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Centrosomal protein cep57l1 (Centrosomal protein 57kDa-like protein 1) (Centrosomal protein of 57 kDa) (Cep57) (XCep57) (Cep57-related protein) (Cep57R)

 CE57L_XENLA             Reviewed;         488 AA.
Q5FWP9;
01-SEP-2009, integrated into UniProtKB/Swiss-Prot.
01-MAR-2005, sequence version 1.
10-MAY-2017, entry version 49.
RecName: Full=Centrosomal protein cep57l1;
AltName: Full=Centrosomal protein 57kDa-like protein 1;
AltName: Full=Centrosomal protein of 57 kDa;
Short=Cep57;
Short=XCep57;
AltName: Full=Cep57-related protein;
Short=Cep57R;
Name=cep57l1; Synonyms=cep57, cep57r;
Xenopus laevis (African clawed frog).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus;
Xenopus.
NCBI_TaxID=8355;
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Egg;
NIH - Xenopus Gene Collection (XGC) project;
Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases.
[2]
FUNCTION, SUBCELLULAR LOCATION, AND INTERACTION WITH CLIP1;
GAMMA-TUBULIN; MIS12; NDC80 AND ZWINT.
PubMed=17803911; DOI=10.1016/j.cell.2007.07.023;
Emanuele M.J., Stukenberg P.T.;
"Xenopus Cep57 is a novel kinetochore component involved in
microtubule attachment.";
Cell 130:893-905(2007).
-!- FUNCTION: Required for spindle microtubule attachment to both
kinetochores and centrosomes. Also functions to tether minus-ends
of spindle microtubules to centrosomes. May act by forming ring-
like structures around microtubules, or by serving as a cross-
linker or scaffold at the attachment site.
{ECO:0000269|PubMed:17803911}.
-!- SUBUNIT: Interacts with clip1, mis12, ndc80 and zwint. Interacts
with gamma-tubulin. {ECO:0000269|PubMed:17803911}.
-!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule
organizing center, centrosome {ECO:0000269|PubMed:17803911}.
Chromosome, centromere, kinetochore {ECO:0000269|PubMed:17803911}.
Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:17803911}.
Note=Localizes to spindle microtubules.
-!- SIMILARITY: Belongs to the translokin family. {ECO:0000305}.
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EMBL; BC089255; AAH89255.1; -; mRNA.
RefSeq; NP_001089236.1; NM_001095767.1.
UniGene; Xl.7519; -.
ProteinModelPortal; Q5FWP9; -.
SMR; Q5FWP9; -.
GeneID; 734283; -.
KEGG; xla:734283; -.
CTD; 734283; -.
Xenbase; XB-GENE-5897421; cep57l1.
KO; K16762; -.
GO; GO:0005813; C:centrosome; IDA:UniProtKB.
GO; GO:0000777; C:condensed chromosome kinetochore; IEA:UniProtKB-SubCell.
GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
GO; GO:0000776; C:kinetochore; IDA:UniProtKB.
GO; GO:0005876; C:spindle microtubule; IDA:UniProtKB.
GO; GO:0043015; F:gamma-tubulin binding; IDA:UniProtKB.
GO; GO:0042802; F:identical protein binding; IEA:InterPro.
GO; GO:0008017; F:microtubule binding; IEA:InterPro.
GO; GO:0008608; P:attachment of spindle microtubules to kinetochore; IMP:UniProtKB.
InterPro; IPR025913; Cep57_CLD.
InterPro; IPR024957; Cep57_MT-bd_dom.
Pfam; PF14073; Cep57_CLD; 1.
Pfam; PF06657; Cep57_MT_bd; 1.
1: Evidence at protein level;
Centromere; Chromosome; Coiled coil; Cytoplasm; Cytoskeleton;
Kinetochore; Microtubule.
CHAIN 1 488 Centrosomal protein cep57l1.
/FTId=PRO_0000381818.
COILED 71 226 {ECO:0000255}.
COILED 377 403 {ECO:0000255}.
SEQUENCE 488 AA; 55108 MW; 351075E06862955B CRC64;
MESVSKESYL PSFHQFPLCA SLSEFESASS KETQSSALKN ISPHPYDILQ APNSRALISA
LKTLQNKICR LESEKTHARD RLTNLSRAAG EHKKVLESEK RSAEWAAQEA TSQKNDVAMQ
LNNAEQRCSL LEKQLDYMRK MMENADIQNN PIHQIPAQKE QKDMLEMQSK LQKLEVLENE
CLRLKATHKS SENKIQFLEE KLSVEEQERK ALQDKAAQVQ TSLEVNRILL SSASSQNSTQ
RKVKKKKQSK QKNAISKEPS SKEPLSKEPP SKCFFPKAGE LPFVAGKSTT SSHSLSANVQ
NMLHMMKHQS PRVSQKDPKT VEHKPSILPG GSRSIPTRLM SSSTGDTLSD ILLALQDELG
QMSFEHQELL KHIDETKNTD MREDLERELD YLVKQMEIKS DQIIKLKRHQ LNVAKLKKTA
KKQPRPPSTT KPAEDEQNIG ATDPCTPRNK GNLANGTGTP NSKASLELLK SVRKIQMTLK
KDDIMWEK


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