Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

Class E basic helix-loop-helix protein 41 (bHLHe41) (Class B basic helix-loop-helix protein 3) (bHLHb3) (Differentially expressed in chondrocytes protein 2) (mDEC2)

 BHE41_MOUSE             Reviewed;         410 AA.
Q99PV5;
05-MAR-2002, integrated into UniProtKB/Swiss-Prot.
01-JUN-2001, sequence version 1.
23-MAY-2018, entry version 134.
RecName: Full=Class E basic helix-loop-helix protein 41;
Short=bHLHe41;
AltName: Full=Class B basic helix-loop-helix protein 3;
Short=bHLHb3;
AltName: Full=Differentially expressed in chondrocytes protein 2;
Short=mDEC2;
Name=Bhlhe41; Synonyms=Bhlhb3, Dec2;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
PubMed=11162494; DOI=10.1006/bbrc.2000.4133;
Fujimoto K., Shen M., Noshiro M., Matsubara K., Shingu S., Honda K.,
Yoshida E., Suardita K., Matsuda Y., Kato Y.;
"Molecular cloning and characterization of DEC2, a new member of basic
helix-loop-helix proteins.";
Biochem. Biophys. Res. Commun. 280:164-171(2001).
[2]
FUNCTION, AND INTERACTION WITH ARNTL.
PubMed=12397359; DOI=10.1038/nature01123;
Honma S., Kawamoto T., Takagi Y., Fujimoto K., Sato F., Noshiro M.,
Kato Y., Honma K.I.;
"Dec1 and Dec2 are regulators of the mammalian molecular clock.";
Nature 419:841-844(2002).
[3]
FUNCTION.
PubMed=14672706; DOI=10.1016/j.bbrc.2003.11.099;
Kawamoto T., Noshiro M., Sato F., Maemura K., Takeda N., Nagai R.,
Iwata T., Fujimoto K., Furukawa M., Miyazaki K., Honma S., Honma K.I.,
Kato Y.;
"A novel autofeedback loop of Dec1 transcription involved in circadian
rhythm regulation.";
Biochem. Biophys. Res. Commun. 313:117-124(2004).
[4]
HETERODIMERIZATION WITH BHLHE40.
PubMed=15560782; DOI=10.1111/j.1432-1033.2004.04379.x;
Sato F., Kawamoto T., Fujimoto K., Noshiro M., Honda K.K., Honma S.,
Honma K., Kato Y.;
"Functional analysis of the basic helix-loop-helix transcription
factor DEC1 in circadian regulation. Interaction with BMAL1.";
Eur. J. Biochem. 271:4409-4419(2004).
[5]
FUNCTION.
PubMed=18411297; DOI=10.1128/MCB.02168-07;
Nakashima A., Kawamoto T., Honda K.K., Ueshima T., Noshiro M.,
Iwata T., Fujimoto K., Kubo H., Honma S., Yorioka N., Kohno N.,
Kato Y.;
"DEC1 modulates the circadian phase of clock gene expression.";
Mol. Cell. Biol. 28:4080-4092(2008).
[6]
FUNCTION, AND INDUCTION.
PubMed=19786558; DOI=10.1124/mol.109.057000;
Cho Y., Noshiro M., Choi M., Morita K., Kawamoto T., Fujimoto K.,
Kato Y., Makishima M.;
"The basic helix-loop-helix proteins differentiated embryo chondrocyte
(DEC) 1 and DEC2 function as corepressors of retinoid X receptors.";
Mol. Pharmacol. 76:1360-1369(2009).
[7]
TRANSGENIC MICE.
PubMed=19679812; DOI=10.1126/science.1174443;
He Y., Jones C.R., Fujiki N., Xu Y., Guo B., Holder J.L. Jr.,
Rossner M.J., Nishino S., Fu Y.H.;
"The transcriptional repressor DEC2 regulates sleep length in
mammals.";
Science 325:866-870(2009).
[8]
FUNCTION, AND INTERACTION WITH CIART.
PubMed=24736997; DOI=10.1371/journal.pbio.1001839;
Goriki A., Hatanaka F., Myung J., Kim J.K., Yoritaka T., Tanoue S.,
Abe T., Kiyonari H., Fujimoto K., Kato Y., Todo T., Matsubara A.,
Forger D., Takumi T.;
"A novel protein, CHRONO, functions as a core component of the
mammalian circadian clock.";
PLoS Biol. 12:E1001839-E1001839(2014).
