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Chloride channel protein CLC-a (AtCLC-a) (CBS domain-containing protein CBSCLC5)

 CLCA_ARATH              Reviewed;         775 AA.
P92941; O64990; Q93YS0;
02-FEB-2004, integrated into UniProtKB/Swiss-Prot.
02-FEB-2004, sequence version 2.
25-APR-2018, entry version 134.
RecName: Full=Chloride channel protein CLC-a;
Short=AtCLC-a;
AltName: Full=CBS domain-containing protein CBSCLC5;
Name=CLC-A; Synonyms=CBSCLC5; OrderedLocusNames=At5g40890;
ORFNames=MHK7.12;
Arabidopsis thaliana (Mouse-ear cress).
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
Spermatophyta; Magnoliophyta; eudicotyledons; Gunneridae;
Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae;
Arabidopsis.
NCBI_TaxID=3702;
[1]
NUCLEOTIDE SEQUENCE [MRNA], AND CHARACTERIZATION.
STRAIN=cv. Columbia;
PubMed=8969232; DOI=10.1074/jbc.271.52.33632;
Hechenberger M., Schwappach B., Fischer W.N., Frommer W.B.,
Jentsch T.J., Steinmeyer K.;
"A family of putative chloride channels from Arabidopsis and
functional complementation of a yeast strain with a CLC gene
disruption.";
J. Biol. Chem. 271:33632-33638(1996).
[2]
NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INDUCTION, AND DISRUPTION
PHENOTYPE.
STRAIN=cv. Wassilewskija;
PubMed=10758477; DOI=10.1046/j.1365-313x.2000.00680.x;
Geelen D., Lurin C., Bouchez D., Frachisse J.-M., Lelievre F.,
Courtial B., Barbier-Brygoo H., Maurel C.;
"Disruption of putative anion channel gene AtCLC-a in Arabidopsis
suggests a role in the regulation of nitrate content.";
Plant J. 21:259-267(2000).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=cv. Columbia;
PubMed=9679202; DOI=10.1093/dnares/5.2.131;
Kaneko T., Kotani H., Nakamura Y., Sato S., Asamizu E., Miyajima N.,
Tabata S.;
"Structural analysis of Arabidopsis thaliana chromosome 5. V. Sequence
features of the regions of 1,381,565 bp covered by twenty one
physically assigned P1 and TAC clones.";
DNA Res. 5:131-145(1998).
[4]
GENOME REANNOTATION.
STRAIN=cv. Columbia;
PubMed=27862469; DOI=10.1111/tpj.13415;
Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
Town C.D.;
"Araport11: a complete reannotation of the Arabidopsis thaliana
reference genome.";
Plant J. 89:789-804(2017).
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=cv. Columbia;
PubMed=14593172; DOI=10.1126/science.1088305;
Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J.,
Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F.,
Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.,
Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J.,
Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y.,
Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P.,
Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F.,
Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M.,
Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J.,
Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T.,
Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y.,
Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.;
"Empirical analysis of transcriptional activity in the Arabidopsis
genome.";
Science 302:842-846(2003).
[6]
GENE FAMILY, AND NOMENCLATURE.
PubMed=19400948; DOI=10.1186/1471-2164-10-200;
Kushwaha H.R., Singh A.K., Sopory S.K., Singla-Pareek S.L., Pareek A.;
"Genome wide expression analysis of CBS domain containing proteins in
Arabidopsis thaliana (L.) Heynh and Oryza sativa L. reveals their
developmental and stress regulation.";
BMC Genomics 10:200-200(2009).
[7]
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
PubMed=19376835; DOI=10.1104/pp.109.138677;
Reiland S., Messerli G., Baerenfaller K., Gerrits B., Endler A.,
Grossmann J., Gruissem W., Baginsky S.;
"Large-scale Arabidopsis phosphoproteome profiling reveals novel
chloroplast kinase substrates and phosphorylation networks.";
Plant Physiol. 150:889-903(2009).
[8]
INTERACTION WITH PP2A5.
PubMed=27676158; DOI=10.1111/pce.12837;
Hu R., Zhu Y., Wei J., Chen J., Shi H., Shen G., Zhang H.;
"Overexpression of PP2A-C5 that encodes the catalytic subunit 5 of
protein phosphatase 2A in Arabidopsis confers better root and shoot
development under salt conditions.";
Plant Cell Environ. 40:150-164(2017).
-!- FUNCTION: Voltage-gated chloride channel that could play a role in
the regulation of nitrate content. {ECO:0000269|PubMed:10758477}.
-!- SUBUNIT: Homodimer (By similarity). Interacts with PP2A5
(PubMed:27676158). {ECO:0000250, ECO:0000269|PubMed:27676158}.
-!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
-!- ALTERNATIVE PRODUCTS:
Event=Alternative splicing; Named isoforms=1;
Comment=A number of isoforms are produced. According to EST
sequences.;
Name=1;
IsoId=P92941-1; Sequence=Displayed;
-!- TISSUE SPECIFICITY: Broadly expressed in the plant.
-!- INDUCTION: In shoots and roots by nitrate treatment.
{ECO:0000269|PubMed:10758477}.
-!- DISRUPTION PHENOTYPE: Loss-of-function mutation clca-1 leads to an
altered nitrate content and hypersensitivity to chlorate.
{ECO:0000269|PubMed:10758477}.
-!- SIMILARITY: Belongs to the chloride channel (TC 2.A.49) family.
{ECO:0000305}.
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EMBL; Z71445; CAA96057.1; -; mRNA.
EMBL; AF044313; AAC05742.1; -; mRNA.
EMBL; AB011477; BAB11351.1; -; Genomic_DNA.
EMBL; CP002688; AED94612.1; -; Genomic_DNA.
EMBL; AY059791; AAL24139.1; -; mRNA.
EMBL; AY150506; AAN13022.1; -; mRNA.
PIR; T52107; T52107.
RefSeq; NP_198905.1; NM_123454.3. [P92941-1]
UniGene; At.25457; -.
ProteinModelPortal; P92941; -.
BioGrid; 19341; 5.
IntAct; P92941; 5.
STRING; 3702.AT5G40890.1; -.
iPTMnet; P92941; -.
PaxDb; P92941; -.
PRIDE; P92941; -.
EnsemblPlants; AT5G40890.1; AT5G40890.1; AT5G40890. [P92941-1]
GeneID; 834090; -.
Gramene; AT5G40890.1; AT5G40890.1; AT5G40890. [P92941-1]
KEGG; ath:AT5G40890; -.
Araport; AT5G40890; -.
TAIR; locus:2164466; AT5G40890.
eggNOG; KOG0474; Eukaryota.
eggNOG; COG0038; LUCA.
HOGENOM; HOG000231081; -.
InParanoid; P92941; -.
KO; K05016; -.
OMA; SEMQLYV; -.
OrthoDB; EOG093602TR; -.
PhylomeDB; P92941; -.
Reactome; R-ATH-2672351; Stimuli-sensing channels.
PRO; PR:P92941; -.
Proteomes; UP000006548; Chromosome 5.
ExpressionAtlas; P92941; baseline and differential.
Genevisible; P92941; AT.
GO; GO:0034707; C:chloride channel complex; IEA:UniProtKB-KW.
GO; GO:0005622; C:intracellular; TAS:TAIR.
GO; GO:0009705; C:plant-type vacuole membrane; IBA:GO_Central.
GO; GO:0015112; F:nitrate transmembrane transporter activity; IDA:TAIR.
GO; GO:0009671; F:nitrate:proton symporter activity; IBA:GO_Central.
GO; GO:0005247; F:voltage-gated chloride channel activity; IBA:GO_Central.
GO; GO:1902476; P:chloride transmembrane transport; IBA:GO_Central.
GO; GO:0006821; P:chloride transport; IDA:TAIR.
GO; GO:0015706; P:nitrate transport; IDA:TAIR.
GO; GO:0034765; P:regulation of ion transmembrane transport; IEA:UniProtKB-KW.
GO; GO:0010167; P:response to nitrate; IMP:TAIR.
InterPro; IPR000644; CBS_dom.
InterPro; IPR014743; Cl-channel_core.
InterPro; IPR001807; Cl-channel_volt-gated.
InterPro; IPR002251; Cl_channel_pln.
Pfam; PF00571; CBS; 2.
Pfam; PF00654; Voltage_CLC; 1.
PRINTS; PR00762; CLCHANNEL.
PRINTS; PR01120; CLCHANNELPLT.
SMART; SM00116; CBS; 2.
SUPFAM; SSF81340; SSF81340; 2.
PROSITE; PS51371; CBS; 2.
1: Evidence at protein level;
Alternative splicing; CBS domain; Chloride; Chloride channel;
Complete proteome; Ion channel; Ion transport; Membrane;
Reference proteome; Repeat; Transmembrane; Transmembrane helix;
Transport; Voltage-gated channel.
CHAIN 1 775 Chloride channel protein CLC-a.
/FTId=PRO_0000094465.
TRANSMEM 88 108 Helical; Name=1. {ECO:0000255}.
TRANSMEM 131 151 Helical; Name=2. {ECO:0000255}.
TRANSMEM 178 198 Helical; Name=3. {ECO:0000255}.
TRANSMEM 206 226 Helical; Name=4. {ECO:0000255}.
TRANSMEM 248 268 Helical; Name=5. {ECO:0000255}.
TRANSMEM 278 298 Helical; Name=6. {ECO:0000255}.
TRANSMEM 328 348 Helical; Name=7. {ECO:0000255}.
TRANSMEM 371 391 Helical; Name=8. {ECO:0000255}.
TRANSMEM 453 473 Helical; Name=9. {ECO:0000255}.
TRANSMEM 478 498 Helical; Name=10. {ECO:0000255}.
TRANSMEM 510 530 Helical; Name=11. {ECO:0000255}.
TRANSMEM 531 551 Helical; Name=12. {ECO:0000255}.
TRANSMEM 730 750 Helical; Name=13. {ECO:0000255}.
DOMAIN 595 658 CBS 1. {ECO:0000255|PROSITE-
ProRule:PRU00703}.
DOMAIN 703 768 CBS 2. {ECO:0000255|PROSITE-
ProRule:PRU00703}.
CONFLICT 330 330 D -> H (in Ref. 1; CAA96057).
{ECO:0000305}.
CONFLICT 506 506 Q -> L (in Ref. 5; AAL24139).
{ECO:0000305}.
SEQUENCE 775 AA; 85406 MW; A352FB24583E714E CRC64;
MDEDGNLQIS NSNYNGEEEG EDPENNTLNQ PLLKRHRTLS STPLALVGAK VSHIESLDYE
INENDLFKHD WRSRSKAQVF QYIFLKWTLA CLVGLFTGLI ATLINLAVEN IAGYKLLAVG
YYIAQDRFWT GLMVFTGANL GLTLVATVLV VYFAPTAAGP GIPEIKAYLN GIDTPNMFGF
TTMMVKIVGS IGAVAAGLDL GKEGPLVHIG SCIASLLGQG GPDNHRIKWR WLRYFNNDRD
RRDLITCGSA SGVCAAFRSP VGGVLFALEE VATWWRSALL WRTFFSTAVV VVVLRAFIEI
CNSGKCGLFG SGGLIMFDVS HVEVRYHAAD IIPVTLIGVF GGILGSLYNH LLHKVLRLYN
LINQKGKIHK VLLSLGVSLF TSVCLFGLPF LAECKPCDPS IDEICPTNGR SGNFKQFNCP
NGYYNDLSTL LLTTNDDAVR NIFSSNTPNE FGMVSLWIFF GLYCILGLIT FGIATPSGLF
LPIILMGSAY GRMLGTAMGS YTNIDQGLYA VLGAASLMAG SMRMTVSLCV IFLELTNNLL
LLPITMFVLL IAKTVGDSFN LSIYEIILHL KGLPFLEANP EPWMRNLTVG ELNDAKPPVV
TLNGVEKVAN IVDVLRNTTH NAFPVLDGAD QNTGTELHGL ILRAHLVKVL KKRWFLNEKR
RTEEWEVREK FTPVELAERE DNFDDVAITS SEMQLYVDLH PLTNTTPYTV VQSMSVAKAL
VLFRSVGLRH LLVVPKIQAS GMSPVIGILT RQDLRAYNIL QAFPHLDKHK SGKAR


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