Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

Cofilin-2 (Cofilin, muscle isoform)

 COF2_MOUSE              Reviewed;         166 AA.
P45591;
01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
01-NOV-1995, sequence version 1.
20-JUN-2018, entry version 143.
RecName: Full=Cofilin-2;
AltName: Full=Cofilin, muscle isoform;
Name=Cfl2;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=C3H/HeJ; TISSUE=Skeletal muscle;
PubMed=8195165;
Ono S., Minami N., Abe H., Obinata T.;
"Characterization of a novel cofilin isoform that is predominantly
expressed in mammalian skeletal muscle.";
J. Biol. Chem. 269:15280-15286(1994).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[3]
FUNCTION, AND TISSUE SPECIFICITY.
PubMed=11809832; DOI=10.1091/mbc.01-07-0331;
Vartiainen M.K., Mustonen T., Mattila P.K., Ojala P.J., Thesleff I.,
Partanen J., Lappalainen P.;
"The three mouse actin-depolymerizing factor/cofilins evolved to
fulfill cell-type-specific requirements for actin dynamics.";
Mol. Biol. Cell 13:183-194(2002).
[4]
ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, CLEAVAGE OF INITIATOR
METHIONINE [LARGE SCALE ANALYSIS], AND IDENTIFICATION BY MASS
SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Brain;
PubMed=16452087; DOI=10.1074/mcp.T500041-MCP200;
Trinidad J.C., Specht C.G., Thalhammer A., Schoepfer R.,
Burlingame A.L.;
"Comprehensive identification of phosphorylation sites in postsynaptic
density preparations.";
Mol. Cell. Proteomics 5:914-922(2006).
[5]
ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, PHOSPHORYLATION [LARGE
SCALE ANALYSIS] AT SER-3 AND THR-6, CLEAVAGE OF INITIATOR METHIONINE
[LARGE SCALE ANALYSIS], AND IDENTIFICATION BY MASS SPECTROMETRY [LARGE
SCALE ANALYSIS].
TISSUE=Embryonic fibroblast;
PubMed=19131326; DOI=10.1074/mcp.M800451-MCP200;
Sweet S.M., Bailey C.M., Cunningham D.L., Heath J.K., Cooper H.J.;
"Large scale localization of protein phosphorylation by use of
electron capture dissociation mass spectrometry.";
Mol. Cell. Proteomics 8:904-912(2009).
[6]
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Brain, Brown adipose tissue, Heart, Kidney, Liver, Lung,
Pancreas, Spleen, and Testis;
PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
"A tissue-specific atlas of mouse protein phosphorylation and
expression.";
Cell 143:1174-1189(2010).
[7]
FUNCTION.
PubMed=22343409; DOI=10.1093/hmg/dds053;
Agrawal P.B., Joshi M., Savic T., Chen Z., Beggs A.H.;
"Normal myofibrillar development followed by progressive sarcomeric
disruption with actin accumulations in a mouse Cfl2 knockout
demonstrates requirement of cofilin-2 for muscle maintenance.";
Hum. Mol. Genet. 21:2341-2356(2012).
[8]
FUNCTION.
PubMed=24598388; DOI=10.1016/j.ejcb.2014.01.007;
Gurniak C.B., Chevessier F., Jokwitz M., Joensson F., Perlas E.,
Richter H., Matern G., Boyl P.P., Chaponnier C., Fuerst D.,
Schroeder R., Witke W.;
"Severe protein aggregate myopathy in a knockout mouse model points to
an essential role of cofilin2 in sarcomeric actin exchange and muscle
maintenance.";
Eur. J. Cell Biol. 93:252-266(2014).
-!- FUNCTION: Controls reversibly actin polymerization and
depolymerization in a pH-sensitive manner. It has the ability to
bind G- and F-actin in a 1:1 ratio of cofilin to actin. It is the
major component of intranuclear and cytoplasmic actin rods.
Required for muscle maintenance. May play a role during the
exchange of alpha-actin forms during the early postnatal
remodeling of the sarcomere. {ECO:0000269|PubMed:11809832,
ECO:0000269|PubMed:22343409, ECO:0000269|PubMed:24598388}.
-!- SUBUNIT: Interacts with CSRP3; possibly two molecules of CFL2 can
interact with one molecule if CSRP3.
