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Cathepsin 7 (EC 3.4.22.-) (Cathepsin 1)

 CAT7_MOUSE              Reviewed;         331 AA.
Q91ZF2; Q9JI84;
25-JAN-2012, integrated into UniProtKB/Swiss-Prot.
01-DEC-2001, sequence version 1.
05-DEC-2018, entry version 113.
RecName: Full=Cathepsin 7 {ECO:0000312|EMBL:AAH64740.1};
EC=3.4.22.-;
AltName: Full=Cathepsin 1 {ECO:0000312|EMBL:AAK00508.1};
Flags: Precursor;
Name=Cts7 {ECO:0000312|EMBL:AAH64740.1,
ECO:0000312|Ensembl:ENSMUSP00000021892, ECO:0000312|MGI:MGI:1860262};
Synonyms=Cts1 {ECO:0000312|EMBL:AAK00508.1},
Epcs24 {ECO:0000312|EMBL:AAF81274.1};
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1] {ECO:0000305, ECO:0000312|EMBL:AAK00508.1}
NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, AND DEVELOPMENTAL
STAGE.
STRAIN=C57BL/6J {ECO:0000312|EMBL:AAK00508.1};
TISSUE=Placenta {ECO:0000312|EMBL:AAK00508.1};
PubMed=11829493; DOI=10.1006/geno.2002.6696;
Deussing J., Kouadio M., Rehman S., Werber I., Schwinde A., Peters C.;
"Identification and characterization of a dense cluster of placenta-
specific cysteine peptidase genes and related genes on mouse
chromosome 13.";
Genomics 79:225-240(2002).
[2] {ECO:0000312|Ensembl:ENSMUSP00000021892}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=C57BL/6J;
PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S.,
She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W.,
Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T.,
Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J.,
Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z.,
Lindblad-Toh K., Eichler E.E., Ponting C.P.;
"Lineage-specific biology revealed by a finished genome assembly of
the mouse.";
PLoS Biol. 7:E1000112-E1000112(2009).
[3] {ECO:0000312|EMBL:EDL41318.1}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
[4] {ECO:0000312|EMBL:AAH64740.1}
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=C57BL/6J {ECO:0000312|EMBL:AAH64740.1};
TISSUE=Embryo {ECO:0000312|EMBL:AAH64740.1};
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[5] {ECO:0000305, ECO:0000312|EMBL:AAF81274.1}
NUCLEOTIDE SEQUENCE [MRNA] OF 1-329, TISSUE SPECIFICITY, AND
DEVELOPMENTAL STAGE.
STRAIN=C57BL/6J {ECO:0000269|PubMed:10885754};
TISSUE=Placenta {ECO:0000269|PubMed:10885754};
PubMed=10885754; DOI=10.1006/dbio.2000.9705;
Hemberger M., Himmelbauer H., Ruschmann J., Zeitz C., Fundele R.;
"cDNA subtraction cloning reveals novel genes whose temporal and
spatial expression indicates association with trophoblast invasion.";
Dev. Biol. 222:158-169(2000).
[6] {ECO:0000305}
FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DEVELOPMENTAL
STAGE, AND NUCLEAR LOCALIZATION SIGNAL.
PubMed=18776147; DOI=10.1242/dev.025627;
Screen M., Dean W., Cross J.C., Hemberger M.;
"Cathepsin proteases have distinct roles in trophoblast function and
vascular remodelling.";
Development 135:3311-3320(2008).
-!- FUNCTION: Involved in trophoblast cell proliferation and
differentiation probably by affecting mitotic cell cycle
progression. Proteolytic activity and nuclear localization are
essential for its role in cell cycle progression.
{ECO:0000269|PubMed:18776147}.
-!- SUBCELLULAR LOCATION: Endosome {ECO:0000269|PubMed:18776147,
ECO:0000305}. Lysosome {ECO:0000269|PubMed:18776147, ECO:0000305}.
