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Corticoliberin (Corticotropin-releasing factor) (CRF) (Corticotropin-releasing hormone)

 CRF_CANLF               Reviewed;         196 AA.
P49926; Q75QJ9;
01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
12-APR-2005, sequence version 2.
05-JUL-2017, entry version 86.
RecName: Full=Corticoliberin;
AltName: Full=Corticotropin-releasing factor;
Short=CRF;
AltName: Full=Corticotropin-releasing hormone;
Flags: Precursor;
Name=CRH;
Canis lupus familiaris (Dog) (Canis familiaris).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae;
Canis.
NCBI_TaxID=9615;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Kansaku N., Yamagishi K., Mizushima S.;
"PCR cloning of dog corticotropin releasing hormone gene.";
Submitted (FEB-2004) to the EMBL/GenBank/DDBJ databases.
[2]
PRELIMINARY NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 73-196, AND TISSUE
SPECIFICITY.
STRAIN=Mongrel; TISSUE=Blood;
PubMed=7969821; DOI=10.1016/0143-4179(94)90010-8;
Mol J.A., van Wolferen M., Kwant M., Meloen R.;
"Predicted primary and antigenic structure of canine corticotropin
releasing hormone.";
Neuropeptides 27:7-13(1994).
-!- FUNCTION: Hormone regulating the release of corticotropin from
pituitary gland (By similarity). Induces NLRP6 in intestinal
epithelial cells, hence may influence gut microbiota profile (By
similarity). {ECO:0000250|UniProtKB:P06296,
ECO:0000250|UniProtKB:Q8CIT0}.
-!- SUBUNIT: Interacts (via C-terminus) with CRFR1 (via N-terminal
extracellular domain). {ECO:0000250|UniProtKB:P06850}.
-!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P06296}.
-!- TISSUE SPECIFICITY: Produced by the hypothalamus.
{ECO:0000269|PubMed:7969821}.
-!- SIMILARITY: Belongs to the sauvagine/corticotropin-releasing
factor/urotensin I family. {ECO:0000305}.
-!- SEQUENCE CAUTION:
Sequence=AAB32322.1; Type=Frameshift; Positions=Several; Evidence={ECO:0000305};
Sequence=AAB32322.1; Type=Miscellaneous discrepancy; Note=Sequencing errors.; Evidence={ECO:0000305};
-----------------------------------------------------------------------
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EMBL; AB162117; BAD10983.1; -; Genomic_DNA.
EMBL; S74126; AAB32322.1; ALT_SEQ; Genomic_DNA.
PIR; I46994; I46994.
UniGene; Cfa.9427; -.
ProteinModelPortal; P49926; -.
SMR; P49926; -.
STRING; 9615.ENSCAFP00000040748; -.
PaxDb; P49926; -.
eggNOG; ENOG410IWZK; Eukaryota.
eggNOG; ENOG4111ZIN; LUCA.
HOVERGEN; HBG001951; -.
InParanoid; P49926; -.
Proteomes; UP000002254; Unplaced.
GO; GO:0005615; C:extracellular space; IBA:GO_Central.
GO; GO:0017045; F:corticotropin-releasing hormone activity; IBA:GO_Central.
GO; GO:0005184; F:neuropeptide hormone activity; IBA:GO_Central.
GO; GO:0032811; P:negative regulation of epinephrine secretion; IBA:GO_Central.
GO; GO:0070093; P:negative regulation of glucagon secretion; IBA:GO_Central.
GO; GO:0051464; P:positive regulation of cortisol secretion; IBA:GO_Central.
GO; GO:0007165; P:signal transduction; IBA:GO_Central.
InterPro; IPR018446; Corticotropin-releasing_fac_CS.
InterPro; IPR000187; CRF.
InterPro; IPR003620; Urocortin_CRF.
PANTHER; PTHR15035; PTHR15035; 1.
Pfam; PF00473; CRF; 1.
PRINTS; PR01612; CRFFAMILY.
SMART; SM00039; CRF; 1.
PROSITE; PS00511; CRF; 1.
2: Evidence at transcript level;
Amidation; Cleavage on pair of basic residues; Complete proteome;
Hormone; Reference proteome; Secreted; Signal.
SIGNAL 1 24 {ECO:0000255}.
PROPEP 25 153 {ECO:0000250}.
/FTId=PRO_0000006210.
PEPTIDE 154 194 Corticoliberin.
/FTId=PRO_0000006211.
MOD_RES 194 194 Isoleucine amide. {ECO:0000250}.
SEQUENCE 196 AA; 21547 MW; A59DE46526C801F8 CRC64;
MRLPLLLSAG VLLVVSLPCP PCRALLSRGP IPGARQAAQH PQPLDFFQLP PQPQQPQQPQ
ARPVLYRMGE EYFLRLGNLN KSPAAPLLPA SSPVAGGSGS RLSPDEAAAN FFRALLQQLP
LPRRQLDSPA GPAERGEENA LGSRQETPER ERRSEEPPIS LDLTFHLLRE VLEMARAEQL
AQQAHSNRKL MEIIGK


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