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Chloride intracellular channel protein 4 (Intracellular chloride ion channel protein p64H1)

 CLIC4_HUMAN             Reviewed;         253 AA.
Q9Y696; Q9UFW9; Q9UQJ6;
30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
23-JAN-2007, sequence version 4.
27-SEP-2017, entry version 165.
RecName: Full=Chloride intracellular channel protein 4;
AltName: Full=Intracellular chloride ion channel protein p64H1;
Name=CLIC4;
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
NCBI_TaxID=9606;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
PubMed=10070163;
Edwards J.C.;
"A novel p64-related Cl- channel: subcellular distribution and nephron
segment-specific expression.";
Am. J. Physiol. 276:F398-F408(1999).
[2]
NUCLEOTIDE SEQUENCE [MRNA].
PubMed=10191309;
Chuang J.Z., Milner T.A., Zhu M., Sung C.H.;
"A 29 kDa intracellular chloride channel p64H1 is associated with
large dense-core vesicles in rat hippocampal neurons.";
J. Neurosci. 19:2919-2928(1999).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Kidney;
PubMed=11230166; DOI=10.1101/gr.GR1547R;
Wiemann S., Weil B., Wellenreuther R., Gassenhuber J., Glassl S.,
Ansorge W., Boecher M., Bloecker H., Bauersachs S., Blum H.,
Lauber J., Duesterhoeft A., Beyer A., Koehrer K., Strack N.,
Mewes H.-W., Ottenwaelder B., Obermaier B., Tampe J., Heubner D.,
Wambutt R., Korn B., Klein M., Poustka A.;
"Towards a catalog of human genes and proteins: sequencing and
analysis of 500 novel complete protein coding human cDNAs.";
Genome Res. 11:422-435(2001).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Ovary;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[5]
PROTEIN SEQUENCE OF 2-24; 41-60; 62-85 AND 125-130, CLEAVAGE OF
INITIATOR METHIONINE, ACETYLATION AT ALA-2, AND IDENTIFICATION BY MASS
SPECTROMETRY.
TISSUE=Platelet;
Bienvenut W.V., Claeys D.;
Submitted (FEB-2006) to UniProtKB.
[6]
SUBUNIT, AND TISSUE SPECIFICITY.
PubMed=10793131; DOI=10.1091/mbc.11.5.1509;
Berryman M., Bretscher A.;
"Identification of a novel member of the chloride intracellular
channel gene family (CLIC5) that associates with the actin
cytoskeleton of placental microvilli.";
Mol. Biol. Cell 11:1509-1521(2000).
[7]
INDUCTION, AND FUNCTION.
PubMed=12163372; DOI=10.1016/S0002-9440(10)64203-4;
Ronnov-Jessen L., Villadsen R., Edwards J.C., Petersen O.W.;
"Differential expression of a chloride intracellular channel gene,
CLIC4, in transforming growth factor-beta1-mediated conversion of
fibroblasts to myofibroblasts.";
Am. J. Pathol. 161:471-480(2002).
[8]
INTERACTION WITH AKAP9.
PubMed=12163479; DOI=10.1074/jbc.M112277200;
Shanks R.A., Larocca M.C., Berryman M., Edwards J.C., Urushidani T.,
Navarre J., Goldenring J.R.;
"AKAP350 at the Golgi apparatus. II. Association of AKAP350 with a
novel chloride intracellular channel (CLIC) family member.";
J. Biol. Chem. 277:40973-40980(2002).
[9]
FUNCTION, AND SUBCELLULAR LOCATION.
PubMed=14569596; DOI=10.1002/cm.10141;
Berryman M.A., Goldenring J.R.;
"CLIC4 is enriched at cell-cell junctions and colocalizes with AKAP350
at the centrosome and midbody of cultured mammalian cells.";
Cell Motil. Cytoskeleton 56:159-172(2003).
[10]
FUNCTION.
PubMed=16239224; DOI=10.1074/jbc.M506724200;
Bohman S., Matsumoto T., Suh K., Dimberg A., Jakobsson L., Yuspa S.,
Claesson-Welsh L.;
"Proteomic analysis of vascular endothelial growth factor-induced
endothelial cell differentiation reveals a role for chloride
intracellular channel 4 (CLIC4) in tubular morphogenesis.";
J. Biol. Chem. 280:42397-42404(2005).
[11]
SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
PubMed=17200346; DOI=10.1158/1078-0432.CCR-06-1562;
Suh K.S., Crutchley J.M., Koochek A., Ryscavage A., Bhat K.,
Tanaka T., Oshima A., Fitzgerald P., Yuspa S.H.;
"Reciprocal modifications of CLIC4 in tumor epithelium and stroma mark
malignant progression of multiple human cancers.";
Clin. Cancer Res. 13:121-131(2007).
[12]
TISSUE SPECIFICITY, INDUCTION, AND SUBCELLULAR LOCATION.
PubMed=17636002; DOI=10.1242/jcs.002741;
Suh K.S., Mutoh M., Mutoh T., Li L., Ryscavage A., Crutchley J.M.,
Dumont R.A., Cheng C., Yuspa S.H.;
"CLIC4 mediates and is required for Ca2+-induced keratinocyte
differentiation.";
J. Cell Sci. 120:2631-2640(2007).
[13]
INTERACTION WITH HRH3, FUNCTION, AND SUBCELLULAR LOCATION.
PubMed=18302930; DOI=10.1016/j.bbrc.2008.02.071;
Maeda K., Haraguchi M., Kuramasu A., Sato T., Ariake K., Sakagami H.,
Kondo H., Yanai K., Fukunaga K., Yanagisawa T., Sukegawa J.;
"CLIC4 interacts with histamine H3 receptor and enhances the receptor
cell surface expression.";
Biochem. Biophys. Res. Commun. 369:603-608(2008).
[14]
ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, CLEAVAGE OF INITIATOR
METHIONINE [LARGE SCALE ANALYSIS], AND IDENTIFICATION BY MASS
SPECTROMETRY [LARGE SCALE ANALYSIS].
PubMed=19413330; DOI=10.1021/ac9004309;
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,
Mohammed S.;
"Lys-N and trypsin cover complementary parts of the phosphoproteome in
a refined SCX-based approach.";
Anal. Chem. 81:4493-4501(2009).
[15]
FUNCTION.
PubMed=19247789; DOI=10.1007/s10456-009-9139-3;
Tung J.J., Hobert O., Berryman M., Kitajewski J.;
"Chloride intracellular channel 4 is involved in endothelial
proliferation and morphogenesis in vitro.";
Angiogenesis 12:209-220(2009).
[16]
ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-130, AND IDENTIFICATION BY
MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
PubMed=19608861; DOI=10.1126/science.1175371;
Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M.,
Walther T.C., Olsen J.V., Mann M.;
"Lysine acetylation targets protein complexes and co-regulates major
cellular functions.";
Science 325:834-840(2009).
[17]
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
PubMed=21269460; DOI=10.1186/1752-0509-5-17;
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.;
"Initial characterization of the human central proteome.";
BMC Syst. Biol. 5:17-17(2011).
[18]
ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, PHOSPHORYLATION [LARGE
SCALE ANALYSIS] AT SER-4, CLEAVAGE OF INITIATOR METHIONINE [LARGE
SCALE ANALYSIS], AND IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE
ANALYSIS].
PubMed=21406692; DOI=10.1126/scisignal.2001570;
Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J.,
Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V.,
Blagoev B.;
"System-wide temporal characterization of the proteome and
phosphoproteome of human embryonic stem cell differentiation.";
Sci. Signal. 4:RS3-RS3(2011).
[19]
ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, CLEAVAGE OF INITIATOR
METHIONINE [LARGE SCALE ANALYSIS], AND IDENTIFICATION BY MASS
SPECTROMETRY [LARGE SCALE ANALYSIS].
PubMed=22223895; DOI=10.1074/mcp.M111.015131;
Bienvenut W.V., Sumpton D., Martinez A., Lilla S., Espagne C.,
Meinnel T., Giglione C.;
"Comparative large-scale characterisation of plant vs. mammal proteins
reveals similar and idiosyncratic N-alpha acetylation features.";
Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012).
