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Cell wall integrity sensor MID2 (Mating pheromone-induced death protein 2) (Protein kinase A interference protein 1) (Serine-rich multicopy suppressor protein 1)

 MID2_YEAST              Reviewed;         376 AA.
P36027; D6VYX3; P41944;
01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
01-JUN-1994, sequence version 1.
28-MAR-2018, entry version 142.
RecName: Full=Cell wall integrity sensor MID2;
AltName: Full=Mating pheromone-induced death protein 2;
AltName: Full=Protein kinase A interference protein 1;
AltName: Full=Serine-rich multicopy suppressor protein 1;
Flags: Precursor;
Name=MID2; Synonyms=KAI1, SMS1; OrderedLocusNames=YLR332W;
ORFNames=L8543.19;
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces.
NCBI_TaxID=559292;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
PubMed=7828875; DOI=10.1016/0378-1119(94)90657-2;
Ono T., Suzuki T., Anraku Y., Iida H.;
"The MID2 gene encodes a putative integral membrane protein with a
Ca(2+)-binding domain and shows mating pheromone-stimulated expression
in Saccharomyces cerevisiae.";
Gene 151:203-208(1994).
[2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=ATCC 70036;
PubMed=7999801; DOI=10.1016/0167-4781(94)00188-9;
Takeuchi J., Okada M., Toh-e A., Kikuchi Y.;
"The SMS1 gene encoding a serine-rich transmembrane protein suppresses
the temperature sensitivity of the htr1 disruptant in Saccharomyces
cerevisiae.";
Biochim. Biophys. Acta 1260:94-96(1995).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 204508 / S288c;
PubMed=9169871;
Johnston M., Hillier L.W., Riles L., Albermann K., Andre B.,
Ansorge W., Benes V., Brueckner M., Delius H., Dubois E.,
Duesterhoeft A., Entian K.-D., Floeth M., Goffeau A., Hebling U.,
Heumann K., Heuss-Neitzel D., Hilbert H., Hilger F., Kleine K.,
Koetter P., Louis E.J., Messenguy F., Mewes H.-W., Miosga T.,
Moestl D., Mueller-Auer S., Nentwich U., Obermaier B., Piravandi E.,
Pohl T.M., Portetelle D., Purnelle B., Rechmann S., Rieger M.,
Rinke M., Rose M., Scharfe M., Scherens B., Scholler P., Schwager C.,
Schwarz S., Underwood A.P., Urrestarazu L.A., Vandenbol M.,
Verhasselt P., Vierendeels F., Voet M., Volckaert G., Voss H.,
Wambutt R., Wedler E., Wedler H., Zimmermann F.K., Zollner A.,
Hani J., Hoheisel J.D.;
"The nucleotide sequence of Saccharomyces cerevisiae chromosome XII.";
Nature 387:87-90(1997).
[4]
GENOME REANNOTATION.
STRAIN=ATCC 204508 / S288c;
PubMed=24374639; DOI=10.1534/g3.113.008995;
Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M.,
Cherry J.M.;
"The reference genome sequence of Saccharomyces cerevisiae: Then and
now.";
G3 (Bethesda) 4:389-398(2014).
[5]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 60-304.
PubMed=8355657; DOI=10.1007/BF00277063;
Daniel J.;
"Potentially rapid walking in cellular regulatory networks using the
gene-gene interference method in yeast.";
Mol. Gen. Genet. 240:245-257(1993).
[6]
FUNCTION, SUBCELLULAR LOCATION, AND TOPOLOGY.
PubMed=10348843;
Ketela T., Green R., Bussey H.;
"Saccharomyces cerevisiae mid2p is a potential cell wall stress sensor
and upstream activator of the PKC1-MPK1 cell integrity pathway.";
J. Bacteriol. 181:3330-3340(1999).
[7]
FUNCTION, SUBCELLULAR LOCATION, AND GLYCOSYLATION.
PubMed=10330137; DOI=10.1128/MCB.19.6.3969;
Rajavel M., Philip B., Buehrer B.M., Errede B., Levin D.E.;
"Mid2 is a putative sensor for cell integrity signaling in
Saccharomyces cerevisiae.";
Mol. Cell. Biol. 19:3969-3976(1999).
[8]
FUNCTION, AND GLYCOSYLATION.
PubMed=11113201; DOI=10.1128/MCB.21.1.271-280.2001;
Philip B., Levin D.E.;
"Wsc1 and Mid2 are cell surface sensors for cell wall integrity
signaling that act through Rom2, a guanine nucleotide exchange factor
for Rho1.";
Mol. Cell. Biol. 21:271-280(2001).
[9]
INTERACTION WITH ZEO1.
PubMed=12949174; DOI=10.1099/mic.0.26471-0;
Green R., Lesage G., Sdicu A.-M., Menard P., Bussey H.;
"A synthetic analysis of the Saccharomyces cerevisiae stress sensor
Mid2p, and identification of a Mid2p-interacting protein, Zeo1p, that
modulates the PKC1-MPK1 cell integrity pathway.";
Microbiology 149:2487-2499(2003).
[10]
SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
PubMed=14562095; DOI=10.1038/nature02026;
Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W.,
Weissman J.S., O'Shea E.K.;
"Global analysis of protein localization in budding yeast.";
Nature 425:686-691(2003).
[11]
SUBCELLULAR LOCATION.
PubMed=13679573; DOI=10.1073/pnas.2033246100;
Shepard K.A., Gerber A.P., Jambhekar A., Takizawa P.A., Brown P.O.,
Herschlag D., DeRisi J.L., Vale R.D.;
"Widespread cytoplasmic mRNA transport in yeast: identification of 22
bud-localized transcripts using DNA microarray analysis.";
Proc. Natl. Acad. Sci. U.S.A. 100:11429-11434(2003).
[12]
FUNCTION.
PubMed=16087742; DOI=10.1128/EC.4.8.1375-1386.2005;
Claret S., Gatti X., Doignon F., Thoraval D., Crouzet M.;
"The Rgd1p Rho GTPase-activating protein and the Mid2p cell wall
sensor are required at low pH for protein kinase C pathway activation
and cell survival in Saccharomyces cerevisiae.";
Eukaryot. Cell 4:1375-1386(2005).
[13]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-260; SER-327; SER-329
AND SER-355, AND IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE
ANALYSIS].
PubMed=19779198; DOI=10.1126/science.1172867;
Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.;
"Global analysis of Cdk1 substrate phosphorylation sites provides
insights into evolution.";
Science 325:1682-1686(2009).
-!- FUNCTION: Cell wall stress sensor. Involved in activation of a
response that includes both stress-related increased chitin
synthesis and the MPK1 mitogen-activated protein kinase cell
integrity pathway. High-copy activator of the SKN7 transcription
factor. Required during induction of MPK1 tyrosine phosphorylation
under a variety of stress conditions. Required for PKC pathway
activation under low pH conditions. Required for cell integrity
signaling during pheromone-induced morphogenesis. Activates ROM1
or ROM2 catalyzed guanine nucleotide exchange toward RHO1 in cell
wall integrity signaling. {ECO:0000269|PubMed:10330137,
ECO:0000269|PubMed:10348843, ECO:0000269|PubMed:11113201,
ECO:0000269|PubMed:16087742}.
-!- SUBUNIT: Interacts with ZEO1. {ECO:0000269|PubMed:12949174}.
-!- INTERACTION:
P25623:SYP1; NbExp=2; IntAct=EBI-10901, EBI-21900;
Q08245:ZEO1; NbExp=3; IntAct=EBI-10901, EBI-32089;
-!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:10330137,
ECO:0000269|PubMed:10348843, ECO:0000269|PubMed:13679573,
ECO:0000269|PubMed:14562095}; Single-pass type I membrane protein
{ECO:0000269|PubMed:10330137, ECO:0000269|PubMed:10348843,
ECO:0000269|PubMed:13679573, ECO:0000269|PubMed:14562095}.
Note=Localizes uniformly around the cell periphery. Also localized
to the mother-bud junction.
-!- PTM: O-mannosylated by PMT2.
-!- SIMILARITY: Belongs to the MID2 like cell wall stress sensor
family. {ECO:0000305}.
-----------------------------------------------------------------------
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Distributed under the Creative Commons Attribution-NoDerivs License
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EMBL; D29945; BAA06220.1; -; Genomic_DNA.
EMBL; D29964; BAA06230.1; -; Genomic_DNA.
EMBL; U20618; AAB64527.1; -; Genomic_DNA.
EMBL; BK006945; DAA09639.1; -; Genomic_DNA.
PIR; S52137; S52137.
RefSeq; NP_013436.1; NM_001182221.1.
ProteinModelPortal; P36027; -.
BioGrid; 31595; 216.
DIP; DIP-4676N; -.
IntAct; P36027; 52.
MINT; P36027; -.
STRING; 4932.YLR332W; -.
iPTMnet; P36027; -.
MaxQB; P36027; -.
PaxDb; P36027; -.
PRIDE; P36027; -.
EnsemblFungi; YLR332W; YLR332W; YLR332W.
GeneID; 851042; -.
KEGG; sce:YLR332W; -.
EuPathDB; FungiDB:YLR332W; -.
SGD; S000004324; MID2.
GeneTree; ENSGT00730000113634; -.
InParanoid; P36027; -.
KO; K11245; -.
OMA; NANTADH; -.
OrthoDB; EOG092C4G04; -.
BioCyc; YEAST:G3O-32412-MONOMER; -.
PRO; PR:P36027; -.
Proteomes; UP000002311; Chromosome XII.
GO; GO:0005887; C:integral component of plasma membrane; IDA:SGD.
GO; GO:0004888; F:transmembrane signaling receptor activity; IMP:SGD.
GO; GO:0030242; P:autophagy of peroxisome; IMP:SGD.
GO; GO:0000767; P:cell morphogenesis involved in conjugation; IMP:SGD.
GO; GO:0031505; P:fungal-type cell wall organization; IMP:SGD.
GO; GO:0030969; P:mRNA splicing via endonucleolytic cleavage and ligation involved in unfolded protein response; IMP:SGD.
GO; GO:0010447; P:response to acidic pH; IMP:SGD.
GO; GO:0006970; P:response to osmotic stress; IGI:SGD.
InterPro; IPR007567; Mid2_dom.
Pfam; PF04478; Mid2; 1.
1: Evidence at protein level;
Cell membrane; Complete proteome; Glycoprotein; Membrane;
Phosphoprotein; Reference proteome; Signal; Stress response;
Transmembrane; Transmembrane helix.
SIGNAL 1 25 {ECO:0000255}.
CHAIN 26 376 Cell wall integrity sensor MID2.
/FTId=PRO_0000096485.
TOPO_DOM 26 224 Extracellular. {ECO:0000255}.
TRANSMEM 225 245 Helical. {ECO:0000255}.
TOPO_DOM 246 376 Cytoplasmic. {ECO:0000255}.
COMPBIAS 31 219 Ser-rich.
MOD_RES 260 260 Phosphoserine.
{ECO:0000244|PubMed:19779198}.
MOD_RES 327 327 Phosphoserine.
{ECO:0000244|PubMed:19779198}.
MOD_RES 329 329 Phosphoserine.
{ECO:0000244|PubMed:19779198}.
MOD_RES 355 355 Phosphoserine.
{ECO:0000244|PubMed:19779198}.
CARBOHYD 35 35 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 211 211 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CONFLICT 303 304 GG -> VV (in Ref. 5; no nucleotide
entry). {ECO:0000305}.
SEQUENCE 376 AA; 39146 MW; 3612E260BC1B04A2 CRC64;
MLSFTTKNSF RLLLLILSCI STIRAQFFVQ SSSSNSSAVS TARSSVSRVS SSSSILSSSM
VSSSSADSSS LTSSTSSRSL VSHTSSSTSI ASISFTSFSF SSDSSTSSSS SASSDSSSSS
SFSISSTSAT SESSTSSTQT STSSSSSLSS TPSSSSSPST ITSAPSTSST PSTTAYNQGS
TITSIINGKT ILSNHYTTVT YTPSATADSS NKSKSSGLSK KNRNIVIGCV VGIGVPLILV
ILALIYMFCI QSSRTDFIDS DGKVVTAYRA NKFTKWWYML LGKKVSDEYH SDSPLGGSAS
SAGGLDLDEA DDVMEQSSLF DVRIRDSDSV LPNANTADHN NTNSGGEPIN SSVASNDIIE
EKFYDEQGNE LSPRNY


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