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Conotoxin PIVE (Kappa-A-conotoxin PIVE) (KappaA-PIVE)

 CA4E_CONPU              Reviewed;          24 AA.
P0C2C5;
23-JAN-2007, integrated into UniProtKB/Swiss-Prot.
23-JAN-2007, sequence version 1.
18-JAN-2017, entry version 21.
RecName: Full=Conotoxin PIVE;
AltName: Full=Kappa-A-conotoxin PIVE;
Short=KappaA-PIVE;
Conus purpurascens (Purple cone).
Eukaryota; Metazoa; Lophotrochozoa; Mollusca; Gastropoda;
Caenogastropoda; Hypsogastropoda; Neogastropoda; Conoidea; Conidae;
Conus.
NCBI_TaxID=41690;
[1]
PROTEIN SEQUENCE, SYNTHESIS, FUNCTION, DISULFIDE BONDS, AMIDATION AT
LYS-24, AND MASS SPECTROMETRY.
TISSUE=Venom;
PubMed=17118419; DOI=10.1016/j.toxicon.2006.10.001;
Teichert R.W., Jacobsen R., Terlau H., Yoshikami D., Olivera B.M.;
"Discovery and characterization of the short kappaA-conotoxins: a
novel subfamily of excitatory conotoxins.";
Toxicon 49:318-328(2007).
-!- FUNCTION: This toxin elicits dose-dependently excitatory activity
upon injection into fish. Its action is slowly reversible. Does
not have any direct effects on neuromuscular nAChRs (human adult
alpha-1/beta-1/epsilon/delta or fetal alpha-1/beta-1/gamma/delta
receptors). Does not have any effects on human Kv1 (KCNA1, KCNA2,
KCNA3, KCNA4, KCNA5, and KCNA), Kv2.1/KCNB1, Kv3.4 (KCNC4), Kv4.2
(KCND2), KCNQ2/3, and on the Drosophilia Shaker potassium
channels. Does not have effects on the fish potassium channels,
TSha1, TSha2 (Kv1 homologs), and Traw (Kv3 homolog), without
detectable activity. {ECO:0000269|PubMed:17118419}.
-!- SUBCELLULAR LOCATION: Secreted.
-!- TISSUE SPECIFICITY: Expressed by the venom duct.
-!- DOMAIN: The cysteine framework is IV (CC-C-C-C-C).
-!- MASS SPECTROMETRY: Mass=2656; Method=LSI; Range=1-24;
Evidence={ECO:0000269|PubMed:17118419};
-!- SIMILARITY: Belongs to the conotoxin A superfamily. {ECO:0000305}.
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ConoServer; 1670; PIVE.
GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
1: Evidence at protein level;
Amidation; Direct protein sequencing; Disulfide bond; Neurotoxin;
Secreted; Toxin.
PEPTIDE 1 24 Conotoxin PIVE.
/FTId=PRO_0000273427.
MOD_RES 24 24 Lysine amide.
{ECO:0000269|PubMed:17118419}.
DISULFID 2 10 {ECO:0000269|PubMed:17118419}.
DISULFID 3 15 {ECO:0000269|PubMed:17118419}.
DISULFID 13 19 {ECO:0000269|PubMed:17118419}.
SEQUENCE 24 AA; 2664 MW; 671F1A3F5AFD0A34 CRC64;
DCCGVKLEMC HPCLCDNSCK NYGK


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Catalog number Product name Quantity
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