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Claudin-5 (Brain endothelial cell clone 1 protein) (Lung-specific membrane protein)

 CLD5_MOUSE              Reviewed;         218 AA.
O54942; O88789;
30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
30-MAY-2000, sequence version 2.
20-JUN-2018, entry version 135.
RecName: Full=Claudin-5;
AltName: Full=Brain endothelial cell clone 1 protein;
AltName: Full=Lung-specific membrane protein;
Name=Cldn5; Synonyms=Bec1;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Brain;
PubMed=9520948;
Chen Z., Zandonatti M., Jakubowski D., Fox H.S.;
"Brain capillary endothelial cells express MBEC1, a protein that is
related to the Clostridium perfringens enterotoxin receptors.";
Lab. Invest. 78:353-363(1998).
[2]
NUCLEOTIDE SEQUENCE [MRNA].
Kim K.K., Baek D.H., Kwon B.S.;
"A mouse lung-specific membrane protein.";
Submitted (DEC-1996) to the EMBL/GenBank/DDBJ databases.
[3]
NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, AND TISSUE
SPECIFICITY.
PubMed=9892664; DOI=10.1073/pnas.96.2.511;
Morita K., Furuse M., Fujimoto K., Tsukita S.;
"Claudin multigene family encoding four-transmembrane domain protein
components of tight junction strands.";
Proc. Natl. Acad. Sci. U.S.A. 96:511-516(1999).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=C57BL/6J; TISSUE=Ovary, and Uterus;
PubMed=16141072; DOI=10.1126/science.1112014;
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M.,
Davis M.J., Wilming L.G., Aidinis V., Allen J.E.,
Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L.,
Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M.,
Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R.,
Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G.,
di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G.,
Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M.,
Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N.,
Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T.,
Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H.,
Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K.,
Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J.,
Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L.,
Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K.,
Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P.,
Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O.,
Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G.,
Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M.,
Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B.,
Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K.,
Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A.,
Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K.,
Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C.,
Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J.,
Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y.,
Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T.,
Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N.,
Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N.,
Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S.,
Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J.,
Hayashizaki Y.;
"The transcriptional landscape of the mammalian genome.";
Science 309:1559-1563(2005).
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=C57BL/6J; TISSUE=Brain, and Mammary tumor;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[6]
INTERACTION WITH TJP1; TJP2 AND TJP3.
PubMed=10601346; DOI=10.1083/jcb.147.6.1351;
Itoh M., Furuse M., Morita K., Kubota K., Saitou M., Tsukita S.;
"Direct binding of three tight junction-associated MAGUKs, ZO-1, ZO-2,
and ZO-3, with the COOH termini of claudins.";
J. Cell Biol. 147:1351-1363(1999).
[7]
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Lung;
PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
"A tissue-specific atlas of mouse protein phosphorylation and
expression.";
Cell 143:1174-1189(2010).
-!- FUNCTION: Plays a major role in tight junction-specific
obliteration of the intercellular space, through calcium-
independent cell-adhesion activity. {ECO:0000250}.
-!- SUBUNIT: Interacts with MPDZ (By similarity). Directly interacts
with TJP1/ZO-1, TJP2/ZO-2 and TJP3/ZO-3. {ECO:0000250,
ECO:0000269|PubMed:10601346}.
-!- SUBCELLULAR LOCATION: Cell junction, tight junction
{ECO:0000269|PubMed:9892664}. Cell membrane
{ECO:0000269|PubMed:9892664}; Multi-pass membrane protein
{ECO:0000269|PubMed:9892664}.
-!- TISSUE SPECIFICITY: Widely expressed with highest levels in the
lung. {ECO:0000269|PubMed:9892664}.
-!- SIMILARITY: Belongs to the claudin family. {ECO:0000305}.
-----------------------------------------------------------------------
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EMBL; AF035814; AAB96653.1; -; mRNA.
EMBL; U82758; AAC27545.1; -; mRNA.
EMBL; AF087823; AAD09758.1; -; mRNA.
EMBL; AK077282; BAC36728.1; -; mRNA.
EMBL; BC002016; AAH02016.1; -; mRNA.
EMBL; BC083341; AAH83341.1; -; mRNA.
CCDS; CCDS28026.1; -.
RefSeq; NP_038833.2; NM_013805.4.
UniGene; Mm.22768; -.
ProteinModelPortal; O54942; -.
SMR; O54942; -.
MINT; O54942; -.
STRING; 10090.ENSMUSP00000041925; -.
iPTMnet; O54942; -.
PhosphoSitePlus; O54942; -.
MaxQB; O54942; -.
PaxDb; O54942; -.
PRIDE; O54942; -.
Ensembl; ENSMUST00000043577; ENSMUSP00000041925; ENSMUSG00000041378.
GeneID; 12741; -.
KEGG; mmu:12741; -.
UCSC; uc007yok.2; mouse.
CTD; 7122; -.
MGI; MGI:1276112; Cldn5.
eggNOG; ENOG410IJT1; Eukaryota.
eggNOG; ENOG410Y9S8; LUCA.
GeneTree; ENSGT00760000118928; -.
HOGENOM; HOG000220937; -.
HOVERGEN; HBG000643; -.
InParanoid; O54942; -.
KO; K06087; -.
OMA; CLVGWVG; -.
OrthoDB; EOG091G0MMR; -.
PhylomeDB; O54942; -.
TreeFam; TF331936; -.
PRO; PR:O54942; -.
Proteomes; UP000000589; Chromosome 16.
Bgee; ENSMUSG00000041378; -.
CleanEx; MM_CLDN5; -.
Genevisible; O54942; MM.
GO; GO:0016327; C:apicolateral plasma membrane; ISO:MGI.
GO; GO:0005923; C:bicellular tight junction; IDA:MGI.
GO; GO:0005911; C:cell-cell junction; ISO:MGI.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0016328; C:lateral plasma membrane; ISO:MGI.
GO; GO:0033270; C:paranode region of axon; ISO:MGI.
GO; GO:0005886; C:plasma membrane; IDA:CAFA.
GO; GO:0043220; C:Schmidt-Lanterman incisure; ISO:MGI.
GO; GO:0042802; F:identical protein binding; ISS:UniProtKB.
GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
GO; GO:0016338; P:calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules; ISS:UniProtKB.
GO; GO:0098609; P:cell-cell adhesion; IC:MGI.
GO; GO:0007043; P:cell-cell junction assembly; ISO:MGI.
GO; GO:0042552; P:myelination; ISO:MGI.
GO; GO:1903142; P:positive regulation of establishment of endothelial barrier; ISO:MGI.
GO; GO:0045471; P:response to ethanol; IEA:Ensembl.
GO; GO:0007179; P:transforming growth factor beta receptor signaling pathway; ISO:MGI.
InterPro; IPR006187; Claudin.
InterPro; IPR003551; Claudin5.
InterPro; IPR017974; Claudin_CS.
InterPro; IPR004031; PMP22/EMP/MP20/Claudin.
PANTHER; PTHR12002; PTHR12002; 1.
Pfam; PF00822; PMP22_Claudin; 1.
PRINTS; PR01380; CLAUDIN5.
PROSITE; PS01346; CLAUDIN; 1.
1: Evidence at protein level;
Cell junction; Cell membrane; Complete proteome; Membrane;
Reference proteome; Tight junction; Transmembrane;
Transmembrane helix.
CHAIN 1 218 Claudin-5.
/FTId=PRO_0000144746.
TOPO_DOM 1 7 Cytoplasmic. {ECO:0000255}.
TRANSMEM 8 28 Helical. {ECO:0000255}.
TOPO_DOM 29 81 Extracellular. {ECO:0000255}.
TRANSMEM 82 102 Helical. {ECO:0000255}.
TOPO_DOM 103 123 Cytoplasmic. {ECO:0000255}.
TRANSMEM 124 144 Helical. {ECO:0000255}.
TOPO_DOM 145 160 Extracellular. {ECO:0000255}.
TRANSMEM 161 181 Helical. {ECO:0000255}.
TOPO_DOM 182 218 Cytoplasmic. {ECO:0000255}.
REGION 217 218 Interactions with TJP1, TJP2 and TJP3.
{ECO:0000250}.
CONFLICT 58 58 S -> N (in Ref. 1; AAB96653).
{ECO:0000305}.
SEQUENCE 218 AA; 23054 MW; 8708F69AE282DE87 CRC64;
MGSAALEILG LVLCLVGWVG LILACGLPMW QVTAFLDHNI VTAQTTWKGL WMSCVVQSTG
HMQCKVYESV LALSAEVQAA RALTVGAVLL ALVALFVTLT GAQCTTCVAP GPVKARVALT
GGALYAVCGL LALVPLCWFA NIVVREFYDP TVPVSQKYEL GAALYIGWAA SALLMCGGGL
VCCGAWVCTG RPEFSFPVKY SAPRRPTANG DYDKKNYV


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