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Chymotrypsin-like elastase family member 1 (EC 3.4.21.36) (Elastase I) (Elastase-1)

 CELA1_BOVIN             Reviewed;         266 AA.
Q28153; A6QPW5;
01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
01-NOV-1997, sequence version 1.
05-DEC-2018, entry version 132.
RecName: Full=Chymotrypsin-like elastase family member 1;
EC=3.4.21.36;
AltName: Full=Elastase I;
AltName: Full=Elastase-1;
Flags: Precursor;
Name=CELA1; Synonyms=ELA1;
Bos taurus (Bovine).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
Pecora; Bovidae; Bovinae; Bos.
NCBI_TaxID=9913;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=Holstein-Friesian; TISSUE=Pancreas;
PubMed=9418008; DOI=10.1016/S0305-0491(97)00031-X;
Gestin M., le Huerou-Luron I., Wicker-Planquart C., le Drean G.,
Chaix J.-C., Puigserver A., Guilloteau P.;
"Bovine pancreatic preproelastases I and II: comparison of nucleotide
and amino acid sequences and tissue specific expression.";
Comp. Biochem. Physiol. 118B:181-187(1997).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=Hereford; TISSUE=Fetal pancreas;
NIH - Mammalian Gene Collection (MGC) project;
Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases.
-!- FUNCTION: Acts upon elastin.
-!- CATALYTIC ACTIVITY:
Reaction=Hydrolysis of proteins, including elastin. Preferential
cleavage: Ala-|-Xaa.; EC=3.4.21.36;
-!- COFACTOR:
Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence={ECO:0000250};
Note=Binds 1 Ca(2+) ion per subunit. {ECO:0000250};
-!- SUBCELLULAR LOCATION: Secreted.
-!- TISSUE SPECIFICITY: Pancreas.
-!- SIMILARITY: Belongs to the peptidase S1 family. Elastase
subfamily. {ECO:0000255|PROSITE-ProRule:PRU00274}.
-----------------------------------------------------------------------
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EMBL; M80838; AAA98525.1; -; mRNA.
EMBL; BC149525; AAI49526.1; -; mRNA.
RefSeq; NP_776473.1; NM_174048.2.
RefSeq; XP_005206313.1; XM_005206256.3.
UniGene; Bt.4522; -.
ProteinModelPortal; Q28153; -.
SMR; Q28153; -.
BioGrid; 158500; 1.
STRING; 9913.ENSBTAP00000011718; -.
BindingDB; Q28153; -.
MEROPS; S01.153; -.
PaxDb; Q28153; -.
PRIDE; Q28153; -.
Ensembl; ENSBTAT00000011718; ENSBTAP00000011718; ENSBTAG00000008900.
GeneID; 281139; -.
KEGG; bta:281139; -.
CTD; 1990; -.
VGNC; VGNC:27166; CELA1.
eggNOG; KOG3627; Eukaryota.
eggNOG; COG5640; LUCA.
GeneTree; ENSGT00940000155254; -.
HOGENOM; HOG000251820; -.
InParanoid; Q28153; -.
KO; K01326; -.
OMA; LYGHSTQ; -.
OrthoDB; EOG091G0DF7; -.
TreeFam; TF330455; -.
Proteomes; UP000009136; Chromosome 5.
Bgee; ENSBTAG00000008900; Expressed in 9 organ(s), highest expression level in spleen.
GO; GO:0005615; C:extracellular space; IBA:GO_Central.
GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO; GO:0004252; F:serine-type endopeptidase activity; IBA:GO_Central.
GO; GO:0060309; P:elastin catabolic process; IEA:Ensembl.
GO; GO:0031017; P:exocrine pancreas development; IEA:Ensembl.
GO; GO:0006954; P:inflammatory response; IEA:Ensembl.
GO; GO:0035264; P:multicellular organism growth; IEA:Ensembl.
GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IEA:Ensembl.
GO; GO:0061113; P:pancreas morphogenesis; IEA:Ensembl.
GO; GO:0045766; P:positive regulation of angiogenesis; IEA:Ensembl.
GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:Ensembl.
GO; GO:0009791; P:post-embryonic development; IEA:Ensembl.
GO; GO:0006508; P:proteolysis; IBA:GO_Central.
GO; GO:0045595; P:regulation of cell differentiation; IEA:Ensembl.
GO; GO:0042127; P:regulation of cell proliferation; IEA:Ensembl.
GO; GO:0048771; P:tissue remodeling; IEA:Ensembl.
GO; GO:0016055; P:Wnt signaling pathway; IEA:Ensembl.
CDD; cd00190; Tryp_SPc; 1.
InterPro; IPR009003; Peptidase_S1_PA.
InterPro; IPR001314; Peptidase_S1A.
InterPro; IPR001254; Trypsin_dom.
InterPro; IPR018114; TRYPSIN_HIS.
InterPro; IPR033116; TRYPSIN_SER.
Pfam; PF00089; Trypsin; 1.
PRINTS; PR00722; CHYMOTRYPSIN.
SMART; SM00020; Tryp_SPc; 1.
SUPFAM; SSF50494; SSF50494; 1.
PROSITE; PS50240; TRYPSIN_DOM; 1.
PROSITE; PS00134; TRYPSIN_HIS; 1.
PROSITE; PS00135; TRYPSIN_SER; 1.
2: Evidence at transcript level;
Calcium; Complete proteome; Disulfide bond; Glycoprotein; Hydrolase;
Metal-binding; Protease; Reference proteome; Secreted;
Serine protease; Signal; Zymogen.
SIGNAL 1 16 {ECO:0000250}.
PROPEP 17 26 Activation peptide. {ECO:0000250}.
/FTId=PRO_0000027671.
CHAIN 27 266 Chymotrypsin-like elastase family member
1.
/FTId=PRO_0000027672.
DOMAIN 27 264 Peptidase S1. {ECO:0000255|PROSITE-
ProRule:PRU00274}.
ACT_SITE 71 71 Charge relay system. {ECO:0000250}.
ACT_SITE 119 119 Charge relay system. {ECO:0000250}.
ACT_SITE 214 214 Charge relay system. {ECO:0000250}.
METAL 85 85 Calcium. {ECO:0000250}.
METAL 90 90 Calcium; via carbonyl oxygen.
{ECO:0000250}.
METAL 95 95 Calcium. {ECO:0000250}.
CARBOHYD 87 87 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 241 241 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
DISULFID 56 72 {ECO:0000255|PROSITE-ProRule:PRU00274}.
DISULFID 153 220 {ECO:0000255|PROSITE-ProRule:PRU00274}.
DISULFID 184 200 {ECO:0000255|PROSITE-ProRule:PRU00274}.
DISULFID 210 240 {ECO:0000255|PROSITE-ProRule:PRU00274}.
SEQUENCE 266 AA; 28518 MW; 927E29C69BAF67E7 CRC64;
MLRLLVFTSL VLYGHSTQDF PETNARVVGG TAVSKNSWPS QISLQYKSGS SWYHTCGGTL
IKQKWVMTAA HCVDSQMTFR VVLGDHNLSQ NDGTEQYISV QKIVVHPSWN SNNVAAGYDI
AVLRLAQSAT LNSYVQLGVL PQSGTILANN TPCYITGWGR TKTNGQLAQT LQQAYLPSVD
YATCSSSSYW GSTVKTTMVC AGGDGVRAGC QGDSGGPLHC LVNGQYAVHG VTSFVSSLGC
NVSKKPTVFT RVSAYISWIN NAIASN


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