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Centromere-associated protein E (Centromere protein E) (CENP-E) (Kinesin superfamily protein 10) (KIF10) (Motor domain of KIF10)

 CENPE_MOUSE             Reviewed;        2474 AA.
Q6RT24; O35059; Q3KQQ6; Q3V044; Q6PD00; Q7TPX4; Q80YB4; Q8BWX6;
03-MAR-2009, integrated into UniProtKB/Swiss-Prot.
05-JUL-2004, sequence version 1.
28-MAR-2018, entry version 97.
RecName: Full=Centromere-associated protein E {ECO:0000312|EMBL:AAR85498.1};
AltName: Full=Centromere protein E;
Short=CENP-E {ECO:0000250|UniProtKB:Q02224};
AltName: Full=Kinesin superfamily protein 10 {ECO:0000303|PubMed:9275178};
Short=KIF10 {ECO:0000303|PubMed:9275178};
AltName: Full=Motor domain of KIF10 {ECO:0000312|EMBL:BAA22386.1};
Flags: Precursor;
Name=Cenpe {ECO:0000312|MGI:MGI:1098230};
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1] {ECO:0000305, ECO:0000312|EMBL:AAR85498.1}
NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INTERACTION WITH BUB1B, AND
SUBCELLULAR LOCATION.
PubMed=12925705; DOI=10.1083/jcb.200303167;
Weaver B.A., Bonday Z.Q., Putkey F.R., Kops G.J., Silk A.D.,
Cleveland D.W.;
"Centromere-associated protein-E is essential for the mammalian
mitotic checkpoint to prevent aneuploidy due to single chromosome
loss.";
J. Cell Biol. 162:551-563(2003).
[2] {ECO:0000305, ECO:0000312|EMBL:AAH52843.1}
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-546 AND 1652-2474.
STRAIN=C57BL/6J {ECO:0000312|EMBL:AAH52843.1}, and
Czech II {ECO:0000312|EMBL:AAI06097.1};
TISSUE=Brain {ECO:0000312|EMBL:AAH59032.1},
Egg {ECO:0000312|EMBL:AAH52843.1},
Mammary tumor {ECO:0000312|EMBL:AAI06097.1}, and
Olfactory epithelium {ECO:0000312|EMBL:AAH49989.1};
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[3] {ECO:0000305, ECO:0000312|EMBL:BAE21661.1}
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-520 AND 1705-2474.
STRAIN=C57BL/6J {ECO:0000312|EMBL:BAE21661.1};
TISSUE=Spinal cord {ECO:0000312|EMBL:BAC33868.1}, and
Testis {ECO:0000312|EMBL:BAE21661.1};
PubMed=16141072; DOI=10.1126/science.1112014;
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M.,
Davis M.J., Wilming L.G., Aidinis V., Allen J.E.,
Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L.,
Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M.,
Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R.,
Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G.,
di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G.,
Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M.,
Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N.,
Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T.,
Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H.,
Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K.,
Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J.,
Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L.,
Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K.,
Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P.,
Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O.,
Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G.,
Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M.,
Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B.,
Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K.,
Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A.,
Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K.,
Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C.,
Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J.,
Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y.,
Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T.,
Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N.,
Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N.,
Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S.,
Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J.,
Hayashizaki Y.;
"The transcriptional landscape of the mammalian genome.";
Science 309:1559-1563(2005).
[4] {ECO:0000305, ECO:0000312|EMBL:BAA22386.1}
NUCLEOTIDE SEQUENCE [MRNA] OF 82-241, AND TISSUE SPECIFICITY.
STRAIN=ICR {ECO:0000312|EMBL:BAA22386.1};
TISSUE=Hippocampus {ECO:0000269|PubMed:9275178};
PubMed=9275178; DOI=10.1073/pnas.94.18.9654;
Nakagawa T., Tanaka Y., Matsuoka E., Kondo S., Okada Y., Noda Y.,
Kanai Y., Hirokawa N.;
"Identification and classification of 16 new kinesin superfamily (KIF)
proteins in mouse genome.";
Proc. Natl. Acad. Sci. U.S.A. 94:9654-9659(1997).
[5] {ECO:0000305}
FUNCTION, SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
PubMed=12361599; DOI=10.1016/S1534-5807(02)00255-1;
Putkey F.R., Cramer T., Morphew M.K., Silk A.D., Johnson R.S.,
McIntosh J.R., Cleveland D.W.;
"Unstable kinetochore-microtubule capture and chromosomal instability
following deletion of CENP-E.";
Dev. Cell 3:351-365(2002).
