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Centrosomal protein of 70 kDa (Cep70) (p10-binding protein)

 CEP70_HUMAN             Reviewed;         597 AA.
Q8NHQ1; B7Z5I8; B7Z7E8; D3DNE9; F5GZX8; Q96B31; Q9H2C3; Q9H2Z1;
Q9H940;
01-FEB-2005, integrated into UniProtKB/Swiss-Prot.
01-FEB-2005, sequence version 2.
18-JUL-2018, entry version 139.
RecName: Full=Centrosomal protein of 70 kDa;
Short=Cep70;
AltName: Full=p10-binding protein;
Name=CEP70; Synonyms=BITE;
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
NCBI_TaxID=9606;
[1]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
TISSUE=Chronic myeloid leukemia cell;
Tschan M.P., Cajot J.-F., Grob T.J., Fey M.F., Tobler A.;
"Cloning and characterization of BITE: a binding partner of the cell
cycle inhibitor p10.";
Submitted (NOV-1999) to the EMBL/GenBank/DDBJ databases.
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (ISOFORMS 1; 4 AND 5),
AND VARIANT ASN-135.
TISSUE=Teratocarcinoma, and Testis;
PubMed=14702039; DOI=10.1038/ng1285;
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
"Complete sequencing and characterization of 21,243 full-length human
cDNAs.";
Nat. Genet. 36:40-45(2004).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
PubMed=16641997; DOI=10.1038/nature04728;
Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R.,
Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R.,
Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V.,
Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.,
Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B.,
Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S.,
Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q.,
Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z.,
Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C.,
Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G.,
Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B.,
Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R.,
Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J.,
Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A.,
Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B.,
Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H.,
Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J.,
Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J.,
Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H.,
Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G.,
Gibbs R.A.;
"The DNA sequence, annotation and analysis of human chromosome 3.";
Nature 440:1194-1198(2006).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND VARIANT ASN-135.
Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
Venter J.C.;
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (ISOFORMS 1 AND 3), AND
VARIANT ASN-135.
TISSUE=Skin, and Testis;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[6]
SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
TISSUE=Lymphoblast;
PubMed=14654843; DOI=10.1038/nature02166;
Andersen J.S., Wilkinson C.J., Mayor T., Mortensen P., Nigg E.A.,
Mann M.;
"Proteomic characterization of the human centrosome by protein
correlation profiling.";
Nature 426:570-574(2003).
[7]
SUBCELLULAR LOCATION, AND INTERACTION WITH TUBULIN-GAMMA.
PubMed=21795687; DOI=10.1074/jbc.M111.252262;
Shi X., Sun X., Liu M., Li D., Aneja R., Zhou J.;
"CEP70 protein interacts with gamma-tubulin to localize at the
centrosome and is critical for mitotic spindle assembly.";
J. Biol. Chem. 286:33401-33408(2011).
-!- FUNCTION: Plays a role in the organization of both preexisting and
nascent microtubules in interphase cells. During mitosis, required
for the organization and orientation of the mitotic spindle.
-!- SUBUNIT: Directly interacts with tubulin-gamma; this interaction
determines centrosomal localization.
{ECO:0000269|PubMed:21795687}.
