Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

Complement factor D (EC 3.4.21.46) (Adipsin) (C3 convertase activator) (Endogenous vascular elastase) (Properdin factor D)

 CFAD_RAT                Reviewed;         263 AA.
P32038;
01-JUL-1993, integrated into UniProtKB/Swiss-Prot.
01-NOV-1997, sequence version 2.
23-MAY-2018, entry version 121.
RecName: Full=Complement factor D;
EC=3.4.21.46;
AltName: Full=Adipsin;
AltName: Full=C3 convertase activator;
AltName: Full=Endogenous vascular elastase;
AltName: Full=Properdin factor D;
Flags: Precursor;
Name=Cfd; Synonyms=Adn, Df;
Rattus norvegicus (Rat).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Rattus.
NCBI_TaxID=10116;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
PubMed=8083356; DOI=10.1172/JCI117432;
Zhu L., Wigle D., Hinek A., Kobayashi J., Ye C., Zuker M., Dodo H.,
Keeley F.W., Rabinovitch M.;
"The endogenous vascular elastase that governs development and
progression of monocrotaline-induced pulmonary hypertension in rats is
a novel enzyme related to the serine proteinase adipsin.";
J. Clin. Invest. 94:1163-1171(1994).
[2]
PROTEIN SEQUENCE OF 26-55.
PubMed=1953671; DOI=10.1042/bj2790775;
Baker B.C., Campbell C.J., Grinham C.J., Turcatti G.;
"Purification and partial characterization of rat factor D.";
Biochem. J. 279:775-779(1991).
-!- FUNCTION: Factor D cleaves factor B when the latter is complexed
with factor C3b, activating the C3bbb complex, which then becomes
the C3 convertase of the alternate pathway. Its function is
homologous to that of C1s in the classical pathway.
-!- CATALYTIC ACTIVITY: Selective cleavage of Arg-|-Lys bond in
complement factor B when in complex with complement subcomponent
C3b or with cobra venom factor.
-!- SUBCELLULAR LOCATION: Secreted.
-!- PTM: N-glycosylated.
-!- SIMILARITY: Belongs to the peptidase S1 family.
{ECO:0000255|PROSITE-ProRule:PRU00274}.
-----------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
Distributed under the Creative Commons Attribution-NoDerivs License
-----------------------------------------------------------------------
EMBL; S73894; AAB31922.1; -; mRNA.
PIR; I55608; I55608.
RefSeq; NP_001071110.1; NM_001077642.1.
UniGene; Rn.16172; -.
ProteinModelPortal; P32038; -.
SMR; P32038; -.
STRING; 10116.ENSRNOP00000015029; -.
MEROPS; S01.191; -.
PaxDb; P32038; -.
PRIDE; P32038; -.
GeneID; 54249; -.
KEGG; rno:54249; -.
UCSC; RGD:2498; rat.
CTD; 1675; -.
RGD; 2498; Cfd.
eggNOG; KOG3627; Eukaryota.
eggNOG; COG5640; LUCA.
HOGENOM; HOG000251820; -.
HOVERGEN; HBG013304; -.
InParanoid; P32038; -.
KO; K01334; -.
PhylomeDB; P32038; -.
PRO; PR:P32038; -.
Proteomes; UP000002494; Unplaced.
GO; GO:0005615; C:extracellular space; IDA:RGD.
GO; GO:0004175; F:endopeptidase activity; IDA:RGD.
GO; GO:0004252; F:serine-type endopeptidase activity; TAS:RGD.
GO; GO:0006957; P:complement activation, alternative pathway; IEA:UniProtKB-KW.
GO; GO:0007219; P:Notch signaling pathway; IMP:RGD.
CDD; cd00190; Tryp_SPc; 1.
InterPro; IPR037561; Complement_factor_D.
InterPro; IPR009003; Peptidase_S1_PA.
InterPro; IPR001314; Peptidase_S1A.
InterPro; IPR001254; Trypsin_dom.
InterPro; IPR018114; TRYPSIN_HIS.
InterPro; IPR033116; TRYPSIN_SER.
PANTHER; PTHR43890:SF17; PTHR43890:SF17; 1.
Pfam; PF00089; Trypsin; 1.
PRINTS; PR00722; CHYMOTRYPSIN.
SMART; SM00020; Tryp_SPc; 1.
SUPFAM; SSF50494; SSF50494; 1.
PROSITE; PS50240; TRYPSIN_DOM; 1.
PROSITE; PS00134; TRYPSIN_HIS; 1.
PROSITE; PS00135; TRYPSIN_SER; 1.
1: Evidence at protein level;
Complement alternate pathway; Complete proteome;
Direct protein sequencing; Disulfide bond; Glycoprotein; Hydrolase;
Immunity; Innate immunity; Protease; Reference proteome; Secreted;
Serine protease; Signal; Zymogen.
SIGNAL 1 20 {ECO:0000255}.
PROPEP 21 25 Activation peptide.
{ECO:0000269|PubMed:1953671}.
/FTId=PRO_0000027566.
CHAIN 26 263 Complement factor D.
/FTId=PRO_0000027567.
DOMAIN 26 254 Peptidase S1. {ECO:0000255|PROSITE-
ProRule:PRU00274}.
ACT_SITE 66 66 Charge relay system.
ACT_SITE 115 115 Charge relay system.
ACT_SITE 209 209 Charge relay system.
CARBOHYD 46 46 N-linked (GlcNAc...) asparagine.
DISULFID 51 67 {ECO:0000255|PROSITE-ProRule:PRU00274}.
DISULFID 149 215 {ECO:0000255|PROSITE-ProRule:PRU00274}.
DISULFID 180 196 {ECO:0000255|PROSITE-ProRule:PRU00274}.
DISULFID 205 230 {ECO:0000255|PROSITE-ProRule:PRU00274}.
SEQUENCE 263 AA; 28442 MW; D573133568A31CE0 CRC64;
MHSSVYLVAL VVLEAAVCVA QPRGRILGGQ EAMAHARPYM ASVQVNGTHV CGGTLVDEQW
VLSAAHCMDG VTKDEVVQVL LGAHSLSSPE PYKHLYDVQS VVLHPGSRPD SVEDDLMLFK
LSHNASLGPH VRPLPLQRED REVKPGTLCD VAGWGVVTHA GRRPDVLQQL TVSIMDRNTC
NLRTYHDGAI TKNMMCAESN RRDTCRGDSG GPLVCGDAVE AVVTWGSRVC GNRRKPGVFT
RVATYVPWIE NVLSGNVSVN VTA


Related products :

Catalog number Product name Quantity
U1833r CLIA kit Adipsin,Adn,C3 convertase activator,Cfd,Complement factor D,Df,Endogenous vascular elastase,Properdin factor D,Rat,Rattus norvegicus 96T
E1833r ELISA kit Adipsin,Adn,C3 convertase activator,Cfd,Complement factor D,Df,Endogenous vascular elastase,Properdin factor D,Rat,Rattus norvegicus 96T
E1833r ELISA Adipsin,Adn,C3 convertase activator,Cfd,Complement factor D,Df,Endogenous vascular elastase,Properdin factor D,Rat,Rattus norvegicus 96T
U1833r CLIA Adipsin,Adn,C3 convertase activator,Cfd,Complement factor D,Df,Endogenous vascular elastase,Properdin factor D,Rat,Rattus norvegicus 96T
E1833p ELISA Adipsin,C3 convertase activator,CFD,Complement factor D,DF,Pig,Properdin factor D,Sus scrofa 96T
U1833p CLIA kit Adipsin,C3 convertase activator,CFD,Complement factor D,DF,Pig,Properdin factor D,Sus scrofa 96T
U1833p CLIA Adipsin,C3 convertase activator,CFD,Complement factor D,DF,Pig,Properdin factor D,Sus scrofa 96T
E1833p ELISA kit Adipsin,C3 convertase activator,CFD,Complement factor D,DF,Pig,Properdin factor D,Sus scrofa 96T
E1833b ELISA Adipsin,Bos taurus,Bovine,C3 convertase activator,CFD,Complement factor D,Properdin factor D 96T
U1833b CLIA Adipsin,Bos taurus,Bovine,C3 convertase activator,CFD,Complement factor D,Properdin factor D 96T
E1833b ELISA kit Adipsin,Bos taurus,Bovine,C3 convertase activator,CFD,Complement factor D,Properdin factor D 96T
U1833b CLIA kit Adipsin,Bos taurus,Bovine,C3 convertase activator,CFD,Complement factor D,Properdin factor D 96T
E1833h ELISA kit Adipsin,C3 convertase activator,CFD,Complement factor D,DF,Homo sapiens,Human,PFD,Properdin factor D 96T
U1833h CLIA kit Adipsin,C3 convertase activator,CFD,Complement factor D,DF,Homo sapiens,Human,PFD,Properdin factor D 96T
U1833h CLIA Adipsin,C3 convertase activator,CFD,Complement factor D,DF,Homo sapiens,Human,PFD,Properdin factor D 96T
E1833h ELISA Adipsin,C3 convertase activator,CFD,Complement factor D,DF,Homo sapiens,Human,PFD,Properdin factor D 96T
E1833m ELISA 28 kDa adipocyte protein,Adipsin,Adn,C3 convertase activator,Cfd,Complement factor D,Df,Mouse,Mus musculus,Properdin factor D 96T
U1833m CLIA 28 kDa adipocyte protein,Adipsin,Adn,C3 convertase activator,Cfd,Complement factor D,Df,Mouse,Mus musculus,Properdin factor D 96T
E1833m ELISA kit 28 kDa adipocyte protein,Adipsin,Adn,C3 convertase activator,Cfd,Complement factor D,Df,Mouse,Mus musculus,Properdin factor D 96T
U1833m CLIA kit 28 kDa adipocyte protein,Adipsin,Adn,C3 convertase activator,Cfd,Complement factor D,Df,Mouse,Mus musculus,Properdin factor D 96T
E2011p ELISA kit BF,C3_C5 convertase,CFB,Complement factor B,Pig,Properdin factor B,Sus scrofa 96T
E2011p ELISA BF,C3_C5 convertase,CFB,Complement factor B,Pig,Properdin factor B,Sus scrofa 96T
U2011p CLIA BF,C3_C5 convertase,CFB,Complement factor B,Pig,Properdin factor B,Sus scrofa 96T
U2011p CLIA kit BF,C3_C5 convertase,CFB,Complement factor B,Pig,Properdin factor B,Sus scrofa 96T
E2011h ELISA kit BF,BFD,C3_C5 convertase,CFB,Complement factor B,GBG,Glycine-rich beta glycoprotein,Homo sapiens,Human,PBF2,Properdin factor B 96T


 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur





GENTAUR Ltd.
Howard Frank Turnberry House
1404-1410 High Road
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017

BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG

france@gentaur.com | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: 0035929830070
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.


ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur