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Corticoliberin (Corticotropin-releasing factor) (CRF) (Corticotropin-releasing hormone)

 CRF_MOUSE               Reviewed;         187 AA.
Q8CIT0; Q14AA2;
12-APR-2005, integrated into UniProtKB/Swiss-Prot.
01-MAR-2003, sequence version 1.
25-OCT-2017, entry version 98.
RecName: Full=Corticoliberin;
AltName: Full=Corticotropin-releasing factor;
Short=CRF;
AltName: Full=Corticotropin-releasing hormone;
Flags: Precursor;
Name=Crh; Synonyms=Gm1347;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND TISSUE SPECIFICITY.
STRAIN=BALB/cJ;
PubMed=19912808;
Seasholtz A.F., Bourbonais F.J., Harnden C.E., Camper S.A.;
"Nucleotide sequence and expression of the mouse corticotropin-
releasing hormone gene.";
Mol. Cell. Neurosci. 2:266-273(1991).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Brain;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[3]
FUNCTION, AND INDUCTION BY STRESS.
PubMed=23470617; DOI=10.1053/j.gastro.2013.02.038;
Sun Y., Zhang M., Chen C.C., Gillilland M. III, Sun X., El-Zaatari M.,
Huffnagle G.B., Young V.B., Zhang J., Hong S.C., Chang Y.M.,
Gumucio D.L., Owyang C., Kao J.Y.;
"Stress-induced corticotropin-releasing hormone-mediated NLRP6
inflammasome inhibition and transmissible enteritis in mice.";
Gastroenterology 144:1478-1487(2013).
-!- FUNCTION: Hormone regulating the release of corticotropin from
pituitary gland. Induces NLRP6 in intestinal epithelial cells,
hence may influence gut microbiota profile (PubMed:23470617).
{ECO:0000250|UniProtKB:P06296, ECO:0000269|PubMed:23470617}.
-!- SUBUNIT: Interacts (via C-terminus) with CRFR1 (via N-terminal
extracellular domain). {ECO:0000250|UniProtKB:P06850}.
-!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P06296}.
-!- TISSUE SPECIFICITY: Expressed in parvocellular paraventricular
nucleus of the hypothalamus and in medial accessory olivary
nucleus. {ECO:0000269|PubMed:19912808}.
-!- INDUCTION: Up-regulated during water-avoidance stress.
{ECO:0000269|PubMed:23470617}.
-!- SIMILARITY: Belongs to the sauvagine/corticotropin-releasing
factor/urotensin I family. {ECO:0000305}.
-----------------------------------------------------------------------
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EMBL; AY128673; AAN07905.1; -; Genomic_DNA.
EMBL; BC116921; AAI16922.1; -; mRNA.
EMBL; BC119036; AAI19037.1; -; mRNA.
CCDS; CCDS17258.1; -.
RefSeq; NP_991338.1; NM_205769.3.
UniGene; Mm.290689; -.
ProteinModelPortal; Q8CIT0; -.
SMR; Q8CIT0; -.
STRING; 10090.ENSMUSP00000061185; -.
PhosphoSitePlus; Q8CIT0; -.
PaxDb; Q8CIT0; -.
PRIDE; Q8CIT0; -.
Ensembl; ENSMUST00000061294; ENSMUSP00000061185; ENSMUSG00000049796.
GeneID; 12918; -.
KEGG; mmu:12918; -.
UCSC; uc008orx.2; mouse.
CTD; 1392; -.
MGI; MGI:88496; Crh.
eggNOG; ENOG410IWZK; Eukaryota.
eggNOG; ENOG4111ZIN; LUCA.
GeneTree; ENSGT00510000048573; -.
HOGENOM; HOG000004762; -.
HOVERGEN; HBG001951; -.
InParanoid; Q8CIT0; -.
KO; K05256; -.
OMA; YFIRLGN; -.
OrthoDB; EOG091G0QDI; -.
PhylomeDB; Q8CIT0; -.
TreeFam; TF332956; -.
Reactome; R-MMU-373080; Class B/2 (Secretin family receptors).
Reactome; R-MMU-418555; G alpha (s) signalling events.
PRO; PR:Q8CIT0; -.
Proteomes; UP000000589; Chromosome 3.
Bgee; ENSMUSG00000049796; -.
CleanEx; MM_CRH; -.
Genevisible; Q8CIT0; MM.
GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
GO; GO:0005615; C:extracellular space; ISO:MGI.
GO; GO:0043204; C:perikaryon; IEA:Ensembl.
GO; GO:0043196; C:varicosity; IEA:Ensembl.
GO; GO:0017045; F:corticotropin-releasing hormone activity; IBA:GO_Central.
GO; GO:0051430; F:corticotropin-releasing hormone receptor 1 binding; IEA:Ensembl.
GO; GO:0051431; F:corticotropin-releasing hormone receptor 2 binding; IEA:Ensembl.
GO; GO:0005184; F:neuropeptide hormone activity; IBA:GO_Central.
GO; GO:0030325; P:adrenal gland development; IMP:MGI.
GO; GO:0008306; P:associative learning; IEA:Ensembl.