{ECO:0000250|UniProtKB:Q9Y281}.
-!- SUBCELLULAR LOCATION: Nucleus matrix. Cytoplasm, cytoskeleton.
Note=Colocalizes with CSPR3 in the Z line of sarcomeres.
{ECO:0000250|UniProtKB:Q9Y281}.
-!- TISSUE SPECIFICITY: Predominantly expressed in skeletal muscle.
{ECO:0000269|PubMed:11809832}.
-!- PTM: The phosphorylation of Ser-24 may prevent recognition of the
nuclear localization signal.
-!- SIMILARITY: Belongs to the actin-binding proteins ADF family.
{ECO:0000305}.
-----------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
Distributed under the Creative Commons Attribution (CC BY 4.0) License
-----------------------------------------------------------------------
EMBL; L29468; AAA37433.1; -; mRNA.
EMBL; BC007138; AAH07138.1; -; mRNA.
CCDS; CCDS36448.1; -.
PIR; A53812; A53812.
RefSeq; NP_031714.1; NM_007688.2.
UniGene; Mm.276826; -.
ProteinModelPortal; P45591; -.
SMR; P45591; -.
BioGrid; 198685; 3.
IntAct; P45591; 6.
MINT; P45591; -.
STRING; 10090.ENSMUSP00000077262; -.
iPTMnet; P45591; -.
PhosphoSitePlus; P45591; -.
SwissPalm; P45591; -.
REPRODUCTION-2DPAGE; P45591; -.
EPD; P45591; -.
PaxDb; P45591; -.
PeptideAtlas; P45591; -.
PRIDE; P45591; -.
Ensembl; ENSMUST00000078124; ENSMUSP00000077262; ENSMUSG00000062929.
GeneID; 12632; -.
KEGG; mmu:12632; -.
UCSC; uc007nnx.1; mouse.
CTD; 1073; -.
MGI; MGI:101763; Cfl2.
eggNOG; KOG1735; Eukaryota.
eggNOG; ENOG41122P5; LUCA.
GeneTree; ENSGT00440000033289; -.
HOGENOM; HOG000039697; -.
HOVERGEN; HBG000381; -.
InParanoid; P45591; -.
KO; K05765; -.
OMA; GLYDATY; -.
OrthoDB; EOG091G0PWC; -.
PhylomeDB; P45591; -.
TreeFam; TF328601; -.
ChiTaRS; Cfl2; mouse.
PRO; PR:P45591; -.
Proteomes; UP000000589; Chromosome 12.
Bgee; ENSMUSG00000062929; -.
CleanEx; MM_CFL2; -.
ExpressionAtlas; P45591; baseline and differential.
Genevisible; P45591; MM.
GO; GO:0015629; C:actin cytoskeleton; IEA:InterPro.
GO; GO:0031674; C:I band; ISO:MGI.
GO; GO:0016363; C:nuclear matrix; IEA:UniProtKB-SubCell.
GO; GO:0030018; C:Z disc; ISO:MGI.
GO; GO:0051015; F:actin filament binding; IDA:UniProtKB.
GO; GO:0030042; P:actin filament depolymerization; IDA:UniProtKB.
GO; GO:0030043; P:actin filament fragmentation; IDA:UniProtKB.
GO; GO:0007015; P:actin filament organization; IMP:MGI.
GO; GO:0046716; P:muscle cell cellular homeostasis; IMP:MGI.
GO; GO:0030836; P:positive regulation of actin filament depolymerization; ISO:MGI.
GO; GO:0045214; P:sarcomere organization; IMP:MGI.
GO; GO:0007519; P:skeletal muscle tissue development; IMP:UniProtKB.
CDD; cd11286; ADF_cofilin_like; 1.
Gene3D; 3.40.20.10; -; 1.
InterPro; IPR002108; ADF-H.
InterPro; IPR029006; ADF-H/Gelsolin-like_dom_sf.
InterPro; IPR017904; ADF/Cofilin.
PANTHER; PTHR11913; PTHR11913; 1.
Pfam; PF00241; Cofilin_ADF; 1.
PRINTS; PR00006; COFILIN.
SMART; SM00102; ADF; 1.
PROSITE; PS51263; ADF_H; 1.
1: Evidence at protein level;
Acetylation; Actin-binding; Complete proteome; Cytoplasm;
Cytoskeleton; Nucleus; Phosphoprotein; Reference proteome.
INIT_MET 1 1 Removed. {ECO:0000244|PubMed:16452087,
ECO:0000244|PubMed:19131326}.
CHAIN 2 166 Cofilin-2.
/FTId=PRO_0000214908.
DOMAIN 4 153 ADF-H. {ECO:0000255|PROSITE-
ProRule:PRU00599}.
MOTIF 30 34 Nuclear localization signal.
{ECO:0000255}.
MOD_RES 2 2 N-acetylalanine.
{ECO:0000244|PubMed:16452087,
ECO:0000244|PubMed:19131326}.
MOD_RES 3 3 Phosphoserine.
{ECO:0000244|PubMed:19131326}.
MOD_RES 6 6 Phosphothreonine.
{ECO:0000244|PubMed:19131326}.
SEQUENCE 166 AA; 18710 MW; 48B6D7E5AE9FE1CC CRC64;
MASGVTVNDE VIKVFNDMKV RKSSTQEEIK KRKKAVLFCL SDDKRQIIVE EAKQILVGDI
GDTVEDPYTS FVKLLPLNDC RYALYDATYE TKESKKEDLV FIFWAPESAP LKSKMIYASS
KDAIKKKFTG IKHEWQVNGL DDIKDRSTLG EKLGGSVVVS LEGKPL


