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Cholinesterase (EC 3.1.1.8) (Acylcholine acylhydrolase) (Butyrylcholine esterase) (Choline esterase II) (Pseudocholinesterase)

 CHLE_BOVIN              Reviewed;         602 AA.
P32749; Q08DR6;
01-OCT-1993, integrated into UniProtKB/Swiss-Prot.
03-APR-2007, sequence version 2.
05-DEC-2018, entry version 125.
RecName: Full=Cholinesterase;
EC=3.1.1.8;
AltName: Full=Acylcholine acylhydrolase;
AltName: Full=Butyrylcholine esterase;
AltName: Full=Choline esterase II;
AltName: Full=Pseudocholinesterase;
Flags: Precursor;
Name=BCHE;
Bos taurus (Bovine).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
Pecora; Bovidae; Bovinae; Bos.
NCBI_TaxID=9913;
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=Hereford; TISSUE=Fetal cerebellum;
NIH - Mammalian Gene Collection (MGC) project;
Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases.
[2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 96-236.
TISSUE=Lung;
PubMed=2016308;
Arpagaus M., Chatonnet A., Masson P., Newton M., Vaughan T.A.,
Bartels C.F., Nogueira C.P., la Du B.N., Lockridge O.;
"Use of the polymerase chain reaction for homology probing of
butyrylcholinesterase from several vertebrates.";
J. Biol. Chem. 266:6966-6974(1991).
-!- FUNCTION: Esterase with broad substrate specificity. Contributes
to the inactivation of the neurotransmitter acetylcholine. Can
degrade neurotoxic organophosphate esters (By similarity).
{ECO:0000250}.
-!- CATALYTIC ACTIVITY:
Reaction=an acylcholine + H2O = a carboxylate + choline + H(+);
Xref=Rhea:RHEA:21964, ChEBI:CHEBI:15354, ChEBI:CHEBI:15377,
ChEBI:CHEBI:15378, ChEBI:CHEBI:29067, ChEBI:CHEBI:35287;
EC=3.1.1.8;
-!- SUBUNIT: Homotetramer; disulfide-linked. Dimer of dimers (By
similarity). {ECO:0000250}.
-!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
-!- TISSUE SPECIFICITY: Present in most cells except erythrocytes.
-!- SIMILARITY: Belongs to the type-B carboxylesterase/lipase family.
{ECO:0000305}.
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EMBL; BC123600; AAI23601.1; -; mRNA.
EMBL; M62410; AAA51412.1; -; Genomic_DNA.
PIR; F39768; F39768.
RefSeq; NP_001070374.1; NM_001076906.1.
UniGene; Bt.42172; -.
ProteinModelPortal; P32749; -.
SMR; P32749; -.
STRING; 9913.ENSBTAP00000014794; -.
ESTHER; bovin-BCHE; BCHE.
MEROPS; S09.980; -.
PaxDb; P32749; -.
PRIDE; P32749; -.
Ensembl; ENSBTAT00000014794; ENSBTAP00000014794; ENSBTAG00000011139.
GeneID; 534616; -.
KEGG; bta:534616; -.
CTD; 590; -.
VGNC; VGNC:26443; BCHE.
eggNOG; KOG4389; Eukaryota.
eggNOG; COG2272; LUCA.
GeneTree; ENSGT00940000157023; -.
HOGENOM; HOG000091866; -.
HOVERGEN; HBG008839; -.
InParanoid; P32749; -.
KO; K01050; -.
OMA; FPGSEMW; -.
OrthoDB; EOG091G0I4G; -.
TreeFam; TF315470; -.
Reactome; R-BTA-112311; Neurotransmitter clearance.
Reactome; R-BTA-1483191; Synthesis of PC.
Reactome; R-BTA-422085; Synthesis, secretion, and deacylation of Ghrelin.
Proteomes; UP000009136; Chromosome 1.
Bgee; ENSBTAG00000011139; Expressed in 10 organ(s), highest expression level in colon.
GO; GO:0005783; C:endoplasmic reticulum; IEA:Ensembl.
GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
GO; GO:0005641; C:nuclear envelope lumen; IEA:Ensembl.
GO; GO:0003990; F:acetylcholinesterase activity; ISS:UniProtKB.
GO; GO:0004104; F:cholinesterase activity; ISS:UniProtKB.
GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
Gene3D; 3.40.50.1820; -; 1.
InterPro; IPR029058; AB_hydrolase.
InterPro; IPR014788; AChE_tetra.
InterPro; IPR002018; CarbesteraseB.
InterPro; IPR019826; Carboxylesterase_B_AS.
InterPro; IPR019819; Carboxylesterase_B_CS.
InterPro; IPR000997; Cholinesterase.
Pfam; PF08674; AChE_tetra; 1.
Pfam; PF00135; COesterase; 1.
PRINTS; PR00878; CHOLNESTRASE.
ProDom; PD415333; AChE_tetra; 1.
SUPFAM; SSF53474; SSF53474; 1.
PROSITE; PS00122; CARBOXYLESTERASE_B_1; 1.
PROSITE; PS00941; CARBOXYLESTERASE_B_2; 1.
2: Evidence at transcript level;
Complete proteome; Disulfide bond; Glycoprotein; Hydrolase;
Phosphoprotein; Reference proteome; Secreted; Serine esterase; Signal.
SIGNAL 1 28 {ECO:0000255}.
CHAIN 29 602 Cholinesterase.
/FTId=PRO_0000070283.
REGION 144 145 Substrate binding. {ECO:0000250}.
ACT_SITE 226 226 Acyl-ester intermediate.
{ECO:0000255|PROSITE-ProRule:PRU10039}.
ACT_SITE 353 353 Charge relay system. {ECO:0000250}.
ACT_SITE 466 466 Charge relay system. {ECO:0000250}.
MOD_RES 226 226 Phosphoserine.
{ECO:0000250|UniProtKB:P06276}.
CARBOHYD 85 85 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 134 134 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 269 269 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 284 284 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 369 369 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 483 483 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 509 509 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 513 513 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 514 514 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
SEQUENCE 602 AA; 68867 MW; CDFB404E64C46935 CRC64;
MQSRSTVIYI RFVLWFLLLW VLFEKSHTEE DIIITTKNGK VRGMHLPVLG GTVTAFLGIP
YAQPPLGRLR FKKPQSLTKW PDIWNATKYA NSCYQNTDQS FPGFLGSEMW NPNTDLSEDC
LYLNVWIPTP KPKNATVMIW IYGGSFQTGT SSLHVYDGKF LARVERVIVV SMNYRVGALG
FLALPGNPEA PGNVGLFDQQ LALQWVQKNI AAFGGNPKSV TLFGESAGAA SVSLHLLSPE
SHPLFTRAIL QSGSSNAPWA VTSRYEARNR TLTLAKFIGC SRENDTEIIK CLRNKDPQEI
LRHEVFVVPY GTLLSVNFGP TVDGDFLTDM PDTLLQLGQF KKTQILVGVN KDEGTAFLVY
GAPGFSKDNN SIITRKEFQE GLKIFFPGVS EFGKESILFH YMDWLDDQRA EKYREALDDV
VGDYNIICPA LEFTKKFSDM GNNAFFYYFE HRSSKLPWPE WMGVMHGYEI EFVFGLPLER
RVNYTKAEEI FSRSIMKRWA NFAKYGNPNG TQNNSTRWPV FKSNEQKYFT LNTESPKVNT
KLRAQQCRFW TLFFPKVLEI TGNIDEVERE WKAGFHRWNN YMMDWKNQFN DYTSKKESCA
GL


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