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Chaperone protein DnaJ

 DNAJ_ORITI              Reviewed;         377 AA.
B3CVD9;
14-APR-2009, integrated into UniProtKB/Swiss-Prot.
22-JUL-2008, sequence version 1.
25-OCT-2017, entry version 68.
RecName: Full=Chaperone protein DnaJ {ECO:0000255|HAMAP-Rule:MF_01152};
Name=dnaJ {ECO:0000255|HAMAP-Rule:MF_01152};
OrderedLocusNames=OTT_1878;
Orientia tsutsugamushi (strain Ikeda) (Rickettsia tsutsugamushi).
Bacteria; Proteobacteria; Alphaproteobacteria; Rickettsiales;
Rickettsiaceae; Rickettsieae; Orientia.
NCBI_TaxID=334380;
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Ikeda;
PubMed=18508905; DOI=10.1093/dnares/dsn011;
Nakayama K., Yamashita A., Kurokawa K., Morimoto T., Ogawa M.,
Fukuhara M., Urakami H., Ohnishi M., Uchiyama I., Ogura Y., Ooka T.,
Oshima K., Tamura A., Hattori M., Hayashi T.;
"The whole-genome sequencing of the obligate intracellular bacterium
Orientia tsutsugamushi revealed massive gene amplification during
reductive genome evolution.";
DNA Res. 15:185-199(2008).
-!- FUNCTION: Participates actively in the response to hyperosmotic
and heat shock by preventing the aggregation of stress-denatured
proteins and by disaggregating proteins, also in an autonomous,
DnaK-independent fashion. Unfolded proteins bind initially to
DnaJ; upon interaction with the DnaJ-bound protein, DnaK
hydrolyzes its bound ATP, resulting in the formation of a stable
complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers
the release of the substrate protein, thus completing the reaction
cycle. Several rounds of ATP-dependent interactions between DnaJ,
DnaK and GrpE are required for fully efficient folding. Also
involved, together with DnaK and GrpE, in the DNA replication of
plasmids through activation of initiation proteins.
{ECO:0000255|HAMAP-Rule:MF_01152}.
-!- COFACTOR:
Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
Evidence={ECO:0000255|HAMAP-Rule:MF_01152};
Note=Binds 2 Zn(2+) ions per monomer. {ECO:0000255|HAMAP-
Rule:MF_01152};
-!- SUBUNIT: Homodimer. {ECO:0000255|HAMAP-Rule:MF_01152}.
-!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01152}.
-!- DOMAIN: The J domain is necessary and sufficient to stimulate DnaK
ATPase activity. Zinc center 1 plays an important role in the
autonomous, DnaK-independent chaperone activity of DnaJ. Zinc
center 2 is essential for interaction with DnaK and for DnaJ
activity. {ECO:0000255|HAMAP-Rule:MF_01152}.
-!- SIMILARITY: Belongs to the DnaJ family. {ECO:0000255|HAMAP-
Rule:MF_01152}.
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EMBL; AP008981; BAG41336.1; -; Genomic_DNA.
RefSeq; WP_012462285.1; NC_010793.1.
ProteinModelPortal; B3CVD9; -.
SMR; B3CVD9; -.
EnsemblBacteria; BAG41336; BAG41336; OTT_1878.
KEGG; ott:OTT_1878; -.
HOGENOM; HOG000226717; -.
KO; K03686; -.
OMA; DMGGFAD; -.
OrthoDB; POG091H00PT; -.
Proteomes; UP000001033; Chromosome.
GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO; GO:0005524; F:ATP binding; IEA:InterPro.
GO; GO:0031072; F:heat shock protein binding; IEA:InterPro.
GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO; GO:0051082; F:unfolded protein binding; IEA:InterPro.
GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
GO; GO:0006457; P:protein folding; IEA:InterPro.
GO; GO:0009408; P:response to heat; IEA:InterPro.
CDD; cd06257; DnaJ; 1.
Gene3D; 1.10.287.110; -; 1.
HAMAP; MF_01152; DnaJ; 1.
InterPro; IPR012724; DnaJ.
InterPro; IPR002939; DnaJ_C.
InterPro; IPR036869; DnaJ_dom_sf.
InterPro; IPR001623; DnaJ_domain.
InterPro; IPR008971; HSP40/DnaJ_pept-bd.
InterPro; IPR001305; HSP_DnaJ_Cys-rich_dom.
InterPro; IPR036410; HSP_DnaJ_Cys-rich_dom_sf.
Pfam; PF00226; DnaJ; 1.
Pfam; PF01556; DnaJ_C; 1.
Pfam; PF00684; DnaJ_CXXCXGXG; 1.
PRINTS; PR00625; JDOMAIN.
SMART; SM00271; DnaJ; 1.
SUPFAM; SSF46565; SSF46565; 1.
SUPFAM; SSF49493; SSF49493; 3.
SUPFAM; SSF57938; SSF57938; 1.
TIGRFAMs; TIGR02349; DnaJ_bact; 1.
PROSITE; PS50076; DNAJ_2; 1.
PROSITE; PS51188; ZF_CR; 1.
3: Inferred from homology;
Chaperone; Complete proteome; Cytoplasm; DNA replication;
Metal-binding; Repeat; Stress response; Zinc; Zinc-finger.
CHAIN 1 377 Chaperone protein DnaJ.
/FTId=PRO_1000137708.
DOMAIN 5 70 J. {ECO:0000255|HAMAP-Rule:MF_01152}.
REPEAT 151 158 CXXCXGXG motif.
REPEAT 168 175 CXXCXGXG motif.
REPEAT 190 197 CXXCXGXG motif.
REPEAT 204 211 CXXCXGXG motif.
ZN_FING 138 216 CR-type. {ECO:0000255|HAMAP-
Rule:MF_01152}.
COMPBIAS 77 121 Gly-rich.
METAL 151 151 Zinc 1. {ECO:0000255|HAMAP-
Rule:MF_01152}.
METAL 154 154 Zinc 1. {ECO:0000255|HAMAP-
Rule:MF_01152}.
METAL 168 168 Zinc 2. {ECO:0000255|HAMAP-
Rule:MF_01152}.
METAL 171 171 Zinc 2. {ECO:0000255|HAMAP-
Rule:MF_01152}.
METAL 190 190 Zinc 2. {ECO:0000255|HAMAP-
Rule:MF_01152}.
METAL 193 193 Zinc 2. {ECO:0000255|HAMAP-
Rule:MF_01152}.
METAL 204 204 Zinc 1. {ECO:0000255|HAMAP-
Rule:MF_01152}.
METAL 207 207 Zinc 1. {ECO:0000255|HAMAP-
Rule:MF_01152}.
SEQUENCE 377 AA; 41492 MW; E36CD05B71E0BD92 CRC64;
MSELDYYQVL GVSRTASQEE IKRAYRKLVL KYHPDHNPGD KNAEQKIKNI NEAYDILKDE
KKRSAYDQLG HQTFKNSGGG NYQQHHGFTG GIDPNDIFEN IFGDFMGARR SSKTAFSKKA
GANLKYDISL TLEEAFYGVT KIISFKTALT CEACTGKGSL DNNSTSSCPT CRGSGVTRSQ
QGFFFFENTC QTCRGAGHVI KNPCTKCYGE GRYINTRNLE VKIPAGVKEG SRIKLTGEGE
AGSRGGKTGD LYVCITLIPH NTFSVDGNDL HCQLDINCTT AALGGEVEVT DITGSKLKLK
IPAGTQNNHK LKLSGKGMQI LHSDRCGNMI VHVNIKVPKS LTKSQRELMI KLDKELNEAS
EEGFLSKVRN FWTSGSE


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U0872h CLIA DnaJ homolog subfamily B member 1,DnaJ protein homolog 1,DNAJ1,DNAJB1,HDJ1,hDj-1,Heat shock 40 kDa protein 1,Heat shock protein 40,Homo sapiens,HSP40,HSPF1,Human,Human DnaJ protein 1 96T
E0872h ELISA kit DnaJ homolog subfamily B member 1,DnaJ protein homolog 1,DNAJ1,DNAJB1,HDJ1,hDj-1,Heat shock 40 kDa protein 1,Heat shock protein 40,Homo sapiens,HSP40,HSPF1,Human,Human DnaJ protein 1 96T
EIAAB11532 DnaJ homolog subfamily A member 1,Dnaja1,DnaJ-like protein 1,Heat shock protein J2,Hsj2,HSJ-2,Rat,Rattus norvegicus,Rdj1
EIAAB11353 DnaJ homolog subfamily C member 27,Dnajc27,Rab and DnaJ domain-containing protein,Rat,Rattus norvegicus,Rbj
EIAAB11351 Bos taurus,Bovine,DnaJ homolog subfamily C member 27,DNAJC27,Rab and DnaJ domain-containing protein,RBJ
EIAAB11350 DnaJ homolog subfamily C member 27,Dnajc27,Mouse,Mus musculus,Rab and DnaJ domain-containing protein,Rabj,Rbj
EIAAB11586 DnaJ homolog subfamily C member 9,DnaJ protein SB73,DNAJC9,Homo sapiens,Human
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