[6]
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Spleen, and Testis;
PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
"A tissue-specific atlas of mouse protein phosphorylation and
expression.";
Cell 143:1174-1189(2010).
-!- FUNCTION: Microtubule plus-end-directed kinetochore motor which
plays an important role in chromosome congression, microtubule-
kinetochore conjugation and spindle assembly checkpoint
activation. Drives chromosome congression (alignment of
chromosomes at the spindle equator resulting in the formation of
the metaphase plate) by mediating the lateral sliding of polar
chromosomes along spindle microtubules towards the spindle equator
and by aiding the establishment and maintenance of connections
between kinetochores and spindle microtubules. The transport of
pole-proximal chromosomes towards the spindle equator is favored
by microtubule tracks that are detyrosinated. Acts as a processive
bi-directional tracker of dynamic microtubule tips; after
chromosomes have congressed, continues to play an active role at
kinetochores, enhancing their links with dynamic microtubule ends.
Suppresses chromosome congression in NDC80-depleted cells and
contributes positively to congression only when microtubules are
stabilized (By similarity). Plays an important role in the
formation of stable attachments between kinetochores and spindle
microtubules (PubMed:12925705). The stabilization of kinetochore-
microtubule attachment also requires CENPE-dependent localization
of other proteins to the kinetochore including BUB1B, MAD1 and
MAD2. Plays a role in spindle assembly checkpoint activation (SAC)
via its interaction with BUB1B resulting in the activation of its
kinase activity, which is important for activating SAC
(PubMed:12361599). Necessary for the mitotic checkpoint signal at
individual kinetochores to prevent aneuploidy due to single
chromosome loss (PubMed:12925705). {ECO:0000250|UniProtKB:Q02224,
ECO:0000269|PubMed:12361599, ECO:0000269|PubMed:12925705}.
-!- SUBUNIT: Monomer. Interacts with CENPF, SEPT7 KIF18A and PRC1 (By
similarity). Interacts with BUB1B (PubMed:12925705). Interacts
with SKAP; this interaction greatly favors SKAP binding to
microtubules. Interacts with TRAPPC12 and CTCF (By similarity).
{ECO:0000250|UniProtKB:Q02224, ECO:0000269|PubMed:12925705}.
-!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, spindle
{ECO:0000269|PubMed:12361599, ECO:0000269|PubMed:12925705}.
Chromosome, centromere, kinetochore {ECO:0000269|PubMed:12361599,
ECO:0000269|PubMed:12925705}. Chromosome, centromere
{ECO:0000250|UniProtKB:Q02224}. Note=Associates with kinetochores
during congression (as early as prometaphase), relocates to the
spindle midzone at anaphase, and is quantitatively discarded at
the end of the cell division (PubMed:12361599, PubMed:12925705).
Recruited to the kinetochore in a SEPT7, CENPQ and TRAPPC12-
dependent manner. Recruited to the pericentromeric/centromeric
regions of the chromosome in a CTCF-dependent manner (By
similarity). {ECO:0000250|UniProtKB:Q02224,
ECO:0000269|PubMed:12361599, ECO:0000269|PubMed:12925705}.
-!- TISSUE SPECIFICITY: Expressed in hippocampus. Also detected in
liver and fibroblasts (at protein level).
{ECO:0000269|PubMed:12361599, ECO:0000269|PubMed:9275178}.
-!- DOMAIN: The protein is composed of a N-terminal kinesin-motor
domain involved in the chromosome movements, a long coil-coiled
region involved in the homodimerization and an inhibitory C-tail
involved in autoinhibition of the N-terminal catalytic part.
{ECO:0000250}.
-!- PTM: The C-terminal inhibitory domain is phosphorylated.
Phosphorylation relieves autoinhibition of the kinetochore motor
(By similarity). {ECO:0000250}.
-!- PTM: Sumoylated with SUMO2 and SUMO3. The sumoylation mediates the
association to the kinetochore. {ECO:0000250|UniProtKB:Q02224}.
-!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
superfamily. Kinesin family. {ECO:0000255|PROSITE-
ProRule:PRU00283}.
-!- SEQUENCE CAUTION:
Sequence=AAH52843.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};
Sequence=AAI06097.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};
Sequence=BAC33868.1; Type=Frameshift; Positions=1759; Evidence={ECO:0000305};
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EMBL; AY493378; AAR85498.1; -; mRNA.
EMBL; BC049989; AAH49989.1; -; mRNA.
EMBL; BC052843; AAH52843.1; ALT_SEQ; mRNA.
EMBL; BC059032; AAH59032.1; -; mRNA.
EMBL; BC106096; AAI06097.1; ALT_SEQ; mRNA.
EMBL; AK049676; BAC33868.1; ALT_FRAME; mRNA.
EMBL; AK133445; BAE21661.1; -; mRNA.
EMBL; AB001426; BAA22386.1; -; mRNA.
RefSeq; NP_776123.3; NM_173762.4.
UniGene; Mm.161470; -.
ProteinModelPortal; Q6RT24; -.
SMR; Q6RT24; -.
BioGrid; 230907; 85.
IntAct; Q6RT24; 4.
STRING; 10090.ENSMUSP00000057938; -.
iPTMnet; Q6RT24; -.
PhosphoSitePlus; Q6RT24; -.
EPD; Q6RT24; -.
MaxQB; Q6RT24; -.
PaxDb; Q6RT24; -.
PRIDE; Q6RT24; -.
GeneID; 229841; -.
KEGG; mmu:229841; -.
CTD; 1062; -.
MGI; MGI:1098230; Cenpe.
eggNOG; KOG0242; Eukaryota.
eggNOG; COG5059; LUCA.
HOVERGEN; HBG097734; -.
InParanoid; Q6RT24; -.
KO; K11498; -.
PhylomeDB; Q6RT24; -.
PRO; PR:Q6RT24; -.
Proteomes; UP000000589; Unplaced.
GO; GO:0005694; C:chromosome; ISO:MGI.
GO; GO:0000775; C:chromosome, centromeric region; ISO:MGI.
GO; GO:0000940; C:condensed chromosome outer kinetochore; IDA:MGI.
GO; GO:0000779; C:condensed chromosome, centromeric region; ISO:MGI.
GO; GO:0000778; C:condensed nuclear chromosome kinetochore; IDA:MGI.
GO; GO:0005829; C:cytosol; ISO:MGI.
GO; GO:0005871; C:kinesin complex; IBA:GO_Central.
GO; GO:0000776; C:kinetochore; IDA:UniProtKB.
GO; GO:0005828; C:kinetochore microtubule; ISO:MGI.
GO; GO:0005874; C:microtubule; ISO:MGI.
GO; GO:0015630; C:microtubule cytoskeleton; ISO:MGI.
GO; GO:0030496; C:midbody; ISO:MGI.
GO; GO:1990023; C:mitotic spindle midzone; ISO:MGI.
GO; GO:0005654; C:nucleoplasm; ISO:MGI.
GO; GO:0005634; C:nucleus; ISO:MGI.
GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO; GO:0016887; F:ATPase activity; IBA:GO_Central.
GO; GO:0043515; F:kinetochore binding; IDA:UniProtKB.
GO; GO:0008017; F:microtubule binding; ISO:MGI.
GO; GO:0003777; F:microtubule motor activity; ISO:MGI.
GO; GO:0019901; F:protein kinase binding; IPI:UniProtKB.
GO; GO:0051315; P:attachment of mitotic spindle microtubules to kinetochore; ISS:UniProtKB.
GO; GO:0008608; P:attachment of spindle microtubules to kinetochore; IMP:UniProtKB.
GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
GO; GO:0007059; P:chromosome segregation; ISO:MGI.
GO; GO:0045184; P:establishment of protein localization; IMP:UniProtKB.
GO; GO:0099607; P:lateral attachment of mitotic spindle microtubules to kinetochore; ISS:UniProtKB.
GO; GO:0051310; P:metaphase plate congression; ISS:UniProtKB.
GO; GO:0099606; P:microtubule plus-end directed mitotic chromosome migration; ISO:MGI.
GO; GO:0007018; P:microtubule-based movement; IBA:GO_Central.
GO; GO:0000278; P:mitotic cell cycle; ISO:MGI.
GO; GO:0007079; P:mitotic chromosome movement towards spindle pole; ISO:MGI.
GO; GO:0007080; P:mitotic metaphase plate congression; ISS:UniProtKB.
GO; GO:0007094; P:mitotic spindle assembly checkpoint; IMP:UniProtKB.
