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Cleavage stimulating factor 64 (AtCstF-64) (AtCstF64) (CF-1 64 kDa subunit) (Cleavage stimulation factor 64 kDa subunit) (CSTF 64 kDa subunit) (Protein ENHANCED SILENCING PHENOTYPE 1) (Protein SUPPRESSORS OF OVEREXPRESSED FCA 19) (SOF19)

 CTF64_ARATH             Reviewed;         461 AA.
Q9M9G6; Q8LKG6;
26-NOV-2014, integrated into UniProtKB/Swiss-Prot.
01-OCT-2000, sequence version 1.
25-OCT-2017, entry version 131.
RecName: Full=Cleavage stimulating factor 64 {ECO:0000303|PubMed:12379796};
Short=AtCstF-64 {ECO:0000303|PubMed:12379796};
Short=AtCstF64 {ECO:0000303|PubMed:16282318};
AltName: Full=CF-1 64 kDa subunit {ECO:0000305};
AltName: Full=Cleavage stimulation factor 64 kDa subunit {ECO:0000305};
Short=CSTF 64 kDa subunit {ECO:0000305};
AltName: Full=Protein ENHANCED SILENCING PHENOTYPE 1 {ECO:0000303|PubMed:17008405};
AltName: Full=Protein SUPPRESSORS OF OVEREXPRESSED FCA 19 {ECO:0000303|PubMed:19965720};
Short=SOF19 {ECO:0000303|PubMed:19965720};
Name=CSTF64 {ECO:0000303|PubMed:12379796};
Synonyms=ESP1 {ECO:0000303|PubMed:17008405};
OrderedLocusNames=At1g71800 {ECO:0000312|Araport:AT1G71800};
ORFNames=F14O23.18 {ECO:0000312|EMBL:AAF43233.1};
Arabidopsis thaliana (Mouse-ear cress).
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
Spermatophyta; Magnoliophyta; eudicotyledons; Gunneridae;
Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae;
Arabidopsis.
NCBI_TaxID=3702 {ECO:0000312|Proteomes:UP000006548};
[1]
NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND INTERACTION WITH CSTF77 AND
MRNA.
STRAIN=cv. Columbia;
PubMed=12379796; DOI=10.1093/jxb/erf073;
Yao Y., Song L., Katz Y., Galili G.;
"Cloning and characterization of Arabidopsis homologues of the animal
CstF complex that regulates 3' mRNA cleavage and polyadenylation.";
J. Exp. Bot. 53:2277-2278(2002).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=cv. Columbia;
PubMed=11130712; DOI=10.1038/35048500;
Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S.,
White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y.,
Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W.,
Chung M.K., Conn L., Conway A.B., Conway A.R., Creasy T.H., Dewar K.,
Dunn P., Etgu P., Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y.,
Gill J.E., Goldsmith A.D., Haas B., Hansen N.F., Hughes B., Huizar L.,
Hunter J.L., Jenkins J., Johnson-Hopson C., Khan S., Khaykin E.,
Kim C.J., Koo H.L., Kremenetskaia I., Kurtz D.B., Kwan A., Lam B.,
Langin-Hooper S., Lee A., Lee J.M., Lenz C.A., Li J.H., Li Y.-P.,
Lin X., Liu S.X., Liu Z.A., Luros J.S., Maiti R., Marziali A.,
Militscher J., Miranda M., Nguyen M., Nierman W.C., Osborne B.I.,
Pai G., Peterson J., Pham P.K., Rizzo M., Rooney T., Rowley D.,
Sakano H., Salzberg S.L., Schwartz J.R., Shinn P., Southwick A.M.,
Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M.,
Wu D., Yu G., Fraser C.M., Venter J.C., Davis R.W.;
"Sequence and analysis of chromosome 1 of the plant Arabidopsis
thaliana.";
Nature 408:816-820(2000).
[3]
GENOME REANNOTATION.
STRAIN=cv. Columbia;
The Arabidopsis Information Portal (Araport);
Submitted (MAY-2016) to the EMBL/GenBank/DDBJ databases.
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=cv. Columbia;
Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A.,
Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y.,
Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.,
Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J.,
Hayashizaki Y., Shinozaki K.;
"Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs.";
Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases.
[5]
GENE FAMILY.
PubMed=16282318; DOI=10.1074/jbc.M510964200;
Forbes K.P., Addepalli B., Hunt A.G.;
"An Arabidopsis Fip1 homolog interacts with RNA and provides
conceptual links with a number of other polyadenylation factor
subunits.";
J. Biol. Chem. 281:176-186(2006).
[6]
FUNCTION, AND DISRUPTION PHENOTYPE.
PubMed=17008405; DOI=10.1073/pnas.0606536103;
Herr A.J., Molnar A., Jones A., Baulcombe D.C.;
"Defective RNA processing enhances RNA silencing and influences
flowering of Arabidopsis.";
Proc. Natl. Acad. Sci. U.S.A. 103:14994-15001(2006).
[7]
INTERACTION WITH CSTF50; CSTF77; FIPS3 AND FIPS5, GENE FAMILY, AND
NOMENCLATURE.
PubMed=18479511; DOI=10.1186/1471-2164-9-220;
Hunt A.G., Xu R., Addepalli B., Rao S., Forbes K.P., Meeks L.R.,
Xing D., Mo M., Zhao H., Bandyopadhyay A., Dampanaboina L., Marion A.,
Von Lanken C., Li Q.Q.;
"Arabidopsis mRNA polyadenylation machinery: comprehensive analysis of
protein-protein interactions and gene expression profiling.";
BMC Genomics 9:220-220(2008).
[8]
INTERACTION WITH CSTF77.
PubMed=18221017; DOI=10.2174/092986608783330431;
Addepalli B., Hunt A.G.;
"The interaction between two Arabidopsis polyadenylation factor
subunits involves an evolutionarily-conserved motif and has
implications for the assembly and function of the polyadenylation
complex.";
Protein Pept. Lett. 15:76-88(2008).
[9]
FUNCTION, AND DISRUPTION PHENOTYPE.
STRAIN=cv. Columbia;
PubMed=19965720; DOI=10.1126/science.1180278;
Liu F., Marquardt S., Lister C., Swiezewski S., Dean C.;
"Targeted 3' processing of antisense transcripts triggers Arabidopsis
FLC chromatin silencing.";
Science 327:94-97(2010).
-!- FUNCTION: One of the multiple factors required for polyadenylation
and 3'-end cleavage of pre-mRNAs (By similarity). This subunit is
directly involved in the binding to pre-mRNAs, especially on the
3' non-coding region (PubMed:12379796). Required for the targeted
3' processing of antisense transcripts that triggers
transcriptional silencing of the corresponding sense gene
(PubMed:17008405, PubMed:19965720). {ECO:0000250|UniProtKB:Q8C7E9,
ECO:0000269|PubMed:12379796, ECO:0000269|PubMed:17008405,
ECO:0000269|PubMed:19965720}.
-!- SUBUNIT: Belongs to the CSTF complex (By similarity). Binds to
mRNA. Forms a complex with cleavage and polyadenylation
specificity factor (CPSF) subunits CSTF50, CSTF77, FIPS3 and FIPS5
(PubMed:12379796, PubMed:18479511, PubMed:18221017).
{ECO:0000250|UniProtKB:P33240, ECO:0000269|PubMed:12379796,
ECO:0000269|PubMed:18221017, ECO:0000269|PubMed:18479511}.
-!- INTERACTION:
Q8GUP1:CSTF77; NbExp=3; IntAct=EBI-1775671, EBI-1775543;
-!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P33240}.
-!- DISRUPTION PHENOTYPE: Impaired antisense-RNA-mediated gene
silencing (e.g. suppression of overexpression of FCA-mediated FLC
repression). Reduced fertility, early flowering, reduced organ
size and pale leaves. {ECO:0000269|PubMed:17008405,
ECO:0000269|PubMed:19965720}.
-----------------------------------------------------------------------
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EMBL; AF515695; AAM64164.1; -; mRNA.
EMBL; AC012654; AAF43233.1; -; Genomic_DNA.
EMBL; CP002684; AEE35234.1; -; Genomic_DNA.
EMBL; AK229116; BAF00992.1; -; mRNA.
PIR; E96740; E96740.
RefSeq; NP_177325.2; NM_105838.5.
UniGene; At.12026; -.
UniGene; At.22646; -.
ProteinModelPortal; Q9M9G6; -.
