.
-!- SUBUNIT: Heterotetramer that consists of two anti-parallel
arranged heterodimers, each one formed by a 18 kDa (p18) and a 11
kDa (p11) subunit. Interacts with BIRC6/bruce. {ECO:0000250}.
-!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
-!- PTM: Cleavages by caspase-3, caspase-8 or -10 generate the two
active subunits. {ECO:0000250}.
-!- SIMILARITY: Belongs to the peptidase C14A family. {ECO:0000305}.
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EMBL; AF025670; AAC25433.1; -; mRNA.
UniGene; Rn.88160; -.
ProteinModelPortal; O35397; -.
STRING; 10116.ENSRNOP00000013049; -.
MEROPS; C14.005; -.
PhosphoSitePlus; O35397; -.
PaxDb; O35397; -.
PRIDE; O35397; -.
UCSC; RGD:70967; rat.
RGD; 70967; Casp6.
eggNOG; KOG3573; Eukaryota.
eggNOG; ENOG410ZQIE; LUCA.
HOGENOM; HOG000231878; -.
HOVERGEN; HBG050802; -.
InParanoid; O35397; -.
PhylomeDB; O35397; -.
PRO; PR:O35397; -.
Proteomes; UP000002494; Unplaced.
GO; GO:0005737; C:cytoplasm; IDA:RGD.
GO; GO:0005829; C:cytosol; IDA:RGD.
GO; GO:0005634; C:nucleus; IDA:RGD.
GO; GO:0097153; F:cysteine-type endopeptidase activity involved in apoptotic process; IBA:GO_Central.
GO; GO:0097200; F:cysteine-type endopeptidase activity involved in execution phase of apoptosis; IEA:InterPro.
GO; GO:0004175; F:endopeptidase activity; IDA:RGD.
GO; GO:0002525; P:acute inflammatory response to non-antigenic stimulus; IDA:RGD.
GO; GO:0006915; P:apoptotic process; TAS:RGD.
GO; GO:0002088; P:lens development in camera-type eye; IEP:RGD.
GO; GO:0043065; P:positive regulation of apoptotic process; IMP:RGD.
GO; GO:0043525; P:positive regulation of neuron apoptotic process; IMP:RGD.
GO; GO:0046670; P:positive regulation of retinal cell programmed cell death; IMP:RGD.
GO; GO:0034097; P:response to cytokine; IDA:RGD.
GO; GO:0032355; P:response to estradiol; IEP:RGD.
GO; GO:0010332; P:response to gamma radiation; IEP:RGD.
GO; GO:0009749; P:response to glucose; IMP:RGD.
GO; GO:0009408; P:response to heat; IEP:RGD.
GO; GO:0042542; P:response to hydrogen peroxide; IDA:RGD.
GO; GO:0010039; P:response to iron ion; IMP:RGD.
GO; GO:0010038; P:response to metal ion; IEP:RGD.
GO; GO:0010033; P:response to organic substance; IEP:RGD.
GO; GO:0010243; P:response to organonitrogen compound; IEP:RGD.
GO; GO:0033574; P:response to testosterone; IEP:RGD.
CDD; cd00032; CASc; 1.
InterPro; IPR029030; Caspase-like_dom_sf.
InterPro; IPR037554; Caspase_6.
InterPro; IPR033139; Caspase_cys_AS.
InterPro; IPR016129; Caspase_his_AS.
InterPro; IPR002138; Pept_C14_p10.
InterPro; IPR001309; Pept_C14_p20.
InterPro; IPR015917; Pept_C14A.
PANTHER; PTHR10454:SF164; PTHR10454:SF164; 1.
PRINTS; PR00376; IL1BCENZYME.
SMART; SM00115; CASc; 1.
SUPFAM; SSF52129; SSF52129; 1.
PROSITE; PS01122; CASPASE_CYS; 1.
PROSITE; PS01121; CASPASE_HIS; 1.
PROSITE; PS50207; CASPASE_P10; 1.
PROSITE; PS50208; CASPASE_P20; 1.
2: Evidence at transcript level;
Apoptosis; Complete proteome; Cytoplasm; Hydrolase; Phosphoprotein;
Protease; Reference proteome; Thiol protease; Zymogen.
PROPEP 1 5 {ECO:0000250}.
/FTId=PRO_0000233177.
CHAIN 6 162 Caspase-6 subunit p18. {ECO:0000250}.
/FTId=PRO_0000233178.
PROPEP 163 177 {ECO:0000250}.
/FTId=PRO_0000233179.
CHAIN 178 277 Caspase-6 subunit p11. {ECO:0000250}.
/FTId=PRO_0000233180.
ACT_SITE 104 104 {ECO:0000250}.
ACT_SITE 146 146 {ECO:0000250}.
MOD_RES 62 62 Phosphoserine.
{ECO:0000250|UniProtKB:O08738}.
MOD_RES 240 240 Phosphoserine; by NUAK1.
{ECO:0000250|UniProtKB:P55212}.
SEQUENCE 277 AA; 31556 MW; 69D999E729B3BDE2 CRC64;
MTETDGFYRS REVLDPAEQY KMDHKRRGTA LIFNHERFFW HLALPERRGT NADRDNPTRR
FSELGFEVKC FNDLRAEELL LKIHEVSTSS HVDADCFLCV FLSHGEGNHI YAYDAKIEIQ
TLTGLFKGDK CQSLVGKPKI FIIQACRGSQ HDVPLVPLDV VDHQTDKLDD NVTQVDAASV
YTLPAGADFL MCYSVAEGYY SHRETVNGSW YIQDLSEMLA RHGSSLEFTE LLTLVNRKVS
QRRVDFCKDP GAIGKKQVPC FASMLTKKLH FCPKPSK


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