-!- FUNCTION: Transcriptional repressor involved in the regulation of
the circadian rhythm by negatively regulating the activity of the
clock genes and clock-controlled genes. Acts as the negative limb
of a novel autoregulatory feedback loop (DEC loop) which differs
from the one formed by the PER and CRY transcriptional repressors
(PER/CRY loop). Both these loops are interlocked as it represses
the expression of PER1 and in turn is repressed by PER1/2 and
CRY1/2. Represses the activity of the circadian transcriptional
activator: CLOCK-ARNTL/BMAL1 heterodimer by competing for the
binding to E-box elements (5'-CACGTG-3') found within the
promoters of its target genes. Negatively regulates its own
expression and the expression of DBP and BHLHE41/DEC2. Acts as a
corepressor of RXR and the RXR-LXR heterodimers and represses the
ligand-induced RXRA/B/G, NR1H3/LXRA, NR1H4 and VDR transactivation
activity. {ECO:0000269|PubMed:12397359,
ECO:0000269|PubMed:14672706, ECO:0000269|PubMed:18411297,
ECO:0000269|PubMed:19786558, ECO:0000269|PubMed:24736997}.
-!- SUBUNIT: Homodimer. Interacts with CIART. Interacts with
ARNTL/BMAL1 and RXRA. {ECO:0000269|PubMed:12397359,
ECO:0000269|PubMed:24736997}.
-!- INTERACTION:
P28033:Cebpb; NbExp=5; IntAct=EBI-6143801, EBI-1029979;
Q3TQ03:Ciart; NbExp=2; IntAct=EBI-6143801, EBI-16101489;
Q16665:HIF1A (xeno); NbExp=3; IntAct=EBI-6143801, EBI-447269;
P25789:PSMA4 (xeno); NbExp=2; IntAct=EBI-6143801, EBI-359310;
-!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-
ProRule:PRU00380, ECO:0000255|PROSITE-ProRule:PRU00981}.
-!- TISSUE SPECIFICITY: Expressed in skeletal muscle, brain and lung.
-!- INDUCTION: Expressed in a circdadian manner in the liver with a
peak at ZT10. {ECO:0000269|PubMed:19786558}.
-!- MISCELLANEOUS: Activity profiles and sleep recordings of
transgenic mice carrying the mutation Arg-325 show increased
vigilance time and less sleep time than control mice in a
zeitgeber time- and sleep deprivation-dependent manner.
-----------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
Distributed under the Creative Commons Attribution-NoDerivs License
-----------------------------------------------------------------------
EMBL; AB044090; BAB21503.1; -; mRNA.
CCDS; CCDS20697.1; -.
PIR; JC7584; JC7584.
RefSeq; NP_001258697.1; NM_001271768.1.
RefSeq; NP_077789.1; NM_024469.2.
UniGene; Mm.154529; -.
ProteinModelPortal; Q99PV5; -.
SMR; Q99PV5; -.
BioGrid; 219755; 3.
DIP; DIP-57696N; -.
IntAct; Q99PV5; 25.
MINT; Q99PV5; -.
STRING; 10090.ENSMUSP00000032386; -.
iPTMnet; Q99PV5; -.
PhosphoSitePlus; Q99PV5; -.
MaxQB; Q99PV5; -.
PaxDb; Q99PV5; -.
PRIDE; Q99PV5; -.
Ensembl; ENSMUST00000032386; ENSMUSP00000032386; ENSMUSG00000030256.
GeneID; 79362; -.
KEGG; mmu:79362; -.
UCSC; uc009ert.2; mouse.
CTD; 79365; -.
MGI; MGI:1930704; Bhlhe41.
eggNOG; KOG4304; Eukaryota.
eggNOG; ENOG4111F0X; LUCA.
GeneTree; ENSGT00510000046898; -.
HOGENOM; HOG000234381; -.
InParanoid; Q99PV5; -.
KO; K03730; -.
OMA; LYMCKSK; -.
OrthoDB; EOG091G0D3I; -.
PhylomeDB; Q99PV5; -.
TreeFam; TF330859; -.
ChiTaRS; Bhlhe41; mouse.
PRO; PR:Q99PV5; -.
Proteomes; UP000000589; Chromosome 6.
Bgee; ENSMUSG00000030256; -.
ExpressionAtlas; Q99PV5; baseline and differential.
Genevisible; Q99PV5; MM.