GO; GO:0071314; P:cellular response to cocaine; IEA:Ensembl.
GO; GO:0071549; P:cellular response to dexamethasone stimulus; IEA:Ensembl.
GO; GO:0016101; P:diterpenoid metabolic process; IEA:Ensembl.
GO; GO:0007565; P:female pregnancy; ISO:MGI.
GO; GO:0006704; P:glucocorticoid biosynthetic process; IMP:MGI.
GO; GO:0008628; P:hormone-mediated apoptotic signaling pathway; IEA:Ensembl.
GO; GO:0021854; P:hypothalamus development; IEA:Ensembl.
GO; GO:0006954; P:inflammatory response; IMP:MGI.
GO; GO:0050801; P:ion homeostasis; IEA:Ensembl.
GO; GO:0035641; P:locomotory exploration behavior; IGI:MGI.
GO; GO:0060291; P:long-term synaptic potentiation; IEA:Ensembl.
GO; GO:0030324; P:lung development; IMP:MGI.
GO; GO:0045776; P:negative regulation of blood pressure; IEA:Ensembl.
GO; GO:0060548; P:negative regulation of cell death; IEA:Ensembl.
GO; GO:0032811; P:negative regulation of epinephrine secretion; IBA:GO_Central.
GO; GO:0010629; P:negative regulation of gene expression; IEA:Ensembl.
GO; GO:0070093; P:negative regulation of glucagon secretion; IBA:GO_Central.
GO; GO:0033685; P:negative regulation of luteinizing hormone secretion; IEA:Ensembl.
GO; GO:0010700; P:negative regulation of norepinephrine secretion; IEA:Ensembl.
GO; GO:2000987; P:positive regulation of behavioral fear response; IEA:Ensembl.
GO; GO:0090280; P:positive regulation of calcium ion import; IEA:Ensembl.
GO; GO:0030819; P:positive regulation of cAMP biosynthetic process; IEA:Ensembl.
GO; GO:0010942; P:positive regulation of cell death; IEA:Ensembl.
GO; GO:0008284; P:positive regulation of cell proliferation; IEA:Ensembl.
GO; GO:2000854; P:positive regulation of corticosterone secretion; IEA:Ensembl.
GO; GO:0051461; P:positive regulation of corticotropin secretion; IEA:Ensembl.
GO; GO:0051464; P:positive regulation of cortisol secretion; ISO:MGI.
GO; GO:0060456; P:positive regulation of digestive system process; IEA:Ensembl.
GO; GO:0010628; P:positive regulation of gene expression; IEA:Ensembl.
GO; GO:0035774; P:positive regulation of insulin secretion involved in cellular response to glucose stimulus; IEA:Ensembl.
GO; GO:0001934; P:positive regulation of protein phosphorylation; IEA:Ensembl.
GO; GO:2000310; P:regulation of NMDA receptor activity; ISO:MGI.
GO; GO:0014062; P:regulation of serotonin secretion; IEA:Ensembl.
GO; GO:0051412; P:response to corticosterone; IEA:Ensembl.
GO; GO:0042493; P:response to drug; IEA:Ensembl.
GO; GO:0043627; P:response to estrogen; IEA:Ensembl.
GO; GO:0045471; P:response to ethanol; IEA:Ensembl.
GO; GO:0045472; P:response to ether; IEA:Ensembl.
GO; GO:0035902; P:response to immobilization stress; IEA:Ensembl.
GO; GO:0048265; P:response to pain; IEA:Ensembl.
GO; GO:0007165; P:signal transduction; IBA:GO_Central.
GO; GO:0001963; P:synaptic transmission, dopaminergic; ISO:MGI.
InterPro; IPR018446; Corticotropin-releasing_fac_CS.
InterPro; IPR000187; CRF.
InterPro; IPR003620; Urocortin_CRF.
PANTHER; PTHR15035; PTHR15035; 1.
Pfam; PF00473; CRF; 1.
PRINTS; PR01612; CRFFAMILY.
SMART; SM00039; CRF; 1.
PROSITE; PS00511; CRF; 1.
2: Evidence at transcript level;
Amidation; Cleavage on pair of basic residues; Complete proteome;
Hormone; Reference proteome; Secreted; Signal.
SIGNAL 1 19 {ECO:0000255}.
PROPEP 20 144 {ECO:0000250}.
/FTId=PRO_0000006214.
PEPTIDE 145 185 Corticoliberin.
/FTId=PRO_0000006215.
MOD_RES 185 185 Isoleucine amide. {ECO:0000250}.
SEQUENCE 187 AA; 20778 MW; 5E51665291FAA998 CRC64;
MRLRLLVSAG MLLVALSSCL PCRALLSRGS VPRAPRAPQP LNFLQPEQPQ QPQPVLIRMG
EEYFLRLGNL NRSPAARLSP NSTPLTAGRG SRPSHDQAAA NFFRVLLQQL QMPQRSLDSR
AEPAERGAED ALGGHQGALE RERRSEEPPI SLDLTFHLLR EVLEMARAEQ LAQQAHSNRK
LMEIIGK


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