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Conserved oligomeric Golgi complex subunit 1 (COG complex subunit 1) (Complexed with DOR1 protein 3) (Component of oligomeric Golgi complex 1) (Protein SEC36)

 COG1_YEAST              Reviewed;         417 AA.
P53079; D6VVB2;
01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
01-OCT-1996, sequence version 1.
23-MAY-2018, entry version 130.
RecName: Full=Conserved oligomeric Golgi complex subunit 1;
Short=COG complex subunit 1;
AltName: Full=Complexed with DOR1 protein 3;
AltName: Full=Component of oligomeric Golgi complex 1;
AltName: Full=Protein SEC36;
Name=COG1; Synonyms=COD3, SEC36, TFI1; OrderedLocusNames=YGL223C;
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces.
NCBI_TaxID=559292;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=ATCC 204508 / S288c;
PubMed=9290212;
DOI=10.1002/(SICI)1097-0061(19970915)13:11<1077::AID-YEA152>3.3.CO;2-P;
Rieger M., Brueckner M., Schaefer M., Mueller-Auer S.;
"Sequence analysis of 203 kilobases from Saccharomyces cerevisiae
chromosome VII.";
Yeast 13:1077-1090(1997).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 204508 / S288c;
PubMed=9169869;
Tettelin H., Agostoni-Carbone M.L., Albermann K., Albers M.,
Arroyo J., Backes U., Barreiros T., Bertani I., Bjourson A.J.,
Brueckner M., Bruschi C.V., Carignani G., Castagnoli L., Cerdan E.,
Clemente M.L., Coblenz A., Coglievina M., Coissac E., Defoor E.,
Del Bino S., Delius H., Delneri D., de Wergifosse P., Dujon B.,
Durand P., Entian K.-D., Eraso P., Escribano V., Fabiani L.,
Fartmann B., Feroli F., Feuermann M., Frontali L., Garcia-Gonzalez M.,
Garcia-Saez M.I., Goffeau A., Guerreiro P., Hani J., Hansen M.,
Hebling U., Hernandez K., Heumann K., Hilger F., Hofmann B.,
Indge K.J., James C.M., Klima R., Koetter P., Kramer B., Kramer W.,
Lauquin G., Leuther H., Louis E.J., Maillier E., Marconi A.,
Martegani E., Mazon M.J., Mazzoni C., McReynolds A.D.K.,
Melchioretto P., Mewes H.-W., Minenkova O., Mueller-Auer S.,
Nawrocki A., Netter P., Neu R., Nombela C., Oliver S.G., Panzeri L.,
Paoluzi S., Plevani P., Portetelle D., Portillo F., Potier S.,
Purnelle B., Rieger M., Riles L., Rinaldi T., Robben J.,
Rodrigues-Pousada C., Rodriguez-Belmonte E., Rodriguez-Torres A.M.,
Rose M., Ruzzi M., Saliola M., Sanchez-Perez M., Schaefer B.,
Schaefer M., Scharfe M., Schmidheini T., Schreer A., Skala J.,
Souciet J.-L., Steensma H.Y., Talla E., Thierry A., Vandenbol M.,
van der Aart Q.J.M., Van Dyck L., Vanoni M., Verhasselt P., Voet M.,
Volckaert G., Wambutt R., Watson M.D., Weber N., Wedler E., Wedler H.,
Wipfli P., Wolf K., Wright L.F., Zaccaria P., Zimmermann M.,
Zollner A., Kleine K.;
"The nucleotide sequence of Saccharomyces cerevisiae chromosome VII.";
Nature 387:81-84(1997).
[3]
GENOME REANNOTATION.
STRAIN=ATCC 204508 / S288c;
PubMed=24374639; DOI=10.1534/g3.113.008995;
Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M.,
Cherry J.M.;
"The reference genome sequence of Saccharomyces cerevisiae: Then and
now.";
G3 (Bethesda) 4:389-398(2014).