GO; GO:0007052; P:mitotic spindle organization; ISO:MGI.
GO; GO:0007275; P:multicellular organism development; IEA:UniProtKB-KW.
GO; GO:0051987; P:positive regulation of attachment of spindle microtubules to kinetochore; IMP:UniProtKB.
GO; GO:0051984; P:positive regulation of chromosome segregation; IMP:UniProtKB.
GO; GO:0045842; P:positive regulation of mitotic metaphase/anaphase transition; IMP:UniProtKB.
GO; GO:0045860; P:positive regulation of protein kinase activity; IDA:UniProtKB.
GO; GO:0050793; P:regulation of developmental process; IMP:UniProtKB.
GO; GO:0030071; P:regulation of mitotic metaphase/anaphase transition; ISO:MGI.
GO; GO:0007088; P:regulation of mitotic nuclear division; IMP:UniProtKB.
Gene3D; 3.40.850.10; -; 1.
InterPro; IPR027640; Kinesin-like_fam.
InterPro; IPR019821; Kinesin_motor_CS.
InterPro; IPR001752; Kinesin_motor_dom.
InterPro; IPR036961; Kinesin_motor_dom_sf.
InterPro; IPR027417; P-loop_NTPase.
PANTHER; PTHR24115; PTHR24115; 6.
Pfam; PF00225; Kinesin; 1.
PRINTS; PR00380; KINESINHEAVY.
SMART; SM00129; KISc; 1.
SUPFAM; SSF52540; SSF52540; 1.
PROSITE; PS00411; KINESIN_MOTOR_1; 1.
PROSITE; PS50067; KINESIN_MOTOR_2; 1.
1: Evidence at protein level;
ATP-binding; Cell cycle; Cell division; Centromere; Chromosome;
Coiled coil; Complete proteome; Cytoplasm; Cytoskeleton;
Developmental protein; Kinetochore; Lipoprotein; Methylation; Mitosis;
Motor protein; Nucleotide-binding; Phosphoprotein; Prenylation;
Reference proteome; Ubl conjugation.
CHAIN 1 2471 Centromere-associated protein E.
/FTId=PRO_0000365106.
PROPEP 2472 2474 Removed in mature form. {ECO:0000250}.
/FTId=PRO_0000396743.
DOMAIN 6 329 Kinesin motor. {ECO:0000255|PROSITE-
ProRule:PRU00283}.
NP_BIND 86 93 ATP. {ECO:0000255|PROSITE-
ProRule:PRU00283}.
REGION 1962 2252 Kinetochore binding domain.
{ECO:0000250|UniProtKB:Q02224}.
REGION 2286 2471 Globular autoinhibitory domain.
{ECO:0000250}.
COILED 334 2366 {ECO:0000255}.
MOD_RES 614 614 Phosphoserine.
{ECO:0000250|UniProtKB:Q02224}.
MOD_RES 2414 2414 Phosphoserine.
{ECO:0000250|UniProtKB:Q02224}.
MOD_RES 2426 2426 Phosphoserine.
{ECO:0000250|UniProtKB:Q02224}.
MOD_RES 2471 2471 Cysteine methyl ester. {ECO:0000250}.
LIPID 2471 2471 S-farnesyl cysteine.
{ECO:0000250|UniProtKB:Q02224}.
CONFLICT 231 241 LNLVDLAGSER -> IKLIDTVDLEG (in Ref. 4;
BAA22386). {ECO:0000305}.
CONFLICT 1760 1760 T -> A (in Ref. 3; BAC33868).
{ECO:0000305}.
SEQUENCE 2474 AA; 286525 MW; BAF52DD6068A2903 CRC64;
MAEEASVAVC VRVRPLNSRE EELGEATHIY WKTDKNAIYQ SDGGKSFQFD RVFDSNETTK
NVYEEIAVPI ISSAIQGYNG TIFAYGQTAS GKTHTMMGSE DCLGVIPRAI HDIFQRIKKF
PEREFLLRVS YMEIYNETIT DLLCNAQKMK PLIIREDTNR TVYVSDLTEE VVYTAEMALK
WLATGEKNRH YGITKMNQRS SRSHTIFRMI LESREKAEPS NCDGSVKVSH LNLVDLAGSE
RAAQTGAEGV RLKEGCFINR NLFILGQVIK KLSDGQVGGF INYRDSKLTR ILQNSLGGNA
KTRIICTITP ASLDETLTTL QFASTAKYMK NTPYVNEVSN DEALLKRYRR EIADLRKQLE
EVNTKTRAQE MEKDQLAQLL DEKDLLQKVQ DEKINNLKRM LVTSSSIALQ QELEIKRKRR
VTWCYGKMKD SNYEKEFKVP TSITTRKRKT SVTSLRENSL MKFGESAASS EFEMLNNTLE
SLAEVEWSSA TTLLSEENVE SELNSLNAQY NDLVLDYEQL RRENEDLKLK LKEKNELEEF
ELLEQKEERD QEMQLMHEVS NLKNLIKHAE EYNQDLENDL SSKVKLLKEK EEQIKNLQEY
IDAQKSEKMK IDLSYTSDAT EDLKQAMRTL SDLDTVALDA KKESAFLRSE NLELKEKINE
LSDSRKQMES DIQMYQRQLE AKKKMQTDLD KELQLAFQEI SKLSALVDGK GLLSNLELEK
RITDLQKELN KEAEEKQTLQ EEVNLLSELK SLPSEVETLR RELYEKSEEL HIITTEREKL
FSEMAHKDSR IQGLLEEIGN TRDDLATSQL SRRGSDGEWQ ALESLHAELE HRHAGVLEER
ERLKQEIGAL SKEAESLAFS LDSVKAELSH KTQELEQKTV EGQERLNKME ALREELESRD
SSLQSVEKEK VLLTEKLQQA LKEVKALTQE KKNLKQLQES LQTERDQLRS DIQDTVNMNI
DTQEQLLNAL ESLKQHQETI NMLKMKAAEE LSDNLHVKDR GGARDEAQQK MDGIDEQNES
AHTLLGGGKD NEVTEEQRKI DSLMQENSGL QQTLESVRAE KEQLKMDLKE NIEMSIENQE
ELRILRDELK RQQEVAAQEK DHATEKTQEL SRTQERLAKT EEKLEEKNQK LQETQQQLLS
TQEAMSKLQA KVIDMESLQN EFRNQGLALE RVETEKLELA QRLHESYEEV KSITKERNDL
KELQESFEIE KKQLKEYARE IEAEGLQAKE ELNIAHANLK EYQEIITELR GSISENEAQG
ASTQDTAKSA PELQGEVPEL LEQELLPVVK EARHSAEKVN GLEPVGAHSR TVHSMTMEGI
EIGNLRLTKK LEESQMEISC LTREREDLRR TQETLQVECT QLKEDARRTL ANHLETEEEL
NLARCCLKEQ ENKIDTLITS LSQRETELSS VRGQLALTTA ELERKVQELC EKQEELTRKE
TSEAQGKMSE LEQLRELLLA QASALQNAES DRLRLNTQLE ESQEEMKTLR EEREELRRMQ
EALHVESEQQ KESMKEISSK LQELQNKEYE CLAMKTINET QGSRCEMDHL NQQLEAQKST
LEKVEMENVN LTQRLHETLE EMRSVAKERD ELWSMEERLT VERDQLKKSL EETVTKGMEK
EEELRVAHVH LEEHQETINK LRKMVSDYTD EISHTQGDLK HTNAVVEAQN QDLREKEHQL
SQVKADLRET VDQMEQLKKK LEAQSSTLES REIEKLELTQ QLNENLKKIT LVTKENDSLK
IMDEALREER DQLRKSLQQT EARDLENQEK LRIAHMNLKE HQETIDRLME TMSEKTEEIS
NMKMELENVN MKLQEKVQEL KTSERQRVKL KADASEAKKE LKEQGLTLSK IEMENLNLAQ
KIHENLEEMK SVRKERDDLK KLEEILRMER DQLKDNLREA MLKAHQNHEE TMKCGKGLLC
AGEYCTGRLR EKCFRIEKLL KRYSEMANDY ECLNKVSLDL ERETKTQKEL SVTVRTKLSL
PHTQTKEMEK LLTANQRCSL EFHRALKRLK YVLSSIARIK EEQHESINKR EMAFIQEVEK
QNELQIQIQS LSQTYRIPAR DLQIKLSQEM DLHIEEMLKD FSENDFLTIK TEVQQVLNNR
KEITEFLGKW LNTLFDTENL KSTIQKENKS IGLVNNFYHS RITAMINEST EFEERSATRS
KDLDQYLKSL KETTEQLSEV YQTLTASQSV VHLHPTVQPS TRDSERPQAA SGAEQLTSKN
KIALGAVPYK EEIEDLKMQL VKSDLEKKAT AKEFDKKILS LKATVEHQEE MIRLLRENLR
GHQQAQDTSM ISEQDSQLLS KPLTCGGGSG IVQSTKALIL KSEYKRMGSE ISKLKQQNEQ
LRKQNNQLLS DNSQLSNEVK TWEERTLKRD SYRETTCENS PKSPKVTRTD SKRRQNTTSQ
CRAQNLQDPV PKDSPKSWFF DNRSKSLPAP HPIRYFDNSS LGLCPEPDDV ENVEPKTDLC
QASLEKDVSQ CKTQ


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EIAAB06767 CENPE,CENP-E,Centromere protein E,Centromere-associated protein E,Homo sapiens,Human,Kinesin-related protein CENPE
EIAAB06764 CENPC,CENP-C 1,CENPC1,Centromere autoantigen C,Centromere protein C 1,Homo sapiens,Human,ICEN7,Interphase centromere complex protein 7
E1125m ELISA kit Cenpb,CENP-B,Cenp-b,Centromere protein B,Major centromere autoantigen B,Mouse,Mus musculus 96T
U1125m CLIA Cenpb,CENP-B,Cenp-b,Centromere protein B,Major centromere autoantigen B,Mouse,Mus musculus 96T
E1125m ELISA Cenpb,CENP-B,Cenp-b,Centromere protein B,Major centromere autoantigen B,Mouse,Mus musculus 96T
EIAAB06780 CENPK,CENP-K,Centromere protein K,FKSG14,Homo sapiens,Human,ICEN37,Interphase centromere complex protein 37,p33,Protein AF-5alpha
EIAAB06789 C22orf18,CENPM,CENP-M,Centromere protein M,Homo sapiens,Human,ICEN39,Interphase centromere complex protein 39,PANE1,Proliferation-associated nuclear element protein 1
20-373-85009 Motor domain of KIF10 - Monoclonal 0.1 ml
20-373-85036 Motor domain of KIF10 - Monoclonal 0.05 ml
20-372-60184 centromere protein C 1 (CENPC1) - Mouse monoclonal anti-human CENPC1 antibody; CENP-C; Centromere autoantigen C; Interphase centromere complex protein 7 Monoclonal 0.1 mg
EIAAB06761 CENPA,CENP-A,Centromere autoantigen A,Centromere protein A,Histone H3-like centromeric protein A,Homo sapiens,Human
EIAAB06771 CENPH,CENP-H,Centromere protein H,Homo sapiens,Human,ICEN35,Interphase centromere complex protein 35
EIAAB06782 C1orf155,CENPL,CENP-L,Centromere protein L,Homo sapiens,Human,ICEN33,Interphase centromere complex protein 33
EIAAB06791 BM-309,C16orf60,CENPN,CENP-N,Centromere protein N,Homo sapiens,Human,ICEN32,Interphase centromere complex protein 32
EIAAB06814 C16orf56,CENPT,CENP-T,Centromere protein T,Homo sapiens,Human,ICEN22,Interphase centromere complex protein 22
EIAAB06799 CENPO,CENP-O,Centromere protein O,Homo sapiens,Human,ICEN36,Interphase centromere complex protein 36,MCM21R
10-663-45663 Centromere Protein A (CENP-A) Human - CENP-A; Centromere autoantigen A N_A 0.005 mg
10-663-45663 Centromere Protein A (CENP-A) Human - CENP-A; Centromere autoantigen A N_A 0.02 mg
10-663-45663 Centromere Protein A (CENP-A) Human - CENP-A; Centromere autoantigen A N_A 1 mg
EIAAB06773 CENPI,CENP-I,Centromere protein I,Follicle-stimulating hormone primary response protein,FSH primary response protein 1,FSHPRH1,Homo sapiens,Human,ICEN19,Interphase centromere complex protein 19,Leucin
EIAAB06765 Cenpc,CENP-C 1,Cenpc1,Centromere autoantigen C,Centromere protein C 1,Mouse,Mus musculus
10-663-45664 Centromere Protein B (CENP-B) Human - Centromere protein B; CENP-B N_A 0.02 mg


 

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