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Caveolin

 A0A075B6D9_SHEEP        Unreviewed;       178 AA.
A0A075B6D9;
01-OCT-2014, integrated into UniProtKB/TrEMBL.
01-OCT-2014, sequence version 1.
30-AUG-2017, entry version 24.
RecName: Full=Caveolin {ECO:0000256|RuleBase:RU000680};
Name=CAV1 {ECO:0000313|Ensembl:ENSOARP00000001394};
Ovis aries (Sheep).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
Pecora; Bovidae; Caprinae; Ovis.
NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000001394, ECO:0000313|Proteomes:UP000002356};
[1] {ECO:0000313|Ensembl:ENSOARP00000001394, ECO:0000313|Proteomes:UP000002356}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000001394};
PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C.,
Wang J., Wang W., Xun X.;
"The sheep genome reference sequence: a work in progress.";
Anim. Genet. 41:449-453(2010).
[2] {ECO:0000313|Ensembl:ENSOARP00000001394}
IDENTIFICATION.
Ensembl;
Submitted (JUL-2014) to UniProtKB.
-!- FUNCTION: May act as a scaffolding protein within caveolar
membranes. Interacts directly with G-protein alpha subunits and
can functionally regulate their activity.
{ECO:0000256|RuleBase:RU000680, ECO:0000256|SAAS:SAAS00674471}.
-!- SUBCELLULAR LOCATION: Cell membrane
{ECO:0000256|SAAS:SAAS00583323}; Peripheral membrane protein
{ECO:0000256|SAAS:SAAS00583323}.
-!- SUBCELLULAR LOCATION: Golgi apparatus membrane
{ECO:0000256|RuleBase:RU000680}; Peripheral membrane protein
{ECO:0000256|RuleBase:RU000680}. Cell membrane
{ECO:0000256|RuleBase:RU000680}; Peripheral membrane protein
{ECO:0000256|RuleBase:RU000680}. Membrane, caveola
{ECO:0000256|RuleBase:RU000680}; Peripheral membrane protein
{ECO:0000256|RuleBase:RU000680}.
-!- SUBCELLULAR LOCATION: Membrane, caveola
{ECO:0000256|SAAS:SAAS00583331}; Peripheral membrane protein
{ECO:0000256|SAAS:SAAS00583331}.
-!- SIMILARITY: Belongs to the caveolin family.
{ECO:0000256|RuleBase:RU000680, ECO:0000256|SAAS:SAAS00583326}.
-!- CAUTION: The sequence shown here is derived from an Ensembl
automatic analysis pipeline and should be considered as
preliminary data. {ECO:0000313|Ensembl:ENSOARP00000001394}.
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EMBL; AMGL01087265; -; NOT_ANNOTATED_CDS; Genomic_DNA.
UniGene; Oar.3169; -.
Ensembl; ENSOART00000001434; ENSOARP00000001394; ENSOARG00000001337.
GeneTree; ENSGT00390000014924; -.
OMA; IYVHTFC; -.
OrthoDB; EOG091G0M1R; -.
Proteomes; UP000002356; Chromosome 4.
GO; GO:0002080; C:acrosomal membrane; IEA:Ensembl.
GO; GO:0005901; C:caveola; IEA:UniProtKB-SubCell.
GO; GO:0005938; C:cell cortex; IEA:Ensembl.
GO; GO:0005929; C:cilium; IEA:Ensembl.
GO; GO:0005768; C:endosome; IEA:Ensembl.
GO; GO:0005925; C:focal adhesion; IEA:Ensembl.
GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
GO; GO:0005887; C:integral component of plasma membrane; IEA:Ensembl.
GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:Ensembl.
GO; GO:0034098; C:VCP-NPL4-UFD1 AAA ATPase complex; IEA:Ensembl.
GO; GO:0051117; F:ATPase binding; IEA:Ensembl.
GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
GO; GO:0070320; F:inward rectifier potassium channel inhibitor activity; IEA:Ensembl.
GO; GO:0044325; F:ion channel binding; IEA:Ensembl.
GO; GO:0050998; F:nitric-oxide synthase binding; IEA:Ensembl.
GO; GO:0016504; F:peptidase activator activity; IEA:Ensembl.
GO; GO:0030674; F:protein binding, bridging; IEA:Ensembl.
GO; GO:0032947; F:protein complex scaffold activity; IEA:Ensembl.
GO; GO:0046982; F:protein heterodimerization activity; IEA:Ensembl.
GO; GO:0019901; F:protein kinase binding; IEA:Ensembl.
GO; GO:0048365; F:Rac GTPase binding; IEA:Ensembl.
GO; GO:0005102; F:receptor binding; IEA:Ensembl.
GO; GO:0001525; P:angiogenesis; IEA:Ensembl.
GO; GO:0086098; P:angiotensin-activated signaling pathway involved in heart process; IEA:Ensembl.
GO; GO:0097190; P:apoptotic signaling pathway; IEA:Ensembl.
GO; GO:0006816; P:calcium ion transport; IEA:Ensembl.
GO; GO:0070836; P:caveola assembly; IEA:Ensembl.
GO; GO:0072584; P:caveolin-mediated endocytosis; IEA:Ensembl.
GO; GO:0071360; P:cellular response to exogenous dsRNA; IEA:Ensembl.
GO; GO:0071455; P:cellular response to hyperoxia; IEA:Ensembl.
GO; GO:0071560; P:cellular response to transforming growth factor beta stimulus; IEA:Ensembl.
GO; GO:0042632; P:cholesterol homeostasis; IEA:Ensembl.
GO; GO:0000188; P:inactivation of MAPK activity; IEA:Ensembl.
GO; GO:0007595; P:lactation; IEA:Ensembl.
GO; GO:0019915; P:lipid storage; IEA:Ensembl.
GO; GO:0060056; P:mammary gland involution; IEA:Ensembl.
GO; GO:0000165; P:MAPK cascade; IEA:Ensembl.
GO; GO:0051899; P:membrane depolarization; IEA:Ensembl.
GO; GO:2000811; P:negative regulation of anoikis; IEA:Ensembl.
GO; GO:0090090; P:negative regulation of canonical Wnt signaling pathway; IEA:Ensembl.
GO; GO:0001960; P:negative regulation of cytokine-mediated signaling pathway; IEA:Ensembl.
GO; GO:0001937; P:negative regulation of endothelial cell proliferation; IEA:Ensembl.
GO; GO:0030857; P:negative regulation of epithelial cell differentiation; IEA:Ensembl.
GO; GO:1903609; P:negative regulation of inward rectifier potassium channel activity; IEA:Ensembl.
GO; GO:0060546; P:negative regulation of necroptotic process; IEA:Ensembl.
GO; GO:0045019; P:negative regulation of nitric oxide biosynthetic process; IEA:Ensembl.
GO; GO:0051001; P:negative regulation of nitric-oxide synthase activity; IEA:Ensembl.
GO; GO:0033137; P:negative regulation of peptidyl-serine phosphorylation; IEA:Ensembl.
GO; GO:1900085; P:negative regulation of peptidyl-tyrosine autophosphorylation; IEA:Ensembl.
GO; GO:0048550; P:negative regulation of pinocytosis; IEA:Ensembl.
GO; GO:0032091; P:negative regulation of protein binding; IEA:Ensembl.
GO; GO:0061099; P:negative regulation of protein tyrosine kinase activity; IEA:Ensembl.
GO; GO:0031397; P:negative regulation of protein ubiquitination; IEA:Ensembl.
GO; GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IEA:Ensembl.
GO; GO:0030512; P:negative regulation of transforming growth factor beta receptor signaling pathway; IEA:Ensembl.
GO; GO:0042532; P:negative regulation of tyrosine phosphorylation of STAT protein; IEA:Ensembl.
GO; GO:0033484; P:nitric oxide homeostasis; IEA:Ensembl.
GO; GO:0010524; P:positive regulation of calcium ion transport into cytosol; IEA:Ensembl.
GO; GO:0090263; P:positive regulation of canonical Wnt signaling pathway; IEA:Ensembl.
GO; GO:0060355; P:positive regulation of cell adhesion molecule production; IEA:Ensembl.
GO; GO:2001238; P:positive regulation of extrinsic apoptotic signaling pathway; IEA:Ensembl.
GO; GO:1903598; P:positive regulation of gap junction assembly; IEA:Ensembl.
GO; GO:0010628; P:positive regulation of gene expression; IEA:Ensembl.
GO; GO:2001244; P:positive regulation of intrinsic apoptotic signaling pathway; IEA:Ensembl.
GO; GO:0033138; P:positive regulation of peptidyl-serine phosphorylation; IEA:Ensembl.
GO; GO:0032092; P:positive regulation of protein binding; IEA:Ensembl.
GO; GO:0031398; P:positive regulation of protein ubiquitination; IEA:Ensembl.
GO; GO:0034141; P:positive regulation of toll-like receptor 3 signaling pathway; IEA:Ensembl.
GO; GO:0045907; P:positive regulation of vasoconstriction; IEA:Ensembl.
GO; GO:0010608; P:posttranscriptional regulation of gene expression; IEA:Ensembl.
GO; GO:0051260; P:protein homooligomerization; IEA:Ensembl.
GO; GO:0008104; P:protein localization; IEA:Ensembl.
GO; GO:2000286; P:receptor internalization involved in canonical Wnt signaling pathway; IEA:Ensembl.
GO; GO:0019065; P:receptor-mediated endocytosis of virus by host cell; IEA:Ensembl.
GO; GO:0030193; P:regulation of blood coagulation; IEA:Ensembl.
GO; GO:1901844; P:regulation of cell communication by electrical coupling involved in cardiac conduction; IEA:Ensembl.
GO; GO:2000535; P:regulation of entry of bacterium into host cell; IEA:Ensembl.
GO; GO:0019217; P:regulation of fatty acid metabolic process; IEA:Ensembl.
GO; GO:0086091; P:regulation of heart rate by cardiac conduction; IEA:Ensembl.
GO; GO:0098903; P:regulation of membrane repolarization during action potential; IEA:Ensembl.
GO; GO:1900027; P:regulation of ruffle assembly; IEA:Ensembl.
GO; GO:0006940; P:regulation of smooth muscle contraction; IEA:Ensembl.
GO; GO:0003057; P:regulation of the force of heart contraction by chemical signal; IEA:Ensembl.
GO; GO:0098911; P:regulation of ventricular cardiac muscle cell action potential; IEA:Ensembl.
GO; GO:0009617; P:response to bacterium; IEA:Ensembl.
GO; GO:0051592; P:response to calcium ion; IEA:Ensembl.
GO; GO:0043627; P:response to estrogen; IEA:Ensembl.
GO; GO:0001666; P:response to hypoxia; IEA:Ensembl.
GO; GO:0002931; P:response to ischemia; IEA:Ensembl.
GO; GO:0032570; P:response to progesterone; IEA:Ensembl.
GO; GO:0007519; P:skeletal muscle tissue development; IEA:Ensembl.
GO; GO:0031295; P:T cell costimulation; IEA:Ensembl.
GO; GO:0006641; P:triglyceride metabolic process; IEA:Ensembl.
GO; GO:0001570; P:vasculogenesis; IEA:Ensembl.
GO; GO:0042310; P:vasoconstriction; IEA:Ensembl.
InterPro; IPR001612; Caveolin.
InterPro; IPR018361; Caveolin_CS.
PANTHER; PTHR10844; PTHR10844; 1.
Pfam; PF01146; Caveolin; 1.
PROSITE; PS01210; CAVEOLIN; 1.
3: Inferred from homology;
Cell membrane {ECO:0000256|RuleBase:RU000680,
ECO:0000256|SAAS:SAAS00116094};
Complete proteome {ECO:0000313|Proteomes:UP000002356};
Golgi apparatus {ECO:0000256|RuleBase:RU000680,
ECO:0000256|SAAS:SAAS00116112};
Membrane {ECO:0000256|RuleBase:RU000680,
ECO:0000256|SAAS:SAAS00116094, ECO:0000256|SAM:Phobius};
Reference proteome {ECO:0000313|Proteomes:UP000002356};
Transmembrane {ECO:0000256|SAM:Phobius};
Transmembrane helix {ECO:0000256|SAM:Phobius}.
TRANSMEM 105 129 Helical. {ECO:0000256|SAM:Phobius}.
SEQUENCE 178 AA; 20655 MW; 6BBBD394283063AA CRC64;
MSGGKYVDSE GHLYTVPIRE QGNIYKPNNK AMAEEMNEKQ VYDAHTKEID LVNRDPKHLN
DDVVKIDFED VIAEPEGTHS FDSIWKASFT TFTVTKYWFY RLLSALFGIP MALIWGIYFA
ILSFLHIWAV VPCIKSFLIE IQCISRVYSI YVHTFCDPLF EAIGKIFSNI RINMQKEI


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