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Cleavage and polyadenylation specificity factor subunit 6 (Cleavage and polyadenylation specificity factor 68 kDa subunit) (CFIm68) (CPSF 68 kDa subunit) (Pre-mRNA cleavage factor Im 68 kDa subunit) (Protein HPBRII-4/7)

 CPSF6_HUMAN             Reviewed;         551 AA.
Q16630; A8K7K9; Q53ES1; Q9BSJ7; Q9BW18;
07-FEB-2006, integrated into UniProtKB/Swiss-Prot.
07-FEB-2006, sequence version 2.
25-OCT-2017, entry version 161.
RecName: Full=Cleavage and polyadenylation specificity factor subunit 6;
AltName: Full=Cleavage and polyadenylation specificity factor 68 kDa subunit;
Short=CFIm68;
Short=CPSF 68 kDa subunit;
AltName: Full=Pre-mRNA cleavage factor Im 68 kDa subunit;
AltName: Full=Protein HPBRII-4/7;
Name=CPSF6; Synonyms=CFIM68;
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
NCBI_TaxID=9606;
[1]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), PROTEIN SEQUENCE OF 125-138
AND 162-168, FUNCTION, IDENTIFICATION IN THE CLEAVAGE FACTOR IM
COMPLEX, AND SUBCELLULAR LOCATION.
TISSUE=Leukemia;
PubMed=9659921; DOI=10.1016/S1097-2765(00)80025-8;
Rueegsegger U., Blank D., Keller W.;
"Human pre-mRNA cleavage factor Im is related to spliceosomal SR
proteins and can be reconstituted in vitro from recombinant
subunits.";
Mol. Cell 1:243-253(1998).
[2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1).
TISSUE=Leukemia;
Fleischhauer K.L.;
Submitted (JUN-1995) to the EMBL/GenBank/DDBJ databases.
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
TISSUE=Spleen;
PubMed=14702039; DOI=10.1038/ng1285;
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
"Complete sequencing and characterization of 21,243 full-length human
cDNAs.";
Nat. Genet. 36:40-45(2004).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
TISSUE=Heart;
Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.;
Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
Venter J.C.;
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
[6]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
TISSUE=Kidney;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[7]
FUNCTION, AND IDENTIFICATION IN A CLEAVAGE FACTOR IM COMPLEX.
PubMed=8626397; DOI=10.1074/jbc.271.11.6107;
Rueegsegger U., Beyer K., Keller W.;
"Purification and characterization of human cleavage factor Im
involved in the 3' end processing of messenger RNA precursors.";
J. Biol. Chem. 271:6107-6113(1996).
[8]
FUNCTION.
PubMed=14690600; DOI=10.1016/S1097-2765(03)00453-2;
Brown K.M., Gilmartin G.M.;
"A mechanism for the regulation of pre-mRNA 3' processing by human
cleavage factor Im.";
Mol. Cell 12:1467-1476(2003).
[9]
IDENTIFICATION IN A CLEAVAGE FACTOR IM COMPLEX, INTERACTION WITH
NUDT21/CPSF5; SFRS3; SFRS7 AND TRA2B, RNA-BINDING, MUTAGENESIS OF
GLY-86 AND ASN-87, AND SUBCELLULAR LOCATION.
PubMed=15169763; DOI=10.1074/jbc.M403927200;
Dettwiler S., Aringhieri C., Cardinale S., Keller W., Barabino S.M.;
"Distinct sequence motifs within the 68-kDa subunit of cleavage factor
Im mediate RNA binding, protein-protein interactions, and subcellular
localization.";
J. Biol. Chem. 279:35788-35797(2004).
[10]
IDENTIFICATION IN A CLEAVAGE FACTOR IM COMPLEX, AND INTERACTION WITH
NUDT21/CPSF5 AND SNRNP70.
PubMed=14561889; DOI=10.1261/rna.5104603;
Awasthi S., Alwine J.C.;
"Association of polyadenylation cleavage factor I with U1 snRNP.";
RNA 9:1400-1409(2003).
[11]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-404, AND IDENTIFICATION
BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Cervix carcinoma;
PubMed=18220336; DOI=10.1021/pr0705441;
Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D.,
Yates J.R. III;
"Combining protein-based IMAC, peptide-based IMAC, and MudPIT for
efficient phosphoproteomic analysis.";
J. Proteome Res. 7:1346-1351(2008).
[12]
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Cervix carcinoma;
PubMed=18669648; DOI=10.1073/pnas.0805139105;
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
Elledge S.J., Gygi S.P.;
"A quantitative atlas of mitotic phosphorylation.";
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
[13]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-407, AND IDENTIFICATION
BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Leukemic T-cell;
PubMed=19690332; DOI=10.1126/scisignal.2000007;
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,
Rodionov V., Han D.K.;
"Quantitative phosphoproteomic analysis of T cell receptor signaling
reveals system-wide modulation of protein-protein interactions.";
Sci. Signal. 2:RA46-RA46(2009).
[14]
FUNCTION, SUBUNIT, AND SUBCELLULAR LOCATION.
PubMed=20695905; DOI=10.1111/j.1365-2443.2010.01436.x;
Kim S., Yamamoto J., Chen Y., Aida M., Wada T., Handa H.,
Yamaguchi Y.;
"Evidence that cleavage factor Im is a heterotetrameric protein
complex controlling alternative polyadenylation.";
Genes Cells 15:1003-1013(2010).
[15]
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
PubMed=21269460; DOI=10.1186/1752-0509-5-17;
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.;
"Initial characterization of the human central proteome.";
BMC Syst. Biol. 5:17-17(2011).
[16]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-404 AND THR-407, AND
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Cervix carcinoma, and Erythroleukemia;
PubMed=23186163; DOI=10.1021/pr300630k;
Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
Mohammed S.;
"Toward a comprehensive characterization of a human cancer cell
phosphoproteome.";
J. Proteome Res. 12:260-271(2013).
[17]
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Liver;
PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D.,
Wang L., Ye M., Zou H.;
"An enzyme assisted RP-RPLC approach for in-depth analysis of human
liver phosphoproteome.";
J. Proteomics 96:253-262(2014).
[18]
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
PubMed=25944712; DOI=10.1002/pmic.201400617;
Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M.,
Ayoub D., Lane L., Bairoch A., Van Dorsselaer A., Carapito C.;
"N-terminome analysis of the human mitochondrial proteome.";
Proteomics 15:2519-2524(2015).
[19]
X-RAY CRYSTALLOGRAPHY (2.9 ANGSTROMS) OF 13-235 IN COMPLEX WITH
NUDT21/CPSF5 AND RNA, FUNCTION, SUBUNIT, AND MUTAGENESIS OF TYR-84;
90-TRP-TRP-91; ASP-94; GLU-111; PHE-126 AND LEU-128.
PubMed=21295486; DOI=10.1016/j.str.2010.12.021;
Yang Q., Coseno M., Gilmartin G.M., Doublie S.;
"Crystal structure of a human cleavage factor CFI(m)25/CFI(m)68/RNA
complex provides an insight into poly(A) site recognition and RNA
looping.";
Structure 19:368-377(2011).
-!- FUNCTION: Component of the cleavage factor Im complex (CFIm) that
plays a key role in pre-mRNA 3'-processing. Involved in
association with NUDT21/CPSF5 in pre-MRNA 3'-end poly(A) site
cleavage and poly(A) addition. CPSF6 binds to cleavage and
polyadenylation RNA substrates and promotes RNA looping.
{ECO:0000269|PubMed:14690600, ECO:0000269|PubMed:20695905,
ECO:0000269|PubMed:21295486, ECO:0000269|PubMed:8626397,
ECO:0000269|PubMed:9659921}.
-!- SUBUNIT: Component of the cleavage factor Im (CFIm) complex,
composed at least of NUDT21/CPSF5 and CPSF6 or CPSF7. Within the
cleavage factor Im complex, the NUDT21/CPSF5 homodimer is at the
core of a heterotetramer, and is clasped by two additional
subunits (CPSF6 or CPSF7). Interacts with NUDT21/CPSF5, SFRS3,
SFRS7, SNRNP70 and TRA2B/SFRS10. {ECO:0000269|PubMed:14561889,
ECO:0000269|PubMed:15169763, ECO:0000269|PubMed:20695905,
ECO:0000269|PubMed:21295486, ECO:0000269|PubMed:8626397,
ECO:0000269|PubMed:9659921}.
-!- INTERACTION:
Q9H6L4:ARMC7; NbExp=4; IntAct=EBI-358410, EBI-742909;
O43809:NUDT21; NbExp=5; IntAct=EBI-358410, EBI-355720;
Q96DC9:OTUB2; NbExp=3; IntAct=EBI-358410, EBI-746259;
O15162:PLSCR1; NbExp=2; IntAct=EBI-358410, EBI-740019;
Q9Y3C6:PPIL1; NbExp=3; IntAct=EBI-358410, EBI-2557649;
Q6FIE9:TOLLIP; NbExp=3; IntAct=EBI-358410, EBI-10249783;
Q9H0M0:WWP1; NbExp=3; IntAct=EBI-358410, EBI-742157;
-!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:15169763,
ECO:0000269|PubMed:20695905, ECO:0000269|PubMed:9659921}. Note=In
punctate subnuclear structures localized adjacent to nuclear
speckles, called paraspeckles.
-!- ALTERNATIVE PRODUCTS:
Event=Alternative splicing; Named isoforms=3;
Name=1;
IsoId=Q16630-1; Sequence=Displayed;
Name=2;
IsoId=Q16630-2; Sequence=VSP_017192;
Name=3;
IsoId=Q16630-3; Sequence=VSP_017191;
-!- SIMILARITY: Belongs to the RRM CPSF6/7 family. {ECO:0000305}.
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EMBL; X67336; CAA47751.1; -; Genomic_DNA.
EMBL; X67337; CAA47752.1; -; mRNA.
EMBL; AK223568; BAD97288.1; -; mRNA.
EMBL; AK292024; BAF84713.1; -; mRNA.
EMBL; CH471054; EAW97215.1; -; Genomic_DNA.
EMBL; BC000714; AAH00714.1; -; mRNA.
EMBL; BC005000; AAH05000.1; -; mRNA.
CCDS; CCDS73494.1; -. [Q16630-2]
CCDS; CCDS8988.1; -. [Q16630-1]
PIR; S57447; S57447.
RefSeq; NP_001287876.1; NM_001300947.1. [Q16630-2]
RefSeq; NP_008938.2; NM_007007.2. [Q16630-1]
UniGene; Hs.369606; -.
PDB; 3P5T; X-ray; 2.70 A; L/M/N/O/P/Q=80-161.
PDB; 3P6Y; X-ray; 2.90 A; C/D/G/H/K/L/O/P=80-161.
PDB; 3Q2S; X-ray; 2.90 A; C/D=13-235.
PDB; 3Q2T; X-ray; 3.06 A; C/D=13-235.
PDB; 4B4N; X-ray; 1.81 A; B=276-290.
PDB; 4U0A; X-ray; 2.05 A; B=276-290.
PDB; 4U0B; X-ray; 2.80 A; M/N/O/P/Q/R/S/T/U/V/W/X=276-290.
PDB; 4WYM; X-ray; 2.60 A; M/N/O/P/Q/R/S/T/U/V/W=276-290.
PDBsum; 3P5T; -.
PDBsum; 3P6Y; -.
PDBsum; 3Q2S; -.
PDBsum; 3Q2T; -.
PDBsum; 4B4N; -.
PDBsum; 4U0A; -.
PDBsum; 4U0B; -.
PDBsum; 4WYM; -.
ProteinModelPortal; Q16630; -.
SMR; Q16630; -.
BioGrid; 116238; 94.
CORUM; Q16630; -.
DIP; DIP-34501N; -.
IntAct; Q16630; 42.
MINT; MINT-1153789; -.
STRING; 9606.ENSP00000391774; -.
iPTMnet; Q16630; -.
PhosphoSitePlus; Q16630; -.
SwissPalm; Q16630; -.
BioMuta; CPSF6; -.
DMDM; 88909266; -.
EPD; Q16630; -.
MaxQB; Q16630; -.
PaxDb; Q16630; -.
PeptideAtlas; Q16630; -.
PRIDE; Q16630; -.
DNASU; 11052; -.
Ensembl; ENST00000266679; ENSP00000266679; ENSG00000111605. [Q16630-2]
Ensembl; ENST00000435070; ENSP00000391774; ENSG00000111605. [Q16630-1]
GeneID; 11052; -.
KEGG; hsa:11052; -.
UCSC; uc001sut.4; human. [Q16630-1]
CTD; 11052; -.
DisGeNET; 11052; -.
EuPathDB; HostDB:ENSG00000111605.16; -.
GeneCards; CPSF6; -.
HGNC; HGNC:13871; CPSF6.
HPA; HPA039973; -.
MIM; 604979; gene.
neXtProt; NX_Q16630; -.
OpenTargets; ENSG00000111605; -.
PharmGKB; PA26846; -.
eggNOG; KOG4849; Eukaryota.
eggNOG; ENOG410Y0H0; LUCA.
GeneTree; ENSGT00730000110905; -.
HOGENOM; HOG000111137; -.
InParanoid; Q16630; -.
KO; K14398; -.
OMA; VMSRNRT; -.
OrthoDB; EOG091G0CVC; -.
PhylomeDB; Q16630; -.
TreeFam; TF316430; -.
Reactome; R-HSA-1839117; Signaling by cytosolic FGFR1 fusion mutants.
Reactome; R-HSA-5655302; Signaling by FGFR1 in disease.
ChiTaRS; CPSF6; human.
GeneWiki; CPSF6; -.
GenomeRNAi; 11052; -.
PRO; PR:Q16630; -.
Proteomes; UP000005640; Chromosome 12.
Bgee; ENSG00000111605; -.
CleanEx; HS_CPSF6; -.
ExpressionAtlas; Q16630; baseline and differential.
Genevisible; Q16630; HS.
GO; GO:0030529; C:intracellular ribonucleoprotein complex; IDA:MGI.
GO; GO:0016020; C:membrane; IDA:UniProtKB.
GO; GO:0005849; C:mRNA cleavage factor complex; IDA:UniProtKB.
GO; GO:0016607; C:nuclear speck; IDA:HPA.
GO; GO:0005654; C:nucleoplasm; IDA:HPA.
GO; GO:0005634; C:nucleus; IDA:UniProtKB.
GO; GO:0042382; C:paraspeckles; IDA:UniProtKB.
GO; GO:0003729; F:mRNA binding; IDA:UniProtKB.
GO; GO:0003723; F:RNA binding; IDA:UniProtKB.
GO; GO:0006378; P:mRNA polyadenylation; IMP:UniProtKB.
GO; GO:0006397; P:mRNA processing; IDA:UniProtKB.
GO; GO:0051262; P:protein tetramerization; IDA:UniProtKB.
InterPro; IPR034769; CPSF6.
InterPro; IPR034772; CPSF6/7.
InterPro; IPR035979; RBD_domain_sf.
InterPro; IPR000504; RRM_dom.
PANTHER; PTHR23204; PTHR23204; 1.
PANTHER; PTHR23204:SF3; PTHR23204:SF3; 1.
Pfam; PF00076; RRM_1; 1.
SMART; SM00360; RRM; 1.
SUPFAM; SSF54928; SSF54928; 1.
PROSITE; PS50102; RRM; 1.
1: Evidence at protein level;
3D-structure; Alternative splicing; Complete proteome;
Direct protein sequencing; mRNA processing; Nucleus; Phosphoprotein;
Reference proteome; RNA-binding.
CHAIN 1 551 Cleavage and polyadenylation specificity
factor subunit 6.
/FTId=PRO_0000081521.
DOMAIN 81 161 RRM. {ECO:0000255|PROSITE-
ProRule:PRU00176}.
REGION 81 161 Necessary for interaction with
NUDT21/CPSF5.
REGION 510 551 Sufficient for nuclear targeting.
COMPBIAS 208 398 Pro-rich.
COMPBIAS 490 551 Arg-rich.
MOD_RES 404 404 Phosphothreonine.
{ECO:0000244|PubMed:18220336,
ECO:0000244|PubMed:23186163}.
MOD_RES 407 407 Phosphothreonine.
{ECO:0000244|PubMed:19690332,
ECO:0000244|PubMed:23186163}.
VAR_SEQ 188 260 Missing (in isoform 3).
{ECO:0000303|PubMed:15489334}.
/FTId=VSP_017191.
VAR_SEQ 231 231 P -> PGNLIKHLVKGTRPLFLETRIPWHMGHSIEEIPIFG
LK (in isoform 2).
{ECO:0000303|PubMed:15489334}.
/FTId=VSP_017192.
MUTAGEN 84 84 Y->A: Reduces affinity for UGUA RNA by
40%; when associated with A-128.
{ECO:0000269|PubMed:21295486}.
MUTAGEN 86 86 G->V: Abolishes interaction with
NUDT21/CPSF5; when associated with V-87.
{ECO:0000269|PubMed:15169763}.
MUTAGEN 87 87 N->V: Abolishes interaction with
NUDT21/CPSF5; when associated with V-86.
{ECO:0000269|PubMed:15169763}.
MUTAGEN 90 91 WW->AA: Reduces affinity for UGUA RNA by
70%. Strongly reduced affinity for UGUA
RNA; when associated with A-94.
{ECO:0000269|PubMed:21295486}.
MUTAGEN 94 94 D->A: Strongly reduced affinity for UGUA
RNA; when associated with 90-A-A-91.
{ECO:0000269|PubMed:21295486}.
MUTAGEN 111 111 E->A: Reduces affinity for UGUA RNA by
85%. {ECO:0000269|PubMed:21295486}.
MUTAGEN 126 126 F->A: Increases affinity for UGUA RNA by
40%. {ECO:0000269|PubMed:21295486}.
MUTAGEN 128 128 L->A: Reduces affinity for UGUA RNA by
40%; when associated with A-84.
{ECO:0000269|PubMed:21295486}.
CONFLICT 9 9 D -> N (in Ref. 2; CAA47751/CAA47752).
{ECO:0000305}.
STRAND 84 87 {ECO:0000244|PDB:3P5T}.
HELIX 94 102 {ECO:0000244|PDB:3P5T}.
TURN 103 105 {ECO:0000244|PDB:3P5T}.
STRAND 112 116 {ECO:0000244|PDB:3P5T}.
TURN 118 120 {ECO:0000244|PDB:3P5T}.
STRAND 123 129 {ECO:0000244|PDB:3P5T}.
HELIX 134 143 {ECO:0000244|PDB:3P5T}.
HELIX 144 146 {ECO:0000244|PDB:3P5T}.
STRAND 149 151 {ECO:0000244|PDB:3P5T}.
STRAND 155 158 {ECO:0000244|PDB:3P6Y}.
HELIX 161 170 {ECO:0000244|PDB:3Q2S}.