[4]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=ATCC 204508 / S288c;
PubMed=17322287; DOI=10.1101/gr.6037607;
Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F.,
Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A.,
Raphael J., Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F.,
Williamson J., Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G.,
Kolodner R.D., LaBaer J.;
"Approaching a complete repository of sequence-verified protein-
encoding clones for Saccharomyces cerevisiae.";
Genome Res. 17:536-543(2007).
[5]
SUBUNIT.
PubMed=11703943; DOI=10.1016/S1534-5807(01)00063-6;
Whyte J.R., Munro S.;
"The Sec34/35 Golgi transport complex is related to the exocyst,
defining a family of complexes involved in multiple steps of membrane
traffic.";
Dev. Cell 1:527-537(2001).
[6]
IDENTIFICATION IN THE COG COMPLEX, AND FUNCTION OF THE COG COMPLEX.
PubMed=12011112; DOI=10.1083/jcb.200111081;
Suvorova E.S., Duden R., Lupashin V.V.;
"The Sec34/Sec35p complex, a Ypt1p effector required for retrograde
intra-Golgi trafficking, interacts with Golgi SNAREs and COPI vesicle
coat proteins.";
J. Cell Biol. 157:631-643(2002).
[7]
FUNCTION, AND IDENTIFICATION IN THE COG COMPLEX.
PubMed=12006647; DOI=10.1091/mbc.01-10-0495;
Ram R.J., Li B., Kaiser C.A.;
"Identification of sec36p, sec37p, and sec38p: components of yeast
complex that contains sec34p and sec35p.";
Mol. Biol. Cell 13:1484-1500(2002).
[8]
LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
PubMed=14562106; DOI=10.1038/nature02046;
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A.,
Dephoure N., O'Shea E.K., Weissman J.S.;
"Global analysis of protein expression in yeast.";
Nature 425:737-741(2003).
[9]
COMPOSITION OF THE COG COMPLEX, AND INTERACTION WITH COG3 AND COG4.
PubMed=15047703; DOI=10.1074/jbc.M400662200;
Loh E., Hong W.;
"The binary interacting network of the conserved oligomeric Golgi
tethering complex.";
J. Biol. Chem. 279:24640-24648(2004).
[10]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-305, AND IDENTIFICATION
BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
PubMed=19779198; DOI=10.1126/science.1172867;
Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.;
"Global analysis of Cdk1 substrate phosphorylation sites provides
insights into evolution.";
Science 325:1682-1686(2009).
[11]
ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, AND IDENTIFICATION BY
MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
PubMed=22814378; DOI=10.1073/pnas.1210303109;
Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A.,
Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E.,
Timmerman E., Prieto J., Arnesen T., Sherman F., Gevaert K.,
Aldabe R.;
"N-terminal acetylome analyses and functional insights of the N-
terminal acetyltransferase NatB.";
Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012).
-!- FUNCTION: Acts as essential component of the peripheral membrane
COG complex that is involved in intra-Golgi protein trafficking.
COG is located at the cis-Golgi, and regulates tethering of
retrograde intra-Golgi vesicles and possibly a number of other
membrane trafficking events. {ECO:0000269|PubMed:12006647,
ECO:0000269|PubMed:12011112}.
-!- SUBUNIT: Component of the conserved oligomeric Golgi (COG or
Sec34/Sec35) complex which consists of eight different proteins
COG1-COG8. {ECO:0000269|PubMed:11703943,
ECO:0000269|PubMed:12006647, ECO:0000269|PubMed:12011112}.
-!- INTERACTION:
P53271:COG2; NbExp=16; IntAct=EBI-4835, EBI-16614;
P40094:COG3; NbExp=12; IntAct=EBI-4835, EBI-16605;
Q06096:COG4; NbExp=9; IntAct=EBI-4835, EBI-4823;
P53951:COG5; NbExp=6; IntAct=EBI-4835, EBI-4841;
P53959:COG6; NbExp=5; IntAct=EBI-4835, EBI-4829;
Q04632:COG8; NbExp=8; IntAct=EBI-4835, EBI-6035;
-!- SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250};
Peripheral membrane protein {ECO:0000250}; Cytoplasmic side
{ECO:0000250}.
-!- MISCELLANEOUS: Present with 2190 molecules/cell in log phase SD
medium. {ECO:0000269|PubMed:14562106}.
-!- SIMILARITY: Belongs to the COG1 family. {ECO:0000305}.
-----------------------------------------------------------------------
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EMBL; Z72745; CAA96939.1; -; Genomic_DNA.
EMBL; AY692796; AAT92815.1; -; Genomic_DNA.
EMBL; BK006941; DAA07896.1; -; Genomic_DNA.
PIR; S64245; S64245.
RefSeq; NP_011292.1; NM_001181088.1.
ProteinModelPortal; P53079; -.
SMR; P53079; -.
BioGrid; 33036; 47.
DIP; DIP-4374N; -.
IntAct; P53079; 9.
MINT; P53079; -.
STRING; 4932.YGL223C; -.
iPTMnet; P53079; -.
MaxQB; P53079; -.
PaxDb; P53079; -.
PRIDE; P53079; -.
EnsemblFungi; YGL223C; YGL223C; YGL223C.
GeneID; 852649; -.
KEGG; sce:YGL223C; -.
EuPathDB; FungiDB:YGL223C; -.
SGD; S000003191; COG1.
InParanoid; P53079; -.
OMA; NWTISIN; -.
OrthoDB; EOG092C53ZO; -.
BioCyc; YEAST:G3O-30697-MONOMER; -.
PRO; PR:P53079; -.
Proteomes; UP000002311; Chromosome VII.
GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
GO; GO:0017119; C:Golgi transport complex; IMP:SGD.
GO; GO:0030674; F:protein binding, bridging; IMP:SGD.
GO; GO:0007030; P:Golgi organization; IMP:SGD.
GO; GO:0006891; P:intra-Golgi vesicle-mediated transport; IMP:SGD.
GO; GO:0032258; P:protein localization by the Cvt pathway; IMP:SGD.
GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
GO; GO:0000301; P:retrograde transport, vesicle recycling within Golgi; IMP:SGD.
1: Evidence at protein level;
Acetylation; Complete proteome; Golgi apparatus; Membrane;
Phosphoprotein; Protein transport; Reference proteome; Transport.
CHAIN 1 417 Conserved oligomeric Golgi complex
subunit 1.
/FTId=PRO_0000213494.
MOD_RES 1 1 N-acetylmethionine.
{ECO:0000244|PubMed:22814378}.
MOD_RES 305 305 Phosphoserine.
{ECO:0000244|PubMed:19779198}.
SEQUENCE 417 AA; 48337 MW; 65F7EF5B5194D9AB CRC64;
MDEVLPLFRD SHIPQIKDYQ LELQNDLTKT NEAFQKNLLK NYNKILSLTD SVNDLSLNLK
NVDQDFKSLC FNDEKFQLNK LTPLPYQTTT HISPPRDEEK VSIPSQNILV ISNWTISINN
FCNRIVTSTT PSRIFDELLL NFHELSLIPV PSKFEALVKD KCCRLQKFLV DSMKTLNLTL
LQWVKLYNLL NTEFSSKWDD DLLSIFNESL FETLFNDNVQ ALLISSANSK DHQYHSNQQY
KDAIVVDFVN SSTFRDHLIR RTVKEINTHL DTLSTLRAKL KEPETLHKLD IFHDNDTNLN
DGTVSPLDDD ALKQYIDTAV FYSKGLTNDT TLQIYQTVQP TIEILQNLEL YKCPQETLTD
LRNKLITQLQ EFKTQISSRL PSPLENSTSV VDDFITSYNN HNLLQLVIDQ ITQLRQQ


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