Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

Coagulation factor X (EC 3.4.21.6) (Stuart factor) (Virus-activating protease) (VAP) [Cleaved into: Factor X light chain; Factor X heavy chain; Activated factor Xa heavy chain]

 FA10_CHICK              Reviewed;         475 AA.
P25155;
01-MAY-1992, integrated into UniProtKB/Swiss-Prot.
01-MAY-1992, sequence version 1.
28-MAR-2018, entry version 155.
RecName: Full=Coagulation factor X;
EC=3.4.21.6;
AltName: Full=Stuart factor;
AltName: Full=Virus-activating protease;
Short=VAP;
Contains:
RecName: Full=Factor X light chain;
Contains:
RecName: Full=Factor X heavy chain;
Contains:
RecName: Full=Activated factor Xa heavy chain;
Flags: Precursor;
Name=F10; Synonyms=FX;
Gallus gallus (Chicken).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes;
Phasianidae; Phasianinae; Gallus.
NCBI_TaxID=9031;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Chorioallantoic membrane;
PubMed=2044767; DOI=10.1016/0014-5793(91)80608-6;
Suzuki H., Harada A., Hayashi Y., Wada K., Asaka J., Gotoh B.,
Ogasawara T., Nagai Y.;
"Primary structure of the virus activating protease from chick embryo.
Its identity with the blood clotting factor Xa.";
FEBS Lett. 283:281-285(1991).
[2]
PROTEIN SEQUENCE OF 41-55 AND 241-261.
TISSUE=Allantoic fluid;
PubMed=2174359;
Gotoh B., Ogasawara T., Toyoda T., Inocencio N.M., Hamaguchi M.,
Nagai Y.;
"An endoprotease homologous to the blood clotting factor X as a
determinant of viral tropism in chick embryo.";
EMBO J. 9:4189-4195(1990).
-!- FUNCTION: Factor Xa is a vitamin K-dependent glycoprotein that
converts prothrombin to thrombin in the presence of factor Va,
calcium and phospholipid during blood clotting. VAP cleaves the
fusion proteins of Sendai virus, NDV, and influenza virus a at a
specific single arginine-containing site, and plays a key role in
the viral spreading in the allantoic sac.
-!- CATALYTIC ACTIVITY: Selective cleavage of Arg-|-Thr and then
Arg-|-Ile bonds in prothrombin to form thrombin.
-!- SUBUNIT: The two chains are formed from a single-chain precursor
by the excision of two Arg residues and are held together by 1 or
more disulfide bonds.
-!- SUBCELLULAR LOCATION: Secreted.
-!- TISSUE SPECIFICITY: Liver and chorioallantoic membrane.
-!- PTM: The vitamin K-dependent, enzymatic carboxylation of some
glutamate residues allows the modified protein to bind calcium.
-!- PTM: The activation peptide is cleaved by factor IXa (in the
intrinsic pathway), or by factor VIIa (in the extrinsic pathway).
-!- PTM: The iron and 2-oxoglutarate dependent 3-hydroxylation of
aspartate and asparagine is (R) stereospecific within EGF domains.
{ECO:0000250}.
-!- SIMILARITY: Belongs to the peptidase S1 family.
{ECO:0000255|PROSITE-ProRule:PRU00274}.
-----------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
Distributed under the Creative Commons Attribution (CC BY 4.0) License
-----------------------------------------------------------------------
EMBL; D00844; BAA00724.1; -; mRNA.
PIR; S15838; EXCH.
RefSeq; NP_990353.1; NM_205022.1.
UniGene; Gga.514; -.
ProteinModelPortal; P25155; -.
SMR; P25155; -.
MEROPS; S01.216; -.
Ensembl; ENSGALT00000044622; ENSGALP00000042191; ENSGALG00000026677.
GeneID; 395876; -.
KEGG; gga:395876; -.
CTD; 2159; -.
GeneTree; ENSGT00760000118890; -.
HOVERGEN; HBG013304; -.
InParanoid; P25155; -.
KO; K01314; -.
OMA; NFLKWID; -.
OrthoDB; EOG091G0AH5; -.
PhylomeDB; P25155; -.
Reactome; R-GGA-140834; Extrinsic Pathway of Fibrin Clot Formation.
Reactome; R-GGA-140837; Intrinsic Pathway of Fibrin Clot Formation.
Reactome; R-GGA-140875; Common Pathway of Fibrin Clot Formation.
Reactome; R-GGA-159763; Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus.
Reactome; R-GGA-159782; Removal of aminoterminal propeptides from gamma-carboxylated proteins.
PRO; PR:P25155; -.
Proteomes; UP000000539; Chromosome 1.
Bgee; ENSGALG00000026677; -.
GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
GO; GO:0005543; F:phospholipid binding; IEA:Ensembl.
GO; GO:0004252; F:serine-type endopeptidase activity; IEA:Ensembl.
GO; GO:0007596; P:blood coagulation; IEA:UniProtKB-KW.
GO; GO:0051897; P:positive regulation of protein kinase B signaling; IEA:Ensembl.
CDD; cd00190; Tryp_SPc; 1.
Gene3D; 4.10.740.10; -; 1.
InterPro; IPR017857; Coagulation_fac-like_Gla_dom.
InterPro; IPR001881; EGF-like_Ca-bd_dom.
InterPro; IPR013032; EGF-like_CS.
InterPro; IPR000742; EGF-like_dom.
InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
InterPro; IPR018097; EGF_Ca-bd_CS.
InterPro; IPR035972; GLA-like_dom_SF.
InterPro; IPR000294; GLA_domain.
InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
InterPro; IPR012224; Pept_S1A_FX.
InterPro; IPR009003; Peptidase_S1_PA.
InterPro; IPR001314; Peptidase_S1A.
InterPro; IPR001254; Trypsin_dom.
InterPro; IPR018114; TRYPSIN_HIS.
InterPro; IPR033116; TRYPSIN_SER.
Pfam; PF00008; EGF; 1.
Pfam; PF00594; Gla; 1.
Pfam; PF00089; Trypsin; 1.
PIRSF; PIRSF001143; Factor_X; 1.
PRINTS; PR00722; CHYMOTRYPSIN.
PRINTS; PR00001; GLABLOOD.
SMART; SM00181; EGF; 2.
SMART; SM00179; EGF_CA; 1.
SMART; SM00069; GLA; 1.
SMART; SM00020; Tryp_SPc; 1.
SUPFAM; SSF50494; SSF50494; 1.
SUPFAM; SSF57184; SSF57184; 1.
SUPFAM; SSF57630; SSF57630; 1.
PROSITE; PS00010; ASX_HYDROXYL; 1.
PROSITE; PS00022; EGF_1; 1.
PROSITE; PS01186; EGF_2; 2.
PROSITE; PS50026; EGF_3; 1.
PROSITE; PS01187; EGF_CA; 1.
PROSITE; PS00011; GLA_1; 1.
PROSITE; PS50998; GLA_2; 1.
PROSITE; PS50240; TRYPSIN_DOM; 1.
PROSITE; PS00134; TRYPSIN_HIS; 1.
PROSITE; PS00135; TRYPSIN_SER; 1.
1: Evidence at protein level;
Blood coagulation; Calcium; Cleavage on pair of basic residues;
Complete proteome; Direct protein sequencing; Disulfide bond;
EGF-like domain; Gamma-carboxyglutamic acid; Glycoprotein; Hemostasis;
Hydrolase; Hydroxylation; Protease; Reference proteome; Repeat;
Secreted; Serine protease; Signal; Zymogen.
SIGNAL 1 20 {ECO:0000255}.
PROPEP 21 40 {ECO:0000269|PubMed:2174359}.
/FTId=PRO_0000027810.
CHAIN 41 475 Coagulation factor X.
/FTId=PRO_0000027811.
CHAIN 41 180 Factor X light chain.
/FTId=PRO_0000027812.
CHAIN 186 475 Factor X heavy chain.
/FTId=PRO_0000027813.
PROPEP 186 240 Activation peptide.
{ECO:0000269|PubMed:2174359}.
/FTId=PRO_0000027814.
CHAIN 241 475 Activated factor Xa heavy chain.
/FTId=PRO_0000027815.
DOMAIN 41 85 Gla. {ECO:0000255|PROSITE-
ProRule:PRU00463}.
DOMAIN 86 122 EGF-like 1; calcium-binding.
{ECO:0000255|PROSITE-ProRule:PRU00076}.
DOMAIN 125 168 EGF-like 2. {ECO:0000255|PROSITE-
ProRule:PRU00076}.
DOMAIN 241 473 Peptidase S1. {ECO:0000255|PROSITE-
ProRule:PRU00274}.
ACT_SITE 282 282 Charge relay system. {ECO:0000250}.
ACT_SITE 328 328 Charge relay system. {ECO:0000250}.
ACT_SITE 425 425 Charge relay system. {ECO:0000250}.
MOD_RES 46 46 4-carboxyglutamate. {ECO:0000255|PROSITE-
ProRule:PRU00463}.
MOD_RES 47 47 4-carboxyglutamate. {ECO:0000255|PROSITE-
ProRule:PRU00463}.
MOD_RES 54 54 4-carboxyglutamate. {ECO:0000255|PROSITE-
ProRule:PRU00463}.
MOD_RES 56 56 4-carboxyglutamate. {ECO:0000255|PROSITE-
ProRule:PRU00463}.
MOD_RES 59 59 4-carboxyglutamate. {ECO:0000255|PROSITE-
ProRule:PRU00463}.
MOD_RES 60 60 4-carboxyglutamate. {ECO:0000255|PROSITE-
ProRule:PRU00463}.
MOD_RES 65 65 4-carboxyglutamate. {ECO:0000255|PROSITE-
ProRule:PRU00463}.
MOD_RES 66 66 4-carboxyglutamate. {ECO:0000255|PROSITE-
ProRule:PRU00463}.
MOD_RES 69 69 4-carboxyglutamate. {ECO:0000255|PROSITE-
ProRule:PRU00463}.
MOD_RES 72 72 4-carboxyglutamate. {ECO:0000255|PROSITE-
ProRule:PRU00463}.
MOD_RES 79 79 4-carboxyglutamate. {ECO:0000255|PROSITE-
ProRule:PRU00463}.
MOD_RES 103 103 (3R)-3-hydroxyaspartate. {ECO:0000250}.
CARBOHYD 196 196 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 207 207 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 228 228 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 285 285 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
DISULFID 57 62 {ECO:0000250}.
DISULFID 90 101 {ECO:0000250}.
DISULFID 95 110 {ECO:0000250}.
DISULFID 112 121 {ECO:0000250}.
DISULFID 129 140 {ECO:0000250}.
DISULFID 136 152 {ECO:0000250}.
DISULFID 154 167 {ECO:0000250}.
DISULFID 175 348 Interchain (between light and heavy
chains). {ECO:0000255|PROSITE-
ProRule:PRU00076, ECO:0000255|PROSITE-
ProRule:PRU00274, ECO:0000255|PROSITE-
ProRule:PRU00463}.
DISULFID 247 252 {ECO:0000250}.
DISULFID 267 283 {ECO:0000250}.
DISULFID 396 410 {ECO:0000250}.
DISULFID 421 449 {ECO:0000250}.
SEQUENCE 475 AA; 53142 MW; 570BF84956C5C74D CRC64;
MAGRLLLLLL CAALPDELRA EGGVFIKKES ADKFLERTKR ANSFLEEMKQ GNIERECNEE
RCSKEEAREA FEDNEKTEEF WNIYVDGDQC SSNPCHYGGQ CKDGLGSYTC SCLDGYQGKN
CEFVIPKYCK INNGDCEQFC SIKKSVQKDV VCSCTSGYEL AEDGKQCVSK VKYPCGKVLM
KRIKRSVILP TNSNTNATSD QDVPSTNGSI LEEVFTTTTE SPTPPPRNGS SITDPNVDTR
IVGGDECRPG ECPWQAVLIN EKGEEFCGGT ILNEDFILTA AHCINQSKEI KVVVGEVDRE
KEEHSETTHT AEKIFVHSKY IAETYDNDIA LIKLKEPIQF SEYVVPACLP QADFANEVLM
NQKSGMVSGF GREFEAGRLS KRLKVLEVPY VDRSTCKQST NFAITENMFC AGYETEQKDA
CQGDSGGPHV TRYKDTYFVT GIVSWGEGCA RKGKYGVYTK LSRFLRWVRT VMRQK


Related products :

Catalog number Product name Quantity
20-272-192177 Factor V Heavy Chain - Mouse monoclonal to Factor V Heavy Chain; Activated protein C cofactor Monoclonal 0.125 mg
20-272-192174 Factor XII heavy chain - Mouse monoclonal [B7C9] to Factor XII heavy chain; EC 3.4.21.38; Hageman factor; HAF Monoclonal 0.125 mg
U0676b CLIA Bos taurus,Bovine,Coagulation factor XIII A chain,Coagulation factor XIIIa,F13A,F13A1,Protein-glutamine gamma-glutamyltransferase A chain,Transglutaminase A chain 96T
U0676m CLIA Coagulation factor XIII A chain,Coagulation factor XIIIa,F13a,F13a1,Mouse,Mus musculus,Protein-glutamine gamma-glutamyltransferase A chain,Transglutaminase A chain 96T
U0676r CLIA Coagulation factor XIII A chain,Coagulation factor XIIIa,F13a,F13a1,Protein-glutamine gamma-glutamyltransferase A chain,Rat,Rattus norvegicus,Transglutaminase A chain 96T
E0676r ELISA kit Coagulation factor XIII A chain,Coagulation factor XIIIa,F13a,F13a1,Protein-glutamine gamma-glutamyltransferase A chain,Rat,Rattus norvegicus,Transglutaminase A chain 96T
E0676m ELISA kit Coagulation factor XIII A chain,Coagulation factor XIIIa,F13a,F13a1,Mouse,Mus musculus,Protein-glutamine gamma-glutamyltransferase A chain,Transglutaminase A chain 96T
E0676b ELISA kit Bos taurus,Bovine,Coagulation factor XIII A chain,Coagulation factor XIIIa,F13A,F13A1,Protein-glutamine gamma-glutamyltransferase A chain,Transglutaminase A chain 96T
E0676b ELISA Bos taurus,Bovine,Coagulation factor XIII A chain,Coagulation factor XIIIa,F13A,F13A1,Protein-glutamine gamma-glutamyltransferase A chain,Transglutaminase A chain 96T
E0676r ELISA Coagulation factor XIII A chain,Coagulation factor XIIIa,F13a,F13a1,Protein-glutamine gamma-glutamyltransferase A chain,Rat,Rattus norvegicus,Transglutaminase A chain 96T
E0676m ELISA Coagulation factor XIII A chain,Coagulation factor XIIIa,F13a,F13a1,Mouse,Mus musculus,Protein-glutamine gamma-glutamyltransferase A chain,Transglutaminase A chain 96T
U0676h CLIA Coagulation factor XIII A chain,Coagulation factor XIIIa,F13A,F13A1,Homo sapiens,Human,Protein-glutamine gamma-glutamyltransferase A chain,Transglutaminase A chain 96T
E0676h ELISA kit Coagulation factor XIII A chain,Coagulation factor XIIIa,F13A,F13A1,Homo sapiens,Human,Protein-glutamine gamma-glutamyltransferase A chain,Transglutaminase A chain 96T
E0676h ELISA Coagulation factor XIII A chain,Coagulation factor XIIIa,F13A,F13A1,Homo sapiens,Human,Protein-glutamine gamma-glutamyltransferase A chain,Transglutaminase A chain 96T
EIAAB13708 Coagulation factor XIII B chain,F13B,Fibrin-stabilizing factor B subunit,Homo sapiens,Human,Protein-glutamine gamma-glutamyltransferase B chain,Transglutaminase B chain
E0834c ELISA Chicken,Coagulation factor X,F10,FX,Gallus gallus,Stuart factor,VAP,Virus-activating protease 96T
E0834c ELISA kit Chicken,Coagulation factor X,F10,FX,Gallus gallus,Stuart factor,VAP,Virus-activating protease 96T
U0834c CLIA Chicken,Coagulation factor X,F10,FX,Gallus gallus,Stuart factor,VAP,Virus-activating protease 96T
BM2328 Coagulation factor V (F5) (Heavy Chain) 0.25 mg
GTX21015 Coagulation factor V (F5) (Heavy Chain) 125 µg
GTX21007 Coagulation factor XII (F12) (Heavy Chain) 125 µg
GTX21007 Coagulation factor XII (F12) (Heavy Chain) 125 µg
GTX40797 Coagulation factor XII (F12) (Heavy Chain) 100 µg
GTX21015 Coagulation factor V (F5) (Heavy Chain) 125 µg
BM2329 Coagulation factor XII (F12) (Heavy Chain) 0.25 mg


 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur





GENTAUR Ltd.
Howard Frank Turnberry House
1404-1410 High Road
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017

BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG

france@gentaur.com | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: 0035929830070
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.


ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur