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Coiled-coil domain-containing protein 39 (Flagellar-associated protein 59)

 CCD39_CHLRE             Reviewed;         894 AA.
A8IQE0;
08-MAR-2011, integrated into UniProtKB/Swiss-Prot.
04-DEC-2007, sequence version 1.
23-MAY-2018, entry version 33.
RecName: Full=Coiled-coil domain-containing protein 39 {ECO:0000305};
AltName: Full=Flagellar-associated protein 59 {ECO:0000303|PubMed:15998802};
Name=CCDC39; Synonyms=FAP59 {ECO:0000303|PubMed:15998802};
ORFNames=CHLREDRAFT_189109 {ECO:0000312|EMBL:EDP04876.1};
Chlamydomonas reinhardtii (Chlamydomonas smithii).
Eukaryota; Viridiplantae; Chlorophyta; Chlorophyceae;
Chlamydomonadales; Chlamydomonadaceae; Chlamydomonas.
NCBI_TaxID=3055;
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=CC-503, and cw92;
PubMed=17932292; DOI=10.1126/science.1143609;
Merchant S.S., Prochnik S.E., Vallon O., Harris E.H., Karpowicz S.J.,
Witman G.B., Terry A., Salamov A., Fritz-Laylin L.K.,
Marechal-Drouard L., Marshall W.F., Qu L.H., Nelson D.R.,
Sanderfoot A.A., Spalding M.H., Kapitonov V.V., Ren Q., Ferris P.,
Lindquist E., Shapiro H., Lucas S.M., Grimwood J., Schmutz J.,
Cardol P., Cerutti H., Chanfreau G., Chen C.L., Cognat V., Croft M.T.,
Dent R., Dutcher S., Fernandez E., Fukuzawa H., Gonzalez-Ballester D.,
Gonzalez-Halphen D., Hallmann A., Hanikenne M., Hippler M., Inwood W.,
Jabbari K., Kalanon M., Kuras R., Lefebvre P.A., Lemaire S.D.,
Lobanov A.V., Lohr M., Manuell A., Meier I., Mets L., Mittag M.,
Mittelmeier T., Moroney J.V., Moseley J., Napoli C., Nedelcu A.M.,
Niyogi K., Novoselov S.V., Paulsen I.T., Pazour G.J., Purton S.,
Ral J.P., Riano-Pachon D.M., Riekhof W., Rymarquis L., Schroda M.,
Stern D., Umen J., Willows R., Wilson N., Zimmer S.L., Allmer J.,
Balk J., Bisova K., Chen C.J., Elias M., Gendler K., Hauser C.,
Lamb M.R., Ledford H., Long J.C., Minagawa J., Page M.D., Pan J.,
Pootakham W., Roje S., Rose A., Stahlberg E., Terauchi A.M., Yang P.,
Ball S., Bowler C., Dieckmann C.L., Gladyshev V.N., Green P.,
Jorgensen R., Mayfield S., Mueller-Roeber B., Rajamani S., Sayre R.T.,
Brokstein P., Dubchak I., Goodstein D., Hornick L., Huang Y.W.,
Jhaveri J., Luo Y., Martinez D., Ngau W.C., Otillar B., Poliakov A.,
Porter A., Szajkowski L., Werner G., Zhou K., Grigoriev I.V.,
Rokhsar D.S., Grossman A.R.;
"The Chlamydomonas genome reveals the evolution of key animal and
plant functions.";
Science 318:245-250(2007).
[2]
IDENTIFICATION BY MASS SPECTROMETRY.
PubMed=15998802; DOI=10.1083/jcb.200504008;
Pazour G.J., Agrin N., Leszyk J., Witman G.B.;
"Proteomic analysis of a eukaryotic cilium.";
J. Cell Biol. 170:103-113(2005).
[3]
FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH CCDC40/FAP172,
DISRUPTION PHENOTYPE, AND PHOSPHORYLATION.
PubMed=25395538; DOI=10.1126/science.1260214;
Oda T., Yanagisawa H., Kamiya R., Kikkawa M.;
"Cilia and flagella. A molecular ruler determines the repeat length in
eukaryotic cilia and flagella.";
Science 346:857-860(2014).
-!- FUNCTION: Required for assembly of dynein regulatory complex (DRC)
and inner dynein arm complexes, which are responsible for ciliary
beat regulation, by acting as a molecular ruler that determines
the 96 nanometer (nm) repeat length and arrangements of components
in cilia and flagella (PubMed:25395538). Together with
CCDC40/FAP172 forms a 96-nm-long complex in flagella. This complex
does not act as a physical ruler, but rather act as a negative
regulator for radial spokes: the complex lays along specific
protofilaments, masking radial spoke binding sites and allowing
recruitment of inner dynein arm (IDA) and nexin-dynein regulatory
complexes (N-DRC) (PubMed:25395538).
{ECO:0000269|PubMed:25395538}.
-!- SUBUNIT: Interacts with CCDC40/FAP172.
{ECO:0000269|PubMed:25395538}.
-!- INTERACTION:
A8IQT2:CCDC40; NbExp=2; IntAct=EBI-16127597, EBI-16127612;
-!- SUBCELLULAR LOCATION: Cell projection, cilium, flagellum
{ECO:0000269|PubMed:25395538}.
-!- PTM: Phosphorylated in flagella. {ECO:0000269|PubMed:25395538}.
-!- DISRUPTION PHENOTYPE: Short and immotile flagella. Inner dynein
arm (IDA) and nexin-dynein regulatory complex (N-DRC) components
are absent or severely reduced. Radial spokes are attached to
doublet microtubules with an irregular periodicity of 32 nm
instead of 96 nm. {ECO:0000269|PubMed:25395538}.
-!- SIMILARITY: Belongs to the CCDC39 family. {ECO:0000305}.
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EMBL; DS496120; EDP04876.1; -; Genomic_DNA.
RefSeq; XP_001691768.1; XM_001691716.1.
SMR; A8IQE0; -.
DIP; DIP-61434N; -.
IntAct; A8IQE0; 1.
STRING; 3055.EDP04876; -.
PaxDb; A8IQE0; -.
PRIDE; A8IQE0; -.
EnsemblPlants; EDP04876; EDP04876; CHLREDRAFT_189109.
GeneID; 5717298; -.
Gramene; EDP04876; EDP04876; CHLREDRAFT_189109.
KEGG; cre:CHLREDRAFT_189109; -.
eggNOG; ENOG410IHS4; Eukaryota.
eggNOG; ENOG410ZNZ9; LUCA.
InParanoid; A8IQE0; -.
GO; GO:0005930; C:axoneme; IBA:GO_Central.
GO; GO:0031514; C:motile cilium; IEA:UniProtKB-SubCell.
GO; GO:0003341; P:cilium movement; IBA:GO_Central.
GO; GO:0060285; P:cilium-dependent cell motility; IBA:GO_Central.
GO; GO:0036159; P:inner dynein arm assembly; IBA:GO_Central.
InterPro; IPR033290; CCDC39.
PANTHER; PTHR18962; PTHR18962; 1.
1: Evidence at protein level;
Cell projection; Cilium; Cilium biogenesis/degradation; Coiled coil;
Flagellum; Phosphoprotein.
CHAIN 1 894 Coiled-coil domain-containing protein 39.
/FTId=PRO_0000405820.
COILED 32 143 {ECO:0000255}.
COILED 187 411 {ECO:0000255}.
COILED 461 609 {ECO:0000255}.
COILED 647 788 {ECO:0000255}.
SEQUENCE 894 AA; 101488 MW; 2E0A53532FA9E717 CRC64;
MANIDPYRTE EELVEDDEEV DMSFLPPFAK GTENEVLYVE NARMERRLER TERALETNMD
RLHIMDEHLK NVQQELKYTQ TRVEAKNKEI ESEKHLNAMA EREMGRLKKD IGKMEAERQE
LADKINGLQN QIYKNNEKLD QFKMLMNWNQ EELEQWALAE RQKAEDNAAL EKYRHADDGK
VKELTLALER VSKQVVGRKE ELEAEVVETQ AAQIQLDKAA EDFRKLHVER QDLIRQWEEA
VEAMRHRDAA IAAASEQFAM QKDVLRERKR ELDAQARFLE NETLNTKEAD ARVAYYEREV
GKQRDVLARE QARTEELNNQ VELVKATLSK AATELAQRTV ENKQAREDLD AKRQKLDAAR
KRFVVLKRKL ENEFGNLDSM EAKASELEAM RRGEEARLKA ILKEHELLKK EQYKRSQVLF
DLRQKERELI SEISGGQGQN KNLAARIHAL DEQVVARAGG VRSEEETRAL NARIEKLTAI
LEGVKRAEDD LLAARRANTS LRADRAKLDE TISTLKLEND MVSRQVKGSV EAREKALVDH
DVLALEVKRL RDILAAHADE VFSLENRKQQ LALSMEERKQ EVEVHRDGLR AELRLLREDV
HRITLELKER LLRCEKLQAK FEIISAKHRG SGEDDGEERT QAYYVIKAAQ EREALQREGD
DLDGRIRVAE KEVAALEATL AQLMAVNTNF AASYKKVGSK EAFEERAALR DKLDKAYDKL
KARRADEAAI AGDIQVSEAR LSNLGQEQRS LQALVDDMTR RKAEAQRQLD EQREKLGRAL
GRTDKLRQKL GLANSPQGAD VELAEVRDVT RAMLLELKAL ALANPGAMIA EACEAAGIRL
PSGGSNPPSL GGSRPGSARS QTSLGSVRSA RSVASQQRGG MGGSPAVRTI QLGA


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