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Chloride anion exchanger (Down-regulated in adenoma) (Protein DRA) (Solute carrier family 26 member 3)

 S26A3_RAT               Reviewed;         757 AA.
Q924C9;
05-MAR-2002, integrated into UniProtKB/Swiss-Prot.
01-DEC-2001, sequence version 1.
23-MAY-2018, entry version 117.
RecName: Full=Chloride anion exchanger;
AltName: Full=Down-regulated in adenoma;
Short=Protein DRA;
AltName: Full=Solute carrier family 26 member 3;
Name=Slc26a3; Synonyms=Dra;
Rattus norvegicus (Rat).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Rattus.
NCBI_TaxID=10116;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Colon;
Ye H.J., Binder H.J., Rajendran V.M.;
"Molecular cloning and characterization of down-regulated in adenoma
(DRA) mRNA from rat colon.";
Submitted (JAN-2001) to the EMBL/GenBank/DDBJ databases.
-!- FUNCTION: Chloride/bicarbonate exchanger. Mediates the efficient
absorption of chloride ions in the colon, participating in fluid
homeostasis. Plays a role in the chloride and bicarbonate
homeostasis during sperm epididymal maturation and capacitation
(By similarity). {ECO:0000250}.
-!- SUBUNIT: Interacts with PDZK1, CFTR, SLC26A6 and SLC9A3R1.
{ECO:0000250}.
-!- SUBCELLULAR LOCATION: Apical cell membrane {ECO:0000250}; Multi-
pass membrane protein {ECO:0000250}. Membrane {ECO:0000250};
Multi-pass membrane protein {ECO:0000250}. Note=Localized in sperm
membranes. Midpiece of sperm tail. Colocalizes with CFTR at the
midpiece of sperm tail (By similarity). {ECO:0000250}.
-!- PTM: N-glycosylation is required for efficient cell surface
expression, and protection from proteolytic degradation.
{ECO:0000250}.
-!- SIMILARITY: Belongs to the SLC26A/SulP transporter (TC 2.A.53)
family. {ECO:0000305}.
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EMBL; AF337809; AAK83221.1; -; mRNA.
RefSeq; NP_446207.1; NM_053755.2.
UniGene; Rn.81026; -.
ProteinModelPortal; Q924C9; -.
STRING; 10116.ENSRNOP00000009473; -.
iPTMnet; Q924C9; -.
PhosphoSitePlus; Q924C9; -.
PaxDb; Q924C9; -.
PRIDE; Q924C9; -.
Ensembl; ENSRNOT00000009473; ENSRNOP00000009473; ENSRNOG00000006878.
GeneID; 114629; -.
KEGG; rno:114629; -.
UCSC; RGD:620623; rat.
CTD; 1811; -.
RGD; 620623; Slc26a3.
eggNOG; KOG0236; Eukaryota.
eggNOG; COG0659; LUCA.
GeneTree; ENSGT00760000119026; -.
HOGENOM; HOG000006546; -.
HOVERGEN; HBG000639; -.
InParanoid; Q924C9; -.
KO; K14078; -.
OMA; FANINFF; -.
OrthoDB; EOG091G07RT; -.
PhylomeDB; Q924C9; -.
TreeFam; TF313784; -.
Reactome; R-RNO-427601; Multifunctional anion exchangers.
PRO; PR:Q924C9; -.
Proteomes; UP000002494; Chromosome 6.
Bgee; ENSRNOG00000006878; -.
Genevisible; Q924C9; RN.
GO; GO:0016324; C:apical plasma membrane; IDA:RGD.
GO; GO:0031526; C:brush border membrane; IDA:RGD.
GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
GO; GO:0016020; C:membrane; ISS:UniProtKB.
GO; GO:0097225; C:sperm midpiece; ISS:UniProtKB.
GO; GO:0015301; F:anion:anion antiporter activity; IBA:GO_Central.
GO; GO:0015106; F:bicarbonate transmembrane transporter activity; ISS:UniProtKB.
GO; GO:0005254; F:chloride channel activity; IBA:GO_Central.
GO; GO:0015108; F:chloride transmembrane transporter activity; ISS:UniProtKB.
GO; GO:0019531; F:oxalate transmembrane transporter activity; IBA:GO_Central.
GO; GO:0008271; F:secondary active sulfate transmembrane transporter activity; IEA:InterPro.
GO; GO:0015116; F:sulfate transmembrane transporter activity; IBA:GO_Central.
GO; GO:0015701; P:bicarbonate transport; IBA:GO_Central.
GO; GO:0071320; P:cellular response to cAMP; ISS:UniProtKB.
GO; GO:1902476; P:chloride transmembrane transport; IBA:GO_Central.
GO; GO:0051454; P:intracellular pH elevation; ISS:UniProtKB.
GO; GO:0060081; P:membrane hyperpolarization; ISS:UniProtKB.
GO; GO:0051453; P:regulation of intracellular pH; IBA:GO_Central.
GO; GO:0042391; P:regulation of membrane potential; IBA:GO_Central.
GO; GO:0048240; P:sperm capacitation; ISS:UniProtKB.
InterPro; IPR018045; S04_transporter_CS.
InterPro; IPR011547; SLC26A/SulP_dom.
InterPro; IPR001902; SLC26A/SulP_fam.
InterPro; IPR030321; SLC26A3.
InterPro; IPR002645; STAS_dom.
InterPro; IPR036513; STAS_dom_sf.
PANTHER; PTHR11814; PTHR11814; 1.
PANTHER; PTHR11814:SF19; PTHR11814:SF19; 1.
Pfam; PF01740; STAS; 1.
Pfam; PF00916; Sulfate_transp; 1.
SUPFAM; SSF52091; SSF52091; 2.
TIGRFAMs; TIGR00815; sulP; 1.
PROSITE; PS01130; SLC26A; 1.
PROSITE; PS50801; STAS; 1.
2: Evidence at transcript level;
Antiport; Cell membrane; Chloride; Complete proteome; Glycoprotein;
Membrane; Reference proteome; Transmembrane; Transmembrane helix;
Transport.
CHAIN 1 757 Chloride anion exchanger.
/FTId=PRO_0000080163.
TOPO_DOM 1 71 Cytoplasmic. {ECO:0000305}.
TRANSMEM 72 92 Helical. {ECO:0000255}.
TOPO_DOM 93 93 Extracellular. {ECO:0000305}.
TRANSMEM 94 114 Helical. {ECO:0000255}.
TOPO_DOM 115 124 Cytoplasmic. {ECO:0000305}.
TRANSMEM 125 145 Helical. {ECO:0000255}.
TOPO_DOM 146 176 Extracellular. {ECO:0000305}.
TRANSMEM 177 197 Helical. {ECO:0000255}.
TOPO_DOM 198 201 Cytoplasmic. {ECO:0000305}.
TRANSMEM 202 222 Helical. {ECO:0000255}.
TOPO_DOM 223 250 Extracellular. {ECO:0000305}.
TRANSMEM 251 271 Helical. {ECO:0000255}.
TOPO_DOM 272 278 Cytoplasmic. {ECO:0000305}.
TRANSMEM 279 299 Helical. {ECO:0000255}.
TOPO_DOM 300 335 Extracellular. {ECO:0000305}.
TRANSMEM 336 356 Helical. {ECO:0000255}.
TOPO_DOM 357 367 Cytoplasmic. {ECO:0000305}.
TRANSMEM 368 388 Helical. {ECO:0000255}.
TOPO_DOM 389 404 Extracellular. {ECO:0000305}.
TRANSMEM 405 425 Helical. {ECO:0000255}.
TOPO_DOM 426 462 Cytoplasmic. {ECO:0000305}.
TRANSMEM 463 483 Helical. {ECO:0000255}.
TOPO_DOM 484 757 Extracellular. {ECO:0000305}.
DOMAIN 518 713 STAS. {ECO:0000255|PROSITE-
ProRule:PRU00198}.
CARBOHYD 161 161 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
SEQUENCE 757 AA; 83369 MW; 195D867306ED8ECF CRC64;
MIEAIGNQYV VARPVYSTKA FGEEFKKTYG HHKTFLDHLK GCCSCSSQKA KKIALSLFPI
ASWLPAYKIK EWLLSDIVSG ISTGLVAVLQ GLAFALLVNI PPAYGLYAAF FPVITYFFLG
TSRHISVGPF PVLSMMVGVV VTRVASGSDT SPALSSSSAE NDSMIEEKVM VAASVTVLSG
IIQLLLGVLQ IGFVVIYLSE SLISGFTTAA AIHVLVSQLK FMLQLTVPAH SDPFSIFKVL
ESVFSQIQKT NIADLVTSVI ILVVVFVVKE INQRYRSKLP VPIPIELIMT VIATGISYGC
NFEQRFGVAV VGNMSLGFQP PITPSVEVFQ DTIGDCFGIA IVGFAVAFSV ASVYSLKYDY
PIDGNQELIA LGVSNIFTGA FKGFAGSTAL SRSGVQESTG GKTQVAGLLS AVIVLIVIVA
IGFLLQPLQK SVLAALALGN LKGMLMQFAE IGRLWKKDKY DCLIWIMTFI FAIVLGLGLG
LAASVAFQLL TIVFRTQFPK CSTLANVGRS NIYKNKKNYA DVYEPEGVKI FRCPSPIYFA
NIGFFKQKLI DAVGFNPLRI LRKRNKALKK IRKLQKQGLI QVTPKGFICT SDGFKDSDEE
LDNNQIEELD QPINTTDLPF EIDWNADLPL NITIPKISLH SLILDFSAVS FLDISSMRGL
RTILQEFIRI KVDVYIVGTD DDFIDKLARC EFFDDEVTDS IFFLTIHDAI LHIWMKKDYS
TSKFNSSQEK ERKFDFTINT NGGLRNRECQ VPVETKF


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