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Clathrin heavy chain

 A8X9P2_CAEBR            Unreviewed;      1660 AA.
A8X9P2;
15-JAN-2008, integrated into UniProtKB/TrEMBL.
16-DEC-2008, sequence version 2.
25-APR-2018, entry version 71.
RecName: Full=Clathrin heavy chain {ECO:0000256|PIRNR:PIRNR002290};
Name=chc-1 {ECO:0000313|WormBase:CBG09806};
Synonyms=Cbr-chc-1 {ECO:0000313|EMBL:CAP29357.2};
ORFNames=CBG09806 {ECO:0000313|WormBase:CBG09806},
CBG_09806 {ECO:0000313|EMBL:CAP29357.2};
Caenorhabditis briggsae.
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis.
NCBI_TaxID=6238 {ECO:0000313|EMBL:CAP29357.2, ECO:0000313|Proteomes:UP000008549};
[1] {ECO:0000313|EMBL:CAP29357.2, ECO:0000313|Proteomes:UP000008549}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=AF16 {ECO:0000313|EMBL:CAP29357.2,
ECO:0000313|Proteomes:UP000008549};
PubMed=14624247; DOI=10.1371/journal.pbio.0000045;
Stein L.D., Bao Z., Blasiar D., Blumenthal T., Brent M.R., Chen N.,
Chinwalla A., Clarke L., Clee C., Coghlan A., Coulson A.,
D'Eustachio P., Fitch D.H., Fulton L.A., Fulton R.E.,
Griffiths-Jones S., Harris T.W., Hillier L.W., Kamath R.,
Kuwabara P.E., Mardis E.R., Marra M.A., Miner T.L., Minx P.,
Mullikin J.C., Plumb R.W., Rogers J., Schein J.E., Sohrmann M.,
Spieth J., Stajich J.E., Wei C., Willey D., Wilson R.K., Durbin R.,
Waterston R.H.;
"The genome sequence of Caenorhabditis briggsae: a platform for
comparative genomics.";
PLoS Biol. 1:166-192(2003).
-!- FUNCTION: Clathrin is the major protein of the polyhedral coat of
coated pits and vesicles. {ECO:0000256|PIRNR:PIRNR002290}.
-!- SUBCELLULAR LOCATION: Cytoplasmic vesicle membrane
{ECO:0000256|PIRNR:PIRNR002290}; Peripheral membrane protein
{ECO:0000256|PIRNR:PIRNR002290}; Cytoplasmic side
{ECO:0000256|PIRNR:PIRNR002290}. Membrane, coated pit
{ECO:0000256|PIRNR:PIRNR002290}; Peripheral membrane protein
{ECO:0000256|PIRNR:PIRNR002290}; Cytoplasmic side
{ECO:0000256|PIRNR:PIRNR002290}.
-!- SIMILARITY: Belongs to the clathrin heavy chain family.
{ECO:0000256|PIRNR:PIRNR002290}.
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EMBL; HE601459; CAP29357.2; -; Genomic_DNA.
STRING; 6238.CBG09806; -.
WormBase; CBG09806; CBP16653; WBGene00031326; Cbr-chc-1.
eggNOG; KOG0985; Eukaryota.
eggNOG; ENOG410XPH1; LUCA.
HOGENOM; HOG000188877; -.
InParanoid; A8X9P2; -.
OMA; VQQCTAF; -.
OrthoDB; EOG091G009O; -.
Proteomes; UP000008549; Chromosome III.
GO; GO:0016324; C:apical plasma membrane; IEA:EnsemblMetazoa.
GO; GO:0005938; C:cell cortex; IEA:EnsemblMetazoa.
GO; GO:0030132; C:clathrin coat of coated pit; IEA:InterPro.
GO; GO:0030130; C:clathrin coat of trans-Golgi network vesicle; IEA:InterPro.
GO; GO:0071439; C:clathrin complex; IEA:InterPro.