-!- INTERACTION:
Self; NbExp=4; IntAct=EBI-739624, EBI-739624;
Q9ULW3:ABT1; NbExp=5; IntAct=EBI-739624, EBI-2602396;
P40507:AIR1 (xeno); NbExp=3; IntAct=EBI-739624, EBI-25083;
Q02040:AKAP17A; NbExp=5; IntAct=EBI-739624, EBI-1042725;
Q02040-3:AKAP17A; NbExp=3; IntAct=EBI-739624, EBI-10222656;
P46682:APL6 (xeno); NbExp=3; IntAct=EBI-739624, EBI-2213;
Q9NR81:ARHGEF3; NbExp=5; IntAct=EBI-739624, EBI-10312733;
P48047:ATP5O; NbExp=5; IntAct=EBI-739624, EBI-355815;
A0AVN2:BARD1; NbExp=3; IntAct=EBI-739624, EBI-9977322;
Q99728:BARD1; NbExp=3; IntAct=EBI-739624, EBI-473181;
Q9BXY8:BEX2; NbExp=5; IntAct=EBI-739624, EBI-745073;
P47041:BIT61 (xeno); NbExp=3; IntAct=EBI-739624, EBI-25889;
P39724:BOL3 (xeno); NbExp=3; IntAct=EBI-739624, EBI-2343154;
Q9HCU9:BRMS1; NbExp=3; IntAct=EBI-739624, EBI-714781;
P53286:BTN2 (xeno); NbExp=3; IntAct=EBI-739624, EBI-3796;
Q13895:BYSL; NbExp=7; IntAct=EBI-739624, EBI-358049;
Q9H7E9:C8orf33; NbExp=4; IntAct=EBI-739624, EBI-715389;
Q9H257:CARD9; NbExp=3; IntAct=EBI-739624, EBI-751319;
Q9BW85:CCDC94; NbExp=5; IntAct=EBI-739624, EBI-10300345;
Q6P1J9:CDC73; NbExp=9; IntAct=EBI-739624, EBI-930143;
Q96GN5:CDCA7L; NbExp=5; IntAct=EBI-739624, EBI-5278764;
Q8IYX8:CEP57L1; NbExp=3; IntAct=EBI-739624, EBI-1104570;
Q8IYX8-2:CEP57L1; NbExp=3; IntAct=EBI-739624, EBI-10181988;
Q8NHQ1-3:CEP70; NbExp=3; IntAct=EBI-739624, EBI-11526150;
Q96M91:CFAP53; NbExp=3; IntAct=EBI-739624, EBI-742422;
Q9H078:CLPB; NbExp=3; IntAct=EBI-739624, EBI-2107221;
P38432:COIL; NbExp=3; IntAct=EBI-739624, EBI-945751;
P47130:CSN12 (xeno); NbExp=3; IntAct=EBI-739624, EBI-763;
Q9UJV9:DDX41; NbExp=3; IntAct=EBI-739624, EBI-1046350;
P26196:DDX6; NbExp=5; IntAct=EBI-739624, EBI-351257;
Q68CQ4:DIEXF; NbExp=5; IntAct=EBI-739624, EBI-747711;
Q14241:ELOA; NbExp=3; IntAct=EBI-739624, EBI-742350;
P50402:EMD; NbExp=6; IntAct=EBI-739624, EBI-489887;
P54849:EMP1; NbExp=3; IntAct=EBI-739624, EBI-4319440;
Q9H0I2:ENKD1; NbExp=4; IntAct=EBI-739624, EBI-744099;
P19447:ERCC3; NbExp=3; IntAct=EBI-739624, EBI-1183307;
Q86V42:FAM124A; NbExp=3; IntAct=EBI-739624, EBI-744506;
Q8N9E0:FAM133A; NbExp=5; IntAct=EBI-739624, EBI-10268158;
Q8NE31:FAM13C; NbExp=3; IntAct=EBI-739624, EBI-751248;
Q3B820:FAM161A; NbExp=5; IntAct=EBI-739624, EBI-719941;
Q7L5A3:FAM214B; NbExp=3; IntAct=EBI-739624, EBI-745689;
Q8WXI9:GATAD2B; NbExp=3; IntAct=EBI-739624, EBI-923440;
Q96CN9:GCC1; NbExp=5; IntAct=EBI-739624, EBI-746252;
P32502:GCD7 (xeno); NbExp=3; IntAct=EBI-11526150, EBI-6260;
Q9NWQ4:GPATCH2L; NbExp=3; IntAct=EBI-739624, EBI-5666657;
Q5T3I0:GPATCH4; NbExp=5; IntAct=EBI-739624, EBI-2372076;
P41911:GPD2 (xeno); NbExp=3; IntAct=EBI-739624, EBI-7791;
