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Conantokin-Oc (Con-Oc)

 CKO_CONOH               Reviewed;          22 AA.
P0DP00;
12-APR-2017, integrated into UniProtKB/Swiss-Prot.
12-APR-2017, sequence version 1.
12-SEP-2018, entry version 6.
RecName: Full=Conantokin-Oc {ECO:0000303|PubMed:17153339};
Short=Con-Oc {ECO:0000303|PubMed:17153339};
Conus ochroleucus (Perfect cone) (Graphiconus ochroleucus).
Eukaryota; Metazoa; Lophotrochozoa; Mollusca; Gastropoda;
Caenogastropoda; Neogastropoda; Conoidea; Conidae; Conus; Phasmoconus.
NCBI_TaxID=72282;
[1]
REVIEW, AND GAMMA-CARBOXYGLUTAMATION AT GLU-3; GLU-4; GLU-10 AND
GLU-18.
PubMed=17153339;
Franco A., Pisarewicz K., Moller C., Mora D., Fields G.B., Mari F.;
"Hyperhydroxylation: a new strategy for neuronal targeting by venomous
marine molluscs.";
Prog. Mol. Subcell. Biol. 43:83-103(2006).
-!- FUNCTION: Conantokins inhibit N-methyl-D-aspartate (NMDA)
receptors. {ECO:0000250}.
-!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
-!- TISSUE SPECIFICITY: Expressed by the venom duct. {ECO:0000305}.
-!- MISCELLANEOUS: The mature peptide does not contain cysteine
residue. {ECO:0000305}.
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GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
GO; GO:0035792; C:other organism postsynaptic membrane; IEA:UniProtKB-KW.
GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
1: Evidence at protein level;
Gamma-carboxyglutamic acid; Ion channel impairing toxin;
Ionotropic glutamate receptor inhibitor; Neurotoxin;
Postsynaptic neurotoxin; Secreted; Toxin.
PEPTIDE 1 22 Conantokin-Oc.
/FTId=PRO_0000439519.
MOD_RES 3 3 4-carboxyglutamate.
{ECO:0000303|PubMed:17153339}.
MOD_RES 4 4 4-carboxyglutamate.
{ECO:0000303|PubMed:17153339}.
MOD_RES 10 10 4-carboxyglutamate.
{ECO:0000303|PubMed:17153339}.
MOD_RES 18 18 4-carboxyglutamate.
{ECO:0000303|PubMed:17153339}.
SEQUENCE 22 AA; 2431 MW; 3F56DA9858EEEBEA CRC64;
GEEERKAMAE LEAKKAQEAL KA


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Catalog number Product name Quantity
08CON009-01000 Conantokin G, Conantokin G inhibits NMDA receptors 1000 ug
08CON009-00500 Conantokin G, Conantokin G inhibits NMDA receptors 500 ug
orb71518 Conantokin T peptide This is Conantokin T peptide. For research use only. 1 mg
orb71516 Conantokin G peptide This is Conantokin G peptide. For research use only. 1 mg
orb70579 Conantokin G peptide This is Conantokin G peptide. For research use only. 1 mg
orb71185 [Glu3,4,7,10,14]-Conantokin G peptide This is [Glu3,4,7,10,14]-Conantokin G peptide. For research use only. 1 mg
ST06-1 Conantokin G 1 mg
KP0625 Conantokin G 1 mg
KP0626 Conantokin G 2 mg
ST06-500 Conantokin G 500 µg
4265-v Conantokin G 0.5mg
4265-v Conantokin G 0.5mg
4264-v Conantokin T 0.5mg
4264-v Conantokin T 0.5mg
4264-v Conantokin T 0.5mg
4265-v Conantokin G 0.5mg
SP-89530-1 Conantokin G (AA: Gly-Glu-Gla-Gla-Leu-Gln-Gla-Asn-Gln-Gla-Leu-Ile-Arg-Gla-Lys-Ser-Asn-NH2) (MW: 2264.18) 1 mg
08CON009-00500 Conantokin G, toxin 500
SP-52574-1 [Glu3,4,7,10,14]-Conantokin G [Gly-Glu-Glu-Glu-Leu-Gln-Glu-Asn-Gln-Glu-Leu-Ile-Arg-Glu-Lys-Ser-Asn-NH2; MW: 2045.16] 1 mg
SP-89530-1 Conantokin G (AA Gly_Glu_Gla_Gla_Leu_Gln_Gla_Asn_Gln_Gla_Leu_Ile_Arg_Gla_Lys_Ser_Asn_NH2) (MW 2264.18) 1 mg
08CON009-01000 Conantokin G, toxin 1000
SP-89531-5 Conantokin G (free acid) (AA: Gly-Glu-Gla-Gla-Leu-Gln-Gla-Asn-Gln-Gla-Leu-Ile-Arg-Gla-Lys-Ser-Asn) (MW: 2265.16) 5 mg
C-2503 Conantokin G (free acid) 98 percent C88H137N25O45 CAS: 5mg
070-89 Conantokin G (Marine Snail _ Conus geographus) _ 500ug 500 µg
070-90 Conantokin T (Marine Snail _ Conus tulipa) _ 500ug 500 µg


 

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