[20]
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Liver;
PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D.,
Wang L., Ye M., Zou H.;
"An enzyme assisted RP-RPLC approach for in-depth analysis of human
liver phosphoproteome.";
J. Proteomics 96:253-262(2014).
[21]
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
PubMed=25944712; DOI=10.1002/pmic.201400617;
Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M.,
Ayoub D., Lane L., Bairoch A., Van Dorsselaer A., Carapito C.;
"N-terminome analysis of the human mitochondrial proteome.";
Proteomics 15:2519-2524(2015).
[22]
X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS), SUBUNIT, FUNCTION, AND
SUBCELLULAR LOCATION.
PubMed=16176272; DOI=10.1111/j.1742-4658.2005.04909.x;
Littler D.R., Assaad N.N., Harrop S.J., Brown L.J., Pankhurst G.J.,
Luciani P., Aguilar M.-I., Mazzanti M., Berryman M.A., Breit S.N.,
Curmi P.M.G.;
"Crystal structure of the soluble form of the redox-regulated chloride
ion channel protein CLIC4.";
FEBS J. 272:4996-5007(2005).
[23]
X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS), AND DOMAIN.
PubMed=16581025; DOI=10.1016/j.bbrc.2006.03.099;
Li Y., Li D., Zeng Z., Wang D.;
"Trimeric structure of the wild soluble chloride intracellular ion
channel CLIC4 observed in crystals.";
Biochem. Biophys. Res. Commun. 343:1272-1278(2006).
-!- FUNCTION: Can insert into membranes and form poorly selective ion
channels that may also transport chloride ions. Channel activity
depends on the pH. Membrane insertion seems to be redox-regulated
and may occur only under oxydizing conditions. Promotes cell-
surface expression of HRH3. Has alternate cellular functions like
a potential role in angiogenesis or in maintaining apical-
basolateral membrane polarity during mitosis and cytokinesis.
Could also promote endothelial cell proliferation and regulate
endothelial morphogenesis (tubulogenesis).
{ECO:0000269|PubMed:12163372, ECO:0000269|PubMed:14569596,
ECO:0000269|PubMed:16176272, ECO:0000269|PubMed:16239224,
ECO:0000269|PubMed:18302930, ECO:0000269|PubMed:19247789}.
-!- SUBUNIT: Component of a multimeric complex consisting of several
cytoskeletal proteins, including actin, ezrin, alpha-actinin,
gelsolin, IQGAP1 and CLIC5A. Binds directly to brain dynamin I in
a complex containing actin, tubulin and 14-3-3 isoforms. Monomer.
Interacts with HRH3. Interacts with AKAP9.
{ECO:0000269|PubMed:10793131, ECO:0000269|PubMed:12163479,
ECO:0000269|PubMed:16176272, ECO:0000269|PubMed:18302930}.
-!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule
organizing center, centrosome. Cytoplasmic vesicle membrane
{ECO:0000305}; Single-pass membrane protein {ECO:0000305}. Nucleus
matrix. Cell membrane {ECO:0000305}; Single-pass membrane protein
{ECO:0000305}. Mitochondrion. Cell junction. Note=Colocalized with
AKAP9 at the centrosome and midbody. Exists both as soluble
cytoplasmic protein and as membrane protein with probably a single
transmembrane domain. Present in an intracellular vesicular
compartment that likely represent trans-Golgi network vesicles.
-!- TISSUE SPECIFICITY: Detected in epithelial cells from colon,
esophagus and kidney (at protein level). Expression is prominent
in heart, kidney, placenta and skeletal muscle.
{ECO:0000269|PubMed:10793131, ECO:0000269|PubMed:17200346,
ECO:0000269|PubMed:17636002}.
-!- INDUCTION: Up-regulated by calcium ions in differentiating
keratinocytes. Up-regulated in myofibroblasts.
{ECO:0000269|PubMed:12163372, ECO:0000269|PubMed:17636002}.