Q96SL4:GPX7; NbExp=3; IntAct=EBI-739624, EBI-749411;
Q96CS2:HAUS1; NbExp=3; IntAct=EBI-739624, EBI-2514791;
Q96CS2-2:HAUS1; NbExp=3; IntAct=EBI-739624, EBI-11742270;
Q6NSH1:HMGB4; NbExp=3; IntAct=EBI-739624, EBI-10250889;
Q8WW32:HMGB4; NbExp=5; IntAct=EBI-739624, EBI-10277297;
P10809:HSPD1; NbExp=6; IntAct=EBI-739624, EBI-352528;
Q13123:IK; NbExp=3; IntAct=EBI-739624, EBI-713456;
Q63ZY3:KANK2; NbExp=5; IntAct=EBI-739624, EBI-2556193;
Q7Z3B3:KANSL1; NbExp=4; IntAct=EBI-739624, EBI-740244;
O60341:KDM1A; NbExp=2; IntAct=EBI-739624, EBI-710124;
Q15323:KRT31; NbExp=3; IntAct=EBI-739624, EBI-948001;
A0A0C4DGV4:LAMTOR5; NbExp=5; IntAct=EBI-739624, EBI-10173304;
Q96BZ8:LENG1; NbExp=5; IntAct=EBI-739624, EBI-726510;
Q96PV6:LENG8; NbExp=3; IntAct=EBI-739624, EBI-739546;
Q96GY3:LIN37; NbExp=3; IntAct=EBI-739624, EBI-748884;
Q9H7H0:METTL17; NbExp=6; IntAct=EBI-739624, EBI-749353;
Q9H7H0-2:METTL17; NbExp=3; IntAct=EBI-739624, EBI-11098807;
P55081:MFAP1; NbExp=5; IntAct=EBI-739624, EBI-1048159;
Q9BU76:MMTAG2; NbExp=4; IntAct=EBI-739624, EBI-742459;
P32902:MRP4 (xeno); NbExp=3; IntAct=EBI-739624, EBI-16248;
Q9UFN0:NIPSNAP3A; NbExp=3; IntAct=EBI-739624, EBI-716291;
Q6ZUT1:NKAPD1; NbExp=5; IntAct=EBI-739624, EBI-3920396;
Q6ZUT1-2:NKAPD1; NbExp=3; IntAct=EBI-739624, EBI-10180231;
Q9UGY1:NOL12; NbExp=3; IntAct=EBI-739624, EBI-716098;
P46087:NOP2; NbExp=3; IntAct=EBI-739624, EBI-356811;
Q12460:NOP56 (xeno); NbExp=3; IntAct=EBI-739624, EBI-17148;
P48552:NRIP1; NbExp=3; IntAct=EBI-739624, EBI-746484;
Q9BXS6:NUSAP1; NbExp=3; IntAct=EBI-739624, EBI-2555618;
A0A087WUI6:PIBF1; NbExp=3; IntAct=EBI-739624, EBI-11749468;
Q9BSJ6:PIMREG; NbExp=6; IntAct=EBI-739624, EBI-2568609;
Q13427:PPIG; NbExp=3; IntAct=EBI-739624, EBI-396072;
Q96T49:PPP1R16B; NbExp=3; IntAct=EBI-739624, EBI-10293968;
Q9H875:PRKRIP1; NbExp=3; IntAct=EBI-739624, EBI-744488;
Q03338:PRP3 (xeno); NbExp=3; IntAct=EBI-739624, EBI-421;
P20053:PRP4 (xeno); NbExp=3; IntAct=EBI-739624, EBI-219;
P28004:PRP45 (xeno); NbExp=3; IntAct=EBI-739624, EBI-20640;
Q8WWY3:PRPF31; NbExp=8; IntAct=EBI-739624, EBI-1567797;
P25786:PSMA1; NbExp=5; IntAct=EBI-739624, EBI-359352;
P53335:PXR1 (xeno); NbExp=3; IntAct=EBI-739624, EBI-23652;
P98175:RBM10; NbExp=5; IntAct=EBI-739624, EBI-721525;
P40348:RFC2 (xeno); NbExp=3; IntAct=EBI-739624, EBI-14992;
A0A0S2Z4G9:RNF6; NbExp=3; IntAct=EBI-739624, EBI-16428950;
P26373:RPL13; NbExp=3; IntAct=EBI-739624, EBI-356849;
Q6NZ55:RPL13; NbExp=3; IntAct=EBI-739624, EBI-10252046;
P40454:RRD1 (xeno); NbExp=3; IntAct=EBI-739624, EBI-25278;
Q9C0A6-2:SETD5; NbExp=3; IntAct=EBI-739624, EBI-10303449;
Q86XK3:SFR1; NbExp=3; IntAct=EBI-739624, EBI-1104535;
Q06132:SGD1 (xeno); NbExp=3; IntAct=EBI-739624, EBI-34377;
Q9H788-2:SH2D4A; NbExp=3; IntAct=EBI-739624, EBI-10308083;
O95391:SLU7; NbExp=3; IntAct=EBI-739624, EBI-750559;
Q969G3:SMARCE1; NbExp=5; IntAct=EBI-739624, EBI-455078;
P62316:SNRPD2; NbExp=3; IntAct=EBI-739624, EBI-297993;
Q06411:SPP382 (xeno); NbExp=3; IntAct=EBI-739624, EBI-576;
Q99909:SSX3; NbExp=3; IntAct=EBI-739624, EBI-10295431;
O00506:STK25; NbExp=3; IntAct=EBI-739624, EBI-618295;
O43463:SUV39H1; NbExp=3; IntAct=EBI-739624, EBI-349968;
Q9BSW7:SYT17; NbExp=3; IntAct=EBI-739624, EBI-745392;
Q96C24:SYTL4; NbExp=3; IntAct=EBI-739624, EBI-747142;
Q8TDW5:SYTL5; NbExp=3; IntAct=EBI-739624, EBI-2939487;
P38340:TAE1 (xeno); NbExp=3; IntAct=EBI-11526150, EBI-21116;
Q9H5J8:TAF1D; NbExp=4; IntAct=EBI-739624, EBI-716128;
A0A0S2Z4E5:TEAD4; NbExp=3; IntAct=EBI-739624, EBI-16432288;
A0A0S2Z4F2:TEAD4; NbExp=3; IntAct=EBI-739624, EBI-16429215;
D3DUQ6:TEAD4; NbExp=3; IntAct=EBI-739624, EBI-10176734;
P35180:TOM20 (xeno); NbExp=3; IntAct=EBI-739624, EBI-12522;
Q14134:TRIM29; NbExp=4; IntAct=EBI-739624, EBI-702370;
Q8IWZ5:TRIM42; NbExp=3; IntAct=EBI-739624, EBI-5235829;
P25372:TRX3 (xeno); NbExp=3; IntAct=EBI-739624, EBI-19616;
P43897:TSFM; NbExp=3; IntAct=EBI-739624, EBI-1049298;
Q3SY00:TSGA10IP; NbExp=5; IntAct=EBI-739624, EBI-10241197;
Q63HK5:TSHZ3; NbExp=3; IntAct=EBI-739624, EBI-9053916;
Q96NG3:TTC25; NbExp=3; IntAct=EBI-739624, EBI-1046387;
Q6ZVT0:TTLL10; NbExp=3; IntAct=EBI-739624, EBI-7844656;
Q8N3L3:TXLNB; NbExp=5; IntAct=EBI-739624, EBI-6116822;
Q02724:ULP1 (xeno); NbExp=3; IntAct=EBI-739624, EBI-20050;
Q9Y3A2:UTP11; NbExp=3; IntAct=EBI-739624, EBI-2876697;
Q05516:ZBTB16; NbExp=3; IntAct=EBI-739624, EBI-711925;
O43167:ZBTB24; NbExp=5; IntAct=EBI-739624, EBI-744471;
Q6ZSB9:ZBTB49; NbExp=3; IntAct=EBI-739624, EBI-2859943;
Q8TBK6:ZCCHC10; NbExp=3; IntAct=EBI-739624, EBI-597063;
G3V1X1:ZFC3H1; NbExp=3; IntAct=EBI-739624, EBI-6448783;
A0A0S2Z6H0:ZGPAT; NbExp=3; IntAct=EBI-739624, EBI-16428984;
Q8N5A5:ZGPAT; NbExp=3; IntAct=EBI-739624, EBI-3439227;
Q8N5A5-2:ZGPAT; NbExp=8; IntAct=EBI-739624, EBI-10183064;
P52737:ZNF136; NbExp=5; IntAct=EBI-739624, EBI-749129;
Q9UQR1:ZNF148; NbExp=3; IntAct=EBI-739624, EBI-2688184;
Q14929:ZNF169; NbExp=3; IntAct=EBI-739624, EBI-10234472;
Q86WZ6:ZNF227; NbExp=5; IntAct=EBI-739624, EBI-2799529;
Q16600:ZNF239; NbExp=5; IntAct=EBI-739624, EBI-8787052;
Q14584:ZNF266; NbExp=5; IntAct=EBI-739624, EBI-7115319;
Q9NR11:ZNF302; NbExp=3; IntAct=EBI-739624, EBI-3916142;
Q86UD4:ZNF329; NbExp=5; IntAct=EBI-739624, EBI-7233259;
Q8N895:ZNF366; NbExp=5; IntAct=EBI-739624, EBI-2813661;
Q9H9D4:ZNF408; NbExp=8; IntAct=EBI-739624, EBI-347633;
