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Corticoliberin (Corticotropin-releasing factor) (CRF) (Corticotropin-releasing hormone) (Endorpholiberin)

 CRF_SHEEP               Reviewed;         190 AA.
P01142;
21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
01-JAN-1988, sequence version 1.
10-MAY-2017, entry version 88.
RecName: Full=Corticoliberin;
AltName: Full=Corticotropin-releasing factor;
Short=CRF;
AltName: Full=Corticotropin-releasing hormone;
AltName: Full=Endorpholiberin;
Flags: Precursor;
Name=CRH;
Ovis aries (Sheep).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
Pecora; Bovidae; Caprinae; Ovis.
NCBI_TaxID=9940;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
PubMed=6600512; DOI=10.1038/301537a0;
Furutani Y., Morimoto Y., Shibahara S., Noda M., Takahashi H.,
Hirose T., Asai M., Inayama S., Hayashida H., Miyata T., Numa S.;
"Cloning and sequence analysis of cDNA for ovine corticotropin-
releasing factor precursor.";
Nature 301:537-540(1983).
[2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND TISSUE SPECIFICITY.
PubMed=3265687; DOI=10.1016/0378-1119(88)90059-5;
Roche P.J., Crawford R.J., Fernley R.T., Tregear G.W., Coghlan J.P.;
"Nucleotide sequence of the gene coding for ovine corticotropin-
releasing factor and regulation of its mRNA levels by
glucocorticoids.";
Gene 71:421-431(1988).
[3]
PROTEIN SEQUENCE OF 148-188, FUNCTION, AMIDATION AT ALA-188, AND
SUBCELLULAR LOCATION.
PubMed=6273874; DOI=10.1073/pnas.78.10.6517;
Spiess J., Rivier J., Rivier C., Vale W.;
"Primary structure of corticotropin-releasing factor from ovine
hypothalamus.";
Proc. Natl. Acad. Sci. U.S.A. 78:6517-6521(1981).
[4]
PROTEIN SEQUENCE OF 148-188, SYNTHESIS OF 148-188, AND FUNCTION.
PubMed=6267699; DOI=10.1126/science.6267699;
Vale W., Spiess J., Rivier C., Rivier J.;
"Characterization of a 41-residue ovine hypothalamic peptide that
stimulates secretion of corticotropin and beta-endorphin.";
Science 213:1394-1397(1981).
[5]
PROTEIN SEQUENCE OF 148-188.
PubMed=2647152; DOI=10.1016/0167-4838(89)90226-4;
Audhya T., Hollander C.S., Schlesinger D.H., Hutchinson B.;
"Structural characterization and localization of corticotropin-
releasing factor in testis.";
Biochim. Biophys. Acta 995:10-16(1989).
-!- FUNCTION: Hormone regulating the release of corticotropin from
pituitary gland (PubMed:6267699, PubMed:6273874). Induces NLRP6 in
intestinal epithelial cells, hence may influence gut microbiota
profile (By similarity). {ECO:0000250|UniProtKB:Q8CIT0,
ECO:0000269|PubMed:6267699, ECO:0000269|PubMed:6273874}.
-!- SUBUNIT: Interacts (via C-terminus) with CRFR1 (via N-terminal
extracellular domain). {ECO:0000250|UniProtKB:P06850}.
-!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:6273874}.
-!- TISSUE SPECIFICITY: Produced by the hypothalamus.
{ECO:0000269|PubMed:3265687}.
-!- SIMILARITY: Belongs to the sauvagine/corticotropin-releasing
factor/urotensin I family. {ECO:0000305}.
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EMBL; J00803; AAA31512.1; -; mRNA.
EMBL; M22853; AAA31513.1; -; Genomic_DNA.
PIR; JS0030; RHSHCE.
ProteinModelPortal; P01142; -.
SMR; P01142; -.
HOVERGEN; HBG001951; -.
Proteomes; UP000002356; Unplaced.
GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
GO; GO:2000310; P:regulation of NMDA receptor activity; IDA:UniProtKB.
GO; GO:0001963; P:synaptic transmission, dopaminergic; IDA:UniProtKB.
InterPro; IPR018446; Corticotropin-releasing_fac_CS.
InterPro; IPR000187; CRF.
InterPro; IPR003620; Urocortin_CRF.
PANTHER; PTHR15035; PTHR15035; 1.
Pfam; PF00473; CRF; 1.
PRINTS; PR01612; CRFFAMILY.
SMART; SM00039; CRF; 1.
PROSITE; PS00511; CRF; 1.
1: Evidence at protein level;
Amidation; Cleavage on pair of basic residues; Complete proteome;
Direct protein sequencing; Hormone; Reference proteome; Secreted;
Signal.
SIGNAL 1 24 {ECO:0000305}.
PROPEP 25 147 {ECO:0000269|PubMed:2647152,
ECO:0000269|PubMed:6267699,
ECO:0000269|PubMed:6273874}.
/FTId=PRO_0000006220.
PEPTIDE 148 188 Corticoliberin.
{ECO:0000269|PubMed:6273874}.
/FTId=PRO_0000006221.
MOD_RES 188 188 Alanine amide.
{ECO:0000269|PubMed:6273874}.
CONFLICT 127 127 K -> E (in Ref. 2; AAA31513).
{ECO:0000305}.
SEQUENCE 190 AA; 20672 MW; E9599B97E85186FE CRC64;
MRLPLLVSVG VLLVALLPSP PCRALLSRGP IPGARQASQH PQPLSFFQPL PQPQEPQALP
TLLRVGEEYF LRLGNLDETR AAPLSPAASP LASRSSSRLS PDKVAANFFR ALLQPRRPLD
SPAGPAKRGT ENALGSRQEA PAARKRRSQE PPISLDLTFH LLREVLEMTK ADQLAQQAHS
NRKLLDIAGK


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