SMR; Q9M9G6; -.
BioGrid; 28730; 5.
IntAct; Q9M9G6; 5.
STRING; 3702.AT1G71800.1; -.
PaxDb; Q9M9G6; -.
EnsemblPlants; AT1G71800.1; AT1G71800.1; AT1G71800.
GeneID; 843510; -.
Gramene; AT1G71800.1; AT1G71800.1; AT1G71800.
KEGG; ath:AT1G71800; -.
Araport; AT1G71800; -.
TAIR; locus:2013016; AT1G71800.
eggNOG; KOG0108; Eukaryota.
eggNOG; ENOG410XQBV; LUCA.
HOGENOM; HOG000214372; -.
InParanoid; Q9M9G6; -.
KO; K14407; -.
OMA; HVGNIPY; -.
OrthoDB; EOG09360AEY; -.
PhylomeDB; Q9M9G6; -.
Reactome; R-ATH-72163; mRNA Splicing - Major Pathway.
Reactome; R-ATH-77595; Processing of Intronless Pre-mRNAs.
PRO; PR:Q9M9G6; -.
Proteomes; UP000006548; Chromosome 1.
Genevisible; Q9M9G6; AT.
GO; GO:0005847; C:mRNA cleavage and polyadenylation specificity factor complex; IBA:GO_Central.
GO; GO:0003729; F:mRNA binding; IDA:TAIR.
GO; GO:0042868; P:antisense RNA metabolic process; IMP:UniProtKB.
GO; GO:0048589; P:developmental growth; IMP:TAIR.
GO; GO:0031047; P:gene silencing by RNA; IMP:UniProtKB.
GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IMP:TAIR.
GO; GO:0098789; P:pre-mRNA cleavage required for polyadenylation; IBA:GO_Central.
GO; GO:0060968; P:regulation of gene silencing; IMP:UniProtKB.
GO; GO:0031123; P:RNA 3'-end processing; IMP:TAIR.
InterPro; IPR025742; CSTF2_hinge.
InterPro; IPR026896; CSTF_C.
InterPro; IPR035979; RBD_domain_sf.
InterPro; IPR000504; RRM_dom.
Pfam; PF14327; CSTF2_hinge; 1.
Pfam; PF14304; CSTF_C; 1.
Pfam; PF00076; RRM_1; 1.
SMART; SM00360; RRM; 1.
SUPFAM; SSF54928; SSF54928; 1.
PROSITE; PS50102; RRM; 1.
1: Evidence at protein level;
Complete proteome; mRNA processing; Nucleus; Reference proteome;
RNA-binding; RNA-mediated gene silencing.
CHAIN 1 461 Cleavage stimulating factor 64.
/FTId=PRO_0000431323.
DOMAIN 9 87 RRM. {ECO:0000255|PROSITE-
ProRule:PRU00176}.
COMPBIAS 224 459 Gln-rich. {ECO:0000255|PROSITE-
ProRule:PRU00006}.
CONFLICT 145 145 L -> I (in Ref. 1; AAM64164).
{ECO:0000305}.
SEQUENCE 461 AA; 50137 MW; C8D010D082AA8657 CRC64;
MASSSSQRRC VFVGNIPYDA TEEQLREICG EVGPVVSFRL VTDRETGKPK GYGFCEYKDE
ETALSARRNL QSYEINGRQL RVDFAENDKG TDKTRDQSQG GPGLPSTTTV TESQKQIGGP
VDSNMHQPVG LHLATTAASV IAGALGGPQV GSQFTQSNLQ VPASDPLALH LAKMSRSQLT
EIISSIKLMA TQNKEHARQL LVSRPQLLKA VFLAQVMLGI VSPQVLQSPN IVQAPSHMTG
SSIQDAQLSG QNLLPPLAQR SQQLSRAPHS QYPVQQSSKQ PFSQIPQLVA QPGPSSVNPP
PRSQVKVENA PFQRQQVVPA STNIGYSSQN SVPNNAIQPS QVPHQALPNS VMQQGGQTVS
LNFGKRINEG PPHQSMNRPS KMMKVEDRRT TSLPGGHVSN SMLPNQAQAP QTHISPDVQS
TLLQQVMNLT PEQLRLLTPE QQQEVLKLQQ ALKQDHMMQP S


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