Q86VK4:ZNF410; NbExp=3; IntAct=EBI-739624, EBI-720304;
Q8TAU3:ZNF417; NbExp=5; IntAct=EBI-739624, EBI-740727;
Q8NDP4:ZNF439; NbExp=3; IntAct=EBI-739624, EBI-747580;
Q9ULM2:ZNF490; NbExp=5; IntAct=EBI-739624, EBI-1105370;
Q8NEP9:ZNF555; NbExp=3; IntAct=EBI-739624, EBI-10270752;
Q7Z3I7:ZNF572; NbExp=6; IntAct=EBI-739624, EBI-10172590;
Q3MI94:ZNF578; NbExp=3; IntAct=EBI-739624, EBI-10241108;
Q96SQ5:ZNF587; NbExp=5; IntAct=EBI-739624, EBI-6427977;
A0A0S2Z5X4:ZNF688; NbExp=3; IntAct=EBI-739624, EBI-16429014;
O43309:ZSCAN12; NbExp=3; IntAct=EBI-739624, EBI-1210440;
-!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule
organizing center, centrosome {ECO:0000269|PubMed:14654843,
ECO:0000269|PubMed:21795687}. Note=Localized at the center of the
radial microtubule array in interphase and at the spindle poles
during various stages of mitosis.
-!- ALTERNATIVE PRODUCTS:
Event=Alternative splicing; Named isoforms=5;
Name=1;
IsoId=Q8NHQ1-1; Sequence=Displayed;
Name=2;
IsoId=Q8NHQ1-2; Sequence=VSP_012746, VSP_012747;
Name=3;
IsoId=Q8NHQ1-3; Sequence=VSP_012745;
Name=4;
IsoId=Q8NHQ1-4; Sequence=VSP_042140;
Note=No experimental confirmation available.;
Name=5;
IsoId=Q8NHQ1-5; Sequence=VSP_042140, VSP_042141;
Note=No experimental confirmation available.;
-!- DOMAIN: The coiled-coil domains may be important for tubulin-
gamma-binding and hence for centrosomal localization.
-----------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
Distributed under the Creative Commons Attribution (CC BY 4.0) License
-----------------------------------------------------------------------
EMBL; AF202146; AAG35616.1; -; mRNA.
EMBL; AF289495; AAG35791.1; -; mRNA.
EMBL; AK023098; BAB14403.1; -; mRNA.
EMBL; AK299003; BAH12924.1; -; mRNA.
EMBL; AK301913; BAH13584.1; -; mRNA.
EMBL; AC020890; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AC072045; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; CH471052; EAW79062.1; -; Genomic_DNA.
EMBL; CH471052; EAW79063.1; -; Genomic_DNA.
EMBL; BC016050; AAH16050.1; -; mRNA.
EMBL; BC030598; AAH30598.1; -; mRNA.
CCDS; CCDS3102.1; -. [Q8NHQ1-1]
CCDS; CCDS75022.1; -. [Q8NHQ1-4]
CCDS; CCDS75023.1; -. [Q8NHQ1-2]
CCDS; CCDS82842.1; -. [Q8NHQ1-3]
RefSeq; NP_001275893.1; NM_001288964.1. [Q8NHQ1-4]
RefSeq; NP_001275894.1; NM_001288965.1. [Q8NHQ1-5]
RefSeq; NP_001275895.1; NM_001288966.1. [Q8NHQ1-2]
RefSeq; NP_001275896.1; NM_001288967.1.
RefSeq; NP_001307527.1; NM_001320598.1. [Q8NHQ1-1]
RefSeq; NP_001307529.1; NM_001320600.1. [Q8NHQ1-3]
RefSeq; NP_077817.2; NM_024491.3. [Q8NHQ1-1]
RefSeq; XP_016862764.1; XM_017007275.1. [Q8NHQ1-1]
UniGene; Hs.531962; -.
ProteinModelPortal; Q8NHQ1; -.
SMR; Q8NHQ1; -.
BioGrid; 123234; 166.
IntAct; Q8NHQ1; 274.
MINT; Q8NHQ1; -.
STRING; 9606.ENSP00000264982; -.
iPTMnet; Q8NHQ1; -.
PhosphoSitePlus; Q8NHQ1; -.
BioMuta; CEP70; -.
DMDM; 84028943; -.
EPD; Q8NHQ1; -.
PaxDb; Q8NHQ1; -.
PeptideAtlas; Q8NHQ1; -.
PRIDE; Q8NHQ1; -.
ProteomicsDB; 73734; -.
ProteomicsDB; 73735; -. [Q8NHQ1-2]
ProteomicsDB; 73736; -. [Q8NHQ1-3]
ProteomicsDB; 73737; -. [Q8NHQ1-4]
ProteomicsDB; 73738; -. [Q8NHQ1-5]
DNASU; 80321; -.
Ensembl; ENST00000264982; ENSP00000264982; ENSG00000114107. [Q8NHQ1-1]
Ensembl; ENST00000464035; ENSP00000419743; ENSG00000114107. [Q8NHQ1-3]
Ensembl; ENST00000474781; ENSP00000419833; ENSG00000114107. [Q8NHQ1-4]
Ensembl; ENST00000481834; ENSP00000417465; ENSG00000114107. [Q8NHQ1-2]
Ensembl; ENST00000484888; ENSP00000419231; ENSG00000114107. [Q8NHQ1-1]
GeneID; 80321; -.
KEGG; hsa:80321; -.
UCSC; uc003esl.5; human. [Q8NHQ1-1]
CTD; 80321; -.
DisGeNET; 80321; -.
EuPathDB; HostDB:ENSG00000114107.8; -.
GeneCards; CEP70; -.
H-InvDB; HIX0018484; -.
HGNC; HGNC:29972; CEP70.
HPA; HPA036941; -.
HPA; HPA036942; -.
MIM; 614310; gene.
neXtProt; NX_Q8NHQ1; -.
OpenTargets; ENSG00000114107; -.
PharmGKB; PA128394729; -.
eggNOG; ENOG410IFWI; Eukaryota.
eggNOG; ENOG4111V7R; LUCA.
GeneTree; ENSGT00390000009029; -.
HOGENOM; HOG000290163; -.
HOVERGEN; HBG050899; -.
InParanoid; Q8NHQ1; -.
KO; K16802; -.
OMA; NVLLMMH; -.
OrthoDB; EOG091G08G2; -.
PhylomeDB; Q8NHQ1; -.
TreeFam; TF330986; -.
Reactome; R-HSA-2565942; Regulation of PLK1 Activity at G2/M Transition.
Reactome; R-HSA-380259; Loss of Nlp from mitotic centrosomes.
Reactome; R-HSA-380270; Recruitment of mitotic centrosome proteins and complexes.
Reactome; R-HSA-380284; Loss of proteins required for interphase microtubule organization from the centrosome.
Reactome; R-HSA-380320; Recruitment of NuMA to mitotic centrosomes.
Reactome; R-HSA-5620912; Anchoring of the basal body to the plasma membrane.
Reactome; R-HSA-8854518; AURKA Activation by TPX2.
ChiTaRS; CEP70; human.
GeneWiki; CEP70; -.
GenomeRNAi; 80321; -.
PRO; PR:Q8NHQ1; -.
Proteomes; UP000005640; Chromosome 3.
Bgee; ENSG00000114107; -.
CleanEx; HS_CEP70; -.
ExpressionAtlas; Q8NHQ1; baseline and differential.
Genevisible; Q8NHQ1; HS.
GO; GO:0005813; C:centrosome; IDA:UniProtKB.
GO; GO:0005829; C:cytosol; IDA:HPA.
GO; GO:0031965; C:nuclear membrane; IDA:HPA.
GO; GO:0005654; C:nucleoplasm; IDA:HPA.
GO; GO:0043015; F:gamma-tubulin binding; IEA:InterPro.
GO; GO:0042802; F:identical protein binding; IPI:IntAct.
GO; GO:0097711; P:ciliary basal body-plasma membrane docking; TAS:Reactome.
GO; GO:0000086; P:G2/M transition of mitotic cell cycle; TAS:Reactome.