SEQUENCE 551 AA; 59210 MW; 721A5DA1B456AA79 CRC64;
MADGVDHIDI YADVGEEFNQ EAEYGGHDQI DLYDDVISPS ANNGDAPEDR DYMDTLPPTV
GDDVGKGAAP NVVYTYTGKR IALYIGNLTW WTTDEDLTEA VHSLGVNDIL EIKFFENRAN
GQSKGFALVG VGSEASSKKL MDLLPKRELH GQNPVVTPCN KQFLSQFEMQ SRKTTQSGQM
SGEGKAGPPG GSSRAAFPQG GRGRGRFPGA VPGGDRFPGP AGPGGPPPPF PAGQTPPRPP
LGPPGPPGPP GPPPPGQVLP PPLAGPPNRG DRPPPPVLFP GQPFGQPPLG PLPPGPPPPV
PGYGPPPGPP PPQQGPPPPP GPFPPRPPGP LGPPLTLAPP PHLPGPPPGA PPPAPHVNPA
FFPPPTNSGM PTSDSRGPPP TDPYGRPPPY DRGDYGPPGR EMDTARTPLS EAEFEEIMNR
NRAISSSAIS RAVSDASAGD YGSAIETLVT AISLIKQSKV SADDRCKVLI SSLQDCLHGI
ESKSYGSGSR RERSRERDHS RSREKSRRHK SRSRDRHDDY YRERSRERER HRDRDRDRDR
ERDREREYRH R


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Catalog number Product name Quantity
EIAAB09123 CFIm68,CFIM68,Cleavage and polyadenylation specificity factor 68 kDa subunit,Cleavage and polyadenylation specificity factor subunit 6,CPSF 68 kDa subunit,CPSF6,Homo sapiens,Human,Pre-mRNA cleavage fa
EIAAB09127 CFIm59,Cleavage and polyadenylation specificity factor 59 kDa subunit,Cleavage and polyadenylation specificity factor subunit 7,CPSF 59 kDa subunit,CPSF7,Homo sapiens,Human,Pre-mRNA cleavage factor Im
EIAAB09112 Cleavage and polyadenylation specificity factor 73 kDa subunit,Cleavage and polyadenylation specificity factor subunit 3,CPSF 73 kDa subunit,CPSF3,CPSF73,Homo sapiens,Human,mRNA 3'-end-processing endo
EIAAB09110 Bos taurus,Bovine,Cleavage and polyadenylation specificity factor 73 kDa subunit,Cleavage and polyadenylation specificity factor subunit 3,CPSF 73 kDa subunit,CPSF3,CPSF73,mRNA 3'-end-processing endon
EIAAB09111 Cleavage and polyadenylation specificity factor 73 kDa subunit,Cleavage and polyadenylation specificity factor subunit 3,CPSF 73 kDa subunit,Cpsf3,Cpsf73,Mouse,mRNA 3'-end-processing endonuclease CPSF
18-003-43627 Cleavage and polyadenylation specificity factor subunit 6 - Cleavage and polyadenylation specificity factor 68 kDa subunit; CPSF 68 kDa subunit; Pre-mRNA cleavage factor Im 68 kDa subunit; Protein HPB 0.1 mg Protein A
18-003-43657 Cleavage and polyadenylation specificity factor subunit 7 - Cleavage and polyadenylation specificity factor 59 kDa subunit; CPSF 59 kDa subunit; Pre-mRNA cleavage factor Im 59 kDa subunit Polyclonal 0.1 mg Protein A
18-003-43626 Cleavage and polyadenylation specificity factor subunit 5 - Cleavage and polyadenylation specificity factor 25 kDa subunit; CPSF 25 kDa subunit; Pre-mRNA cleavage factor Im 25 kDa subunit; Nucleoside 0.1 mg Protein A
EIAAB09115 Cleavage and polyadenylation specificity factor 30 kDa subunit,Cleavage and polyadenylation specificity factor subunit 4,CPSF 30 kDa subunit,CPSF30,CPSF4,Homo sapiens,Human,NAR,NEB1,Neb-1,No arches ho
18-003-44209 Cleavage and polyadenylation specificity factor subunit 4 - Cleavage and polyadenylation specificity factor 30 kDa subunit; CPSF 30 kDa subunit; NS1 effector domain-binding protein 1; Neb-1; No arches 0.05 mg Aff Pur
EIAAB09116 Cleavage and polyadenylation specificity factor 30 kDa subunit,Cleavage and polyadenylation specificity factor subunit 4,Clipper homolog,Clipper_CPSF 30K,CPSF 30 kDa subunit,Cpsf30,Cpsf4,Mouse,Mus mus
EIAAB09107 Cleavage and polyadenylation specificity factor 100 kDa subunit,Cleavage and polyadenylation specificity factor subunit 2,CPSF 100 kDa subunit,CPSF100,CPSF2,Homo sapiens,Human,KIAA1367
EIAAB09109 Cleavage and polyadenylation specificity factor 100 kDa subunit,Cleavage and polyadenylation specificity factor subunit 2,CPSF 100 kDa subunit,Cpsf100,Cpsf2,Mcpsf,Mouse,Mus musculus
EIAAB09106 Cleavage and polyadenylation specificity factor 160 kDa subunit,Cleavage and polyadenylation specificity factor subunit 1,CPSF 160 kDa subunit,CPSF1,CPSF160,Homo sapiens,Human
20-372-60192 cleavage and polyadenylation specific factor 4. 30kDa (CPSF4). mRNA - Mouse monoclonal anti-human CPSF4 antibody; Cleavage and polyadenylation specificity factor 30 kDa subunit; CPSF 30 kDa subunit; N 0.1 mg
EIAAB09104 Cleavage and polyadenylation specificity factor 160 kDa subunit,Cleavage and polyadenylation specificity factor subunit 1,CPSF 160 kDa subunit,Cpsf1,Cpsf160,Mouse,Mus musculus
EIAAB09105 Bos taurus,Bovine,Cleavage and polyadenylation specificity factor 160 kDa subunit,Cleavage and polyadenylation specificity factor subunit 1,CPSF 160 kDa subunit,CPSF1,CPSF160
EIAAB09114 Bos taurus,Bovine,Cleavage and polyadenylation specificity factor 30 kDa subunit,Cleavage and polyadenylation specificity factor subunit 4,CPSF 30 kDa subunit,CPSF30,CPSF4
EIAAB09108 Bos taurus,Bovine,Cleavage and polyadenylation specificity factor 100 kDa subunit,Cleavage and polyadenylation specificity factor subunit 2,CPSF 100 kDa subunit,CPSF100,CPSF2
EIAAB09120 CFIm25,CFIM25,Cleavage and polyadenylation specificity factor 25 kDa subunit,Cleavage and polyadenylation specificity factor subunit 5,CPSF 25 kDa subunit,CPSF25,CPSF5,Homo sapiens,Human,Nucleoside di
EIAAB09113 Cleavage and polyadenylation specificity factor 30 kDa subunit,Cleavage and polyadenylation specificity factor subunit 4,CPSF 30 kDa subunit,Cpsf4,Rat,Rattus norvegicus
20-372-60265 nudix (nucleoside diphosphate linked moiety X)-type motif 21 (NUDT21). mRNA - Mouse monoclonal anti-human NUDT21 antibody; Cleavage and polyadenylation specificity factor 25 kDa subunit; CPSF 25 kDa s 0.1 mg
29-398 NUDT21 is one subunit of a cleavage factor required for 3' RNA cleavage and polyadenylation processing. The interaction of the protein with the RNA is one of the earliest steps in the assembly of the 0.1 mg
29-399 CPSF6 is one subunit of a cleavage factor required for 3' RNA cleavage and polyadenylation processing. The interaction of the protein with the RNA is one of the earliest steps in the assembly of the 3 0.1 mg
CPSF4_RAT Rat ELISA Kit FOR Cleavage and polyadenylation specificity factor subunit 4 96T


 

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