Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

Copper-transporting ATPase 1 (EC 3.6.3.54) (Copper pump 1) (Fragment)

 ATP7A_CRIGR             Reviewed;        1476 AA.
P49015;
01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
01-FEB-1996, sequence version 1.
25-OCT-2017, entry version 119.
RecName: Full=Copper-transporting ATPase 1;
EC=3.6.3.54;
AltName: Full=Copper pump 1;
Flags: Fragment;
Name=ATP7A;
Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Cricetidae; Cricetinae; Cricetulus.
NCBI_TaxID=10029;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=Ovary;
PubMed=8589689; DOI=10.1093/hmg/4.11.2117;
Camakaris J., Petris M.J., Bailey L., Shen P., Lockhart P.,
Glover T.W., Barcroft C., Patton J., Mercer J.F.B.;
"Gene amplification of the Menkes (MNK; ATP7A) P-type ATPase gene of
CHO cells is associated with copper resistance and enhanced copper
efflux.";
Hum. Mol. Genet. 4:2117-2123(1995).
-!- FUNCTION: May function in the export of copper from the cytoplasm
to an intracellular organelle. It may serve as well for the export
of other metals.
-!- CATALYTIC ACTIVITY: ATP + H(2)O + Cu(+)(Side 1) = ADP + phosphate
+ Cu(+)(Side 2).
-!- SUBUNIT: Monomer. Interacts with PDZD11 (By similarity). Interacts
with ATOX1 and COMMD1 (By similarity).
{ECO:0000250|UniProtKB:Q04656}.
-!- SUBCELLULAR LOCATION: Golgi apparatus, trans-Golgi network
membrane {ECO:0000250|UniProtKB:Q04656}; Multi-pass membrane
protein {ECO:0000255}. Cell membrane
{ECO:0000250|UniProtKB:Q04656}; Multi-pass membrane protein
{ECO:0000255}. Note=Cycles constitutively between the trans-Golgi
network (TGN) and the plasma membrane. Predominantly found in the
TGN and relocalized to the plasma membrane in response to elevated
copper levels. {ECO:0000250|UniProtKB:Q04656}.
-!- TISSUE SPECIFICITY: Expressed in most tissues except liver.
-!- SIMILARITY: Belongs to the cation transport ATPase (P-type) (TC
3.A.3) family. {ECO:0000305}.
-!- WEB RESOURCE: Name=Protein Spotlight; Note=Heavy metal - Issue 79
of February 2007;
URL="http://web.expasy.org/spotlight/back_issues/079";
-----------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
Distributed under the Creative Commons Attribution-NoDerivs License
-----------------------------------------------------------------------
EMBL; U29946; AAB39918.1; -; mRNA.
ProteinModelPortal; P49015; -.
iPTMnet; P49015; -.
HOVERGEN; HBG050616; -.
GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO; GO:0019829; F:cation-transporting ATPase activity; IEA:InterPro.
GO; GO:0005507; F:copper ion binding; IEA:InterPro.
GO; GO:0006825; P:copper ion transport; IEA:UniProtKB-KW.
CDD; cd00371; HMA; 6.
Gene3D; 3.40.1110.10; -; 1.
Gene3D; 3.40.50.1000; -; 1.
InterPro; IPR023299; ATPase_P-typ_cyto_domN.
InterPro; IPR018303; ATPase_P-typ_P_site.
InterPro; IPR023298; ATPase_P-typ_TM_dom.
InterPro; IPR008250; ATPase_P-typ_transduc_dom_A.
InterPro; IPR036412; HAD-like_sf.
InterPro; IPR023214; HAD_sf.
InterPro; IPR017969; Heavy-metal-associated_CS.
InterPro; IPR006122; HMA_Cu_ion-bd.
InterPro; IPR006121; HMA_dom.
InterPro; IPR036163; HMA_dom_sf.
InterPro; IPR027256; P-typ_ATPase_IB.
InterPro; IPR001757; P_typ_ATPase.
Pfam; PF00403; HMA; 6.
SUPFAM; SSF55008; SSF55008; 6.
SUPFAM; SSF56784; SSF56784; 2.
SUPFAM; SSF81653; SSF81653; 1.
SUPFAM; SSF81660; SSF81660; 2.
SUPFAM; SSF81665; SSF81665; 3.
TIGRFAMs; TIGR01525; ATPase-IB_hvy; 1.
TIGRFAMs; TIGR01494; ATPase_P-type; 2.
TIGRFAMs; TIGR00003; TIGR00003; 5.
PROSITE; PS00154; ATPASE_E1_E2; 1.
PROSITE; PS01047; HMA_1; 5.
PROSITE; PS50846; HMA_2; 6.
2: Evidence at transcript level;
ATP-binding; Cell membrane; Copper; Copper transport; Glycoprotein;
Golgi apparatus; Hydrolase; Ion transport; Membrane; Metal-binding;
Nucleotide-binding; Phosphoprotein; Repeat; Transmembrane;
Transmembrane helix; Transport.
CHAIN 1 >1476 Copper-transporting ATPase 1.
/FTId=PRO_0000046310.
TOPO_DOM 1 642 Cytoplasmic. {ECO:0000255}.
TRANSMEM 643 665 Helical. {ECO:0000255}.
TRANSMEM 695 717 Helical. {ECO:0000255}.
TRANSMEM 736 760 Helical. {ECO:0000255}.
TRANSMEM 770 788 Helical. {ECO:0000255}.
TRANSMEM 930 952 Helical. {ECO:0000255}.
TRANSMEM 978 998 Helical. {ECO:0000255}.
TRANSMEM 1347 1373 Helical. {ECO:0000255}.
TRANSMEM 1379 1397 Helical. {ECO:0000255}.
DOMAIN 9 75 HMA 1. {ECO:0000255|PROSITE-
ProRule:PRU00280}.
DOMAIN 172 238 HMA 2. {ECO:0000255|PROSITE-
ProRule:PRU00280}.
DOMAIN 277 343 HMA 3. {ECO:0000255|PROSITE-
ProRule:PRU00280}.
DOMAIN 377 443 HMA 4. {ECO:0000255|PROSITE-
ProRule:PRU00280}.
DOMAIN 479 545 HMA 5. {ECO:0000255|PROSITE-
ProRule:PRU00280}.
DOMAIN 555 621 HMA 6. {ECO:0000255|PROSITE-
ProRule:PRU00280}.
ACT_SITE 1034 1034 4-aspartylphosphate intermediate.
{ECO:0000305}.
MOD_RES 152 152 Phosphothreonine.
{ECO:0000250|UniProtKB:Q04656}.
MOD_RES 326 326 Phosphothreonine.
{ECO:0000250|UniProtKB:Q04656}.
MOD_RES 338 338 Phosphoserine.
{ECO:0000250|UniProtKB:Q04656}.
MOD_RES 352 352 Phosphoserine.
{ECO:0000250|UniProtKB:P70705}.
MOD_RES 356 356 Phosphoserine.
{ECO:0000250|UniProtKB:Q04656}.
MOD_RES 361 361 Phosphoserine.
{ECO:0000250|UniProtKB:Q64430}.
MOD_RES 1420 1420 Phosphoserine.
{ECO:0000250|UniProtKB:Q04656}.
MOD_RES 1422 1422 Phosphoserine.
{ECO:0000250|UniProtKB:Q04656}.
MOD_RES 1450 1450 Phosphoserine.
{ECO:0000250|UniProtKB:Q04656}.
MOD_RES 1453 1453 Phosphoserine.
{ECO:0000250|UniProtKB:Q04656}.
MOD_RES 1456 1456 Phosphoserine.
{ECO:0000250|UniProtKB:Q04656}.
MOD_RES 1459 1459 Phosphoserine.
{ECO:0000250|UniProtKB:Q04656}.
MOD_RES 1463 1463 Phosphoserine.
{ECO:0000250|UniProtKB:Q04656}.
MOD_RES 1466 1466 Phosphoserine.
{ECO:0000250|UniProtKB:Q64430}.
MOD_RES 1476 1476 Phosphoserine.
{ECO:0000250|UniProtKB:Q64430}.
CARBOHYD 674 674 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 685 685 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 887 887 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 953 953 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 1130 1130 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 1134 1134 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 1448 1448 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
NON_TER 1476 1476
SEQUENCE 1476 AA; 160336 MW; 6B36F5A2AC358C0B CRC64;
MEPSMDVNSV TISVEGMTCI SCVRTIEQKI GKENGIHHIK VSLEEKSATI IYDPKLQTPK
TLQEAIDDMG FDALLHNANP LPVLTDTLFL TVTASLTLPW DHIQSTLLKT KGVTDIKIFP
QKRTLAVTII PSIVNANQIK ELVPELSLET GTLEKRSGAC EDHSMAQAGE VVLKIKVEGM
TCHSCTSTTE GKIGKLQGVQ RIKVSLDNQE ATIVYQPHLI SVEEIKKQIE AMGFPAFVKK
QPKYLKLGAI DVERLKNTPV KSLEGSQQRP SYPSDSTATF IIEGMHCKSC VSNIESALPT
LQYVSSIAVS LENRSAIVKY NASSVTPEML IKAIEAVSPG QYRVSIANEV ESTSSSPSSS
SLQKMPLNVV SQPLTQETVI NISGMTCNSC VQSIEGVVSK KPGVKSIHVS LANSFGTVEY
DPLLTAPETL REVIVDMGFD AVLPDMSEPL VVIAQPSLET PLLPSTNDQD NMMTAVHSKC
YIQVSGMTCA SCVANIERNL RREEGIYSVL VALMAGKAEV RYNPAVIQPP VIAEFIRELG
FGATVMENAD EGDGILKLVV RGMTCASCVH KIESTLTKHK GIFYCSVALA TNKAHIKYDP
EIIGPRDIIH TIGSLGFEAS LVKKDRSASH LDHKREIKQW RSSFLVSLFF CTPVMGLMMY
MMAMEHHFAT IHHNQSMSNE EMIKNHSSMF LERQILPGLS IMNLLSLLLC LPVQFFGGWY
FYIQAYKALK HKTANMDVLI VLATTIAFAY SLIILLVAMY ERAKVNPITS FDTPPMLFVF
IALGRWLEHI AKGKTSEALA KLISLQATEA TIVTLDSDNI LLSEEQVDVE LVQRGDIIKV
VPGGKFPVDG RVIEGHSMVD ESLITGEAMP VAKKPGSTVI AGSINQNGSL LICATHVGAD
TTLSQIVKLV EEAQTSKAPI QQFADKLGGY FVPFIVLVSI ATLLVWIIIG FQNFTIVETY
FPGYSRSISR TETIIRFAFQ ASITVLCIAC PCSLGLATPT AVMVGTGVGA QNGILIKGGE
PLEMAHKVKV VVFDKTGTIT HGTPVVNQVK VLVESNKIPR SKILAIVGTA ESNSEHPLGA
AVTKYCKQEL DTETLGTCTD FQVVPGCGIS CKVTNIEGLL HKSNLKIEEN NTKNASLVQI
DAINEQSSTS SSMIIDAPLS NAVDTQQYKV LIGNREWMIR NGLVISNDVD DSMIDHGRKG
RPAVLVTIDD ELCGLIAIAD TVKPEAELAV HILKSMGLEV VLMTGDNSKT ARSIASQVGI
TKVFAEVLPS HKVAKVKQLQ EEGKRVAMVG DGINDSPALA MANVGIAIGT GTDVTIEAAD
VVFIRNDLLD VVASIDLSRK TVKRIRINFL FPLIYNLVGI PIAAGVFLPI GLVFQPWMGS
AAMAASSVSV VLSSLFLKLY RKPTYDNYEL RTRSHTGQRS PSEISVHVGI DDASRNSPRL
GLLDRIVNYS RASINSLLSD KRSLNSVVNS EPDKHS


Related products :

Catalog number Product name Quantity
18-003-42435 Copper-transporting ATPase 1 - EC 3.6.3.4; Copper pump 1; Menkes disease-associated protein Polyclonal 0.1 mg Protein A
15-288-21023 Copper-transporting ATPase 1 - EC 3.6.3.4; Copper pump 1; Menkes disease-associated protein Polyclonal 0.1 mg
15-288-21023 Copper-transporting ATPase 1 - EC 3.6.3.4; Copper pump 1; Menkes disease-associated protein Polyclonal 0.05 mg
18-003-42435 Copper-transporting ATPase 1 - EC 3.6.3.4; Copper pump 1; Menkes disease-associated protein Polyclonal 0.05 mg Aff Pur
SMC-398D Copper Transporting ATPase1 Antibody Monoclonal, Clone number: S60-4 Host: Mouse, Isotype: IgG2b Immunogen: Synthetic peptide amino acids 42-61 (cytoplasmic C-terminus) of human Copper- transporting A 100ug
SMC-399D Copper Transporting ATPase2 Antibody Monoclonal, Clone number: S62-29 Host: Mouse, Isotype: IgG1 Immunogen: Synthetic peptide amino acids 3-21 (cytoplasmic N-terminus) of human Copper-transporting ATP 100ug
EH1732 Copper-transporting ATPase 1 Elisa Kit 96T
SMC-398D Menke's Disease Protein_Cu2+ Transporting Atpase Protein, S60-4 Monoclonals AntibodiesS60_4 Synthetic peptide amino acids 42-61 (cytoplasmic C-terminus) of human Copper- transporting ATPase1 100ug
CSB-EL002414RA Rat Copper-transporting ATPase 1(ATP7A) ELISA kit 96T
CSB-EL002415RA Rat Copper-transporting ATPase 2(ATP7B) ELISA kit 96T
E1425h Human ELISA Kit FOR Copper-transporting ATPase 2 96T
CSB-EL002414HU Human Copper-transporting ATPase 1(ATP7A) ELISA kit 96T
AE54895SH Sheep Copper-transporting ATPase 2 (ATP7B) ELISA Kit 48T
CSB-EL002415HU Human Copper-transporting ATPase 2(ATP7B) ELISA kit 96T
CSB-EL002415RA Rat Copper-transporting ATPase 2(ATP7B) ELISA kit SpeciesRat 96T
CSB-EL002414RA Rat Copper-transporting ATPase 1(ATP7A) ELISA kit SpeciesRat 96T
CSB-EL002414MO Mouse Copper-transporting ATPase 1(ATP7A) ELISA kit 96T
CSB-EL002415MO Mouse Copper-transporting ATPase 2(ATP7B) ELISA kit 96T
CSB-EL002415SH Sheep Copper-transporting ATPase 2(ATP7B) ELISA kit SpeciesSheep 96T
CSB-EL002415MO Mouse Copper-transporting ATPase 2(ATP7B) ELISA kit SpeciesMouse 96T
CSB-EL002414MO Mouse Copper-transporting ATPase 1(ATP7A) ELISA kit SpeciesMouse 96T
CSB-EL002415HU Human Copper-transporting ATPase 2(ATP7B) ELISA kit SpeciesHuman 96T
CSB-EL002414HU Human Copper-transporting ATPase 1(ATP7A) ELISA kit SpeciesHuman 96T
ATP7B_MOUSE ELISA Kit FOR Copper-transporting ATPase 2; organism: Mouse; gene name: Atp7b 96T
ATP7A_HUMAN ELISA Kit FOR Copper-transporting ATPase 1; organism: Human; gene name: ATP7A 96T


 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur





GENTAUR Ltd.
Howard Frank Turnberry House
1404-1410 High Road
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017

BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG

france@gentaur.com | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: 0035929830070
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.


ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur