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Cationic amino acid transporter 2 (CAT-2) (CAT2) (Low affinity cationic amino acid transporter 2) (Solute carrier family 7 member 2)

 CTR2_RAT                Reviewed;         657 AA.
B5D5N9; B5D5P0;
26-MAY-2009, integrated into UniProtKB/Swiss-Prot.
14-OCT-2008, sequence version 1.
07-JUN-2017, entry version 65.
RecName: Full=Cationic amino acid transporter 2;
Short=CAT-2;
Short=CAT2;
AltName: Full=Low affinity cationic amino acid transporter 2;
AltName: Full=Solute carrier family 7 member 2;
Name=Slc7a2; Synonyms=Atrc2, Cat2;
Rattus norvegicus (Rat).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Rattus.
NCBI_TaxID=10116;
[1]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
STRAIN=Wistar; TISSUE=Aortic smooth muscle;
Cui Z., Kelly J., Brzeski H., Marber M., Pearson J.D., Baydoun A.R.;
"Rattus cationic amino acid transporter-2 (rCAT-2) mRNA.";
Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases.
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Brown Norway;
Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
[3]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-645, AND IDENTIFICATION
BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
PubMed=22673903; DOI=10.1038/ncomms1871;
Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A.,
Lundby C., Olsen J.V.;
"Quantitative maps of protein phosphorylation sites across 14
different rat organs and tissues.";
Nat. Commun. 3:876-876(2012).
-!- FUNCTION: Functions as permease involved in the transport of the
cationic amino acids (arginine, lysine and ornithine). The
affinity for its substrates differs between isoforms created by
alternative splicing. May play a role in classical or alternative
activation of macrophages via its role in arginine transport.
{ECO:0000250|UniProtKB:P18581}.
-!- SUBCELLULAR LOCATION: Cell membrane
{ECO:0000250|UniProtKB:P18581}; Multi-pass membrane protein
{ECO:0000250|UniProtKB:P18581}.
-!- ALTERNATIVE PRODUCTS:
Event=Alternative splicing; Named isoforms=2;
Name=1; Synonyms=CAT2A;
IsoId=B5D5N9-1; Sequence=Displayed;
Name=2; Synonyms=CAT2B;
IsoId=B5D5N9-2; Sequence=VSP_037355;
-!- SIMILARITY: Belongs to the amino acid-polyamine-organocation (APC)
superfamily. Cationic amino acid transporter (CAT) (TC 2.A.3.3)
family. {ECO:0000305}.
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EMBL; AF245001; AAQ14243.1; -; mRNA.
EMBL; AF245002; AAQ14244.1; -; mRNA.
EMBL; CH473995; EDL78824.1; -; Genomic_DNA.
EMBL; CH473995; EDL78825.1; -; Genomic_DNA.
RefSeq; NP_001128158.1; NM_001134686.2. [B5D5N9-2]
RefSeq; NP_072141.2; NM_022619.3. [B5D5N9-1]
UniGene; Rn.48707; -.
iPTMnet; B5D5N9; -.
PhosphoSitePlus; B5D5N9; -.
PeptideAtlas; B5D5N9; -.
PRIDE; B5D5N9; -.
Ensembl; ENSRNOT00000014809; ENSRNOP00000014809; ENSRNOG00000011016. [B5D5N9-2]
Ensembl; ENSRNOT00000015127; ENSRNOP00000015127; ENSRNOG00000011016. [B5D5N9-1]
GeneID; 64554; -.
KEGG; rno:64554; -.
CTD; 6542; -.
RGD; 68387; Slc7a2.
GeneTree; ENSGT00760000119151; -.
HOGENOM; HOG000250623; -.
InParanoid; B5D5N9; -.
KO; K13864; -.
OMA; SQVTMLQ; -.
OrthoDB; EOG091G05NM; -.
PhylomeDB; B5D5N9; -.
Reactome; R-RNO-352230; Amino acid transport across the plasma membrane.
PRO; PR:B5D5N9; -.
Proteomes; UP000002494; Chromosome 16.
Bgee; ENSRNOG00000011016; -.
GO; GO:0030054; C:cell junction; IEA:Ensembl.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0005886; C:plasma membrane; IC:RGD.
GO; GO:0015181; F:arginine transmembrane transporter activity; IDA:RGD.
GO; GO:0005289; F:high-affinity arginine transmembrane transporter activity; IEA:Ensembl.
GO; GO:0097627; F:high-affinity L-ornithine transmembrane transporter activity; IEA:Ensembl.
GO; GO:0005292; F:high-affinity lysine transmembrane transporter activity; IEA:Ensembl.
GO; GO:0097626; F:low-affinity L-arginine transmembrane transporter activity; IEA:Ensembl.
GO; GO:0015809; P:arginine transport; IDA:RGD.
GO; GO:0097638; P:L-arginine import across plasma membrane; IEA:Ensembl.
GO; GO:0097639; P:L-lysine import across plasma membrane; IEA:Ensembl.
GO; GO:0097640; P:L-ornithine import across plasma membrane; IEA:Ensembl.
GO; GO:0042116; P:macrophage activation; IEA:Ensembl.
GO; GO:0006809; P:nitric oxide biosynthetic process; IEA:Ensembl.
GO; GO:0002537; P:nitric oxide production involved in inflammatory response; IEA:Ensembl.
