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Corticoliberin (Corticotropin-releasing factor) (CRF) (Corticotropin-releasing hormone)

 CRF_PIG                 Reviewed;         191 AA.
P06296; O62637; Q0ZLZ2; Q8HZV1;
01-JAN-1988, integrated into UniProtKB/Swiss-Prot.
26-FEB-2008, sequence version 3.
30-AUG-2017, entry version 107.
RecName: Full=Corticoliberin;
AltName: Full=Corticotropin-releasing factor;
Short=CRF;
AltName: Full=Corticotropin-releasing hormone;
Flags: Precursor;
Name=CRH;
Sus scrofa (Pig).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Suina; Suidae;
Sus.
NCBI_TaxID=9823;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
PubMed=9734873; DOI=10.2527/1998.7682205x;
Mimmack M.L., Parrott R.F., Vellucci S.V.;
"Molecular cloning of the porcine corticotropin-releasing factor
gene.";
J. Anim. Sci. 76:2205-2206(1998).
[2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
PubMed=12030933; DOI=10.1046/j.1365-2052.2002.t01-3-00876.x;
Wimmers K., Murani E., Ponsuksili S., Schellander K.;
"Sequence variation and linkage mapping of the porcine corticotropin
releasing hormone (CRH) gene.";
Anim. Genet. 33:233-234(2002).
[3]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
PubMed=16483545; DOI=10.1016/j.bbrc.2006.01.143;
Murani E., Muraniova M., Ponsuksili S., Schellander K., Wimmers K.;
"Molecular characterization and evidencing of the porcine CRH gene as
a functional-positional candidate for growth and body composition.";
Biochem. Biophys. Res. Commun. 342:394-405(2006).
[4]
PROTEIN SEQUENCE OF 149-189, FUNCTION, SUBCELLULAR LOCATION, AND
TISSUE SPECIFICITY.
PubMed=3878520; DOI=10.1073/pnas.82.24.8762;
Patthy M., Horvath J., Mason-Garcia M., Szoke B., Schlesinger D.H.,
Schally A.V.;
"Isolation and amino acid sequence of corticotropin-releasing factor
from pig hypothalami.";
Proc. Natl. Acad. Sci. U.S.A. 82:8762-8766(1985).
-!- FUNCTION: Hormone regulating the release of corticotropin from
pituitary gland (PubMed:3878520). Induces NLRP6 in intestinal
epithelial cells, hence may influence gut microbiota profile (By
similarity). {ECO:0000250|UniProtKB:Q8CIT0,
ECO:0000269|PubMed:3878520}.
-!- SUBUNIT: Interacts (via C-terminus) with CRFR1 (via N-terminal
extracellular domain). {ECO:0000250|UniProtKB:P06850}.
-!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:3878520}.
-!- TISSUE SPECIFICITY: Produced by the hypothalamus.
{ECO:0000269|PubMed:3878520}.
-!- SIMILARITY: Belongs to the sauvagine/corticotropin-releasing
factor/urotensin I family. {ECO:0000305}.
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EMBL; Y15159; CAA75424.1; -; Genomic_DNA.
EMBL; AF440229; AAN40888.1; -; Genomic_DNA.
EMBL; DQ358705; ABD34973.1; -; Genomic_DNA.
PIR; A01404; RHPGCE.
RefSeq; NP_001106533.1; NM_001113062.1.
RefSeq; XP_013852166.1; XM_013996712.1.
UniGene; Ssc.69887; -.
ProteinModelPortal; P06296; -.
SMR; P06296; -.
STRING; 9823.ENSSSCP00000006626; -.
PaxDb; P06296; -.
PRIDE; P06296; -.
Ensembl; ENSSSCT00000006811; ENSSSCP00000006626; ENSSSCG00000006215.
GeneID; 100127468; -.
KEGG; ssc:100127468; -.
CTD; 1392; -.
eggNOG; ENOG410IWZK; Eukaryota.
eggNOG; ENOG4111ZIN; LUCA.
GeneTree; ENSGT00510000048573; -.
HOGENOM; HOG000004762; -.
HOVERGEN; HBG001951; -.
InParanoid; P06296; -.
KO; K05256; -.
OMA; YFIRLGN; -.
OrthoDB; EOG091G0QDI; -.
TreeFam; TF332956; -.
Reactome; R-SSC-373080; Class B/2 (Secretin family receptors).
Reactome; R-SSC-418555; G alpha (s) signalling events.
Proteomes; UP000008227; Chromosome 4.
Bgee; ENSSSCG00000006215; -.
ExpressionAtlas; P06296; differential.
GO; GO:0005615; C:extracellular space; IBA:GO_Central.
GO; GO:0017045; F:corticotropin-releasing hormone activity; IBA:GO_Central.
GO; GO:0005184; F:neuropeptide hormone activity; IBA:GO_Central.
GO; GO:0030325; P:adrenal gland development; IEA:Ensembl.
GO; GO:0007565; P:female pregnancy; IEA:Ensembl.
GO; GO:0006704; P:glucocorticoid biosynthetic process; IEA:Ensembl.
GO; GO:0006954; P:inflammatory response; IEA:Ensembl.
GO; GO:0035641; P:locomotory exploration behavior; IEA:Ensembl.
GO; GO:0030324; P:lung development; IEA:Ensembl.
GO; GO:0032811; P:negative regulation of epinephrine secretion; IBA:GO_Central.
GO; GO:0070093; P:negative regulation of glucagon secretion; IBA:GO_Central.
GO; GO:0051464; P:positive regulation of cortisol secretion; IBA:GO_Central.
GO; GO:2000310; P:regulation of NMDA receptor activity; IEA:Ensembl.
GO; GO:0007165; P:signal transduction; IBA:GO_Central.
GO; GO:0001963; P:synaptic transmission, dopaminergic; IEA:Ensembl.
InterPro; IPR018446; Corticotropin-releasing_fac_CS.
InterPro; IPR000187; CRF.
InterPro; IPR003620; Urocortin_CRF.
PANTHER; PTHR15035; PTHR15035; 1.
Pfam; PF00473; CRF; 1.
PRINTS; PR01612; CRFFAMILY.
SMART; SM00039; CRF; 1.
PROSITE; PS00511; CRF; 1.
1: Evidence at protein level;
Amidation; Cleavage on pair of basic residues; Complete proteome;
Direct protein sequencing; Hormone; Reference proteome; Secreted;
Signal.
SIGNAL 1 24 {ECO:0000255}.
PROPEP 25 148 {ECO:0000269|PubMed:3878520}.
/FTId=PRO_0000006216.
PEPTIDE 149 189 Corticoliberin.
/FTId=PRO_0000006217.
MOD_RES 189 189 Isoleucine amide.
{ECO:0000250|UniProtKB:P06850}.
CONFLICT 7 7 V -> A (in Ref. 2; AAN40888).
{ECO:0000305}.
CONFLICT 39 40 QH -> HS (in Ref. 1; CAA75424).
{ECO:0000305}.
CONFLICT 79 79 S -> N (in Ref. 1; CAA75424).
{ECO:0000305}.
CONFLICT 120 120 P -> R (in Ref. 1; CAA75424).
{ECO:0000305}.
CONFLICT 188 188 I -> F (in Ref. 4; AA sequence).
{ECO:0000305}.
SEQUENCE 191 AA; 20997 MW; 587E58F516AB9006 CRC64;
MRLPLLVSAG VLLVALLPCP PCRALLSRGP VLGARQAPQH PQALDFLQPQ QQPQQPQPRP
VLLRMGEEYF LRLGNLNKSP AAPLSPASSP LTGSSGNRPD EVAANFFRAL LQQLPLPRRP
LDSPSGPAER GAENALSSRQ EAPERERRSE EPPISLDLTF HLLREVLEMA RAEQLAQQAH
SNRKLMEIIG K


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