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Class A basic helix-loop-helix protein 15 (bHLHa15) (Class B basic helix-loop-helix protein 8) (bHLHb8) (Muscle, intestine and stomach expression 1) (MIST-1)

 BHA15_RAT               Reviewed;         197 AA.
P70562;
19-JUL-2004, integrated into UniProtKB/Swiss-Prot.
01-FEB-1997, sequence version 1.
25-OCT-2017, entry version 116.
RecName: Full=Class A basic helix-loop-helix protein 15;
Short=bHLHa15;
AltName: Full=Class B basic helix-loop-helix protein 8;
Short=bHLHb8;
AltName: Full=Muscle, intestine and stomach expression 1;
Short=MIST-1;
Name=Bhlha15; Synonyms=Bhlhb8, Mist1;
Rattus norvegicus (Rat).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Rattus.
NCBI_TaxID=10116;
[1]
NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, AND CHARACTERIZATION.
STRAIN=Sprague-Dawley; TISSUE=Olfactory epithelium;
PubMed=9073453; DOI=10.1006/dbio.1996.8454;
Lemercier C., To R.Q., Swanson B.J., Lyons G.E., Konieczny S.F.;
"Mist1: a novel basic helix-loop-helix transcription factor exhibits a
developmentally regulated expression pattern.";
Dev. Biol. 182:101-113(1997).
[2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=Sprague-Dawley;
PubMed=10721714; DOI=10.1016/S0378-1119(99)00523-5;
Lemercier C., Brown A., Mamani M., Ripoche J., Reiffers J.;
"The rat Mist1 gene: structure and promoter characterization.";
Gene 242:209-218(2000).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Prostate;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[4]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-25, AND IDENTIFICATION
BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
PubMed=22673903; DOI=10.1038/ncomms1871;
Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A.,
Lundby C., Olsen J.V.;
"Quantitative maps of protein phosphorylation sites across 14
different rat organs and tissues.";
Nat. Commun. 3:876-876(2012).
-!- FUNCTION: Plays a role in controlling the transcriptional activity
of MyoD, ensuring that expanding myoblast populations remain
undifferentiated. Repression may occur through muscle-specific E-
box occupancy by homodimers. May also negatively regulate bHLH-
mediated transcription through an N-terminal repressor domain.
Serves as a key regulator of acinar cell function, stability, and
identity. Also required for normal organelle localization in
exocrine cells and for mitochondrial calcium ion transport. May
function as a unique regulator of gene expression in several
different embryonic and postnatal cell lineages. Binds to the E-
box consensus sequence 5'-CANNTG-3' (By similarity).
{ECO:0000250|UniProtKB:Q9QYC3}.
-!- SUBUNIT: Forms homodimers or heterodimers with TCF3 gene products
E12 and E47. These dimers bind to the E-box site, however,
heterodimer with MYOD1 does not bind target DNA.
-!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
-!- TISSUE SPECIFICITY: Expressed in liver, spleen and olfactory
epithelium. Weaker expression is seen in skeletal muscle, cardiac
muscle, eye and brain tissue. {ECO:0000269|PubMed:9073453}.
-!- DOMAIN: Lacks a classic transcription activation domain and
instead possesses an N-terminal region capable of inhibiting
heterologous activators. {ECO:0000250}.
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EMBL; U58279; AAC53111.1; -; mRNA.
EMBL; AF049874; AAF17707.1; -; Genomic_DNA.
EMBL; BC061868; AAH61868.1; -; mRNA.
RefSeq; NP_036995.1; NM_012863.1.
UniGene; Rn.9897; -.
ProteinModelPortal; P70562; -.
SMR; P70562; -.
BioGrid; 247373; 1.
STRING; 10116.ENSRNOP00000035219; -.
iPTMnet; P70562; -.
PhosphoSitePlus; P70562; -.
PaxDb; P70562; -.
PRIDE; P70562; -.
Ensembl; ENSRNOT00000037251; ENSRNOP00000035219; ENSRNOG00000025164.
GeneID; 25334; -.
KEGG; rno:25334; -.
CTD; 168620; -.
RGD; 3091; Bhlha15.
eggNOG; ENOG410IQ4H; Eukaryota.
eggNOG; ENOG4111ZMK; LUCA.
GeneTree; ENSGT00680000099860; -.
HOGENOM; HOG000095227; -.
InParanoid; P70562; -.
KO; K08040; -.
OMA; HRYSTQI; -.
OrthoDB; EOG091G15AI; -.
PhylomeDB; P70562; -.
TreeFam; TF315153; -.
PRO; PR:P70562; -.
Proteomes; UP000002494; Chromosome 12.
Bgee; ENSRNOG00000025164; -.
Genevisible; P70562; RN.
GO; GO:0005634; C:nucleus; IDA:MGI.
GO; GO:0003677; F:DNA binding; IDA:MGI.
GO; GO:0042803; F:protein homodimerization activity; IEA:Ensembl.
GO; GO:0000977; F:RNA polymerase II regulatory region sequence-specific DNA binding; IEA:Ensembl.
GO; GO:0001228; F:transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding; IEA:Ensembl.
GO; GO:0019722; P:calcium-mediated signaling; IEA:Ensembl.
GO; GO:0048469; P:cell maturation; IEA:Ensembl.
GO; GO:0007267; P:cell-cell signaling; IEA:Ensembl.
GO; GO:0042149; P:cellular response to glucose starvation; ISS:UniProtKB.
GO; GO:0030968; P:endoplasmic reticulum unfolded protein response; ISS:UniProtKB.
GO; GO:0007186; P:G-protein coupled receptor signaling pathway; IEA:Ensembl.
GO; GO:0042593; P:glucose homeostasis; IEA:Ensembl.
GO; GO:0007030; P:Golgi organization; IEA:Ensembl.
GO; GO:0048312; P:intracellular distribution of mitochondria; IEA:Ensembl.
GO; GO:0006851; P:mitochondrial calcium ion transmembrane transport; IEA:Ensembl.
GO; GO:0010832; P:negative regulation of myotube differentiation; ISS:UniProtKB.
CDD; cd00083; HLH; 1.
Gene3D; 4.10.280.10; -; 1.
InterPro; IPR011598; bHLH_dom.
InterPro; IPR036638; HLH_DNA-bd_sf.
Pfam; PF00010; HLH; 1.
SMART; SM00353; HLH; 1.
SUPFAM; SSF47459; SSF47459; 1.
PROSITE; PS50888; BHLH; 1.
1: Evidence at protein level;
Complete proteome; DNA-binding; Nucleus; Phosphoprotein;
Reference proteome; Repressor; Transcription;
Transcription regulation.
CHAIN 1 197 Class A basic helix-loop-helix protein
15.
/FTId=PRO_0000127152.
DOMAIN 72 124 bHLH. {ECO:0000255|PROSITE-
ProRule:PRU00981}.
COMPBIAS 152 189 Gln-rich.
MOD_RES 12 12 Phosphothreonine.
{ECO:0000250|UniProtKB:Q9QYC3}.
MOD_RES 25 25 Phosphothreonine.
{ECO:0000244|PubMed:22673903}.
SEQUENCE 197 AA; 22196 MW; 067AEAC33B5D49CE CRC64;
MKTKNRPPRR RTPMQDAEAT PGEQTPDRSQ SGSGASEVTK GLRSRTARAS GTRAEVSRRR
QGSSSRRENS VQRRLESNER ERQRMHKLNN AFQALREVIP HVRADKKLSK IETLTLAKNY
IKSLTATILT MSSSRLPGLE APGPAPGPKL YQHYHHQQQQ QQQQQQVAGA VLGVTEDQPQ
GHLQRYSTQI HSFREGS


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