GO; GO:0005654; C:nucleoplasm; TAS:Reactome.
GO; GO:0017053; C:transcriptional repressor complex; TAS:MGI.
GO; GO:0043425; F:bHLH transcription factor binding; IDA:BHF-UCL.
GO; GO:0070888; F:E-box binding; IDA:BHF-UCL.
GO; GO:0042826; F:histone deacetylase binding; IDA:BHF-UCL.
GO; GO:0043426; F:MRF binding; IDA:BHF-UCL.
GO; GO:0046982; F:protein heterodimerization activity; IDA:BHF-UCL.
GO; GO:0042803; F:protein homodimerization activity; IPI:BHF-UCL.
GO; GO:0001102; F:RNA polymerase II activating transcription factor binding; IDA:BHF-UCL.
GO; GO:0000978; F:RNA polymerase II proximal promoter sequence-specific DNA binding; IDA:BHF-UCL.
GO; GO:0000981; F:RNA polymerase II transcription factor activity, sequence-specific DNA binding; IDA:BHF-UCL.
GO; GO:0003714; F:transcription corepressor activity; IDA:UniProtKB.
GO; GO:0003705; F:transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding; IDA:BHF-UCL.
GO; GO:0001078; F:transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding; IDA:BHF-UCL.
GO; GO:0001191; F:transcriptional repressor activity, RNA polymerase II transcription factor binding; IDA:BHF-UCL.
GO; GO:0032922; P:circadian regulation of gene expression; IMP:BHF-UCL.
GO; GO:0007623; P:circadian rhythm; IEP:UniProtKB.
GO; GO:0010832; P:negative regulation of myotube differentiation; IDA:BHF-UCL.
GO; GO:0010944; P:negative regulation of transcription by competitive promoter binding; IDA:BHF-UCL.
GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IDA:BHF-UCL.
GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IDA:UniProtKB.
GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
CDD; cd00083; HLH; 1.
Gene3D; 4.10.280.10; -; 1.
InterPro; IPR011598; bHLH_dom.
InterPro; IPR036638; HLH_DNA-bd_sf.
InterPro; IPR003650; Orange_dom.
Pfam; PF07527; Hairy_orange; 1.
Pfam; PF00010; HLH; 1.
SMART; SM00353; HLH; 1.
SMART; SM00511; ORANGE; 1.
SUPFAM; SSF47459; SSF47459; 1.
PROSITE; PS50888; BHLH; 1.
PROSITE; PS51054; ORANGE; 1.
1: Evidence at protein level;
Biological rhythms; Complete proteome; DNA-binding; Isopeptide bond;
Nucleus; Reference proteome; Repressor; Transcription;
Transcription regulation; Ubl conjugation.
CHAIN 1 410 Class E basic helix-loop-helix protein
41.
/FTId=PRO_0000127148.
DOMAIN 44 99 bHLH. {ECO:0000255|PROSITE-
ProRule:PRU00981}.
DOMAIN 131 166 Orange. {ECO:0000255|PROSITE-
ProRule:PRU00380}.
COMPBIAS 321 373 Ala/Gly-rich.
CROSSLNK 31 31 Glycyl lysine isopeptide (Lys-Gly)
(interchain with G-Cter in SUMO2).
{ECO:0000250|UniProtKB:Q9C0J9}.
CROSSLNK 121 121 Glycyl lysine isopeptide (Lys-Gly)
(interchain with G-Cter in SUMO2).
{ECO:0000250|UniProtKB:Q9C0J9}.
CROSSLNK 240 240 Glycyl lysine isopeptide (Lys-Gly)
(interchain with G-Cter in SUMO2).
{ECO:0000250|UniProtKB:Q9C0J9}.
SEQUENCE 410 AA; 43946 MW; 40A87281B08E233D CRC64;
MDEGIPHLQE RQLLEHRDFI GLDYSSLYMC KPKRSLKRDD TKDTYKLPHR LIEKKRRDRI
NECIAQLKDL LPEHLKLTTL GHLEKAVVLE LTLKHLKALT ALTEQQHQKI IALQNGERSL
KSPVQADLDA FHSGFQTCAK EVLQYLARFE SWTPREPRCA QLVSHLHAVA TQLLTPQVPS
GRGSGRAPCS AGAAAASGPE RVARCVPVIQ RTQPGTEPEH DTDTDSGYGG EAEQGRAAVK
QEPPGDSSPA PKRPKLEARG ALLGPEPALL GSLVALGGGA PFAQPAAAPF CLPFYLLSPS
AAAYVQPWLD KSGLDKYLYP AAAAPFPLLY PGIPAAAAAA AAAAFPCLSS VLSPPPEKAG
ATAGAPFLAH EVAPPGPLRP QHAHSRTHLP RAVNPESSQE DATQPAKDAP


Related products :

Catalog number Product name Quantity
EIAAB37697 Basic helix-loop-helix transcription factor scleraxis,bHLHa41,BHLHA41,bHLHa48,Class A basic helix-loop-helix protein 41,Class A basic helix-loop-helix protein 48,Homo sapiens,Human,SCX,SCXA
18-003-43865 Class B basic helix-loop-helix protein 2 - bHLHB2; Differentially expressed in chondrocytes protein 1; DEC1; Enhancer-of-split and hairy-related protein 2; SHARP-2; Stimulated by retinoic acid gene 13 0.05 mg Aff Pur
U2004h CLIA Basic-helix-loop-helix-PAS protein MOP2,bHLHe73,BHLHE73,Class E basic helix-loop-helix protein 73,Endothelial PAS domain-containing protein 1,EPAS1,EPAS-1,HIF-1-alpha-like factor,HIF2A,HIF-2-alph 96T
U2004h CLIA kit Basic-helix-loop-helix-PAS protein MOP2,bHLHe73,BHLHE73,Class E basic helix-loop-helix protein 73,Endothelial PAS domain-containing protein 1,EPAS1,EPAS-1,HIF-1-alpha-like factor,HIF2A,HIF-2 96T
E2004h ELISA Basic-helix-loop-helix-PAS protein MOP2,bHLHe73,BHLHE73,Class E basic helix-loop-helix protein 73,Endothelial PAS domain-containing protein 1,EPAS1,EPAS-1,HIF-1-alpha-like factor,HIF2A,HIF-2-alp 96T
E2004h ELISA kit Basic-helix-loop-helix-PAS protein MOP2,bHLHe73,BHLHE73,Class E basic helix-loop-helix protein 73,Endothelial PAS domain-containing protein 1,EPAS1,EPAS-1,HIF-1-alpha-like factor,HIF2A,HIF- 96T
EIAAB28826 bHLHb1,BHLHB1,bHLHe19,BHLHE19,Class B basic helix-loop-helix protein 1,Class E basic helix-loop-helix protein 19,Homo sapiens,Human,OLIG2,Oligo2,Oligodendrocyte transcription factor 2,PRKCBP2,Protein
EIAAB28828 bHLHb7,BHLHB7,bHLHe20,BHLHE20,Class B basic helix-loop-helix protein 7,Class E basic helix-loop-helix protein 20,Homo sapiens,Human,OLIG3,Oligo3,Oligodendrocyte transcription factor 3
EIAAB28821 bHLHb6,BHLHB6,bHLHe21,BHLHE21,Class B basic helix-loop-helix protein 6,Class E basic helix-loop-helix protein 21,Homo sapiens,Human,OLIG1,Oligo1,Oligodendrocyte transcription factor 1
U0798h CLIA ARNT-interacting protein,Basic-helix-loop-helix-PAS protein MOP1,bHLHe78,BHLHE78,Class E basic helix-loop-helix protein 78,HIF1A,HIF-1-alpha,HIF1-alpha,Homo sapiens,Human,Hypoxia-inducible factor 96T
E0798h ELISA ARNT-interacting protein,Basic-helix-loop-helix-PAS protein MOP1,bHLHe78,BHLHE78,Class E basic helix-loop-helix protein 78,HIF1A,HIF-1-alpha,HIF1-alpha,Homo sapiens,Human,Hypoxia-inducible facto 96T
E0798h ELISA kit ARNT-interacting protein,Basic-helix-loop-helix-PAS protein MOP1,bHLHe78,BHLHE78,Class E basic helix-loop-helix protein 78,HIF1A,HIF-1-alpha,HIF1-alpha,Homo sapiens,Human,Hypoxia-inducible 96T
U0255h CLIA ATH1,ATOH1,bHLHa14,BHLHA14,Class A basic helix-loop-helix protein 14,hATH1,Helix-loop-helix protein hATH-1,Homo sapiens,Human,Protein atonal homolog 1 96T
E0255h ELISA ATH1,ATOH1,bHLHa14,BHLHA14,Class A basic helix-loop-helix protein 14,hATH1,Helix-loop-helix protein hATH-1,Homo sapiens,Human,Protein atonal homolog 1 96T
E0255h ELISA kit ATH1,ATOH1,bHLHa14,BHLHA14,Class A basic helix-loop-helix protein 14,hATH1,Helix-loop-helix protein hATH-1,Homo sapiens,Human,Protein atonal homolog 1 96T
EIAAB14718 Basic helix-loop-helix protein N-twist,bHLHa31,BHLHA31,Class A basic helix-loop-helix protein 31,Fer3-like protein,FERD3L,Homo sapiens,Human,NATO3,Nephew of atonal 3,Neuronal twist,NTWIST
CSB-EL002692HU Human Class E basic helix-loop-helix protein 41(BHLHE41) ELISA kit 96T
CSB-EL002692MO Mouse Class E basic helix-loop-helix protein 41(BHLHE41) ELISA kit 96T
CSB-EL002692HU Human Class E basic helix-loop-helix protein 41(BHLHE41) ELISA kit SpeciesHuman 96T
CSB-EL002692MO Mouse Class E basic helix-loop-helix protein 41(BHLHE41) ELISA kit SpeciesMouse 96T
BHE41_MOUSE ELISA Kit FOR Class E basic helix-loop-helix protein 41; organism: Mouse; gene name: Bhlhe41 96T
BHE41_HUMAN ELISA Kit FOR Class E basic helix-loop-helix protein 41; organism: Human; gene name: BHLHE41 96T
EIAAB27132 bHLHa6,BHLHA6,Class A basic helix-loop-helix protein 6,Homo sapiens,Human,NeuroD3,NEUROD3,NEUROG1,Neurogenic basic-helix-loop-helix protein,Neurogenic differentiation factor 3,Neurogenin-1,NGN,NGN1,NG
EIAAB27618 Basic-helix-loop-helix-PAS protein MOP6,bHLHe12,BHLHE12,Class E basic helix-loop-helix protein 12,Homo sapiens,Human,Member of PAS protein 6,MOP6,Neuronal PAS domain-containing protein 3,Neuronal PAS3
EIAAB27612 Basic-helix-loop-helix-PAS protein MOP5,bHLHe11,BHLHE11,Class E basic helix-loop-helix protein 11,Homo sapiens,Human,Member of PAS protein 5,MOP5,Neuronal PAS domain-containing protein 1,Neuronal PAS1


 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur





GENTAUR Ltd.
Howard Frank Turnberry House
1404-1410 High Road
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017

BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG

france@gentaur.com | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: 0035929830070
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.


ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur