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Connective tissue growth factor (CCN family member 2) (Hypertrophic chondrocyte-specific protein 24) (Insulin-like growth factor-binding protein 8) (IBP-8) (IGF-binding protein 8) (IGFBP-8)

 CTGF_HUMAN              Reviewed;         349 AA.
P29279; E1P578; Q6LCY0; Q96A79; Q96QX2; Q9UDL6;
01-DEC-1992, integrated into UniProtKB/Swiss-Prot.
17-OCT-2006, sequence version 2.
30-AUG-2017, entry version 171.
RecName: Full=Connective tissue growth factor;
AltName: Full=CCN family member 2;
AltName: Full=Hypertrophic chondrocyte-specific protein 24;
AltName: Full=Insulin-like growth factor-binding protein 8;
Short=IBP-8;
Short=IGF-binding protein 8;
Short=IGFBP-8;
Flags: Precursor;
Name=CTGF; Synonyms=CCN2, HCS24, IGFBP8;
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
NCBI_TaxID=9606;
[1]
NUCLEOTIDE SEQUENCE [MRNA], AND VARIANT ASP-83.
TISSUE=Umbilical vein endothelial cell;
PubMed=1654338; DOI=10.1083/jcb.114.6.1285;
Bradham D.M., Igarashi A., Potter R.L., Grotendorst G.R.;
"Connective tissue growth factor: a cysteine-rich mitogen secreted by
human vascular endothelial cells is related to the SRC-induced
immediate early gene product CEF-10.";
J. Cell Biol. 114:1285-1294(1991).
[2]
NUCLEOTIDE SEQUENCE [MRNA], AND VARIANT ASP-83.
TISSUE=Umbilical vein endothelial cell;
PubMed=1293144; DOI=10.1111/j.1346-8138.1992.tb03748.x;
Igarashi A., Bradham D.M., Okochi H., Grotendorst G.R.;
"Connective tissue growth factor.";
J. Dermatol. 19:642-643(1992).
[3]
NUCLEOTIDE SEQUENCE [MRNA], AND VARIANT ASP-83.
TISSUE=Aorta;
PubMed=9054739; DOI=10.1161/01.CIR.95.4.831;
Oemar B.S., Werner A., Garnier J.-M., Do D.D., Godoy N., Nauck M.,
Marz W., Rupp J., Pech M., Luescher T.F.;
"Human connective tissue growth factor is expressed in advanced
atherosclerotic lesions.";
Circulation 95:831-839(1997).
[4]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND VARIANT ASP-83.
Li Q.-H., Wang L.-C., Liu L.-D., Dong S.-Z., Wang J.-J., Hu F.,
Wang J., He S.-Q., Dong C.-H., Zhao S.-D., Zhao H.-L.;
"Expression, purification and bio-activity of human connective tissue
growth factor.";
Submitted (SEP-2003) to the EMBL/GenBank/DDBJ databases.
[5]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND VARIANT ASP-83.
TISSUE=Liver;
Dai W.-J., Jiang H.-C., Fu S.-B.;
"Complete mRNA sequence of human connective tissue growth factor.";
Submitted (FEB-2004) to the EMBL/GenBank/DDBJ databases.
[6]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND VARIANT
ASP-83.
Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S.,
Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y.,
Phelan M., Farmer A.;
"Cloning of human full-length CDSs in BD Creator(TM) system donor
vector.";
Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases.
[7]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND VARIANT
ASP-83.
Halleck A., Ebert L., Mkoundinya M., Schick M., Eisenstein S.,
Neubert P., Kstrang K., Schatten R., Shen B., Henze S., Mar W.,
Korn B., Zuo D., Hu Y., LaBaer J.;
"Cloning of human full open reading frames in Gateway(TM) system entry
vector (pDONR201).";
Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
[8]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
PubMed=14574404; DOI=10.1038/nature02055;
Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E.,
Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R.,
Almeida J.P., Ambrose K.D., Andrews T.D., Ashwell R.I.S.,
Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J.,
Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P.,
Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y.,
Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E.,
Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A.,
Frankland J., French L., Garner P., Garnett J., Ghori M.J.,
Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M.,
Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S.,
Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R.,
Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E.,
Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A.,
Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C.,
Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M.,
Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K.,
McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T.,
Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R.,
Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W.,
Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M.,
Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L.,
Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J.,
Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B.,
Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L.,
Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W.,
Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A.,
Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.;
"The DNA sequence and analysis of human chromosome 6.";
Nature 425:805-811(2003).
[9]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
Venter J.C.;
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
[10]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-20.
TISSUE=Placenta;
Xin L.W., Martinerie C., Zumkeller W., Westphal M., Perbal B.;
"Differential expression of novH and CTGF in human glioma cell
lines.";
Clin. Mol. Pathol. 49:91-97(1996).
[11]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-20.
Blom I.E., van Dijk A.J., de Weger R.A., Tilanus M.G.J.,
Goldschmeding R.;
"Identification of human CCN2 (connective tissue growth factor)
promoter polymorphisms.";
J. Clin. Pathol. 54:192-196(2001).
[12]
NUCLEOTIDE SEQUENCE [MRNA] OF 75-349, AND VARIANT ASP-83.
Cody C.W., Walker N.J., Greenlee W.F., Sutter T.R.;
"Connective tissue growth factor mRNA is expressed in human
keratinocytes as an immediate early gene that responds to serum, EGF,
or wounding.";
Submitted (SEP-1994) to the EMBL/GenBank/DDBJ databases.
[13]
NUCLEOTIDE SEQUENCE [MRNA] OF 99-176 AND 204-225 (ISOFORM 1), AND
TISSUE SPECIFICITY.
PubMed=1756408;
Martinerie C., Perbal B.;
"Expression of a gene encoding a novel potential IGF binding protein
in human tissues.";
C. R. Acad. Sci. III, Sci. Vie 313:345-351(1991).
[14]
FUNCTION.
TISSUE=Chondrocyte;
PubMed=10614647; DOI=10.1210/endo.141.1.7267;
Nakanishi T., Nishida T., Shimo T., Kobayashi K., Kubo T.,
Tamatani T., Tezuka K., Takigawa M.;
"Effects of CTGF/Hcs24, a product of a hypertrophic chondrocyte-
specific gene, on the proliferation and differentiation of
chondrocytes in culture.";
Endocrinology 141:264-273(2000).
[15]
HEPARIN-BINDING, AND FUNCTION IN CELL ADHESION.
PubMed=12553878; DOI=10.1677/joe.0.176R001;
Ball D.K., Rachfal A.W., Kemper S.A., Brigstock D.R.;
"The heparin-binding 10 kDa fragment of connective tissue growth
factor (CTGF) containing module 4 alone stimulates cell adhesion.";
J. Endocrinol. 176:R1-R7(2003).
-!- FUNCTION: Major connective tissue mitoattractant secreted by
vascular endothelial cells. Promotes proliferation and
differentiation of chondrocytes. Mediates heparin- and divalent
cation-dependent cell adhesion in many cell types including
fibroblasts, myofibroblasts, endothelial and epithelial cells.
Enhances fibroblast growth factor-induced DNA synthesis.
{ECO:0000269|PubMed:10614647, ECO:0000269|PubMed:12553878}.
-!- SUBUNIT: Monomer.
-!- INTERACTION:
P02751:FN1; NbExp=5; IntAct=EBI-2835375, EBI-1220319;
-!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
matrix {ECO:0000250}. Secreted {ECO:0000250}.
-!- ALTERNATIVE PRODUCTS:
Event=Alternative splicing; Named isoforms=2;
Name=1; Synonyms=Long;
IsoId=P29279-1; Sequence=Displayed;
Name=2; Synonyms=Short;
IsoId=P29279-2; Sequence=VSP_002460;
Note=No experimental confirmation available.;
-!- TISSUE SPECIFICITY: Expressed in bone marrow and thymic cells.
Also expressed one of two Wilms tumors tested.
{ECO:0000269|PubMed:1756408}.
-!- SIMILARITY: Belongs to the CCN family. {ECO:0000305}.
-!- WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology
and Haematology;
URL="http://atlasgeneticsoncology.org/Genes/CTGFID40192ch6q23.html";
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EMBL; M92934; AAA91279.1; -; mRNA.
EMBL; X78947; CAA55544.1; -; mRNA.
EMBL; AY395801; AAQ95223.1; -; mRNA.
EMBL; AY550024; AAS55639.1; -; mRNA.
EMBL; BT019794; AAV38597.1; -; mRNA.
EMBL; BT019795; AAV38598.1; -; mRNA.
EMBL; CR541759; CAG46559.1; -; mRNA.
EMBL; AL354866; CAC44023.1; -; Genomic_DNA.
EMBL; X92511; CAA63267.1; -; Genomic_DNA.
EMBL; CH471051; EAW48038.1; -; Genomic_DNA.
EMBL; CH471051; EAW48039.1; -; Genomic_DNA.
EMBL; AF316366; AAK60505.1; -; Genomic_DNA.
EMBL; AF316367; AAK60506.1; -; Genomic_DNA.
EMBL; AF316368; AAK60507.1; -; Genomic_DNA.
EMBL; U14750; AAA75378.1; -; mRNA.
CCDS; CCDS5151.1; -. [P29279-1]
PIR; A40551; A40551.
RefSeq; NP_001892.1; NM_001901.2.
UniGene; Hs.410037; -.
ProteinModelPortal; P29279; -.
BioGrid; 107872; 14.
IntAct; P29279; 15.
MINT; MINT-1779737; -.
STRING; 9606.ENSP00000356954; -.
ChEMBL; CHEMBL3712901; -.
iPTMnet; P29279; -.
PhosphoSitePlus; P29279; -.
BioMuta; CTGF; -.
DMDM; 116241320; -.
EPD; P29279; -.
MaxQB; P29279; -.
PaxDb; P29279; -.
PeptideAtlas; P29279; -.
PRIDE; P29279; -.
DNASU; 1490; -.
Ensembl; ENST00000367976; ENSP00000356954; ENSG00000118523. [P29279-1]
GeneID; 1490; -.
KEGG; hsa:1490; -.
UCSC; uc003qcz.4; human. [P29279-1]
CTD; 1490; -.
DisGeNET; 1490; -.
GeneCards; CTGF; -.
HGNC; HGNC:2500; CTGF.
HPA; CAB005123; -.
HPA; HPA031074; -.
HPA; HPA031075; -.
MalaCards; CTGF; -.
MIM; 121009; gene.
neXtProt; NX_P29279; -.
OpenTargets; ENSG00000118523; -.
Orphanet; 220393; Diffuse cutaneous systemic sclerosis.
Orphanet; 220402; Limited cutaneous systemic sclerosis.
PharmGKB; PA27003; -.
eggNOG; ENOG410IH0W; Eukaryota.
eggNOG; ENOG4111F77; LUCA.
GeneTree; ENSGT00760000119225; -.
HOGENOM; HOG000231462; -.
HOVERGEN; HBG000635; -.
InParanoid; P29279; -.
KO; K06827; -.
OMA; CTPHRTA; -.
OrthoDB; EOG091G0SQP; -.
PhylomeDB; P29279; -.
TreeFam; TF326070; -.
Reactome; R-HSA-1989781; PPARA activates gene expression.
Reactome; R-HSA-2032785; YAP1- and WWTR1 (TAZ)-stimulated gene expression.
Reactome; R-HSA-8951671; RUNX3 regulates YAP1-mediated transcription.
SIGNOR; P29279; -.
ChiTaRS; CTGF; human.
GeneWiki; CTGF; -.
GenomeRNAi; 1490; -.
PRO; PR:P29279; -.
Proteomes; UP000005640; Chromosome 6.
Bgee; ENSG00000118523; -.
CleanEx; HS_CTGF; -.
Genevisible; P29279; HS.
GO; GO:0005938; C:cell cortex; IEA:Ensembl.
GO; GO:0005801; C:cis-Golgi network; IEA:Ensembl.
GO; GO:0005829; C:cytosol; IEA:Ensembl.
GO; GO:0005576; C:extracellular region; TAS:Reactome.
GO; GO:0005615; C:extracellular space; IEA:Ensembl.
GO; GO:0005794; C:Golgi apparatus; IDA:HPA.
GO; GO:0043231; C:intracellular membrane-bounded organelle; IDA:HPA.
GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:Ensembl.
GO; GO:0005886; C:plasma membrane; TAS:ProtInc.
GO; GO:0005578; C:proteinaceous extracellular matrix; IBA:GO_Central.
GO; GO:0001968; F:fibronectin binding; IEA:Ensembl.
GO; GO:0008083; F:growth factor activity; IEA:Ensembl.
GO; GO:0008201; F:heparin binding; IBA:GO_Central.
GO; GO:0005520; F:insulin-like growth factor binding; TAS:ProtInc.
GO; GO:0005178; F:integrin binding; IBA:GO_Central.
GO; GO:0008022; F:protein C-terminus binding; IPI:UniProtKB.
GO; GO:0007568; P:aging; IEA:Ensembl.
GO; GO:0001525; P:angiogenesis; IEA:Ensembl.
GO; GO:0001502; P:cartilage condensation; IEA:Ensembl.
GO; GO:0007155; P:cell adhesion; IBA:GO_Central.
GO; GO:0030154; P:cell differentiation; IEA:Ensembl.
GO; GO:0016477; P:cell migration; IEA:Ensembl.
GO; GO:0007267; P:cell-cell signaling; IBA:GO_Central.
GO; GO:0007160; P:cell-matrix adhesion; IEA:Ensembl.
GO; GO:0035988; P:chondrocyte proliferation; IEA:Ensembl.
GO; GO:0060401; P:cytosolic calcium ion transport; IEA:Ensembl.
GO; GO:0071897; P:DNA biosynthetic process; IEA:UniProtKB-KW.
GO; GO:0008544; P:epidermis development; TAS:ProtInc.
GO; GO:0070278; P:extracellular matrix constituent secretion; IEA:Ensembl.
GO; GO:0008543; P:fibroblast growth factor receptor signaling pathway; IEA:Ensembl.
GO; GO:0007229; P:integrin-mediated signaling pathway; IEA:Ensembl.
GO; GO:0035556; P:intracellular signal transduction; IEA:Ensembl.
GO; GO:0030324; P:lung development; IEA:Ensembl.
GO; GO:0060548; P:negative regulation of cell death; IBA:GO_Central.
GO; GO:0010629; P:negative regulation of gene expression; IEA:Ensembl.
GO; GO:0001503; P:ossification; IEA:Ensembl.
GO; GO:0060452; P:positive regulation of cardiac muscle contraction; IEA:Ensembl.
GO; GO:0050867; P:positive regulation of cell activation; IEA:Ensembl.
GO; GO:0045597; P:positive regulation of cell differentiation; IDA:BHF-UCL.
GO; GO:0008284; P:positive regulation of cell proliferation; IEA:Ensembl.
GO; GO:0032967; P:positive regulation of collagen biosynthetic process; IEA:Ensembl.
GO; GO:0043280; P:positive regulation of cysteine-type endopeptidase activity involved in apoptotic process; IEA:Ensembl.
GO; GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IDA:BHF-UCL.
GO; GO:0070318; P:positive regulation of G0 to G1 transition; IEA:Ensembl.
GO; GO:0010628; P:positive regulation of gene expression; IEA:Ensembl.
GO; GO:0046330; P:positive regulation of JNK cascade; IDA:BHF-UCL.
GO; GO:0051496; P:positive regulation of stress fiber assembly; IDA:BHF-UCL.
GO; GO:0072593; P:reactive oxygen species metabolic process; IEA:Ensembl.
GO; GO:0001558; P:regulation of cell growth; IEA:InterPro.
GO; GO:0032330; P:regulation of chondrocyte differentiation; IEA:Ensembl.
GO; GO:0019216; P:regulation of lipid metabolic process; TAS:Reactome.
GO; GO:0043200; P:response to amino acid; IEA:Ensembl.
GO; GO:0034059; P:response to anoxia; IEA:Ensembl.
GO; GO:0032355; P:response to estradiol; IEA:Ensembl.
GO; GO:0070542; P:response to fatty acid; IEA:Ensembl.
GO; GO:0009749; P:response to glucose; IEA:Ensembl.
GO; GO:0051385; P:response to mineralocorticoid; IEA:Ensembl.
GO; GO:0043434; P:response to peptide hormone; IEA:Ensembl.
GO; GO:0009611; P:response to wounding; TAS:ProtInc.
GO; GO:0001894; P:tissue homeostasis; IEA:Ensembl.
GO; GO:0006367; P:transcription initiation from RNA polymerase II promoter; TAS:Reactome.
InterPro; IPR006207; Cys_knot_C.
InterPro; IPR006208; Glyco_hormone_CN.
InterPro; IPR009030; Growth_fac_rcpt_.
InterPro; IPR000867; IGFBP-like.
InterPro; IPR012395; IGFBP_CNN.
InterPro; IPR017891; Insulin_GF-bd_Cys-rich_CS.
InterPro; IPR000884; TSP1_rpt.
InterPro; IPR001007; VWF_dom.
Pfam; PF00007; Cys_knot; 1.
Pfam; PF00219; IGFBP; 1.
Pfam; PF00090; TSP_1; 1.
Pfam; PF00093; VWC; 1.
PIRSF; PIRSF036495; IGFBP_rP_CNN; 1.
SMART; SM00041; CT; 1.
SMART; SM00121; IB; 1.
SMART; SM00209; TSP1; 1.
SMART; SM00214; VWC; 1.
SUPFAM; SSF57184; SSF57184; 1.
SUPFAM; SSF82895; SSF82895; 1.
PROSITE; PS01185; CTCK_1; 1.
PROSITE; PS01225; CTCK_2; 1.
PROSITE; PS00222; IGFBP_N_1; 1.
PROSITE; PS51323; IGFBP_N_2; 1.
PROSITE; PS50092; TSP1; 1.
PROSITE; PS01208; VWFC_1; 1.
PROSITE; PS50184; VWFC_2; 1.
1: Evidence at protein level;
Alternative splicing; Cell adhesion; Complete proteome;
Disulfide bond; DNA synthesis; Extracellular matrix; Glycoprotein;
Heparin-binding; Polymorphism; Reference proteome; Secreted; Signal.
SIGNAL 1 26 {ECO:0000255}.
CHAIN 27 349 Connective tissue growth factor.
/FTId=PRO_0000014402.
DOMAIN 27 98 IGFBP N-terminal. {ECO:0000255|PROSITE-
ProRule:PRU00653}.
DOMAIN 101 167 VWFC. {ECO:0000255|PROSITE-
ProRule:PRU00220}.
DOMAIN 198 243 TSP type-1. {ECO:0000255|PROSITE-
ProRule:PRU00210}.
DOMAIN 256 330 CTCK. {ECO:0000255|PROSITE-
ProRule:PRU00039}.
REGION 247 349 Heparin-binding.
CARBOHYD 28 28 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 225 225 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
DISULFID 256 293 {ECO:0000250}.
DISULFID 273 307 {ECO:0000250}.
DISULFID 284 323 {ECO:0000250}.
DISULFID 287 325 {ECO:0000250}.
DISULFID 292 329 {ECO:0000250}.
VAR_SEQ 172 198 Missing (in isoform 2). {ECO:0000305}.
/FTId=VSP_002460.
VARIANT 83 83 H -> D (in dbSNP:rs7451102).
{ECO:0000269|PubMed:1293144,
ECO:0000269|PubMed:1654338,
ECO:0000269|PubMed:9054739,
ECO:0000269|Ref.12, ECO:0000269|Ref.4,
ECO:0000269|Ref.5, ECO:0000269|Ref.6,
ECO:0000269|Ref.7}.
/FTId=VAR_027925.
CONFLICT 175 175 V -> L (in Ref. 13; no nucleotide entry).
{ECO:0000305}.
SEQUENCE 349 AA; 38091 MW; 62CF878C7F57EC1F CRC64;
MTAASMGPVR VAFVVLLALC SRPAVGQNCS GPCRCPDEPA PRCPAGVSLV LDGCGCCRVC
AKQLGELCTE RDPCDPHKGL FCHFGSPANR KIGVCTAKDG APCIFGGTVY RSGESFQSSC
KYQCTCLDGA VGCMPLCSMD VRLPSPDCPF PRRVKLPGKC CEEWVCDEPK DQTVVGPALA
AYRLEDTFGP DPTMIRANCL VQTTEWSACS KTCGMGISTR VTNDNASCRL EKQSRLCMVR
PCEADLEENI KKGKKCIRTP KISKPIKFEL SGCTSMKTYR AKFCGVCTDG RCCTPHRTTT
LPVEFKCPDG EVMKKNMMFI KTCACHYNCP GDNDIFESLY YRKMYGDMA


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10-663-45262 Connective tissue Growth Factor (CTGF) Human - Hypertrophic chondrocyte-specific protein 24 N_A 1 mg
10-663-45262 Connective tissue Growth Factor (CTGF) Human - Hypertrophic chondrocyte-specific protein 24 N_A 0.01 mg
EIAAB10298 CCN family member 1,Ccn1,Cyr61,Cysteine-rich angiogenic inducer 61,IBP-10,IGF-binding protein 10,Igfbp10,IGFBP-10,Insulin-like growth factor-binding protein 10,Protein CYR61,Rat,Rattus norvegicus
EIAAB10296 3CH61,CCN family member 1,Ccn1,Cyr61,Cysteine-rich angiogenic inducer 61,IBP-10,IGF-binding protein 10,Igfbp10,IGFBP-10,Insulin-like growth factor-binding protein 10,Mouse,Mus musculus,Protein CYR61
20-783-72936 MOUSE ANTI HUMAN INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN 3 - INSULIN LIKE GROWTH FACTOR BINDING PROTEIN 3; IGFBP-3; IBP-3; IGF-binding protein 3 Monoclonal 0.2 mg
EIAAB27560 CCN family member 3,CCN3,Homo sapiens,Human,IBP-9,IGF-binding protein 9,IGFBP9,IGFBP-9,Insulin-like growth factor-binding protein 9,Nephroblastoma-overexpressed gene protein homolog,NOV,NovH,NOVH,Prot
EIAAB10297 CCN family member 1,CCN1,CYR61,Cysteine-rich angiogenic inducer 61,GIG1,Homo sapiens,Human,IBP-10,IGF-binding protein 10,IGFBP10,IGFBP-10,Insulin-like growth factor-binding protein 10,Protein CYR61,Pr
U2153h CLIA kit CCN family member 5,CCN5,Connective tissue growth factor-like protein,Connective tissue growth factor-related protein 58,CT58,CTGFL,CTGF-L,Homo sapiens,Human,UNQ228_PRO261,WISP2,WISP-2,WNT1- 96T
E2153h ELISA kit CCN family member 5,CCN5,Connective tissue growth factor-like protein,Connective tissue growth factor-related protein 58,CT58,CTGFL,CTGF-L,Homo sapiens,Human,UNQ228_PRO261,WISP2,WISP-2,WNT1 96T
E2153h ELISA CCN family member 5,CCN5,Connective tissue growth factor-like protein,Connective tissue growth factor-related protein 58,CT58,CTGFL,CTGF-L,Homo sapiens,Human,UNQ228_PRO261,WISP2,WISP-2,WNT1-indu 96T
U2153h CLIA CCN family member 5,CCN5,Connective tissue growth factor-like protein,Connective tissue growth factor-related protein 58,CT58,CTGFL,CTGF-L,Homo sapiens,Human,UNQ228_PRO261,WISP2,WISP-2,WNT1-induc 96T
26-065 IGFBP4 is a member of the insulin-like growth factor binding protein (IGFBP) family. IGFBP4 is a protein with an IGFBP domain and a thyroglobulin type-I domain. The protein binds both insulin-like gro 0.05 mg
18-003-44208 Insulin-like growth factor 2 mRNA-binding protein 1 - IGF2 mRNA-binding protein 1; IGF-II mRNA-binding protein 1; IMP-1; Coding region determinant-binding protein; CRD-BP; VICKZ family member 1 Polycl 0.05 mg Aff Pur
10-663-45148 Insulin Like Growth Factor Binding Protein-1 (IGFBP-1) Human - IGFBP-1; IBP-1; IGF-binding protein 1; Placental protein 12; PP12 N_A 1 mg
10-663-45148 Insulin Like Growth Factor Binding Protein-1 (IGFBP-1) Human - IGFBP-1; IBP-1; IGF-binding protein 1; Placental protein 12; PP12 N_A 0.005 mg
10-663-45148 Insulin Like Growth Factor Binding Protein-1 (IGFBP-1) Human - IGFBP-1; IBP-1; IGF-binding protein 1; Placental protein 12; PP12 N_A 0.02 mg
E0053m ELISA IBP-2,IGF-binding protein 2,Igfbp2,IGFBP-2,Igfbp-2,Insulin-like growth factor-binding protein 2,mIGFBP-2,Mouse,Mus musculus 96T
U0053m CLIA IBP-2,IGF-binding protein 2,Igfbp2,IGFBP-2,Igfbp-2,Insulin-like growth factor-binding protein 2,mIGFBP-2,Mouse,Mus musculus 96T


 

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