Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

Complement C3 [Cleaved into: Complement C3 beta chain; Complement C3 alpha chain; C3a anaphylatoxin; Complement C3b alpha' chain; Complement C3c alpha' chain fragment 1; Complement C3dg fragment; Complement C3g fragment; Complement C3d fragment; Complement C3f fragment; Complement C3c alpha' chain fragment 2] (Fragment)

 CO3_ONCMY               Reviewed;        1640 AA.
P98093;
01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
01-FEB-1996, sequence version 1.
05-DEC-2018, entry version 99.
RecName: Full=Complement C3;
Contains:
RecName: Full=Complement C3 beta chain;
Contains:
RecName: Full=Complement C3 alpha chain;
Contains:
RecName: Full=C3a anaphylatoxin;
Contains:
RecName: Full=Complement C3b alpha' chain;
Contains:
RecName: Full=Complement C3c alpha' chain fragment 1;
Contains:
RecName: Full=Complement C3dg fragment;
Contains:
RecName: Full=Complement C3g fragment;
Contains:
RecName: Full=Complement C3d fragment;
Contains:
RecName: Full=Complement C3f fragment;
Contains:
RecName: Full=Complement C3c alpha' chain fragment 2;
Flags: Fragment;
Name=c3;
Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii;
Salmoniformes; Salmonidae; Salmoninae; Oncorhynchus.
NCBI_TaxID=8022;
[1]
NUCLEOTIDE SEQUENCE [MRNA], AND PROTEIN SEQUENCE OF 1-23; 647-666;
723-733; 946-960; 1034-1046; 1296-1312 AND 1310-1329.
TISSUE=Liver;
PubMed=8245455;
Lambris J.D., Lao Z., Pang J., Alsenz J.;
"Third component of trout complement. cDNA cloning and conservation of
functional sites.";
J. Immunol. 151:6123-6134(1993).
-!- FUNCTION: C3 plays a central role in the activation of the
complement system. Its processing by C3 convertase is the central
reaction in both classical and alternative complement pathways.
After activation C3b can bind covalently, via its reactive
thioester, to cell surface carbohydrates or immune aggregates.
-!- SUBUNIT: C3 precursor is first processed by the removal of 4 Arg
residues, forming two chains, beta and alpha, linked by a
disulfide bond. C3 convertase activates C3 by cleaving the alpha
chain, releasing C3a anaphylatoxin and generating C3b (beta chain
+ alpha' chain).
-!- SUBCELLULAR LOCATION: Secreted.
-!- PTM: C3b is rapidly split in two positions by factor I and a
cofactor to form iC3b (inactivated C3b) and C3f which is released.
Then iC3b is slowly cleaved (possibly by factor I) to form C3c
(beta chain + alpha' chain fragment 1 + alpha' chain fragment 2),
C3dg and C3f. Other proteases produce other fragments such as C3d
or C3g.
-!- SEQUENCE CAUTION:
Sequence=AAB05029.1; Type=Erroneous initiation; Evidence={ECO:0000305};
-----------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
Distributed under the Creative Commons Attribution (CC BY 4.0) License
-----------------------------------------------------------------------
EMBL; L24433; AAB05029.1; ALT_INIT; mRNA.
PIR; I51339; I51339.
UniGene; Omy.30588; -.
ProteinModelPortal; P98093; -.
SMR; P98093; -.
MEROPS; I39.950; -.
PRIDE; P98093; -.
HOVERGEN; HBG005110; -.
PMAP-CutDB; P98093; -.
GO; GO:0005623; C:cell; IDA:AgBase.
GO; GO:0005615; C:extracellular space; IEA:InterPro.
GO; GO:0001872; F:(1->3)-beta-D-glucan binding; IDA:AgBase.
GO; GO:0003823; F:antigen binding; IDA:AgBase.
GO; GO:0001848; F:complement binding; IDA:AgBase.
GO; GO:0004866; F:endopeptidase inhibitor activity; IEA:InterPro.
GO; GO:0006957; P:complement activation, alternative pathway; IEA:UniProtKB-KW.
GO; GO:0006958; P:complement activation, classical pathway; IEA:UniProtKB-KW.
GO; GO:0042742; P:defense response to bacterium; IDA:AgBase.
GO; GO:0006954; P:inflammatory response; IEA:UniProtKB-KW.
CDD; cd00017; ANATO; 1.
CDD; cd03583; NTR_complement_C3; 1.
Gene3D; 2.60.40.10; -; 2.
Gene3D; 2.60.40.690; -; 1.
InterPro; IPR009048; A-macroglobulin_rcpt-bd.
InterPro; IPR036595; A-macroglobulin_rcpt-bd_sf.
InterPro; IPR011625; A2M_N_BRD.
InterPro; IPR011626; Alpha-macroglobulin_TED.
InterPro; IPR000020; Anaphylatoxin/fibulin.
InterPro; IPR018081; Anaphylatoxin_comp_syst.
InterPro; IPR035711; Complement_C3-like.
InterPro; IPR013783; Ig-like_fold.
InterPro; IPR001599; Macroglobln_a2.
InterPro; IPR019742; MacrogloblnA2_CS.
InterPro; IPR002890; MG2.
InterPro; IPR001134; Netrin_domain.
InterPro; IPR018933; Netrin_module_non-TIMP.
InterPro; IPR035815; NTR_complement_C3.
InterPro; IPR008930; Terpenoid_cyclase/PrenylTrfase.
InterPro; IPR008993; TIMP-like_OB-fold.
PANTHER; PTHR11412:SF81; PTHR11412:SF81; 1.
Pfam; PF00207; A2M; 1.
Pfam; PF07703; A2M_BRD; 1.
Pfam; PF07677; A2M_recep; 1.
Pfam; PF01821; ANATO; 1.
Pfam; PF01835; MG2; 1.
Pfam; PF01759; NTR; 1.
Pfam; PF07678; TED_complement; 1.
SMART; SM01360; A2M; 1.
SMART; SM01359; A2M_N_2; 1.
SMART; SM01361; A2M_recep; 1.
SMART; SM00104; ANATO; 1.
SMART; SM00643; C345C; 1.
SUPFAM; SSF47686; SSF47686; 1.
SUPFAM; SSF48239; SSF48239; 1.
SUPFAM; SSF49410; SSF49410; 1.
SUPFAM; SSF50242; SSF50242; 1.
PROSITE; PS00477; ALPHA_2_MACROGLOBULIN; 1.
PROSITE; PS01177; ANAPHYLATOXIN_1; 1.
PROSITE; PS01178; ANAPHYLATOXIN_2; 1.
PROSITE; PS50189; NTR; 1.
1: Evidence at protein level;
Cleavage on pair of basic residues; Complement alternate pathway;
Complement pathway; Direct protein sequencing; Disulfide bond;
Glycoprotein; Immunity; Inflammatory response; Innate immunity;
Secreted; Thioester bond.
CHAIN 1 1640 Complement C3.
/FTId=PRO_0000005952.
CHAIN 1 642 Complement C3 beta chain.
/FTId=PRO_0000005953.
CHAIN 647 1640 Complement C3 alpha chain.
/FTId=PRO_0000005954.
CHAIN 647 722 C3a anaphylatoxin.
/FTId=PRO_0000005955.
CHAIN 723 1640 Complement C3b alpha' chain.
/FTId=PRO_0000005956.
CHAIN 723 931 Complement C3c alpha' chain fragment 1.
{ECO:0000250}.
/FTId=PRO_0000005957.
CHAIN 932 1278 Complement C3dg fragment. {ECO:0000250}.
/FTId=PRO_0000005958.
CHAIN 932 1033 Complement C3g fragment. {ECO:0000250}.
/FTId=PRO_0000005959.
CHAIN 1034 1278 Complement C3d fragment.
/FTId=PRO_0000005960.
PEPTIDE 1279 1295 Complement C3f fragment. {ECO:0000250}.
/FTId=PRO_0000005961.
CHAIN 1296 1640 Complement C3c alpha' chain fragment 2.
/FTId=PRO_0000273956.
DOMAIN 668 703 Anaphylatoxin-like. {ECO:0000255|PROSITE-
ProRule:PRU00022}.
DOMAIN 1493 1638 NTR. {ECO:0000255|PROSITE-
ProRule:PRU00295}.
REGION 1420 1430 Properdin-binding.
SITE 722 723 Cleavage; by C3 convertase.
SITE 931 932 Cleavage; by factor I. {ECO:0000250}.
SITE 1278 1279 Cleavage; by factor I. {ECO:0000250}.
SITE 1295 1296 Cleavage; by factor I.
CARBOHYD 164 164 N-linked (GlcNAc...) asparagine.
DISULFID 536 797 Interchain (between beta and alpha
chains). {ECO:0000255|PROSITE-
ProRule:PRU00022, ECO:0000255|PROSITE-
ProRule:PRU00295}.
DISULFID 603 638 {ECO:0000250}.
DISULFID 668 695 {ECO:0000250}.
DISULFID 669 702 {ECO:0000250}.
DISULFID 682 703 {ECO:0000250}.
DISULFID 853 1488 {ECO:0000250}.
DISULFID 1079 1135 {ECO:0000250}.
DISULFID 1335 1464 {ECO:0000250}.
DISULFID 1481 1486 {ECO:0000250}.
DISULFID 1493 1563 {ECO:0000250}.
DISULFID 1510 1638 {ECO:0000250}.
DISULFID 1614 1623 {ECO:0000250}.
CROSSLNK 988 991 Isoglutamyl cysteine thioester (Cys-Gln).
{ECO:0000250}.
NON_TER 1 1
SEQUENCE 1640 AA; 182105 MW; 0965B4FAF1E87812 CRC64;
AALQVLSAPN LLRVGSNENI FVESQDHVGG PLNVKIMVKN HPTQSKELAS KSVVLDQANN
FQAMTQLVIQ RGPLVDDPKQ KQYVVLQAQF PDRLLEKVVL VSFQSGYIFI QTDKTIYTPA
STVHYRVFSM TPGLEPLTRE IFEDQEVAKN KEIAVSVEIM TPENITIFRE IVNPDKGVKS
GQFKLPDIVS FGTWHVVTRF QSTPQKTFSS EFEVKEYVLP SFEVSLTPAK AFFYVDDNDL
TVDITARYLY GKEVTGTGYV VFGVITTESE KKSFPASLQR VEIKDGKGVA CLKKEHITQT
FPKIHDLVKQ SIFVSVSVLT EGGGEMVEAE KRGIQIVTSP YSILFKRTPK YFKPGMPFDV
SVYITNPDNS PAIGVEVEVT PDHAKGVTRA NGFAKIPLNT VASATELVIT VKTKDPGDPR
QQTGGGTMKA LPYRTSTKNF LHVGVDSNEL KIGDPIKIDL NLGPTTIPNH DLTYMFLSRG
QLVKVGRFKR QGNALVTLSV PVSKELLPSF RIVAYYHVGA ADLVADSVWV DIKVSCMGSL
KVTSTRPKAS YEPRRAFSLT ITGDPGAKVG LVAVDKGVYV LNSKHRLTQT KIWDTIEKHD
TGCTAGGGAD NMGVFYDAGL VFETNTAKGT GIRTDPSCPV SSRRRRAVTI SDVITSMASK
YHGLAKECCV DGMRDNTMGY TCDRRAQYIS DGDVCVQAFL VCCTEMASKK IESKQDALLL
SRSEEDDDDD AYMRSEDIVS RSQFPESWMW EDTNLPECPA QNKHCESTSV IRNNFLKDSI
TTWQITAISL SKTHGICVAD PFEMIVLKEF FIDLKLPYSA VRNEQLEVKA ILHNYSEDPI
IVRVELMENG EVCSSASKKG KYRQEVNMDP MSTRVVPYVI IPMKLGLHSI EVKASVKNSG
SNDGVKRDLR VVAEGVLVKK ETNVLLNPVK HGGEQTSHIP SGVPRNQVPN SDADTLISVT
AGEQTSVLVE QAISGDSLGS LIVQPVGCGE QNMIYMTLPV IATHYLDNTK KWEDIGLDKR
NTAIKYINIG YQRQLAYRKE DGSYAAWVSR QSSTWLTAYV VKVFAMSSTL ISVQENVLCT
AVKWLILNTQ QPDGIFNEFA PVIHAEMTGN VRGSDNDASM TAFVLIAMQE ASSVCEQSVN
SLPGSMAKAV AYLEKRLPHL TNPYAVAMTS YALANAGKLN KETLLKFASP QLDHWPVPGG
YQYTLEATSY ALLALVKVKA FEEAGPIVRW LNKQKKVGGG YGSTQSTIMV FQAVAEYWSH
VKDLKDFDLN INLEVAGRAS VTKWSINNKN QFHTRTDKVN SIDKDLTVKA SGNGEATLSV
VTLYYALPEE KDSDCESFDL SVTLTKMDKT SHEDAKESFM LTIEVLYKNS ERDATMSILD
IGLLTGFIVD TDDLNQLSKG RERYIEKFEM DKVLSERGSL ILYLDKVSHK LEDRISFKIH
RVQEVGVLQP AAVSVYEYYN QKRCVKFYHP QREGGTLSRL CLGDVCTCAE ESCSMQKKGE
PDVQRIDKAC GAGLDYVYKA TVVDSKLTTH TDTYTVKIDL VIKPGTDEGV EGKNRDFMGL
AYCREALGLM QGKTYMIMGK SEDLHRVEDK GLLQYKYVLG EQTWIEYWPS QQECTSRDYR
EVCLGIDEFI NQITTFGCPV


Related products :

Catalog number Product name Quantity
bs-4874R Rabbit Anti-Complement C3c alpha' chain fragment 1 Polyclonal Antibody 100ul
bs-4878R Rabbit Anti-Complement C3c alpha' chain fragment 2 Polyclonal Antibody 100ul
bs-4874R-Cy5.5 Rabbit Anti-Complement C3c alpha' chain fragment 1 Polyclonal Antibody, Cy5.5 Conjugated 100ul
bs-4874R-Cy7 Rabbit Anti-Complement C3c alpha' chain fragment 1 Polyclonal Antibody, Cy7 Conjugated 100ul
bs-4878R-Cy3 Rabbit Anti-Complement C3c alpha' chain fragment 2 Polyclonal Antibody, Cy3 Conjugated 100ul
bs-4874R-Cy5 Rabbit Anti-Complement C3c alpha' chain fragment 1 Polyclonal Antibody, Cy5 Conjugated 100ul
bs-4878R-Cy5.5 Rabbit Anti-Complement C3c alpha' chain fragment 2 Polyclonal Antibody, Cy5.5 Conjugated 100ul
bs-4878R-Cy7 Rabbit Anti-Complement C3c alpha' chain fragment 2 Polyclonal Antibody, Cy7 Conjugated 100ul
bs-4878R-Cy5 Rabbit Anti-Complement C3c alpha' chain fragment 2 Polyclonal Antibody, Cy5 Conjugated 100ul
bs-4874R-Cy3 Rabbit Anti-Complement C3c alpha' chain fragment 1 Polyclonal Antibody, Cy3 Conjugated 100ul
bs-4878R-A647 Rabbit Anti-Complement C3c alpha' chain fragment 2 Polyclonal Antibody, ALEXA FLUOR 647 Conjugated 100ul
bs-4878R-A488 Rabbit Anti-Complement C3c alpha' chain fragment 2 Polyclonal Antibody, ALEXA FLUOR 488 Conjugated 100ul
bs-4874R-A647 Rabbit Anti-Complement C3c alpha' chain fragment 1 Polyclonal Antibody, ALEXA FLUOR 647 Conjugated 100ul
bs-4878R-A555 Rabbit Anti-Complement C3c alpha' chain fragment 2 Polyclonal Antibody, ALEXA FLUOR 555 Conjugated 100ul
bs-4878R-A350 Rabbit Anti-Complement C3c alpha' chain fragment 2 Polyclonal Antibody, ALEXA FLUOR 350 Conjugated 100ul
bs-4874R-A350 Rabbit Anti-Complement C3c alpha' chain fragment 1 Polyclonal Antibody, ALEXA FLUOR 350 Conjugated 100ul
bs-4874R-A488 Rabbit Anti-Complement C3c alpha' chain fragment 1 Polyclonal Antibody, ALEXA FLUOR 488 Conjugated 100ul
bs-4874R-A555 Rabbit Anti-Complement C3c alpha' chain fragment 1 Polyclonal Antibody, ALEXA FLUOR 555 Conjugated 100ul
bs-4878R-FITC Rabbit Anti-Complement C3c alpha' chain fragment 2 Polyclonal Antibody, FITC Conjugated 100ul
bs-4874R-Biotin Rabbit Anti-Complement C3c alpha' chain fragment 1 Polyclonal Antibody, Biotin Conjugated 100ul
bs-4874R-FITC Rabbit Anti-Complement C3c alpha' chain fragment 1 Polyclonal Antibody, FITC Conjugated 100ul
bs-4878R-Biotin Rabbit Anti-Complement C3c alpha' chain fragment 2 Polyclonal Antibody, Biotin Conjugated 100ul
E1970h ELISA kit C8A,Complement component 8 subunit alpha,Complement component C8 alpha chain,Homo sapiens,Human 96T
E1970h ELISA C8A,Complement component 8 subunit alpha,Complement component C8 alpha chain,Homo sapiens,Human 96T
E1970Rb ELISA kit C8A,Complement component 8 subunit alpha,Complement component C8 alpha chain,Oryctolagus cuniculus,Rabbit 96T


 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur | Gentaur





GENTAUR Ltd.
Unicorn House, Station Cl
Hertfordshire, Potters Bar EN6 1TL
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017
RIB 30004 00187 00010092253 10
BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG
IBAN FR76 3000 4001 8700 0100 9225 310
france@gentaur.com | Gentaur | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: +49 0241 40 08 90 86, +49 0241 95 78 94 78, +49 0241 40 08 90 86
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.


ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur | Gentaur