GO; GO:0045334; C:clathrin-coated endocytic vesicle; IEA:EnsemblMetazoa.
GO; GO:0009898; C:cytoplasmic side of plasma membrane; IEA:EnsemblMetazoa.
GO; GO:0072686; C:mitotic spindle; IEA:EnsemblMetazoa.
GO; GO:0032051; F:clathrin light chain binding; IEA:InterPro.
GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
GO; GO:0045176; P:apical protein localization; IEA:EnsemblMetazoa.
GO; GO:0048268; P:clathrin coat assembly; IEA:InterPro.
GO; GO:0030866; P:cortical actin cytoskeleton organization; IEA:EnsemblMetazoa.
GO; GO:0008340; P:determination of adult lifespan; IEA:EnsemblMetazoa.
GO; GO:0009792; P:embryo development ending in birth or egg hatching; IEA:EnsemblMetazoa.
GO; GO:0006886; P:intracellular protein transport; IEA:UniProtKB-UniRule.
GO; GO:2000370; P:positive regulation of clathrin-dependent endocytosis; IEA:EnsemblMetazoa.
GO; GO:0006898; P:receptor-mediated endocytosis; IEA:EnsemblMetazoa.
Gene3D; 1.25.40.10; -; 4.
Gene3D; 2.130.10.110; -; 1.
InterPro; IPR016024; ARM-type_fold.
InterPro; IPR000547; Clathrin_H-chain/VPS_repeat.
InterPro; IPR015348; Clathrin_H-chain_linker_core.
InterPro; IPR016025; Clathrin_H-chain_N.
InterPro; IPR022365; Clathrin_H-chain_propeller_rpt.
InterPro; IPR016341; Clathrin_heavy_chain.
InterPro; IPR011990; TPR-like_helical_dom_sf.
Pfam; PF00637; Clathrin; 7.
Pfam; PF09268; Clathrin-link; 1.
Pfam; PF01394; Clathrin_propel; 4.
PIRSF; PIRSF002290; Clathrin_H_chain; 2.
SMART; SM00299; CLH; 7.
SUPFAM; SSF48371; SSF48371; 6.
SUPFAM; SSF50989; SSF50989; 1.
PROSITE; PS50236; CHCR; 7.
3: Inferred from homology;
Coated pit {ECO:0000256|PIRNR:PIRNR002290};
Coiled coil {ECO:0000256|SAM:Coils};
Complete proteome {ECO:0000313|Proteomes:UP000008549};
Cytoplasmic vesicle {ECO:0000256|PIRNR:PIRNR002290};
Membrane {ECO:0000256|PIRNR:PIRNR002290};
Reference proteome {ECO:0000313|Proteomes:UP000008549}.
DOMAIN 304 327 Clathrin-link.
{ECO:0000259|Pfam:PF09268}.
REPEAT 518 664 CHCR. {ECO:0000256|PROSITE-
ProRule:PRU01006}.
REPEAT 667 809 CHCR. {ECO:0000256|PROSITE-
ProRule:PRU01006}.
REPEAT 814 953 CHCR. {ECO:0000256|PROSITE-
ProRule:PRU01006}.
REPEAT 960 1105 CHCR. {ECO:0000256|PROSITE-
ProRule:PRU01006}.
REPEAT 1109 1250 CHCR. {ECO:0000256|PROSITE-
ProRule:PRU01006}.
REPEAT 1255 1401 CHCR. {ECO:0000256|PROSITE-
ProRule:PRU01006}.
REPEAT 1404 1547 CHCR. {ECO:0000256|PROSITE-
ProRule:PRU01006}.
COILED 1584 1612 {ECO:0000256|SAM:Coils}.
SEQUENCE 1660 AA; 189506 MW; BCC7D844E225EB56 CRC64;
MAALPIKFHE HLQLPNAGIR VPNITFSNVT MESDKNIVVR EMVNTVKTFL NWRSTTTGKT
LQIFNIELKA KVKAHQNVED VVYWKWISDK LIALVSDTAV YHWSIEGDAA PVKMFDRHQS
LAGTQIINYR ADAESKWLVL IGISAKDSRV VGSMQLYSTE RKVSQPIEGH AASFVRFKVD
GNQQPSNLFC FSVKTETGGK LHIIEVGTPA TGNSPFQKKN VDVPYTADTA GDFPVSMQVS
TKQGIIYLVT KQGYVHLYDV ESGLRIYSNR ISTDTVFVTC EYTATGGIMG INRKGQVLSV
SIDEANLVPF VTNQLQNPDL ALKLAVRCDL PGAEELFVRK FNLLFSNGQF GEAAKVAASA
PQGILRTPAT IQKFQQCPST GSGPSPLLQF FGILLDQGKL NKYETLELCR PVLAQGRKEL
ITKWLNEQKL ECCEELGDLI KPHDVNTALS VYLRGNVPHK VVQSFAETGQ FDKIVMYAKR
VGFQPDYLFQ LRQILRNSNP DNGAKFAQLL VSESENGEPL ADLSQRLFQI IDCFMEVQAV
QPCTSFLLEV LKGDKPEEGH LQTRLLEMNL LAAPAVADAI LANKMFSHYD RAAIGQLCEK
AGLLQRALEH FTDLYDIKRT VVHTHLLKPD WLVGYFGSLS VEDSLECLKA MLTQNIRQNL
QVVVQIASKY HEQLGADKLI EMFETHKSYE GLFYFLGSIV NFSQDPEVHF KYIQAATRTG
QIKEVERICR ESQCYDAERV KNFLKEAKLN DQLPLIIVCD RHNMVHDLVL YLYRNQLQKY
IEVFVQKVNA ARLPIVVGAL LDVDCSEDAI KQLIINTRGK FDIDELVEEV EKRNRLKLLN
HWLESRIQEG ATDAATHNAM AKIYIDSNNN PERFLKENPY YDSKVVGKYC EKRDPHYAFL
SYERGQCDAE LINVCNENSL FKNLARYLVK RRDFTLWEQV LNEENVYRRQ LIDQVVQTAL
SETQDPEDIS VTVKAFMAAD LPNELIELLE KIVLDNSAFS EHRNLQNLLI LTAMRADRTR
VMEYIQKLDN YDAPDIANIA ITSELYEEAF AIFKKFDVNS SAINVLIENV NNLDRAYEFA
EKCNQSDVWA SLAKAQLKQD LVKEAVDSFI KADDPGAYME VVNKCSQTEH WEDLVRYLQM
ARKKSRESYI ETELVYALAK TGRLTELEEF IAGPNHAQIG QIGDRCFDNG MFDAAKILFN
NVSNFAKLSV TLVRLGEYQG AVDAARKANS TKTWKQVCFS CVENGEFRLA QMCGLHIVVH
ADELEELINF YQDRGHFEEL IALLEAALGL ERAHMGMFTE LAILYSKYKP EKMREHLELF
WSRVNIPKVL RAAEQAHLWS ELVFLYDKYE EYDNAALTMM QHPTESWREQ HFKEVIAKVA
NVELYYKAMQ FYLDFKPLLL NDLLAVLSPR LDHSRTVLFF NKLKQIPLVK PYLRQVQNLN
NKAINEALNQ LLIDEEDHAG LRSSIEAQDN FDNISLAQQL EKHPLVEFRR ISAYLFKGNN
RWKQSIELCK KDKLYKDAME YAAESRNGEL AEELLSFFLD EKLYDCFAAS LYHCYDLLHP
DVIMELAWKH KIMDYAMPYM IQVMRDYQTR LEKLERSEHE RKEEKAEQQQ NNKMTMEPQL
MLTYGAPAPQ MGYPGAPAGY GGQPAYGQPG QPGFNAPGFM


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