-!- DOMAIN: Members of this family may change from a globular, soluble
state to a state where the N-terminal domain is inserted into the
membrane and functions as chloride channel. A conformation change
of the N-terminal domain is thought to expose hydrophobic surfaces
that trigger membrane insertion. {ECO:0000269|PubMed:16581025}.
-!- SIMILARITY: Belongs to the chloride channel CLIC family.
{ECO:0000305}.
-!- WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology
and Haematology;
URL="http://atlasgeneticsoncology.org/Genes/CLIC4ID40102ch1p36.html";
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EMBL; AF097330; AAD38446.1; -; mRNA.
EMBL; AF109196; AAD26136.1; -; mRNA.
EMBL; AL117424; CAB55916.1; -; mRNA.
EMBL; BC012444; AAH12444.1; -; mRNA.
CCDS; CCDS256.1; -.
PIR; T17226; T17226.
RefSeq; NP_039234.1; NM_013943.2.
UniGene; Hs.440544; -.
PDB; 2AHE; X-ray; 1.80 A; A=1-251.
PDB; 2D2Z; X-ray; 2.20 A; A/B/C=1-253.
PDB; 3OQS; X-ray; 2.00 A; B=198-207.
PDBsum; 2AHE; -.
PDBsum; 2D2Z; -.
PDBsum; 3OQS; -.
ProteinModelPortal; Q9Y696; -.
SMR; Q9Y696; -.
BioGrid; 117431; 47.
IntAct; Q9Y696; 6.
MINT; MINT-3087884; -.
STRING; 9606.ENSP00000363500; -.
TCDB; 1.A.12.1.6; the intracellular chloride channel (clic) family.
iPTMnet; Q9Y696; -.
PhosphoSitePlus; Q9Y696; -.
SwissPalm; Q9Y696; -.
BioMuta; CLIC4; -.
DMDM; 20141285; -.
OGP; Q9Y696; -.
REPRODUCTION-2DPAGE; IPI00001960; -.
EPD; Q9Y696; -.
MaxQB; Q9Y696; -.
PaxDb; Q9Y696; -.
PeptideAtlas; Q9Y696; -.
PRIDE; Q9Y696; -.
TopDownProteomics; Q9Y696; -.
DNASU; 25932; -.
Ensembl; ENST00000374379; ENSP00000363500; ENSG00000169504.
Ensembl; ENST00000488683; ENSP00000436538; ENSG00000169504.
GeneID; 25932; -.
KEGG; hsa:25932; -.
UCSC; uc001bjo.3; human.
CTD; 25932; -.
DisGeNET; 25932; -.
EuPathDB; HostDB:ENSG00000169504.14; -.
GeneCards; CLIC4; -.
HGNC; HGNC:13518; CLIC4.
HPA; HPA008019; -.
HPA; HPA060804; -.
MIM; 606536; gene.
neXtProt; NX_Q9Y696; -.
OpenTargets; ENSG00000169504; -.
PharmGKB; PA26591; -.
eggNOG; KOG1422; Eukaryota.
eggNOG; ENOG410ZRK6; LUCA.
GeneTree; ENSGT00550000074477; -.
HOGENOM; HOG000231548; -.
HOVERGEN; HBG050994; -.
InParanoid; Q9Y696; -.
KO; K05024; -.
OMA; IDHNSIE; -.
OrthoDB; EOG091G0IHT; -.
PhylomeDB; Q9Y696; -.
TreeFam; TF315438; -.
ChiTaRS; CLIC4; human.
EvolutionaryTrace; Q9Y696; -.
GeneWiki; CLIC4; -.
GenomeRNAi; 25932; -.
PRO; PR:Q9Y696; -.
Proteomes; UP000005640; Chromosome 1.
Bgee; ENSG00000169504; -.
CleanEx; HS_CLIC4; -.
ExpressionAtlas; Q9Y696; baseline and differential.
Genevisible; Q9Y696; HS.
GO; GO:0015629; C:actin cytoskeleton; TAS:UniProtKB.
GO; GO:0045177; C:apical part of cell; IDA:UniProtKB.
GO; GO:0009986; C:cell surface; IDA:UniProtKB.
GO; GO:0005911; C:cell-cell junction; IDA:UniProtKB.
GO; GO:0005813; C:centrosome; IDA:UniProtKB.
GO; GO:0034707; C:chloride channel complex; IEA:UniProtKB-KW.
GO; GO:0005737; C:cytoplasm; IDA:UniProtKB.
GO; GO:0030659; C:cytoplasmic vesicle membrane; IEA:UniProtKB-SubCell.
GO; GO:0005829; C:cytosol; IDA:UniProtKB.
GO; GO:0070062; C:extracellular exosome; IDA:UniProtKB.
GO; GO:0005622; C:intracellular; IDA:LIFEdb.
GO; GO:0005902; C:microvillus; IDA:UniProtKB.
GO; GO:0030496; C:midbody; IDA:UniProtKB.
GO; GO:0005739; C:mitochondrion; IDA:UniProtKB.
GO; GO:0016363; C:nuclear matrix; IDA:UniProtKB.
GO; GO:0048471; C:perinuclear region of cytoplasm; IDA:UniProtKB.
GO; GO:0005886; C:plasma membrane; IDA:UniProtKB.
GO; GO:0005254; F:chloride channel activity; IBA:GO_Central.
GO; GO:0005244; F:voltage-gated ion channel activity; IEA:UniProtKB-KW.
GO; GO:0001525; P:angiogenesis; IBA:GO_Central.
GO; GO:0048754; P:branching morphogenesis of an epithelial tube; IEA:Ensembl.
GO; GO:0030154; P:cell differentiation; TAS:UniProtKB.
GO; GO:0071277; P:cellular response to calcium ion; IMP:UniProtKB.
GO; GO:1902476; P:chloride transmembrane transport; IBA:GO_Central.
GO; GO:0006821; P:chloride transport; NAS:UniProtKB.
GO; GO:0001886; P:endothelial cell morphogenesis; IEA:Ensembl.
GO; GO:0035088; P:establishment or maintenance of apical/basal cell polarity; NAS:UniProtKB.
GO; GO:0009566; P:fertilization; IEA:Ensembl.
GO; GO:0030216; P:keratinocyte differentiation; IMP:UniProtKB.
GO; GO:0035264; P:multicellular organism growth; IEA:Ensembl.
GO; GO:0030336; P:negative regulation of cell migration; IDA:UniProtKB.
GO; GO:0051493; P:regulation of cytoskeleton organization; NAS:UniProtKB.
GO; GO:0061299; P:retina vasculature morphogenesis in camera-type eye; IEA:Ensembl.
GO; GO:0007035; P:vacuolar acidification; IEA:Ensembl.
InterPro; IPR002946; CLIC.
InterPro; IPR010987; Glutathione-S-Trfase_C-like.
InterPro; IPR012336; Thioredoxin-like_fold.
PRINTS; PR01263; INTCLCHANNEL.
SFLD; SFLDG01175; Main.10_; 1.
SUPFAM; SSF47616; SSF47616; 1.
SUPFAM; SSF52833; SSF52833; 1.
TIGRFAMs; TIGR00862; O-ClC; 1.
PROSITE; PS50405; GST_CTER; 1.
1: Evidence at protein level;
3D-structure; Acetylation; Cell junction; Cell membrane; Chloride;
Chloride channel; Complete proteome; Cytoplasm; Cytoplasmic vesicle;
Cytoskeleton; Direct protein sequencing; Ion channel; Ion transport;
Membrane; Mitochondrion; Nucleus; Phosphoprotein; Reference proteome;
Transmembrane; Transmembrane helix; Transport; Voltage-gated channel.
INIT_MET 1 1 Removed. {ECO:0000244|PubMed:19413330,
ECO:0000244|PubMed:21406692,
ECO:0000244|PubMed:22223895,
ECO:0000269|Ref.5}.
CHAIN 2 253 Chloride intracellular channel protein 4.
/FTId=PRO_0000144210.
TRANSMEM 37 57 Helical; Note=After insertion into the
membrane. {ECO:0000255}.
DOMAIN 104 244 GST C-terminal.
REGION 2 101 Required for insertion into the membrane.
{ECO:0000305}.
MOD_RES 2 2 N-acetylalanine.
{ECO:0000244|PubMed:19413330,
ECO:0000244|PubMed:21406692,
ECO:0000244|PubMed:22223895,
ECO:0000269|Ref.5}.
MOD_RES 4 4 Phosphoserine.
{ECO:0000244|PubMed:21406692}.
MOD_RES 130 130 N6-acetyllysine.
{ECO:0000244|PubMed:19608861}.
MOD_RES 236 236 Phosphoserine.
{ECO:0000250|UniProtKB:Q9QYB1}.
CONFLICT 14 14 D -> Y (in Ref. 2; AAD26136).
{ECO:0000305}.
CONFLICT 133 134 RP -> SA (in Ref. 1; AAD38446 and 2;
AAD26136). {ECO:0000305}.
CONFLICT 225 225 Y -> S (in Ref. 2; AAD26136).
{ECO:0000305}.
CONFLICT 233 233 T -> A (in Ref. 2; AAD26136).
{ECO:0000305}.
STRAND 19 25 {ECO:0000244|PDB:2AHE}.
STRAND 29 32 {ECO:0000244|PDB:2AHE}.
HELIX 36 48 {ECO:0000244|PDB:2AHE}.
STRAND 53 57 {ECO:0000244|PDB:2AHE}.
HELIX 64 69 {ECO:0000244|PDB:2AHE}.
STRAND 77 80 {ECO:0000244|PDB:2AHE}.
STRAND 83 85 {ECO:0000244|PDB:2AHE}.
HELIX 88 98 {ECO:0000244|PDB:2AHE}.
TURN 101 103 {ECO:0000244|PDB:2AHE}.
HELIX 112 115 {ECO:0000244|PDB:2AHE}.
TURN 116 120 {ECO:0000244|PDB:2AHE}.
HELIX 121 130 {ECO:0000244|PDB:2AHE}.
HELIX 134 136 {ECO:0000244|PDB:2AHE}.
HELIX 137 156 {ECO:0000244|PDB:2AHE}.
STRAND 181 183 {ECO:0000244|PDB:2AHE}.
HELIX 186 206 {ECO:0000244|PDB:2AHE}.
HELIX 215 225 {ECO:0000244|PDB:2AHE}.
HELIX 228 231 {ECO:0000244|PDB:2AHE}.
HELIX 237 243 {ECO:0000244|PDB:2AHE}.
TURN 244 247 {ECO:0000244|PDB:2AHE}.
SEQUENCE 253 AA; 28772 MW; 3DD21A33C66626A5 CRC64;
MALSMPLNGL KEEDKEPLIE LFVKAGSDGE SIGNCPFSQR LFMILWLKGV VFSVTTVDLK
RKPADLQNLA PGTHPPFITF NSEVKTDVNK IEEFLEEVLC PPKYLKLSPK HPESNTAGMD
IFAKFSAYIK NSRPEANEAL ERGLLKTLQK LDEYLNSPLP DEIDENSMED IKFSTRKFLD
GNEMTLADCN LLPKLHIVKV VAKKYRNFDI PKEMTGIWRY LTNAYSRDEF TNTCPSDKEV
EIAYSDVAKR LTK


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C212 Chloride Intracellular Channel Protein 5 CLIC5 500
18-003-42637 Chloride intracellular channel protein 5 - N_A Polyclonal 0.1 mg Protein A
C266 Chloride Intracellular Channel Protein 2 CLIC2 500
CG13 Chloride Intracellular Channel Protein 1 CLIC1 500
CLIC5_RAT Rat ELISA Kit FOR Chloride intracellular channel protein 5 96T
CE14 Chloride Intracellular Channel Protein 4 CLIC4 500
15-288-22400 Chloride intracellular channel protein 3 - Polyclonal 0.1 mg


 

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