GO; GO:0010389; P:regulation of G2/M transition of mitotic cell cycle; TAS:Reactome.
GO; GO:0070507; P:regulation of microtubule cytoskeleton organization; IEA:InterPro.
InterPro; IPR037692; CEP70.
InterPro; IPR013026; TPR-contain_dom.
InterPro; IPR019734; TPR_repeat.
PANTHER; PTHR14594; PTHR14594; 1.
PROSITE; PS50005; TPR; 1.
PROSITE; PS50293; TPR_REGION; 1.
1: Evidence at protein level;
Alternative splicing; Coiled coil; Complete proteome; Cytoplasm;
Cytoskeleton; Polymorphism; Reference proteome; TPR repeat.
CHAIN 1 597 Centrosomal protein of 70 kDa.
/FTId=PRO_0000089497.
REPEAT 483 516 TPR.
COILED 75 179 {ECO:0000255}.
COILED 254 326 {ECO:0000255}.
VAR_SEQ 1 18 Missing (in isoform 4 and isoform 5).
{ECO:0000305}.
/FTId=VSP_042140.
VAR_SEQ 22 23 Missing (in isoform 5). {ECO:0000305}.
/FTId=VSP_042141.
VAR_SEQ 213 597 Missing (in isoform 3). {ECO:0000305}.
/FTId=VSP_012745.
VAR_SEQ 551 554 SIIY -> RYLF (in isoform 2).
{ECO:0000303|Ref.1}.
/FTId=VSP_012746.
VAR_SEQ 555 597 Missing (in isoform 2).
{ECO:0000303|Ref.1}.
/FTId=VSP_012747.
VARIANT 135 135 S -> N (in dbSNP:rs1673607).
{ECO:0000269|PubMed:14702039,
ECO:0000269|PubMed:15489334,
ECO:0000269|Ref.4}.
/FTId=VAR_021177.
VARIANT 537 537 N -> S (in dbSNP:rs35340237).
/FTId=VAR_061590.
CONFLICT 52 52 Missing (in Ref. 2; BAB14403).
{ECO:0000305}.
CONFLICT 293 293 Q -> L (in Ref. 2; BAH12924).
{ECO:0000305}.
CONFLICT 371 371 Q -> R (in Ref. 2; BAB14403).
{ECO:0000305}.
CONFLICT 385 385 Q -> R (in Ref. 2; BAH13584).
{ECO:0000305}.
CONFLICT 393 393 V -> A (in Ref. 2; BAH13584).
{ECO:0000305}.
CONFLICT 471 471 S -> P (in Ref. 1; AAG35616/AAG35791).
{ECO:0000305}.
CONFLICT 478 478 D -> G (in Ref. 1; AAG35616/AAG35791).
{ECO:0000305}.
SEQUENCE 597 AA; 69752 MW; 345EEEB9B1F0D6C7 CRC64;
MFPVAPKPQD SSQPSDRLMT EKQQEEAEWE SINVLLMMHG LKPLSLVKRT DLKDLIIFDK
QSSQRMRQNL KLLVEETSCQ QNMIQELIET NQQLRNELQL EQSRAANQEQ RANDLEQIME
SVKSKIGELE DESLSRACHQ QNKIKDLQKE QKTLQVKCQH YKKKRTEQEE TIASLQMEVC
RLKKEEEDRI VTQNRVFAYL CKRVPHTVLD RQLLCLIDYY ESKIRKIHTQ RQYKEDESQS
EEENDYRNLD ASPTYKGLLM SLQNQLKESK SKIDALSSEK LNLQKDLETR PTQHELRLYK
QQVKKLEKAL KKNVKLQELI NHKKAEDTEK KDEPSKYNQQ QALIDQRYFQ VLCSINSIIH
NPRAPVIIYK QTKGGVQNFN KDLVQDCGFE HLVPVIEMWA DQLTSLKDLY KSLKTLSAEL
VPWLNLKKQD ENEGIKVEDL LFIVDTMLEE VENKEKDSNM PHFQTLQAIV SHFQKLFDVP
SLNGVYPRMN EVYTRLGEMN NAVRNLQELL ELDSSSSLCV LVSTVGKLCR LINEDVNEQV
MQVLGPEDLQ SIIYKLEEHE EFFPAFQAFT NDLLEILEID DLDAIVPAVK KLKVLSY


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