Related products :

Catalog number Product name Quantity
18-783-78354 GOAT ANTI HUMAN COFILIN 2 (C-TERMINAL) - CFL2; Cofilin 2 (Muscle). isoform CRA_a; Cofilin 2 (Muscle). isoform CRA_c Polyclonal 0.1 mg
18-272-195325 Cofilin - Rabbit polyclonal to Cofilin; Cofilin. non-muscle isoform; 18 kDa phosphoprotein; p18 Polyclonal 0.05 ml
18-272-196098 Cofilin - Rabbit polyclonal to Cofilin; Cofilin. non-muscle isoform; 18 kDa phosphoprotein; p18 Polyclonal 0.05 ml
E1525r ELISA kit Cfl1,Cofilin, non-muscle isoform,Cofilin-1,Rat,Rattus norvegicus 96T
U1525b CLIA Bos taurus,Bovine,CFL1,Cofilin, non-muscle isoform,Cofilin-1 96T
18-785-210094 cofilin (Phospho-Ser3) - Cofilin. non-muscle isoform; 18 kDa phosphoprotein; p18 Polyclonal 0.1 mg
18-785-210094 cofilin (Phospho-Ser3) - Cofilin. non-muscle isoform; 18 kDa phosphoprotein; p18 Polyclonal 0.05 mg
E1861m ELISA kit Cfl2,Cofilin, muscle isoform,Cofilin-2,Mouse,Mus musculus 96T
U1861m CLIA Cfl2,Cofilin, muscle isoform,Cofilin-2,Mouse,Mus musculus 96T
U1861b CLIA kit Bos taurus,Bovine,CFL2,Cofilin, muscle isoform,Cofilin-2 96T
U1861m CLIA kit Cfl2,Cofilin, muscle isoform,Cofilin-2,Mouse,Mus musculus 96T
E1861b ELISA kit Bos taurus,Bovine,CFL2,Cofilin, muscle isoform,Cofilin-2 96T
U1525m CLIA Cfl1,Cofilin, non-muscle isoform,Cofilin-1,Mouse,Mus musculus 96T
U1525r CLIA Cfl1,Cofilin, non-muscle isoform,Cofilin-1,Rat,Rattus norvegicus 96T
E1525b ELISA kit Bos taurus,Bovine,CFL1,Cofilin, non-muscle isoform,Cofilin-1 96T
E1525m ELISA kit Cfl1,Cofilin, non-muscle isoform,Cofilin-1,Mouse,Mus musculus 96T
U1861b CLIA Bos taurus,Bovine,CFL2,Cofilin, muscle isoform,Cofilin-2 96T
E1861m ELISA Cfl2,Cofilin, muscle isoform,Cofilin-2,Mouse,Mus musculus 96T
E1861b ELISA Bos taurus,Bovine,CFL2,Cofilin, muscle isoform,Cofilin-2 96T
E1525m ELISA Cfl1,Cofilin, non-muscle isoform,Cofilin-1,Mouse,Mus musculus 96T
E1525r ELISA Cfl1,Cofilin, non-muscle isoform,Cofilin-1,Rat,Rattus norvegicus 96T
E1525b ELISA Bos taurus,Bovine,CFL1,Cofilin, non-muscle isoform,Cofilin-1 96T
U1861p CLIA CFL2,Cofilin, muscle isoform,Cofilin-2,Pig,Sus scrofa 96T
E1861p ELISA kit CFL2,Cofilin, muscle isoform,Cofilin-2,Pig,Sus scrofa 96T
U1861p CLIA kit CFL2,Cofilin, muscle isoform,Cofilin-2,Pig,Sus scrofa 96T


 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur





GENTAUR Ltd.
Howard Frank Turnberry House
1404-1410 High Road
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017

BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG

france@gentaur.com | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: 0035929830070
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.


ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur