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Chymotrypsin-like elastase family member 2A (EC 3.4.21.71) (Elastase-2) (Elastase-2A)

 CEL2A_MOUSE             Reviewed;         271 AA.
P05208;
13-AUG-1987, integrated into UniProtKB/Swiss-Prot.
13-AUG-1987, sequence version 1.
25-OCT-2017, entry version 146.
RecName: Full=Chymotrypsin-like elastase family member 2A;
EC=3.4.21.71;
AltName: Full=Elastase-2;
AltName: Full=Elastase-2A;
Flags: Precursor;
Name=Cela2a; Synonyms=Ela-2, Ela2, Ela2a;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
PubMed=3641189; DOI=10.1093/nar/14.21.8307;
Stevenson B.J., Hagenbuechle O., Wellauer P.K.;
"Sequence organisation and transcriptional regulation of the mouse
elastase II and trypsin genes.";
Nucleic Acids Res. 14:8307-8330(1986).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=FVB/N; TISSUE=Colon;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[3]
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Liver, Lung, Pancreas, and Spleen;
PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
"A tissue-specific atlas of mouse protein phosphorylation and
expression.";
Cell 143:1174-1189(2010).
-!- FUNCTION: Acts upon elastin.
-!- CATALYTIC ACTIVITY: Preferential cleavage: Leu-|-Xaa, Met-|-Xaa
and Phe-|-Xaa. Hydrolyzes elastin.
-!- SUBCELLULAR LOCATION: Secreted.
-!- TISSUE SPECIFICITY: Pancreas.
-!- SIMILARITY: Belongs to the peptidase S1 family. Elastase
subfamily. {ECO:0000255|PROSITE-ProRule:PRU00274}.
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EMBL; X04573; CAA28242.1; -; mRNA.
EMBL; X04576; CAA28244.1; -; Genomic_DNA.
EMBL; BC026552; AAH26552.1; -; mRNA.
CCDS; CCDS18884.1; -.
PIR; A25528; A25528.
RefSeq; NP_031945.1; NM_007919.3.
UniGene; Mm.45316; -.
ProteinModelPortal; P05208; -.
SMR; P05208; -.
STRING; 10090.ENSMUSP00000099539; -.
MEROPS; S01.155; -.
PhosphoSitePlus; P05208; -.
MaxQB; P05208; -.
PaxDb; P05208; -.
PeptideAtlas; P05208; -.
PRIDE; P05208; -.
Ensembl; ENSMUST00000102481; ENSMUSP00000099539; ENSMUSG00000058579.
GeneID; 13706; -.
KEGG; mmu:13706; -.
UCSC; uc008vpj.1; mouse.
CTD; 63036; -.
MGI; MGI:95316; Cela2a.
eggNOG; KOG3627; Eukaryota.
eggNOG; COG5640; LUCA.
GeneTree; ENSGT00760000119027; -.
HOGENOM; HOG000251820; -.
InParanoid; P05208; -.
KO; K01346; -.
OMA; KIQLGCL; -.
OrthoDB; EOG091G0DF7; -.
PhylomeDB; P05208; -.
TreeFam; TF330455; -.
Reactome; R-MMU-6809371; Formation of the cornified envelope.
ChiTaRS; Cela2a; mouse.
PRO; PR:P05208; -.
Proteomes; UP000000589; Chromosome 4.
Bgee; ENSMUSG00000058579; -.
CleanEx; MM_ELA2; -.
Genevisible; P05208; MM.
GO; GO:0005615; C:extracellular space; IBA:GO_Central.
GO; GO:0036457; C:keratohyalin granule; ISO:MGI.
GO; GO:0017171; F:serine hydrolase activity; IDA:MGI.
GO; GO:0004252; F:serine-type endopeptidase activity; IBA:GO_Central.
GO; GO:0061436; P:establishment of skin barrier; IMP:MGI.
GO; GO:0006508; P:proteolysis; IMP:MGI.
CDD; cd00190; Tryp_SPc; 1.
InterPro; IPR009003; Peptidase_S1_PA.
InterPro; IPR001314; Peptidase_S1A.
InterPro; IPR001254; Trypsin_dom.
InterPro; IPR018114; TRYPSIN_HIS.
InterPro; IPR033116; TRYPSIN_SER.
Pfam; PF00089; Trypsin; 1.
PRINTS; PR00722; CHYMOTRYPSIN.
SMART; SM00020; Tryp_SPc; 1.
SUPFAM; SSF50494; SSF50494; 1.
PROSITE; PS50240; TRYPSIN_DOM; 1.
PROSITE; PS00134; TRYPSIN_HIS; 1.
PROSITE; PS00135; TRYPSIN_SER; 1.
1: Evidence at protein level;
Complete proteome; Disulfide bond; Hydrolase; Protease;
Reference proteome; Secreted; Serine protease; Signal; Zymogen.
SIGNAL 1 16
PROPEP 17 30 Activation peptide.
/FTId=PRO_0000027687.
CHAIN 31 271 Chymotrypsin-like elastase family member
2A.
/FTId=PRO_0000027688.
DOMAIN 31 269 Peptidase S1. {ECO:0000255|PROSITE-
ProRule:PRU00274}.
ACT_SITE 75 75 Charge relay system. {ECO:0000250}.
ACT_SITE 123 123 Charge relay system. {ECO:0000250}.
ACT_SITE 218 218 Charge relay system. {ECO:0000250}.
DISULFID 60 76 {ECO:0000255|PROSITE-ProRule:PRU00274}.
DISULFID 157 224 {ECO:0000255|PROSITE-ProRule:PRU00274}.
DISULFID 188 204 {ECO:0000255|PROSITE-ProRule:PRU00274}.
DISULFID 214 245 {ECO:0000255|PROSITE-ProRule:PRU00274}.
SEQUENCE 271 AA; 28914 MW; FA542AE38FED3B4B CRC64;
MIRTLLLSAL VAGALSCGYP TYEVEDDVSR VVGGQEATPN TWPWQVSLQV LSSGRWRHNC
GGSLVANNWV LTAAHCLSNY QTYRVLLGAH SLSNPGAGSA AVQVSKLVVH QRWNSQNVGN
GYDIALIKLA SPVTLSKNIQ TACLPPAGTI LPRNYVCYVT GWGLLQTNGN SPDTLRQGRL
LVVDYATCSS ASWWGSSVKS SMVCAGGDGV TSSCNGDSGG PLNCRASNGQ WQVHGIVSFG
SSLGCNYPRK PSVFTRVSNY IDWINSVMAR N


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