GO; GO:0050727; P:regulation of inflammatory response; IEA:Ensembl.
GO; GO:0043030; P:regulation of macrophage activation; IEA:Ensembl.
InterPro; IPR002293; AA/rel_permease1.
InterPro; IPR004755; Cat_AA_permease.
InterPro; IPR029485; CAT_C.
Pfam; PF13520; AA_permease_2; 1.
Pfam; PF13906; AA_permease_C; 1.
TIGRFAMs; TIGR00906; 2A0303; 1.
1: Evidence at protein level;
Alternative splicing; Amino-acid transport; Cell membrane;
Complete proteome; Glycoprotein; Membrane; Phosphoprotein;
Reference proteome; Transmembrane; Transmembrane helix; Transport.
CHAIN 1 657 Cationic amino acid transporter 2.
/FTId=PRO_0000375227.
TOPO_DOM 1 38 Cytoplasmic. {ECO:0000255}.
TRANSMEM 39 59 Helical. {ECO:0000255}.
TOPO_DOM 60 66 Extracellular. {ECO:0000255}.
TRANSMEM 67 87 Helical. {ECO:0000255}.
TOPO_DOM 88 104 Cytoplasmic. {ECO:0000255}.
TRANSMEM 105 125 Helical. {ECO:0000255}.
TOPO_DOM 126 163 Extracellular. {ECO:0000255}.
TRANSMEM 164 184 Helical. {ECO:0000255}.
TOPO_DOM 185 192 Cytoplasmic. {ECO:0000255}.
TRANSMEM 193 213 Helical. {ECO:0000255}.
TOPO_DOM 214 248 Extracellular. {ECO:0000255}.
TRANSMEM 249 269 Helical. {ECO:0000255}.
TOPO_DOM 270 289 Cytoplasmic. {ECO:0000255}.
TRANSMEM 290 310 Helical. {ECO:0000255}.
TOPO_DOM 311 339 Extracellular. {ECO:0000255}.
TRANSMEM 340 360 Helical. {ECO:0000255}.
TOPO_DOM 361 385 Cytoplasmic. {ECO:0000255}.
TRANSMEM 386 406 Helical. {ECO:0000255}.
TOPO_DOM 407 409 Extracellular. {ECO:0000255}.
TRANSMEM 410 430 Helical. {ECO:0000255}.
TOPO_DOM 431 489 Cytoplasmic. {ECO:0000255}.
TRANSMEM 490 510 Helical. {ECO:0000255}.
TOPO_DOM 511 523 Extracellular. {ECO:0000255}.
TRANSMEM 524 544 Helical. {ECO:0000255}.
TOPO_DOM 545 554 Cytoplasmic. {ECO:0000255}.
TRANSMEM 555 575 Helical. {ECO:0000255}.
TOPO_DOM 576 581 Extracellular. {ECO:0000255}.
TRANSMEM 582 602 Helical. {ECO:0000255}.
TOPO_DOM 603 657 Cytoplasmic. {ECO:0000255}.
MOD_RES 24 24 Phosphoserine.
{ECO:0000250|UniProtKB:P52569}.
MOD_RES 463 463 Phosphoserine.
{ECO:0000250|UniProtKB:P52569}.
MOD_RES 645 645 Phosphoserine.
{ECO:0000244|PubMed:22673903}.
CARBOHYD 157 157 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 227 227 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 239 239 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
VAR_SEQ 357 397 MFPLPRILFAMARDGLLFRFLARVSKRQSPVAATMTAGVIS
-> IFPMPRVIYAMAEDGLLFKCLAQINSKTKTPIIATLSS
GAVA (in isoform 2). {ECO:0000303|Ref.1}.
/FTId=VSP_037355.
SEQUENCE 657 AA; 71694 MW; 313E0A05771931B7 CRC64;
MIPCRAVLTF TRCLIRRKIV TLDSLEDSKL CRCLTTMDLI ALGVGSTLGA GVYVLAGEVA
KADSGPSIVV SFLIAALASV MAGLCYAEFG ARVPKTGSAY LYTYVTVGEL WAFITGWNLI
LSYVIGTSSV ARAWSGTFDE LLNKQIGQFF KTYFKMNYTG LAEYPDFFAV CLVLLLAGLL
SFGVKESAWV NKFFTAINIL VLLFVMVAGF VKGNVANWKI SEEFLKNISA SAREPPSENG
TSIYGAGGFM PYGFTGTLAG AATCFYAFVG FDCIATTGEE VRNPQKAIPI GIVTSLLVCF
MAYFGVSAAL TLMMPYYLLD EKSPLPVAFE YVGWGPAKYV VAAGSLCALS TSLLGSMFPL
PRILFAMARD GLLFRFLARV SKRQSPVAAT MTAGVISAVM AFLFDLKALV DMMSIGTLMA
YSLVAACVLI LRYQPGLCYE QPKYTPEKDI LESCTNATSK SESQVTMLQG QGFSLRTLFN
PSALPTRQSA SLVSFLVGFL AFLIAGLSIL TTYGVQAIAR LEAWSLALLA LFLVLCAAVI
LTIWRQPQNQ QKVAFMVPFL PFLPAFSILV NIYLMVQLSA DTWVRFSIWM VLGFLIYFAY
GIRHSLEGNP RDEEEDEDVC PDNVNAAAEE KSAMQANDHH QRNLSLPFIL HEKTSEC


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