Cytoplasm, perinuclear region {ECO:0000269|PubMed:18776147}. Golgi
apparatus {ECO:0000269|PubMed:18776147, ECO:0000305}. Nucleus
{ECO:0000269|PubMed:18776147}. Secreted, extracellular space
{ECO:0000269|PubMed:18776147}.
-!- TISSUE SPECIFICITY: Expressed in placenta. Expressed in parietal
and spiral artery-associated trophoblast giant cells, most
abundantly during the phase of trophoblast invasion. From E14.5
onwards, expressed at lower levels in labyrinth trophoblast cells.
Expressed in trophoblast stem cells. Expressed in heart, liver and
testis. {ECO:0000269|PubMed:10885754, ECO:0000269|PubMed:11829493,
ECO:0000269|PubMed:18776147}.
-!- DEVELOPMENTAL STAGE: Expressed in adult but not in embryo.
Expressed in the placenta from early post-implantation (E5.5)
onwards. After E9.5 expression declines.
{ECO:0000269|PubMed:10885754, ECO:0000269|PubMed:11829493,
ECO:0000269|PubMed:18776147}.
-!- SIMILARITY: Belongs to the peptidase C1 family.
{ECO:0000255|PROSITE-ProRule:PRU10088, ECO:0000255|PROSITE-
ProRule:PRU10089}.
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EMBL; AY014779; AAK00508.1; -; mRNA.
EMBL; CT030645; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; CH466546; EDL41318.1; -; Genomic_DNA.
EMBL; BC064740; AAH64740.1; -; mRNA.
EMBL; AF250837; AAF81274.1; -; mRNA.
CCDS; CCDS26588.1; -.
RefSeq; NP_062412.1; NM_019539.3.
RefSeq; XP_006517360.1; XM_006517297.1.
UniGene; Mm.3692; -.
ProteinModelPortal; Q91ZF2; -.
SMR; Q91ZF2; -.
STRING; 10090.ENSMUSP00000021892; -.
MEROPS; C01.016; -.
PaxDb; Q91ZF2; -.
PRIDE; Q91ZF2; -.
Ensembl; ENSMUST00000021892; ENSMUSP00000021892; ENSMUSG00000021440.
Ensembl; ENSMUST00000224986; ENSMUSP00000153603; ENSMUSG00000021440.
GeneID; 56092; -.
KEGG; mmu:56092; -.
UCSC; uc007qwi.1; mouse.
CTD; 56092; -.
MGI; MGI:1860262; Cts7.
eggNOG; KOG1543; Eukaryota.
eggNOG; COG4870; LUCA.
GeneTree; ENSGT00940000153321; -.
HOGENOM; HOG000230774; -.
HOVERGEN; HBG011513; -.
InParanoid; Q91ZF2; -.
OMA; WLLKNSH; -.
OrthoDB; EOG091G0AKT; -.
PhylomeDB; Q91ZF2; -.
TreeFam; TF313739; -.
Reactome; R-MMU-1442490; Collagen degradation.
Reactome; R-MMU-1474228; Degradation of the extracellular matrix.
Reactome; R-MMU-1679131; Trafficking and processing of endosomal TLR.
Reactome; R-MMU-2022090; Assembly of collagen fibrils and other multimeric structures.
Reactome; R-MMU-2132295; MHC class II antigen presentation.
Reactome; R-MMU-8939242; RUNX1 regulates transcription of genes involved in differentiation of keratinocytes.
PRO; PR:Q91ZF2; -.
Proteomes; UP000000589; Chromosome 13.
Bgee; ENSMUSG00000021440; Expressed in 20 organ(s), highest expression level in placenta.
ExpressionAtlas; Q91ZF2; differential.
Genevisible; Q91ZF2; MM.
GO; GO:0005768; C:endosome; IDA:MGI.
GO; GO:0005576; C:extracellular region; IDA:MGI.
GO; GO:0005615; C:extracellular space; IBA:GO_Central.
GO; GO:0005794; C:Golgi apparatus; IDA:MGI.
GO; GO:0005764; C:lysosome; IDA:MGI.
GO; GO:0005634; C:nucleus; IDA:MGI.
GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
GO; GO:0004197; F:cysteine-type endopeptidase activity; IBA:GO_Central.
GO; GO:0008233; F:peptidase activity; ISA:MGI.
GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
GO; GO:0045930; P:negative regulation of mitotic cell cycle; IMP:MGI.
GO; GO:0006508; P:proteolysis; ISA:MGI.
GO; GO:0051603; P:proteolysis involved in cellular protein catabolic process; IBA:GO_Central.
GO; GO:0060707; P:trophoblast giant cell differentiation; IMP:MGI.
CDD; cd02248; Peptidase_C1A; 1.
InterPro; IPR038765; Papain_like_cys_pep_sf.
InterPro; IPR000169; Pept_cys_AS.
InterPro; IPR025660; Pept_his_AS.
InterPro; IPR013128; Peptidase_C1A.
InterPro; IPR000668; Peptidase_C1A_C.
InterPro; IPR039417; Peptidase_C1A_papain-like.
InterPro; IPR013201; Prot_inhib_I29.
PANTHER; PTHR12411; PTHR12411; 1.
Pfam; PF08246; Inhibitor_I29; 1.
Pfam; PF00112; Peptidase_C1; 1.
PRINTS; PR00705; PAPAIN.
SMART; SM00848; Inhibitor_I29; 1.
SMART; SM00645; Pept_C1; 1.
SUPFAM; SSF54001; SSF54001; 1.
PROSITE; PS00139; THIOL_PROTEASE_CYS; 1.
PROSITE; PS00639; THIOL_PROTEASE_HIS; 1.
2: Evidence at transcript level;
Cell cycle; Cell division; Complete proteome; Cytoplasm;
Disulfide bond; Endosome; Glycoprotein; Golgi apparatus; Hydrolase;
Lysosome; Mitosis; Nucleus; Protease; Reference proteome; Secreted;
Signal; Thiol protease; Zymogen.
SIGNAL 1 17 {ECO:0000255,
ECO:0000312|EMBL:AAK00508.1}.
PROPEP 18 111 Activation peptide.
{ECO:0000250|UniProtKB:O60911}.
/FTId=PRO_0000415396.
CHAIN 112 331 Cathepsin 7.
{ECO:0000250|UniProtKB:O60911}.
/FTId=PRO_5000088249.
MOTIF 33 50 Nuclear localization signal.
{ECO:0000269|PubMed:18776147}.
ACT_SITE 136 136 {ECO:0000250|UniProtKB:O60911}.
ACT_SITE 274 274 {ECO:0000250|UniProtKB:O60911}.
ACT_SITE 298 298 {ECO:0000250|UniProtKB:O60911}.
CARBOHYD 72 72 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
DISULFID 133 176 {ECO:0000250|UniProtKB:O60911}.
DISULFID 167 209 {ECO:0000250|UniProtKB:O60911}.
DISULFID 267 320 {ECO:0000250|UniProtKB:O60911}.
CONFLICT 329 329 P -> L (in Ref. 5; AAF81274).
{ECO:0000305|PubMed:10885754}.
SEQUENCE 331 AA; 37725 MW; 985E9FAF4F671FCA CRC64;
MTPTVFLSIL CLGVALAAPA PDYNLDAEWE EWKRSNDRTY SPEEEKQRRA VWEGNVKWIK
QHIMENGLWM NNFTIEMNEF GDMTGEEMKM LTESSSYPLR NGKHIQKRNP KIPPTLDWRK
EGYVTPVRRQ GSCGACWAFS VTACIEGQLF KKTGKLIPLS VQNLMDCSVS YGTKGCDGGR
PYDAFQYVKN NGGLEAEATY PYEAKAKHCR YRPERSVVKV NRFFVVPRNE EALLQALVTH
GPIAVAIDGS HASFHSYRGG IYHEPKCRKD TLDHGLLLVG YGYEGHESEN RKYWLLKNSH
GERWGENGYM KLPRGQNNYC GIASYAMYPA L


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