Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

Chymotrypsin-like elastase family member 2A (EC 3.4.21.71) (Elastase-2) (Elastase-2A)

 CEL2A_RAT               Reviewed;         271 AA.
P00774;
21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
21-JUL-1986, sequence version 1.
05-DEC-2018, entry version 140.
RecName: Full=Chymotrypsin-like elastase family member 2A;
EC=3.4.21.71;
AltName: Full=Elastase-2;
AltName: Full=Elastase-2A;
Flags: Precursor;
Name=Cela2a; Synonyms=Ela2, Ela2a;
Rattus norvegicus (Rat).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Rattus.
NCBI_TaxID=10116;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
PubMed=6918221; DOI=10.1021/bi00535a053;
MacDonald R.J., Swift G.H., Quinto C., Swain W., Pictet R.L.,
Nikovits W., Rutter W.J.;
"Primary structure of two distinct rat pancreatic preproelastases
determined by sequence analysis of the complete cloned messenger
ribonucleic acid sequences.";
Biochemistry 21:1453-1463(1982).
[2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
PubMed=6094548;
Swift G.H., Craik C.S., Stary S.J., Quinto C., Lahaie R.G.,
Rutter W.J., MacDonald R.J.;
"Structure of the two related elastase genes expressed in the rat
pancreas.";
J. Biol. Chem. 259:14271-14278(1984).
-!- FUNCTION: Acts upon elastin.
-!- CATALYTIC ACTIVITY:
Reaction=Preferential cleavage: Leu-|-Xaa, Met-|-Xaa and Phe-|-
Xaa. Hydrolyzes elastin.; EC=3.4.21.71;
-!- SUBCELLULAR LOCATION: Secreted.
-!- TISSUE SPECIFICITY: Pancreas.
-!- SIMILARITY: Belongs to the peptidase S1 family. Elastase
subfamily. {ECO:0000255|PROSITE-ProRule:PRU00274}.
-----------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
Distributed under the Creative Commons Attribution (CC BY 4.0) License
-----------------------------------------------------------------------
EMBL; V01233; CAA24543.1; -; mRNA.
EMBL; L00124; AAA98780.1; -; Genomic_DNA.
EMBL; L00118; AAA98780.1; JOINED; Genomic_DNA.
EMBL; L00119; AAA98780.1; JOINED; Genomic_DNA.
EMBL; L00120; AAA98780.1; JOINED; Genomic_DNA.
EMBL; L00121; AAA98780.1; JOINED; Genomic_DNA.
EMBL; L00122; AAA98780.1; JOINED; Genomic_DNA.
EMBL; L00123; AAA98780.1; JOINED; Genomic_DNA.
PIR; A00961; ELRT2.
RefSeq; NP_036685.1; NM_012553.2.
UniGene; Rn.10272; -.
ProteinModelPortal; P00774; -.
SMR; P00774; -.
STRING; 10116.ENSRNOP00000018349; -.
BindingDB; P00774; -.
ChEMBL; CHEMBL3888; -.
MEROPS; S01.155; -.
PhosphoSitePlus; P00774; -.
PaxDb; P00774; -.
PRIDE; P00774; -.
Ensembl; ENSRNOT00000018349; ENSRNOP00000018349; ENSRNOG00000013628.
GeneID; 24332; -.
KEGG; rno:24332; -.
UCSC; RGD:2548; rat.
CTD; 63036; -.
RGD; 2548; Cela2a.
eggNOG; KOG3627; Eukaryota.
eggNOG; COG5640; LUCA.
GeneTree; ENSGT00940000154643; -.
HOGENOM; HOG000251820; -.
InParanoid; P00774; -.
KO; K01346; -.
OMA; DKIQLGC; -.
OrthoDB; EOG091G0DF7; -.
PhylomeDB; P00774; -.
TreeFam; TF330455; -.
Reactome; R-RNO-6809371; Formation of the cornified envelope.
PRO; PR:P00774; -.
Proteomes; UP000002494; Chromosome 5.
Bgee; ENSRNOG00000013628; Expressed in 9 organ(s), highest expression level in brain.
Genevisible; P00774; RN.
GO; GO:0005615; C:extracellular space; IBA:GO_Central.
GO; GO:0004252; F:serine-type endopeptidase activity; IBA:GO_Central.
GO; GO:0006508; P:proteolysis; IBA:GO_Central.
CDD; cd00190; Tryp_SPc; 1.
InterPro; IPR009003; Peptidase_S1_PA.
InterPro; IPR001314; Peptidase_S1A.
InterPro; IPR001254; Trypsin_dom.
InterPro; IPR018114; TRYPSIN_HIS.
InterPro; IPR033116; TRYPSIN_SER.
Pfam; PF00089; Trypsin; 1.
PRINTS; PR00722; CHYMOTRYPSIN.
SMART; SM00020; Tryp_SPc; 1.
SUPFAM; SSF50494; SSF50494; 1.
PROSITE; PS50240; TRYPSIN_DOM; 1.
PROSITE; PS00134; TRYPSIN_HIS; 1.
PROSITE; PS00135; TRYPSIN_SER; 1.
2: Evidence at transcript level;
Complete proteome; Disulfide bond; Hydrolase; Protease;
Reference proteome; Secreted; Serine protease; Signal; Zymogen.
SIGNAL 1 16
PROPEP 17 30 Activation peptide.
/FTId=PRO_0000027691.
CHAIN 31 271 Chymotrypsin-like elastase family member
2A.
/FTId=PRO_0000027692.
DOMAIN 31 269 Peptidase S1. {ECO:0000255|PROSITE-
ProRule:PRU00274}.
ACT_SITE 75 75 Charge relay system. {ECO:0000250}.
ACT_SITE 123 123 Charge relay system. {ECO:0000250}.
ACT_SITE 218 218 Charge relay system. {ECO:0000250}.
DISULFID 60 76 {ECO:0000255|PROSITE-ProRule:PRU00274}.
DISULFID 157 224 {ECO:0000255|PROSITE-ProRule:PRU00274}.
DISULFID 188 204 {ECO:0000255|PROSITE-ProRule:PRU00274}.
DISULFID 214 245 {ECO:0000255|PROSITE-ProRule:PRU00274}.
SEQUENCE 271 AA; 28885 MW; 125C783B857B71E3 CRC64;
MIRTLLLSAL VAGALSCGYP TYEVQHDVSR VVGGQEASPN SWPWQVSLQY LSSGKWHHTC
GGSLVANNWV LTAAHCISNS RTYRVLLGRH SLSTSESGSL AVQVSKLVVH EKWNAQKLSN
GNDIALVKLA SPVALTSKIQ TACLPPAGTI LPNNYPCYVT GWGRLQTNGA TPDVLQQGRL
LVVDYATCSS ASWWGSSVKT NMVCAGGDGV TSSCNGDSGG PLNCQASNGQ WQVHGIVSFG
STLGCNYPRK PSVFTRVSNY IDWINSVIAK N


Related products :

Catalog number Product name Quantity
EIAAB06723 Bos taurus,Bovine,CELA2A,Chymotrypsin-like elastase family member 2A,ELA2,ELA2A,Elastase II,Elastase-2,Elastase-2A
EIAAB06726 Cela2a,Chymotrypsin-like elastase family member 2A,Ela2,Ela2a,Elastase-2,Elastase-2A,Rat,Rattus norvegicus
EIAAB06724 Cela2a,Chymotrypsin-like elastase family member 2A,Ela2,Ela-2,Ela2a,Elastase-2,Elastase-2A,Mouse,Mus musculus
U1483b CLIA Bos taurus,Bovine,CELA1,Chymotrypsin-like elastase family member 1,ELA1,Elastase I,Elastase-1 96T
E1483b ELISA Bos taurus,Bovine,CELA1,Chymotrypsin-like elastase family member 1,ELA1,Elastase I,Elastase-1 96T
E1483b ELISA kit Bos taurus,Bovine,CELA1,Chymotrypsin-like elastase family member 1,ELA1,Elastase I,Elastase-1 96T
EIAAB06722 CELA2A,Chymotrypsin-like elastase family member 2A,ELA2,ELA2A,Elastase-2,Elastase-2A,Pig,Sus scrofa
EIAAB06729 CELA3B,Chymotrypsin-like elastase family member 3B,ELA3B,Elastase IIIB,Elastase-3B,Homo sapiens,Human,Protease E
EIAAB06728 CELA3A,Chymotrypsin-like elastase family member 3A,ELA3,ELA3A,Elastase IIIA,Elastase-3A,Homo sapiens,Human,Protease E
U1483p CLIA CELA1,Chymotrypsin-like elastase family member 1,ELA1,Elastase-1,Pig,Sus scrofa 96T
E1483p ELISA CELA1,Chymotrypsin-like elastase family member 1,ELA1,Elastase-1,Pig,Sus scrofa 96T
E1483p ELISA kit CELA1,Chymotrypsin-like elastase family member 1,ELA1,Elastase-1,Pig,Sus scrofa 96T
EIAAB06727 CELA2B,Chymotrypsin-like elastase family member 2B,ELA2B,Elastase-2B,Homo sapiens,Human
EIAAB06725 CELA2A,Chymotrypsin-like elastase family member 2A,ELA2A,Elastase-2A,Homo sapiens,Human
E1483r ELISA Cela1,Chymotrypsin-like elastase family member 1,Ela1,Elastase-1,Rat,Rattus norvegicus 96T
E1483r ELISA kit Cela1,Chymotrypsin-like elastase family member 1,Ela1,Elastase-1,Rat,Rattus norvegicus 96T
U1483r CLIA Cela1,Chymotrypsin-like elastase family member 1,Ela1,Elastase-1,Rat,Rattus norvegicus 96T
E1483h ELISA kit CELA1,Chymotrypsin-like elastase family member 1,ELA1,Elastase-1,Homo sapiens,Human 96T
E1483h ELISA CELA1,Chymotrypsin-like elastase family member 1,ELA1,Elastase-1,Homo sapiens,Human 96T
U1483h CLIA CELA1,Chymotrypsin-like elastase family member 1,ELA1,Elastase-1,Homo sapiens,Human 96T
20-272-191518 Elastase 2. prediluted - Mouse monoclonal [SPM205] to Elastase 2. prediluted; EC 3.4.21.37; Elastase-2; Neutrophil elastase; PMN elastase; Bone marrow serine protease; Medullasin; Human leukocyte elas 7 ml
E1483c ELISA kit Canis familiaris,Canis lupus familiaris,CELA1,Chymotrypsin-like elastase family member 1,Dog,ELA1,Elastase-1,ELS1 96T
U1483c CLIA Canis familiaris,Canis lupus familiaris,CELA1,Chymotrypsin-like elastase family member 1,Dog,ELA1,Elastase-1,ELS1 96T
E1483c ELISA Canis familiaris,Canis lupus familiaris,CELA1,Chymotrypsin-like elastase family member 1,Dog,ELA1,Elastase-1,ELS1 96T
E0181h ELISA kit Bone marrow serine protease,ELA2,ELANE,Elastase-2,HLE,Homo sapiens,Human,Human leukocyte elastase,Medullasin,Neutrophil elastase,PMN elastase 96T


 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur | Gentaur





GENTAUR Ltd.
Unicorn House, Station Cl
Hertfordshire, Potters Bar EN6 1TL
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017
RIB 30004 00187 00010092253 10
BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG
IBAN FR76 3000 4001 8700 0100 9225 310
france@gentaur.com | Gentaur | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: 0035929830070
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.


ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur | Gentaur