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Common pilus major fimbrillin subunit EcpA (MatB fimbrillin) (Meningitis associated and temperature regulated protein B)

 ECPA_ECOKI              Reviewed;         195 AA.
P0C8Z8; D5CVK0; D7RNS2; Q9AME1;
14-APR-2009, integrated into UniProtKB/Swiss-Prot.
14-APR-2009, sequence version 1.
28-MAR-2018, entry version 29.
RecName: Full=Common pilus major fimbrillin subunit EcpA;
AltName: Full=MatB fimbrillin;
AltName: Full=Meningitis associated and temperature regulated protein B;
Flags: Precursor;
Name=ecpA; Synonyms=matB; OrderedLocusNames=ECOK1_0280;
Escherichia coli O18:K1:H7 (strain IHE3034 / ExPEC).
Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
Enterobacteriaceae; Escherichia.
NCBI_TaxID=714962;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 23-62 AND
69-85, FUNCTION, INDUCTION, AND DISRUPTION PHENOTYPE.
STRAIN=IHE3034 / ExPEC;
PubMed=11466275; DOI=10.1128/JB.183.16.4727-4736.2001;
Pouttu R., Westerlund-Wikstrom B., Lang H., Alsti K., Virkola R.,
Saarela U., Siitonen A., Kalkkinen N., Korhonen T.K.;
"matB, a common fimbrillin gene of Escherichia coli, expressed in a
genetically conserved, virulent clonal group.";
J. Bacteriol. 183:4727-4736(2001).
[2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, AND DISRUPTION PHENOTYPE.
STRAIN=IHE3034 / ExPEC;
PubMed=20522494; DOI=10.1099/mic.0.039610-0;
Lehti T.A., Bauchart P., Heikkinen J., Hacker J., Korhonen T.K.,
Dobrindt U., Westerlund-Wikstrom B.;
"Mat fimbriae promote biofilm formation by meningitis-associated
Escherichia coli.";
Microbiology 156:2408-2417(2010).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=IHE3034 / ExPEC;
PubMed=20439758; DOI=10.1073/pnas.0915077107;
Moriel D.G., Bertoldi I., Spagnuolo A., Marchi S., Rosini R.,
Nesta B., Pastorello I., Corea V.A., Torricelli G., Cartocci E.,
Savino S., Scarselli M., Dobrindt U., Hacker J., Tettelin H.,
Tallon L.J., Sullivan S., Wieler L.H., Ewers C., Pickard D.,
Dougan G., Fontana M.R., Rappuoli R., Pizza M., Serino L.;
"Identification of protective and broadly conserved vaccine antigens
from the genome of extraintestinal pathogenic Escherichia coli.";
Proc. Natl. Acad. Sci. U.S.A. 107:9072-9077(2010).
-!- FUNCTION: Part of the ecpRABCDE operon, which encodes the E.coli
common pilus (ECP). ECP is found in both commensal and pathogenic
strains and plays a dual role in early-stage biofilm development
and host cell recognition. Major subunit of the fimbria.
{ECO:0000269|PubMed:11466275, ECO:0000269|PubMed:20522494}.
-!- SUBUNIT: Self-associates. Forms filaments. Interacts with EcpD (By
similarity). {ECO:0000250}.
-!- SUBCELLULAR LOCATION: Fimbrium {ECO:0000250}.
-!- INDUCTION: Negatively regulated by H-NS. Positively regulated by
IHF and EcpR (By similarity). Induced by low temperature.
{ECO:0000250, ECO:0000269|PubMed:11466275}.
-!- DISRUPTION PHENOTYPE: Mutants do not express ECP and are defective
in biofilm formation. {ECO:0000269|PubMed:11466275,
ECO:0000269|PubMed:20522494}.
-!- SIMILARITY: Belongs to the EcpA/MatB fimbrillin family.
{ECO:0000305}.
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EMBL; AF325731; AAK01671.1; -; Genomic_DNA.
EMBL; HM102365; ADI59488.1; -; Genomic_DNA.
EMBL; CP001969; ADE92295.1; -; Genomic_DNA.
RefSeq; WP_000730982.1; NC_017628.1.
SMR; P0C8Z8; -.
EnsemblBacteria; ADE92295; ADE92295; ECOK1_0280.
KEGG; eih:ECOK1_0280; -.
PATRIC; fig|714962.3.peg.280; -.
HOGENOM; HOG000269503; -.
KO; K21964; -.
OMA; QDQFTFT; -.
GO; GO:0009289; C:pilus; IEA:UniProtKB-SubCell.
Gene3D; 2.60.40.3290; -; 1.
InterPro; IPR016514; EcpA.
InterPro; IPR038478; Fimbrillin_EcpA_sf.
Pfam; PF16449; MatB; 1.
PIRSF; PIRSF007320; Fimbrillin_MatB; 1.
1: Evidence at protein level;
Direct protein sequencing; Fimbrium; Signal.
SIGNAL 1 22 {ECO:0000269|PubMed:11466275}.
CHAIN 23 195 Common pilus major fimbrillin subunit
EcpA.
/FTId=PRO_0000367920.
SEQUENCE 195 AA; 20081 MW; E0601C888446758C CRC64;
MKKKVLAIAL VTVFTGTGVA QAADVTAQAV ATWSATAKKD TTSKLVVTPL GSLAFQYAEG
IKGFNSQKGL FDVAIEGDST ATAFKLTSRL ITNTLTQLDT SGSTLNVGVD YNGAAVEKTG
DTVMIDTANG VLGGNLSPLA NGYNASNRTT AQDGFTFSII SGTTNGTTAV TDYSTLPEGI
WSGDVSVQFD ATWTS


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